JP2019048806A5 - - Google Patents
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- Publication number
- JP2019048806A5 JP2019048806A5 JP2018185491A JP2018185491A JP2019048806A5 JP 2019048806 A5 JP2019048806 A5 JP 2019048806A5 JP 2018185491 A JP2018185491 A JP 2018185491A JP 2018185491 A JP2018185491 A JP 2018185491A JP 2019048806 A5 JP2019048806 A5 JP 2019048806A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- compound
- organic acid
- formula
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000007524 organic acids Chemical class 0.000 claims 13
- 238000000034 method Methods 0.000 claims 5
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 organic acid salt Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016247607 | 2016-12-21 | ||
| JP2016247607 | 2016-12-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518551A Division JP6434678B2 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019048806A JP2019048806A (ja) | 2019-03-28 |
| JP2019048806A5 true JP2019048806A5 (enExample) | 2021-02-04 |
| JP7098496B2 JP7098496B2 (ja) | 2022-07-11 |
Family
ID=62627423
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518551A Active JP6434678B2 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
| JP2018185491A Active JP7098496B2 (ja) | 2016-12-21 | 2018-09-28 | ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518551A Active JP6434678B2 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11673900B2 (enExample) |
| EP (2) | EP4793278A2 (enExample) |
| JP (2) | JP6434678B2 (enExample) |
| KR (1) | KR102546513B1 (enExample) |
| CN (2) | CN117865992A (enExample) |
| AU (2) | AU2017384317C1 (enExample) |
| BR (1) | BR112019012688A2 (enExample) |
| CA (1) | CA3047891A1 (enExample) |
| ES (1) | ES3068086T3 (enExample) |
| IL (2) | IL288080B2 (enExample) |
| MX (2) | MX2019007542A (enExample) |
| PL (1) | PL3560932T3 (enExample) |
| TW (2) | TWI816651B (enExample) |
| WO (1) | WO2018117152A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017026173A2 (pt) | 2015-07-07 | 2018-08-14 | Japan Tobacco, Inc. | Método para produção de derivado de 7h-pirrolo [2,3-d]pirimidina e intermediário do mesmo |
| PL3560932T3 (pl) | 2016-12-21 | 2026-06-29 | Japan Tobacco Inc. | Sposób wytwarzania pochodnych 7H‑pirolo[2,3‑d]pirymidyny i ich syntetycznych produktów pośrednich |
| CN111606929B (zh) * | 2020-06-30 | 2023-07-07 | 中瀚(齐河县)生物医药科技有限公司 | 德高替尼的制备方法 |
| CN111560021B (zh) * | 2020-06-30 | 2023-05-26 | 上海鲲博玖瑞医药科技发展有限公司 | 一种德高替尼中间体及其制备方法 |
| CN111574540B (zh) * | 2020-06-30 | 2023-08-29 | 云南华派医药科技有限公司 | 一种德高替尼的制备方法 |
| JP2026509302A (ja) | 2023-03-17 | 2026-03-17 | レオ ファーマ アクティーゼルスカブ | 中等症ないし重症の慢性手湿疹を有する患者における慢性手湿疹を処置する方法 |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662960B2 (en) | 2001-04-26 | 2010-02-16 | Choongwae Pharma Corporation | Beta-strand mimetics and method relating thereto |
| EP1646633B1 (en) * | 2003-05-30 | 2009-04-15 | Choongwae Pharma Corporation | Beta-strand mimetics |
| US7230119B2 (en) | 2004-08-25 | 2007-06-12 | Biocryst Pharmaceuticals, Inc. | Process for the preparation of substituted pyrrolidine derivatives and intermediates |
| WO2008036755A1 (en) | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines used as vasopressin antagonists |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| SG191291A1 (en) | 2011-01-19 | 2013-07-31 | Galapagos Nv | Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases |
| CN103570601B (zh) | 2012-07-20 | 2016-03-30 | 重庆博腾制药科技股份有限公司 | 一种光学活性药物中间体的制备方法 |
| HUE034210T2 (hu) | 2013-03-05 | 2018-02-28 | Theravance Biopharma R&D Ip Llc | Neprilizininhibitorok |
| JP6500634B2 (ja) * | 2015-06-24 | 2019-04-17 | 株式会社Ihi | 溶接装置及び溶接方法 |
| BR112017026173A2 (pt) * | 2015-07-07 | 2018-08-14 | Japan Tobacco, Inc. | Método para produção de derivado de 7h-pirrolo [2,3-d]pirimidina e intermediário do mesmo |
| TWI822666B (zh) * | 2016-12-21 | 2023-11-21 | 日商日本煙草產業股份有限公司 | Ｊａｎｕｓ激酶抑制劑之結晶型 |
| PL3560932T3 (pl) | 2016-12-21 | 2026-06-29 | Japan Tobacco Inc. | Sposób wytwarzania pochodnych 7H‑pirolo[2,3‑d]pirymidyny i ich syntetycznych produktów pośrednich |
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2017
- 2017-12-20 PL PL17885424.6T patent/PL3560932T3/pl unknown
- 2017-12-20 CN CN202410021834.4A patent/CN117865992A/zh active Pending
- 2017-12-20 EP EP26163662.5A patent/EP4793278A2/en active Pending
- 2017-12-20 KR KR1020197020824A patent/KR102546513B1/ko active Active
- 2017-12-20 US US16/470,888 patent/US11673900B2/en active Active
- 2017-12-20 BR BR112019012688-0A patent/BR112019012688A2/pt active Search and Examination
- 2017-12-20 WO PCT/JP2017/045729 patent/WO2018117152A1/ja not_active Ceased
- 2017-12-20 AU AU2017384317A patent/AU2017384317C1/en active Active
- 2017-12-20 TW TW106144830A patent/TWI816651B/zh active
- 2017-12-20 ES ES17885424T patent/ES3068086T3/es active Active
- 2017-12-20 CN CN201780086625.6A patent/CN110300756B/zh active Active
- 2017-12-20 MX MX2019007542A patent/MX2019007542A/es unknown
- 2017-12-20 JP JP2018518551A patent/JP6434678B2/ja active Active
- 2017-12-20 EP EP17885424.6A patent/EP3560932B1/en active Active
- 2017-12-20 CA CA3047891A patent/CA3047891A1/en active Pending
- 2017-12-20 TW TW112133483A patent/TWI854815B/zh active
- 2017-12-20 IL IL288080A patent/IL288080B2/en unknown
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2018
- 2018-09-28 JP JP2018185491A patent/JP7098496B2/ja active Active
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2019
- 2019-06-16 IL IL267385A patent/IL267385B2/en unknown
- 2019-06-21 MX MX2024005335A patent/MX2024005335A/es unknown
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2022
- 2022-05-24 AU AU2022203506A patent/AU2022203506B2/en active Active
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2023
- 2023-04-19 US US18/136,661 patent/US12195481B2/en active Active
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2024
- 2024-11-26 US US18/960,075 patent/US20250084106A1/en active Pending