JP2018030858A5 - - Google Patents
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- Publication number
- JP2018030858A5 JP2018030858A5 JP2017178964A JP2017178964A JP2018030858A5 JP 2018030858 A5 JP2018030858 A5 JP 2018030858A5 JP 2017178964 A JP2017178964 A JP 2017178964A JP 2017178964 A JP2017178964 A JP 2017178964A JP 2018030858 A5 JP2018030858 A5 JP 2018030858A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- stereoisomer
- following
- compound according
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610746P | 2012-03-14 | 2012-03-14 | |
| US61/610,746 | 2012-03-14 | ||
| US201261644648P | 2012-05-09 | 2012-05-09 | |
| US61/644,648 | 2012-05-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500541A Division JP6212534B2 (ja) | 2012-03-14 | 2013-03-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148465A Division JP6743256B2 (ja) | 2012-03-14 | 2019-08-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018030858A JP2018030858A (ja) | 2018-03-01 |
| JP2018030858A5 true JP2018030858A5 (enExample) | 2018-05-10 |
| JP6572273B2 JP6572273B2 (ja) | 2019-09-04 |
Family
ID=49161940
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500541A Active JP6212534B2 (ja) | 2012-03-14 | 2013-03-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
| JP2017178964A Active JP6572273B2 (ja) | 2012-03-14 | 2017-09-19 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
| JP2019148465A Active JP6743256B2 (ja) | 2012-03-14 | 2019-08-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500541A Active JP6212534B2 (ja) | 2012-03-14 | 2013-03-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148465A Active JP6743256B2 (ja) | 2012-03-14 | 2019-08-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2825044B1 (enExample) |
| JP (3) | JP6212534B2 (enExample) |
| KR (7) | KR20220164616A (enExample) |
| CN (1) | CN104168768B (enExample) |
| AU (1) | AU2013232196C1 (enExample) |
| BR (1) | BR112014022542A8 (enExample) |
| CA (1) | CA2865944C (enExample) |
| MX (1) | MX346252B (enExample) |
| RU (1) | RU2672056C2 (enExample) |
| WO (1) | WO2013138418A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9174989B2 (en) * | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| CN105037210A (zh) * | 2015-05-27 | 2015-11-11 | 江苏大学 | 一种α，β-脱氢-α-氨基酸的合成方法 |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| US20230183234A1 (en) * | 2020-05-04 | 2023-06-15 | Otsuka Pharmaceutical Co., Ltd. | Iap antagonist compounds and intermediates and methods for synthesizing the same |
| WO2024134683A1 (en) * | 2022-12-21 | 2024-06-27 | Msn Laboratories Private Limited, R&D Center | Novel process for the preparation of intermediate compounds used in the treatment of migraine |
| CN119431222B (zh) * | 2024-11-04 | 2025-10-17 | 杭州澳赛诺生物科技有限公司 | 一种不对称合成乌布吉泮手性中间体的方法 |
| CN119350337A (zh) * | 2024-12-24 | 2025-01-24 | 药康众拓(北京)医药科技有限公司 | 一类氘代哌啶酮酸酰胺氮杂茚满类cgrp抑制剂药物及用途 |
| CN120398716A (zh) * | 2025-04-17 | 2025-08-01 | 珠海奥博凯生物医药技术有限公司 | 一种基于连续流反应技术合成5-氰基-2-氟苯基化合物的方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| WO2005000109A2 (en) * | 2003-06-27 | 2005-01-06 | University Of Maryland Biotechnology Institute | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids |
| CA2554351A1 (en) | 2004-01-29 | 2005-08-11 | Merck & Co., Inc. | Cgrp receptor antagonists |
| CA2599925A1 (en) * | 2005-03-14 | 2006-09-21 | Merck & Co., Inc. | Cgrp receptor antagonists |
| MX2008014353A (es) * | 2006-05-09 | 2008-11-24 | Merck & Co Inc | Antagonistas de los receptores del peptido relacionado con el gen de calcitonina (cgrp) monociclicos sustituidos. |
| WO2008073251A1 (en) | 2006-12-08 | 2008-06-19 | Merck & Co., Inc. | Constrained spirocyclic compounds as cgrp receptor antagonists |
| US8097750B2 (en) * | 2006-12-20 | 2012-01-17 | Brandeis University | Cinchona alkaloid-catalyzed asymmetric mannich reactions |
| EP2146712A4 (en) | 2007-04-16 | 2010-10-13 | Merck Sharp & Dohme | HETEROCYCLIC ARYL-CGRP RECEPTOR ANTAGONISTS |
| ES2504565T3 (es) * | 2007-06-05 | 2014-10-08 | Merck Sharp & Dohme Corp. | Antagonistas del receptor CGRP de carboxamida heterocíclica |
| JP5233457B2 (ja) * | 2007-07-17 | 2013-07-10 | セントラル硝子株式会社 | 新規な含フッ素ジカルボン酸およびそれを用いた新規な高分子化合物 |
| KR101098335B1 (ko) * | 2008-07-18 | 2011-12-26 | 성균관대학교산학협력단 | 신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 |
| US8552023B2 (en) * | 2008-08-20 | 2013-10-08 | Merck Sharp & Dohme Corp. | Non-amidic linkers with branched termini as CGRP receptor antagonists |
| EP2331518A1 (en) * | 2008-08-22 | 2011-06-15 | Evotec AG | New bradykinin b1 antagonists |
| EP2331101A4 (en) | 2008-09-08 | 2012-08-29 | Merck Sharp & Dohme | MONOCYCLIC AMID-CGRP RECEPTOR ANTAGONISTS |
| EP2438067B1 (de) * | 2009-06-05 | 2015-08-26 | Boehringer Ingelheim International GmbH | Spirolactame als cgrp-antagonisten |
| WO2011005731A2 (en) * | 2009-07-08 | 2011-01-13 | Merck Sharp & Dohme Corp. | Process for making cgrp receptor antagonist |
| US20120121508A1 (en) * | 2009-07-27 | 2012-05-17 | Merck Sharp & Dohme Corp. | Radiolabeled cgrp antagonists |
| TWI522355B (zh) * | 2010-11-12 | 2016-02-21 | 默沙東藥廠 | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| US8883807B2 (en) * | 2010-11-12 | 2014-11-11 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide indane CGRP receptor antagonists |
-
2013
- 2013-03-13 WO PCT/US2013/030696 patent/WO2013138418A2/en not_active Ceased
- 2013-03-13 KR KR1020227041223A patent/KR20220164616A/ko not_active Ceased
- 2013-03-13 RU RU2014141158A patent/RU2672056C2/ru active
- 2013-03-13 CN CN201380013890.3A patent/CN104168768B/zh active Active
- 2013-03-13 KR KR1020257005576A patent/KR20250028525A/ko active Pending
- 2013-03-13 KR KR1020147025146A patent/KR102071278B1/ko active Active
- 2013-03-13 KR KR1020217005005A patent/KR20210022150A/ko not_active Abandoned
- 2013-03-13 BR BR112014022542A patent/BR112014022542A8/pt not_active Application Discontinuation
- 2013-03-13 MX MX2014011000A patent/MX346252B/es active IP Right Grant
- 2013-03-13 KR KR1020247001330A patent/KR20240010553A/ko not_active Ceased
- 2013-03-13 KR KR1020217029942A patent/KR20210116717A/ko not_active Abandoned
- 2013-03-13 JP JP2015500541A patent/JP6212534B2/ja active Active
- 2013-03-13 CA CA2865944A patent/CA2865944C/en active Active
- 2013-03-13 AU AU2013232196A patent/AU2013232196C1/en active Active
- 2013-03-13 EP EP13760317.1A patent/EP2825044B1/en active Active
- 2013-03-13 KR KR1020207001976A patent/KR102220242B1/ko active Active
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2017
- 2017-09-19 JP JP2017178964A patent/JP6572273B2/ja active Active
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2019
- 2019-08-13 JP JP2019148465A patent/JP6743256B2/ja active Active