JP2018030858A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018030858A5 JP2018030858A5 JP2017178964A JP2017178964A JP2018030858A5 JP 2018030858 A5 JP2018030858 A5 JP 2018030858A5 JP 2017178964 A JP2017178964 A JP 2017178964A JP 2017178964 A JP2017178964 A JP 2017178964A JP 2018030858 A5 JP2018030858 A5 JP 2018030858A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- stereoisomer
- following
- compound according
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261610746P | 2012-03-14 | 2012-03-14 | |
| US61/610,746 | 2012-03-14 | ||
| US201261644648P | 2012-05-09 | 2012-05-09 | |
| US61/644,648 | 2012-05-09 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500541A Division JP6212534B2 (ja) | 2012-03-14 | 2013-03-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148465A Division JP6743256B2 (ja) | 2012-03-14 | 2019-08-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018030858A JP2018030858A (ja) | 2018-03-01 |
| JP2018030858A5 true JP2018030858A5 (enExample) | 2018-05-10 |
| JP6572273B2 JP6572273B2 (ja) | 2019-09-04 |
Family
ID=49161940
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500541A Active JP6212534B2 (ja) | 2012-03-14 | 2013-03-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
| JP2017178964A Active JP6572273B2 (ja) | 2012-03-14 | 2017-09-19 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
| JP2019148465A Active JP6743256B2 (ja) | 2012-03-14 | 2019-08-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500541A Active JP6212534B2 (ja) | 2012-03-14 | 2013-03-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019148465A Active JP6743256B2 (ja) | 2012-03-14 | 2019-08-13 | Ｃｇｒｐ受容体アンタゴニストの製造方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9487523B2 (enExample) |
| EP (1) | EP2825044B1 (enExample) |
| JP (3) | JP6212534B2 (enExample) |
| KR (7) | KR20220164616A (enExample) |
| CN (1) | CN104168768B (enExample) |
| AU (1) | AU2013232196C1 (enExample) |
| BR (1) | BR112014022542A8 (enExample) |
| CA (1) | CA2865944C (enExample) |
| MX (1) | MX346252B (enExample) |
| RU (1) | RU2672056C2 (enExample) |
| WO (1) | WO2013138418A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI501968B (zh) * | 2010-11-12 | 2015-10-01 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| WO2013138413A1 (en) | 2012-03-14 | 2013-09-19 | Merck Sharp & Dohme Corp. | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts |
| US9174989B2 (en) * | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| US12168004B2 (en) | 2014-02-05 | 2024-12-17 | Merck Sharp & Dohme Llc | Treatment of migraine |
| US10117836B2 (en) | 2014-02-05 | 2018-11-06 | Merck Sharp & Dohme Corp. | Tablet formulation for CGRP active compounds |
| CN105037210A (zh) * | 2015-05-27 | 2015-11-11 | 江苏大学 | 一种α，β-脱氢-α-氨基酸的合成方法 |
| GB201707938D0 (en) | 2017-05-17 | 2017-06-28 | Univ Sheffield | Compounds |
| US12383545B1 (en) | 2018-06-08 | 2025-08-12 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| JP7690493B2 (ja) * | 2020-05-04 | 2025-06-10 | 大鵬薬品工業株式会社 | Ｉａｐアンタゴニスト化合物及びその中間体、並びにそれを合成する方法 |
| MX2023001071A (es) | 2020-07-29 | 2023-05-12 | Allergan Pharmaceuticals Int Ltd | Tratamiento de la migraña. |
| CA3206184A1 (en) | 2020-12-22 | 2022-06-30 | Allergan Pharmaceuticals International Limited | Treatment of migraine |
| JP2024533756A (ja) | 2021-09-27 | 2024-09-12 | アラガン ファーマスーティカルズ インターナショナル リミテッド | アトゲパントを含む片頭痛の併用療法 |
| WO2024134683A1 (en) * | 2022-12-21 | 2024-06-27 | Msn Laboratories Private Limited, R&D Center | Novel process for the preparation of intermediate compounds used in the treatment of migraine |
| CN117603205A (zh) * | 2023-12-20 | 2024-02-27 | 杭州澳赛诺生物科技有限公司 | 一种奎尼丁衍生物手性相转移催化剂的合成方法及应用 |
| CN119431222B (zh) * | 2024-11-04 | 2025-10-17 | 杭州澳赛诺生物科技有限公司 | 一种不对称合成乌布吉泮手性中间体的方法 |
| CN119350337A (zh) * | 2024-12-24 | 2025-01-24 | 药康众拓(北京)医药科技有限公司 | 一类氘代哌啶酮酸酰胺氮杂茚满类cgrp抑制剂药物及用途 |
| CN120398716A (zh) * | 2025-04-17 | 2025-08-01 | 珠海奥博凯生物医药技术有限公司 | 一种基于连续流反应技术合成5-氰基-2-氟苯基化合物的方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE0102616D0 (sv) * | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
| ATE520661T1 (de) * | 2003-06-27 | 2011-09-15 | Univ Maryland | Heterocyclische verbindungen mit quaternärem stickstoff zum nachweis von wässrigen monosacchariden in physiologischen flüssigkeiten |
| CN101124217A (zh) * | 2004-01-29 | 2008-02-13 | 默克公司 | Cgrp受体拮抗剂 |
| EP1861399B1 (en) * | 2005-03-14 | 2011-12-14 | Merck Sharp & Dohme Corp. | Cgrp receptor antagonists |
| WO2007133491A1 (en) * | 2006-05-09 | 2007-11-22 | Merck & Co., Inc. | Substituted spirocyclic cgrp receptor antagonists |
| US7951795B2 (en) * | 2006-12-08 | 2011-05-31 | Merck Sharp & Dohme Corp. | Constrained spirocyclic compounds as CGRP receptor antagonists |
| US8097750B2 (en) * | 2006-12-20 | 2012-01-17 | Brandeis University | Cinchona alkaloid-catalyzed asymmetric mannich reactions |
| WO2008130524A1 (en) * | 2007-04-16 | 2008-10-30 | Merck & Co., Inc. | Aryl heterocyclic cgrp receptor antagonists |
| CA2689217C (en) * | 2007-06-05 | 2016-02-16 | Merck & Co., Inc. | Carboxamide heterocyclic cgrp receptor antagonists |
| JP5233457B2 (ja) * | 2007-07-17 | 2013-07-10 | セントラル硝子株式会社 | 新規な含フッ素ジカルボン酸およびそれを用いた新規な高分子化合物 |
| KR101098335B1 (ko) * | 2008-07-18 | 2011-12-26 | 성균관대학교산학협력단 | 신코나 기재 이작용성 유기 촉매 및 이를 이용한 메소-고리산무수물의 비대칭 고리 열림 반응을 통한 키랄성헤미에스터의 제조방법 |
| AU2009283085A1 (en) * | 2008-08-20 | 2010-02-25 | Merck Sharp & Dohme Corp. | Non-amidic linkers with branched termini as CGRP receptor antagonists |
| JP2012500783A (ja) * | 2008-08-22 | 2012-01-12 | エヴォテック・アクチエンゲゼルシャフト | 新しいブラジキニンｂ１拮抗薬 |
| EP2331101A4 (en) * | 2008-09-08 | 2012-08-29 | Merck Sharp & Dohme | MONOCYCLIC AMID-CGRP RECEPTOR ANTAGONISTS |
| US8765763B2 (en) * | 2009-06-05 | 2014-07-01 | Boehringer Ingelheim International Gmbh | Substituted piperazines as CGRP antagonists |
| WO2011005731A2 (en) * | 2009-07-08 | 2011-01-13 | Merck Sharp & Dohme Corp. | Process for making cgrp receptor antagonist |
| US20120121508A1 (en) * | 2009-07-27 | 2012-05-17 | Merck Sharp & Dohme Corp. | Radiolabeled cgrp antagonists |
| TWI501968B (zh) * | 2010-11-12 | 2015-10-01 | Merck Sharp & Dohme | 六氫吡啶酮甲醯胺氮雜茚滿ｃｇｒｐ受體拮抗劑 |
| WO2012064911A1 (en) | 2010-11-12 | 2012-05-18 | Merck Sharp & Dohme Corp. | Piperidinone carboxamide indane cgrp receptor antagonists |
| WO2013138413A1 (en) | 2012-03-14 | 2013-09-19 | Merck Sharp & Dohme Corp. | Bis-quarternary cinchona alkaloid salts as asymmetric phase transfer catalysts |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
-
2013
- 2013-03-13 WO PCT/US2013/030696 patent/WO2013138418A2/en not_active Ceased
- 2013-03-13 KR KR1020227041223A patent/KR20220164616A/ko not_active Ceased
- 2013-03-13 KR KR1020207001976A patent/KR102220242B1/ko active Active
- 2013-03-13 KR KR1020247001330A patent/KR20240010553A/ko not_active Ceased
- 2013-03-13 US US14/384,624 patent/US9487523B2/en active Active
- 2013-03-13 RU RU2014141158A patent/RU2672056C2/ru active
- 2013-03-13 AU AU2013232196A patent/AU2013232196C1/en active Active
- 2013-03-13 BR BR112014022542A patent/BR112014022542A8/pt not_active Application Discontinuation
- 2013-03-13 CA CA2865944A patent/CA2865944C/en active Active
- 2013-03-13 KR KR1020147025146A patent/KR102071278B1/ko active Active
- 2013-03-13 EP EP13760317.1A patent/EP2825044B1/en active Active
- 2013-03-13 CN CN201380013890.3A patent/CN104168768B/zh active Active
- 2013-03-13 KR KR1020217005005A patent/KR20210022150A/ko not_active Abandoned
- 2013-03-13 KR KR1020217029942A patent/KR20210116717A/ko not_active Abandoned
- 2013-03-13 JP JP2015500541A patent/JP6212534B2/ja active Active
- 2013-03-13 MX MX2014011000A patent/MX346252B/es active IP Right Grant
- 2013-03-13 KR KR1020257005576A patent/KR20250028525A/ko active Pending
-
2017
- 2017-09-19 JP JP2017178964A patent/JP6572273B2/ja active Active
-
2019
- 2019-08-13 JP JP2019148465A patent/JP6743256B2/ja active Active