MX2019007542A - Proceso para la preparación de derivados de 7h-pirrolo [2, 3-d] pirimidina y sus intermedios sintéticos. - Google Patents

Proceso para la preparación de derivados de 7h-pirrolo [2, 3-d] pirimidina y sus intermedios sintéticos.

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Publication number
MX2019007542A
MX2019007542A MX2019007542A MX2019007542A MX2019007542A MX 2019007542 A MX2019007542 A MX 2019007542A MX 2019007542 A MX2019007542 A MX 2019007542A MX 2019007542 A MX2019007542 A MX 2019007542A MX 2019007542 A MX2019007542 A MX 2019007542A
Authority
MX
Mexico
Prior art keywords
producing
pyrrolo
same
pyrimidine derivative
synthetic intermediate
Prior art date
Application number
MX2019007542A
Other languages
English (en)
Inventor
Watanabe Takashi
Inaba Takashi
Takeichi Tsubasa
Takiguchi Hiromu
Higashi Akinobu
Klarskov Petersen Anders
Vedsoe Per
Lebek Jensen Kim
Bornholdt Jan
Ebdrup Soren
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of MX2019007542A publication Critical patent/MX2019007542A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona procesos para preparar derivados de 7Hpirrolo[ 2,3-d]pirimidina, que son útiles como un inhibidor de Janus quinasa (JAK), intermedios de los mismos, y procesos para preparar los intermedios; la presente invención proporciona procesos para preparar 3-[(3S,4R)-3-metil-6-(7H-pirrol o[2,3-d]pirimidin-4-il)-1,6-diazaespiro[3.4]octan-1-il]-3- oxopropanonitrilo usando sales de (3S,4R)-1-bencil-3-metil-1,6-dia zaespiro[3.4]octano con ácidos orgánicos.
MX2019007542A 2016-12-21 2017-12-20 Proceso para la preparación de derivados de 7h-pirrolo [2, 3-d] pirimidina y sus intermedios sintéticos. MX2019007542A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016247607 2016-12-21
PCT/JP2017/045729 WO2018117152A1 (ja) 2016-12-21 2017-12-20 ７Ｈ－ピロロ［２，３－ｄ］ピリミジン誘導体の製造方法及びその合成中間体

Publications (1)

Publication Number Publication Date
MX2019007542A true MX2019007542A (es) 2019-11-18

Family

ID=62627423

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007542A MX2019007542A (es) 2016-12-21 2017-12-20 Proceso para la preparación de derivados de 7h-pirrolo [2, 3-d] pirimidina y sus intermedios sintéticos.

Country Status (12)

Country Link
US (2) US11673900B2 (es)
EP (1) EP3560932A4 (es)
JP (2) JP6434678B2 (es)
KR (1) KR102546513B1 (es)
CN (2) CN117865992A (es)
AU (2) AU2017384317C1 (es)
BR (1) BR112019012688A2 (es)
CA (1) CA3047891A1 (es)
IL (2) IL288080B2 (es)
MX (1) MX2019007542A (es)
TW (2) TW202400613A (es)
WO (1) WO2018117152A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2991020A1 (en) 2015-07-07 2017-01-12 Japan Tobacco Inc. Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof
JP6434678B2 (ja) 2016-12-21 2018-12-05 日本たばこ産業株式会社 ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体
CN111574540B (zh) * 2020-06-30 2023-08-29 云南华派医药科技有限公司 一种德高替尼的制备方法
CN111560021B (zh) * 2020-06-30 2023-05-26 上海鲲博玖瑞医药科技发展有限公司 一种德高替尼中间体及其制备方法
CN111606929B (zh) * 2020-06-30 2023-07-07 中瀚(齐河县)生物医药科技有限公司 德高替尼的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7662960B2 (en) 2001-04-26 2010-02-16 Choongwae Pharma Corporation Beta-strand mimetics and method relating thereto
WO2004108731A1 (en) * 2003-05-30 2004-12-16 Choongwae Pharma Corporation Beta-strand mimetics and method relating thereto
US7230119B2 (en) 2004-08-25 2007-06-12 Biocryst Pharmaceuticals, Inc. Process for the preparation of substituted pyrrolidine derivatives and intermediates
PL2078022T3 (pl) 2006-09-22 2012-04-30 Janssen Pharmaceutica Nv Spirobenzoazepiny stosowane jako antagoniści wazopresyny
TWI466885B (zh) * 2009-07-31 2015-01-01 Japan Tobacco Inc 含氮螺環化合物及其醫藥用途
GB2489382A (en) 2011-01-19 2012-09-26 Galapagos Nv Azetidine derivatives useful for the treatment of metabolic and inflammatory diseases
CN103570601B (zh) 2012-07-20 2016-03-30 重庆博腾制药科技股份有限公司 一种光学活性药物中间体的制备方法
CA2902456A1 (en) * 2013-03-05 2014-09-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
JP6500634B2 (ja) * 2015-06-24 2019-04-17 株式会社Ihi 溶接装置及び溶接方法
CA2991020A1 (en) * 2015-07-07 2017-01-12 Japan Tobacco Inc. Method for producing 7h-pyrrolo[2, 3-d]pyrimidine derivative and intermediate thereof
KR20190092440A (ko) * 2016-12-21 2019-08-07 니뽄 다바코 산교 가부시키가이샤 야누스 키나제 억제제의 결정질 형태
JP6434678B2 (ja) 2016-12-21 2018-12-05 日本たばこ産業株式会社 ７Ｈ−ピロロ［２，３−ｄ］ピリミジン誘導体の製造方法及びその合成中間体

Also Published As

Publication number Publication date
EP3560932A4 (en) 2020-10-28
JP7098496B2 (ja) 2022-07-11
US20240140967A1 (en) 2024-05-02
US11673900B2 (en) 2023-06-13
AU2022203506B2 (en) 2024-02-08
JP2019048806A (ja) 2019-03-28
KR102546513B1 (ko) 2023-06-23
JP6434678B2 (ja) 2018-12-05
EP3560932A1 (en) 2019-10-30
TW202400613A (zh) 2024-01-01
AU2022203506A1 (en) 2022-06-09
WO2018117152A1 (ja) 2018-06-28
IL288080B2 (en) 2024-03-01
IL288080A (en) 2022-01-01
CN110300756B (zh) 2024-01-02
CN110300756A (zh) 2019-10-01
RU2019122691A (ru) 2021-01-25
RU2019122691A3 (es) 2021-02-08
CA3047891A1 (en) 2018-06-28
AU2017384317A1 (en) 2019-07-11
TW201829422A (zh) 2018-08-16
IL267385B1 (es) 2023-02-01
BR112019012688A2 (pt) 2019-11-19
IL267385A (es) 2019-07-31
KR20190095408A (ko) 2019-08-14
TWI816651B (zh) 2023-10-01
AU2017384317C1 (en) 2022-06-30
IL267385B2 (en) 2023-06-01
IL288080B1 (en) 2023-11-01
JPWO2018117152A1 (ja) 2018-12-20
US20200216470A1 (en) 2020-07-09
CN117865992A (zh) 2024-04-12
AU2017384317B2 (en) 2022-03-10

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