JP2020513021A5 - - Google Patents
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- JP2020513021A5 JP2020513021A5 JP2019555001A JP2019555001A JP2020513021A5 JP 2020513021 A5 JP2020513021 A5 JP 2020513021A5 JP 2019555001 A JP2019555001 A JP 2019555001A JP 2019555001 A JP2019555001 A JP 2019555001A JP 2020513021 A5 JP2020513021 A5 JP 2020513021A5
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- JP
- Japan
- Prior art keywords
- compound
- salt
- represented
- formula
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 35
- 150000003839 salts Chemical class 0.000 claims 20
- 0 C[C@@](CC(C[C@](C)[C@@]1O[C@@](CN)[C@](*)C[C@@]1*)=O)[C@](*)C=CI Chemical compound C[C@@](CC(C[C@](C)[C@@]1O[C@@](CN)[C@](*)C[C@@]1*)=O)[C@](*)C=CI 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022106421A JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
| JP2023206236A JP7696416B2 (ja) | 2017-04-05 | 2023-12-06 | 大環状化合物およびその使用 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762482030P | 2017-04-05 | 2017-04-05 | |
| US62/482,030 | 2017-04-05 | ||
| US201762526677P | 2017-06-29 | 2017-06-29 | |
| US62/526,677 | 2017-06-29 | ||
| US201762586416P | 2017-11-15 | 2017-11-15 | |
| US62/586,416 | 2017-11-15 | ||
| US15/814,105 | 2017-11-15 | ||
| US15/814,105 US9938288B1 (en) | 2017-04-05 | 2017-11-15 | Macrocyclic compound and uses thereof |
| PCT/US2018/025887 WO2018187331A1 (en) | 2017-04-05 | 2018-04-03 | Macrocyclic compound and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022106421A Division JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513021A JP2020513021A (ja) | 2020-04-30 |
| JP2020513021A5 true JP2020513021A5 (enExample) | 2021-05-13 |
| JP7168580B2 JP7168580B2 (ja) | 2022-11-09 |
Family
ID=63104288
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019555001A Active JP7168580B2 (ja) | 2017-04-05 | 2018-04-03 | 大環状化合物およびその使用 |
| JP2018071700A Active JP6366873B1 (ja) | 2017-04-05 | 2018-04-03 | 大環状化合物およびその使用 |
| JP2022106421A Active JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
| JP2023206236A Active JP7696416B2 (ja) | 2017-04-05 | 2023-12-06 | 大環状化合物およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018071700A Active JP6366873B1 (ja) | 2017-04-05 | 2018-04-03 | 大環状化合物およびその使用 |
| JP2022106421A Active JP7400025B2 (ja) | 2017-04-05 | 2022-06-30 | 大環状化合物およびその使用 |
| JP2023206236A Active JP7696416B2 (ja) | 2017-04-05 | 2023-12-06 | 大環状化合物およびその使用 |
Country Status (33)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| JP7168580B2 (ja) | 2017-04-05 | 2022-11-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびその使用 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| IL295588B2 (en) * | 2017-07-06 | 2024-03-01 | Harvard College | Synthesis of halichondrins |
| ES2974243T3 (es) * | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
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| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| US5338865A (en) | 1992-03-12 | 1994-08-16 | President And Fellows Of Harvard College | Synthesis of halichondrin B and norhalichondrin B |
| US5436238A (en) | 1992-03-12 | 1995-07-25 | President And Fellows Of Harvard College | Halichondrins and related compounds |
| GB9206244D0 (en) | 1992-03-23 | 1992-05-06 | Pharma Mar Sa | Cytotoxic compound from a marine sponge |
| DE4229425A1 (de) | 1992-09-03 | 1994-03-10 | Kodak Ag | Vorrichtung zum stapelweisen Ablegen und Ausrichten von einzeln zugeführten Blättern |
| US5426194A (en) * | 1993-01-19 | 1995-06-20 | Arizona Board Of Regents, A Body Corporate Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 1 |
| US5352804A (en) * | 1993-01-19 | 1994-10-04 | Arizona Board Of Regents, A Body Corporate, Acting On Behalf Of Arizona State University | Isolation and structure of Halistatin 2 |
| JP2818381B2 (ja) | 1994-01-18 | 1998-10-30 | 帝人株式会社 | ７−チアプロスタグランジン類およびその製造法 |
| US8097648B2 (en) * | 1998-06-17 | 2012-01-17 | Eisai R&D Management Co., Ltd. | Methods and compositions for use in treating cancer |
| US6653341B1 (en) | 1998-06-17 | 2003-11-25 | Eisai Co., Ltd. | Methods and compositions for use in treating cancer |
| IL139960A0 (en) | 1998-06-17 | 2002-02-10 | Eisai Co Ltd | Macrocylic analogs and methods of their use and preparation |
| JP2001305734A (ja) | 2000-04-20 | 2001-11-02 | Fuji Photo Film Co Ltd | 光重合性組成物 |
| JP2003261447A (ja) | 2002-03-07 | 2003-09-16 | Kyosei Seiyaku Kk | 抗腫瘍剤 |
| CN101899026B (zh) | 2004-06-03 | 2016-08-03 | 卫材R&D管理有限公司 | 用于制备软海绵素b的类似物的中间体 |
| US7842815B2 (en) * | 2004-06-17 | 2010-11-30 | Infinity Pharmaceuticals, Inc. | Compounds and methods for inhibiting the interaction of BCL proteins with binding partners |
| WO2006076100A2 (en) | 2004-12-09 | 2006-07-20 | Eisai Co. Ltd. | Tubulin isotype screening in cancer therapy using halichondrin b analogs |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| BRPI0808252A2 (pt) | 2007-03-07 | 2014-07-01 | Interdigital Tech Corp | Método e dispositivo para que se gere e se processe uma unidade de dados de protocolo mac-ehs. |
| CN101918844A (zh) | 2007-06-18 | 2010-12-15 | 米迪缪尼有限公司 | 表达epha2和erbb2的细胞的协同治疗 |
| BRPI0817909B1 (pt) | 2007-10-03 | 2022-06-21 | Eisai R&D Management Co., Ltd | Métodos de obtenção e de preparação de uma composição diastereomericamente pura, compostos, e método para produzir os referidos compostos |
| JP5134686B2 (ja) | 2007-11-16 | 2013-01-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂアナログ合成のための新規な中間体及び前記中間体に用いるための新規な脱スルホニル化反応 |
| JP6001857B2 (ja) | 2008-04-04 | 2016-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンｂ類似体 |
| BR112012018232B8 (pt) | 2010-01-26 | 2023-01-10 | Eisai R&D Man Co Ltd | Compostos derivados de furo [3,2-b] pirano úteis na síntese de análogos de halicondrina b e métodos de sintetização de er-80402 e de eribulina |
| EP2663337A4 (en) | 2011-01-10 | 2014-06-11 | Harvard College | METHOD OF DELIVERING AGENTS IN CELLS BY BACTERIAL TOXINE |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| EP2791123B1 (en) | 2011-12-16 | 2018-07-18 | Sandoz AG | Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl) propanol derivatives and intermediates useful thereof |
| AU2012363334B2 (en) | 2011-12-29 | 2017-02-02 | Alphora Research Inc. | 2-((2s,3s,4r,5r)-5-((s)-3-amino-2-hydroxyprop-1-yl)-4-methoxy-3-(phenylsulfonylmethyl) tetrahydrofuran-2-yl)acetaldehyde derivatives and process for their preparation |
| CN104334562A (zh) | 2012-03-30 | 2015-02-04 | 阿方拉研究股份有限公司 | 用于制备软海绵素b的大环c1-酮类似物的合成方法及其中有用的中间体 |
| AU2012395673A1 (en) * | 2012-11-30 | 2014-08-14 | Hangzhou Zylox Pharma Co., Ltd. | Rapamycin analogs and methods for making same |
| WO2014183211A1 (en) | 2013-05-15 | 2014-11-20 | Alphora Research Inc. | 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof |
| AU2014286880B2 (en) | 2013-07-03 | 2017-12-14 | Sandoz Ag | Synthetic process for preparation of macrocyclic C1-keto analogs of Halichondrin B and intermediates useful therein including intermediates containing -SO2-(p-TOLYL) groups |
| HUE049387T2 (hu) | 2013-11-04 | 2020-09-28 | Eisai R&D Man Co Ltd | A halichondrin B analógjainak szintézisében hasznos makrociklizációs reakciók és köztitermékek |
| SG10201805024YA (en) | 2013-12-06 | 2018-07-30 | Eisai R&D Man Co Ltd | Methods useful in the synthesis of halichondrin b analogs |
| US10556910B2 (en) | 2014-06-30 | 2020-02-11 | President And Fellows Of Harvard College | Synthesis of halichondrin analogs and uses thereof |
| WO2016038624A1 (en) | 2014-09-09 | 2016-03-17 | Cipla Limited | "process for the preparation of macrocyclic ketone analogs of halichondrin b or pharmaceutically acceptable salts and intermediates thereof" |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| MX380284B (es) | 2015-05-07 | 2025-03-12 | Eisai R&D Man Co Ltd | Reacciones de macrociclización e intermediarios y otros fragmentos útiles en la síntesis de macrólidos de halicondrina. |
| JP6795525B2 (ja) * | 2015-07-01 | 2020-12-02 | シグナルケム・ライフサイエンシーズ・コーポレイションＳｉｇｎａｌｃｈｅｍ Ｌｉｆｅｓｃｉｅｎｃｅｓ Ｃｏｒｐｏｒａｔｉｏｎ | 炭酸脱水酵素阻害剤としてのアリールスルホンアミド化合物およびその治療的使用 |
| JOP20170053B1 (ar) | 2016-03-02 | 2021-08-17 | Eisai Randd Man Co Ltd | مترافقات جسم مضاد وعقار أساسها إيريبولين وطرق استخدامها |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| SG11201907217RA (en) | 2017-02-20 | 2019-09-27 | Polyphor Ag | Pharmaceutical combinations for treating cancer |
| US9938288B1 (en) * | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| JP7168580B2 (ja) * | 2017-04-05 | 2022-11-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 大環状化合物およびその使用 |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| WO2019009956A1 (en) | 2017-07-06 | 2019-01-10 | President And Fellows Of Harvard College | SUMMARY OF MEDIUM MEDIATED KETONE |
| US20230135188A1 (en) | 2017-07-06 | 2023-05-04 | President And Fellows Of Harvard College | Fe/cu-mediated ketone synthesis |
| IL295588B2 (en) | 2017-07-06 | 2024-03-01 | Harvard College | Synthesis of halichondrins |
| ES2974243T3 (es) | 2017-11-15 | 2024-06-26 | Harvard College | Compuestos macrocíclicos y usos de los mismos |
| WO2022019921A1 (en) | 2020-07-24 | 2022-01-27 | President And Fellows Of Harvard College | Ketone synthesis and applications |
-
2018
- 2018-04-03 JP JP2019555001A patent/JP7168580B2/ja active Active
- 2018-04-03 AU AU2018250147A patent/AU2018250147B2/en active Active
- 2018-04-03 HU HUE18719390A patent/HUE060466T2/hu unknown
- 2018-04-03 MD MDE20200167T patent/MD3606928T2/ro unknown
- 2018-04-03 CA CA3056945A patent/CA3056945A1/en active Pending
- 2018-04-03 TW TW107111975A patent/TWI781163B/zh active
- 2018-04-03 SI SI201830813T patent/SI3606928T1/sl unknown
- 2018-04-03 EP EP18719390.9A patent/EP3606928B1/en active Active
- 2018-04-03 ES ES18719390T patent/ES2931533T3/es active Active
- 2018-04-03 KR KR1020247003838A patent/KR102836514B1/ko active Active
- 2018-04-03 RS RS20221078A patent/RS63755B1/sr unknown
- 2018-04-03 PT PT187193909T patent/PT3606928T/pt unknown
- 2018-04-03 MA MA48027A patent/MA48027B1/fr unknown
- 2018-04-03 PE PE2019001975A patent/PE20200602A1/es unknown
- 2018-04-03 JO JOP/2019/0234A patent/JOP20190234B1/ar active
- 2018-04-03 EP EP22187494.4A patent/EP4119563A3/en active Pending
- 2018-04-03 PL PL18719390.9T patent/PL3606928T3/pl unknown
- 2018-04-03 SM SM20220455T patent/SMT202200455T1/it unknown
- 2018-04-03 TW TW112141425A patent/TWI863657B/zh active
- 2018-04-03 SG SG11201908603P patent/SG11201908603PA/en unknown
- 2018-04-03 KR KR1020197032300A patent/KR102634732B1/ko active Active
- 2018-04-03 HR HRP20221385TT patent/HRP20221385T1/hr unknown
- 2018-04-03 JP JP2018071700A patent/JP6366873B1/ja active Active
- 2018-04-03 LT LTEPPCT/US2018/025887T patent/LT3606928T/lt unknown
- 2018-04-03 MX MX2019011982A patent/MX389899B/es unknown
- 2018-04-03 CN CN202210696425.5A patent/CN115093429B/zh active Active
- 2018-04-03 UA UAA201910898A patent/UA124399C2/uk unknown
- 2018-04-03 CN CN201880033165.5A patent/CN110831946B/zh active Active
- 2018-04-03 IL IL288991A patent/IL288991B2/en unknown
- 2018-04-03 DK DK18719390.9T patent/DK3606928T3/da active
- 2018-04-03 WO PCT/US2018/025887 patent/WO2018187331A1/en not_active Ceased
- 2018-04-03 TW TW111137406A patent/TWI836643B/zh active
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2019
- 2019-09-23 ZA ZA2019/06279A patent/ZA201906279B/en unknown
- 2019-09-24 PH PH12019502197A patent/PH12019502197A1/en unknown
- 2019-10-03 IL IL269788A patent/IL269788B/en unknown
- 2019-10-04 CL CL2019002854A patent/CL2019002854A1/es unknown
- 2019-10-06 SA SA519410259A patent/SA519410259B1/ar unknown
- 2019-10-17 CO CONC2019/0011538A patent/CO2019011538A2/es unknown
- 2019-10-23 EC ECSENADI201975677A patent/ECSP19075677A/es unknown
-
2021
- 2021-02-04 US US17/167,480 patent/US11725015B2/en active Active
-
2022
- 2022-06-30 JP JP2022106421A patent/JP7400025B2/ja active Active
- 2022-12-20 AU AU2022291454A patent/AU2022291454B2/en active Active
-
2023
- 2023-06-21 US US18/339,227 patent/US12421248B2/en active Active
- 2023-12-06 JP JP2023206236A patent/JP7696416B2/ja active Active
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