CN110300756B - 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 - Google Patents
7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 Download PDFInfo
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- CN110300756B CN110300756B CN201780086625.6A CN201780086625A CN110300756B CN 110300756 B CN110300756 B CN 110300756B CN 201780086625 A CN201780086625 A CN 201780086625A CN 110300756 B CN110300756 B CN 110300756B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410021834.4A CN117865992A (zh) | 2016-12-21 | 2017-12-20 | 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2016-247607 | 2016-12-21 | ||
| JP2016247607 | 2016-12-21 | ||
| PCT/JP2017/045729 WO2018117152A1 (ja) | 2016-12-21 | 2017-12-20 | ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその合成中間体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410021834.4A Division CN117865992A (zh) | 2016-12-21 | 2017-12-20 | 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110300756A CN110300756A (zh) | 2019-10-01 |
| CN110300756B true CN110300756B (zh) | 2024-01-02 |
Family
ID=62627423
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410021834.4A Pending CN117865992A (zh) | 2016-12-21 | 2017-12-20 | 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 |
| CN201780086625.6A Active CN110300756B (zh) | 2016-12-21 | 2017-12-20 | 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410021834.4A Pending CN117865992A (zh) | 2016-12-21 | 2017-12-20 | 7H-吡咯并[2,3-d]嘧啶衍生物的制备方法及其合成中间体 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11673900B2 (enExample) |
| EP (1) | EP3560932A4 (enExample) |
| JP (2) | JP6434678B2 (enExample) |
| KR (1) | KR102546513B1 (enExample) |
| CN (2) | CN117865992A (enExample) |
| AU (2) | AU2017384317C1 (enExample) |
| BR (1) | BR112019012688A2 (enExample) |
| CA (1) | CA3047891A1 (enExample) |
| IL (2) | IL288080B2 (enExample) |
| MX (2) | MX2019007542A (enExample) |
| TW (2) | TWI854815B (enExample) |
| WO (1) | WO2018117152A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1251223A1 (en) | 2015-07-07 | 2019-01-25 | Japan Tobacco, Inc. | Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof |
| CA3047891A1 (en) | 2016-12-21 | 2018-06-28 | Japan Tobacco Inc. | Process for preparing 7h-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof |
| CN111574540B (zh) * | 2020-06-30 | 2023-08-29 | 云南华派医药科技有限公司 | 一种德高替尼的制备方法 |
| CN111606929B (zh) * | 2020-06-30 | 2023-07-07 | 中瀚(齐河县)生物医药科技有限公司 | 德高替尼的制备方法 |
| CN111560021B (zh) * | 2020-06-30 | 2023-05-26 | 上海鲲博玖瑞医药科技发展有限公司 | 一种德高替尼中间体及其制备方法 |
| KR20250159260A (ko) | 2023-03-17 | 2025-11-10 | 레오 파마 에이/에스 | 중등도 내지 중증의 만성 손 습진 환자의 만성 손 습진 치료 방법 |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102510865A (zh) * | 2009-07-31 | 2012-06-20 | 日本烟草产业株式会社 | 含氮螺环化合物及其药物用途 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7662960B2 (en) | 2001-04-26 | 2010-02-16 | Choongwae Pharma Corporation | Beta-strand mimetics and method relating thereto |
| DE60327263D1 (de) * | 2003-05-30 | 2009-05-28 | Choongwae Pharma Corp | Beta-strang-mimetika |
| US7230119B2 (en) | 2004-08-25 | 2007-06-12 | Biocryst Pharmaceuticals, Inc. | Process for the preparation of substituted pyrrolidine derivatives and intermediates |
| WO2008036755A1 (en) | 2006-09-22 | 2008-03-27 | Janssen Pharmaceutica N.V. | Spiro benzazepines used as vasopressin antagonists |
| RU2013138372A (ru) | 2011-01-19 | 2015-02-27 | Галапаго Нв | Производные азетидина, применяемые для лечения метаболических и воспалительных заболеваний |
| CN103570601B (zh) | 2012-07-20 | 2016-03-30 | 重庆博腾制药科技股份有限公司 | 一种光学活性药物中间体的制备方法 |
| CA2902456A1 (en) | 2013-03-05 | 2014-09-12 | Theravance Biopharma R&D Ip, Llc | Neprilysin inhibitors |
| JP6500634B2 (ja) * | 2015-06-24 | 2019-04-17 | 株式会社Ihi | 溶接装置及び溶接方法 |
| HK1251223A1 (en) | 2015-07-07 | 2019-01-25 | Japan Tobacco, Inc. | Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof |
| WO2018117153A1 (en) | 2016-12-21 | 2018-06-28 | Japan Tobacco Inc. | Crystalline forms of a janus kinase inhibitor |
| CA3047891A1 (en) | 2016-12-21 | 2018-06-28 | Japan Tobacco Inc. | Process for preparing 7h-pyrrolo[2,3-d]pyrimidine derivatives and synthetic intermediates thereof |
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2017
- 2017-12-20 CA CA3047891A patent/CA3047891A1/en active Pending
- 2017-12-20 BR BR112019012688-0A patent/BR112019012688A2/pt active Search and Examination
- 2017-12-20 TW TW112133483A patent/TWI854815B/zh active
- 2017-12-20 CN CN202410021834.4A patent/CN117865992A/zh active Pending
- 2017-12-20 CN CN201780086625.6A patent/CN110300756B/zh active Active
- 2017-12-20 AU AU2017384317A patent/AU2017384317C1/en active Active
- 2017-12-20 US US16/470,888 patent/US11673900B2/en active Active
- 2017-12-20 JP JP2018518551A patent/JP6434678B2/ja active Active
- 2017-12-20 MX MX2019007542A patent/MX2019007542A/es unknown
- 2017-12-20 WO PCT/JP2017/045729 patent/WO2018117152A1/ja not_active Ceased
- 2017-12-20 EP EP17885424.6A patent/EP3560932A4/en active Pending
- 2017-12-20 IL IL288080A patent/IL288080B2/en unknown
- 2017-12-20 KR KR1020197020824A patent/KR102546513B1/ko active Active
- 2017-12-20 TW TW106144830A patent/TWI816651B/zh active
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2018
- 2018-09-28 JP JP2018185491A patent/JP7098496B2/ja active Active
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2019
- 2019-06-16 IL IL267385A patent/IL267385B2/en unknown
- 2019-06-21 MX MX2024005335A patent/MX2024005335A/es unknown
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2022
- 2022-05-24 AU AU2022203506A patent/AU2022203506B2/en active Active
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2023
- 2023-04-19 US US18/136,661 patent/US12195481B2/en active Active
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2024
- 2024-11-26 US US18/960,075 patent/US20250084106A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102510865A (zh) * | 2009-07-31 | 2012-06-20 | 日本烟草产业株式会社 | 含氮螺环化合物及其药物用途 |
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| WO2018117151A1 (ja) | ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその共結晶 | |
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