JP2019048806A5 - - Google Patents
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- Publication number
- JP2019048806A5 JP2019048806A5 JP2018185491A JP2018185491A JP2019048806A5 JP 2019048806 A5 JP2019048806 A5 JP 2019048806A5 JP 2018185491 A JP2018185491 A JP 2018185491A JP 2018185491 A JP2018185491 A JP 2018185491A JP 2019048806 A5 JP2019048806 A5 JP 2019048806A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- compound
- organic acid
- formula
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 16
- 150000007524 organic acids Chemical class 0.000 claims 13
- 238000000034 method Methods 0.000 claims 5
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 1
- -1 organic acid salt Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016247607 | 2016-12-21 | ||
| JP2016247607 | 2016-12-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518551A Division JP6434678B2 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019048806A JP2019048806A (ja) | 2019-03-28 |
| JP2019048806A5 true JP2019048806A5 (enExample) | 2021-02-04 |
| JP7098496B2 JP7098496B2 (ja) | 2022-07-11 |
Family
ID=62627423
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518551A Active JP6434678B2 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
| JP2018185491A Active JP7098496B2 (ja) | 2016-12-21 | 2018-09-28 | ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018518551A Active JP6434678B2 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11673900B2 (enExample) |
| EP (1) | EP3560932B1 (enExample) |
| JP (2) | JP6434678B2 (enExample) |
| KR (1) | KR102546513B1 (enExample) |
| CN (2) | CN110300756B (enExample) |
| AU (2) | AU2017384317C1 (enExample) |
| BR (1) | BR112019012688A2 (enExample) |
| CA (1) | CA3047891A1 (enExample) |
| IL (2) | IL288080B2 (enExample) |
| MX (2) | MX2019007542A (enExample) |
| TW (2) | TWI854815B (enExample) |
| WO (1) | WO2018117152A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI729990B (zh) | 2015-07-07 | 2021-06-11 | 日商日本煙草產業股份有限公司 | 7H-吡咯并[2,3-d]嘧啶衍生物的製造方法及其中間物 |
| TWI854815B (zh) | 2016-12-21 | 2024-09-01 | 日商日本煙草產業股份有限公司 | 7H-吡咯并[2,3-d]嘧啶衍生物的製造方法及其合成中間體 |
| CN111574540B (zh) * | 2020-06-30 | 2023-08-29 | 云南华派医药科技有限公司 | 一种德高替尼的制备方法 |
| CN111560021B (zh) * | 2020-06-30 | 2023-05-26 | 上海鲲博玖瑞医药科技发展有限公司 | 一种德高替尼中间体及其制备方法 |
| CN111606929B (zh) * | 2020-06-30 | 2023-07-07 | 中瀚(齐河县)生物医药科技有限公司 | 德高替尼的制备方法 |
| EP4680246A1 (en) | 2023-03-17 | 2026-01-21 | LEO Pharma A/S | A method for the treatment of chronic hand eczema in patients with moderate to severe chronic hand eczema |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662960B2 (en) | 2001-04-26 | 2010-02-16 | Choongwae Pharma Corporation | Beta-strand mimetics and method relating thereto |
| WO2004108731A1 (en) * | 2003-05-30 | 2004-12-16 | Choongwae Pharma Corporation | Beta-strand mimetics and method relating thereto |
| US7230119B2 (en) | 2004-08-25 | 2007-06-12 | Biocryst Pharmaceuticals, Inc. | Process for the preparation of substituted pyrrolidine derivatives and intermediates |
| DK2078022T3 (da) | 2006-09-22 | 2012-02-13 | Janssen Pharmaceutica Nv | Spirobenzazepiner anvendt som vasopressinantagonister |
| TWI466885B (zh) * | 2009-07-31 | 2015-01-01 | Japan Tobacco Inc | 含氮螺環化合物及其醫藥用途 |
| JP2014507414A (ja) | 2011-01-19 | 2014-03-27 | ガラパゴス・ナムローゼ・フェンノートシャップ | 代謝疾患及び炎症疾患の治療に有用なアゼチジン誘導体 |
| CN103570601B (zh) | 2012-07-20 | 2016-03-30 | 重庆博腾制药科技股份有限公司 | 一种光学活性药物中间体的制备方法 |
| HUE034210T2 (hu) | 2013-03-05 | 2018-02-28 | Theravance Biopharma R&D Ip Llc | Neprilizininhibitorok |
| JP6500634B2 (ja) * | 2015-06-24 | 2019-04-17 | 株式会社Ihi | 溶接装置及び溶接方法 |
| TWI729990B (zh) * | 2015-07-07 | 2021-06-11 | 日商日本煙草產業股份有限公司 | 7H-吡咯并[2,3-d]嘧啶衍生物的製造方法及其中間物 |
| KR102788829B1 (ko) * | 2016-12-21 | 2025-03-31 | 니뽄 다바코 산교 가부시키가이샤 | 야누스 키나제 억제제의 결정질 형태 |
| TWI854815B (zh) | 2016-12-21 | 2024-09-01 | 日商日本煙草產業股份有限公司 | 7H-吡咯并[2,3-d]嘧啶衍生物的製造方法及其合成中間體 |
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2017
- 2017-12-20 TW TW112133483A patent/TWI854815B/zh active
- 2017-12-20 US US16/470,888 patent/US11673900B2/en active Active
- 2017-12-20 KR KR1020197020824A patent/KR102546513B1/ko active Active
- 2017-12-20 CN CN201780086625.6A patent/CN110300756B/zh active Active
- 2017-12-20 MX MX2019007542A patent/MX2019007542A/es unknown
- 2017-12-20 CA CA3047891A patent/CA3047891A1/en active Pending
- 2017-12-20 BR BR112019012688-0A patent/BR112019012688A2/pt active Search and Examination
- 2017-12-20 WO PCT/JP2017/045729 patent/WO2018117152A1/ja not_active Ceased
- 2017-12-20 EP EP17885424.6A patent/EP3560932B1/en active Active
- 2017-12-20 AU AU2017384317A patent/AU2017384317C1/en active Active
- 2017-12-20 CN CN202410021834.4A patent/CN117865992A/zh active Pending
- 2017-12-20 TW TW106144830A patent/TWI816651B/zh active
- 2017-12-20 IL IL288080A patent/IL288080B2/en unknown
- 2017-12-20 JP JP2018518551A patent/JP6434678B2/ja active Active
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2018
- 2018-09-28 JP JP2018185491A patent/JP7098496B2/ja active Active
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2019
- 2019-06-16 IL IL267385A patent/IL267385B2/en unknown
- 2019-06-21 MX MX2024005335A patent/MX2024005335A/es unknown
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2022
- 2022-05-24 AU AU2022203506A patent/AU2022203506B2/en active Active
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2023
- 2023-04-19 US US18/136,661 patent/US12195481B2/en active Active
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2024
- 2024-11-26 US US18/960,075 patent/US20250084106A1/en active Pending