MX2010009458A - Derivados biciclicos heterociclicos o espirobiciclicos heterociclicos enlazados, de pirazolo[1,5-a]pirimidinas, procedimientos para su preparacion y usos de los mismos. - Google Patents

Derivados biciclicos heterociclicos o espirobiciclicos heterociclicos enlazados, de pirazolo[1,5-a]pirimidinas, procedimientos para su preparacion y usos de los mismos.

Info

Publication number
MX2010009458A
MX2010009458A MX2010009458A MX2010009458A MX2010009458A MX 2010009458 A MX2010009458 A MX 2010009458A MX 2010009458 A MX2010009458 A MX 2010009458A MX 2010009458 A MX2010009458 A MX 2010009458A MX 2010009458 A MX2010009458 A MX 2010009458A
Authority
MX
Mexico
Prior art keywords
bicyclic heterocyclic
pyrazolo
pyrimidines
bridged
preparation
Prior art date
Application number
MX2010009458A
Other languages
English (en)
Inventor
Jeremy Ian Levin
Darrin William Hopper
Nancy Torres
Minu Dhanjish Dutia
Xiaolun Wang
Grandi Martin Joseph Di
Chunchun Zhang
Alejandro Lee Dunnick
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of MX2010009458A publication Critical patent/MX2010009458A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen compuestos de fórmula A: (ver fórmula I) y sales farmacéuticamente aceptables de los mismos, que inhiben selectivamente la actividad Raf quinasa y son útiles para tratar trastornos mediados por Rafquinasas.
MX2010009458A 2008-02-29 2009-02-27 Derivados biciclicos heterociclicos o espirobiciclicos heterociclicos enlazados, de pirazolo[1,5-a]pirimidinas, procedimientos para su preparacion y usos de los mismos. MX2010009458A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6784308P 2008-02-29 2008-02-29
US11680908P 2008-11-21 2008-11-21
PCT/US2009/035422 WO2009108838A1 (en) 2008-02-29 2009-02-27 Bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines, methods for preparation and uses thereof

Publications (1)

Publication Number Publication Date
MX2010009458A true MX2010009458A (es) 2010-09-24

Family

ID=40548843

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010009458A MX2010009458A (es) 2008-02-29 2009-02-27 Derivados biciclicos heterociclicos o espirobiciclicos heterociclicos enlazados, de pirazolo[1,5-a]pirimidinas, procedimientos para su preparacion y usos de los mismos.

Country Status (24)

Country Link
US (1) US20100029657A1 (es)
EP (1) EP2271649A1 (es)
JP (1) JP2011513334A (es)
KR (1) KR20100123725A (es)
CN (1) CN102083835A (es)
AP (1) AP2010005363A0 (es)
AR (1) AR070728A1 (es)
AU (1) AU2009219175A1 (es)
BR (1) BRPI0908403A2 (es)
CA (1) CA2716499A1 (es)
CO (1) CO6321261A2 (es)
CR (1) CR11650A (es)
DO (1) DOP2010000261A (es)
EA (1) EA201001188A1 (es)
EC (1) ECSP10010429A (es)
IL (1) IL207576A0 (es)
MA (1) MA32110B1 (es)
MX (1) MX2010009458A (es)
NI (1) NI201000143A (es)
PE (1) PE20091833A1 (es)
SV (1) SV2010003654A (es)
TW (1) TW200951134A (es)
WO (1) WO2009108838A1 (es)
ZA (1) ZA201005603B (es)

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JP2007089031A (ja) 2005-09-26 2007-04-05 Fuji Xerox Co Ltd 出力装置
HUE031972T2 (en) 2005-12-29 2017-08-28 Celtaxsys Inc Diamin derivatives as leukotriene A4 hydrolase inhibitors
EP2512239A4 (en) * 2009-12-14 2014-11-26 Inspire Pharmaceuticals Inc BROKEN BICYCLIC RHO-KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE
AU2010331175B2 (en) 2009-12-18 2014-08-28 Mitsubishi Tanabe Pharma Corporation Novel antiplatelet agent
EP2402343A1 (en) * 2010-06-29 2012-01-04 Basf Se Pyrazole-fused bicyclic compounds
US8969363B2 (en) 2011-07-19 2015-03-03 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2852939A1 (en) * 2011-10-20 2013-04-25 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
US9957271B2 (en) 2011-10-20 2018-05-01 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
EP2920181B1 (en) 2012-11-16 2019-01-09 University Health Network Pyrazolopyrimidine compounds
ES2864862T3 (es) 2013-03-12 2021-10-14 Celltaxis Llc Métodos de inhibición de la leucotrieno A4 hidrolasa
WO2014152229A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
MX2015011676A (es) 2013-03-14 2016-04-25 Celtaxsys Inc Inhibidores de leucotrieno a4 hidrolasa.
RU2678196C2 (ru) 2013-03-14 2019-01-24 Селтакссис, Инк. Производные 2-фениламино-3-цианопиразоло[1,5-а]пиримидина, полезные в качестве ингибитора лейкотриен-a4-гидролазы
US10280170B2 (en) 2014-03-27 2019-05-07 Janssen Pharmaceutica Nv Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine derivatives and 5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a][1,4]diazepine derivatives as Ros1 inhibitors
EA031639B1 (ru) * 2014-03-27 2019-01-31 Янссен Фармацевтика Нв ЗАМЕЩЕННЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-а]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ И 2,3-ДИГИДРО-1H-ИМИДАЗО[1,2-b]ПИРАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ROS1
AR100448A1 (es) 2014-05-21 2016-10-05 Bayer Cropscience Ag 5-(hetero)aril-piridazinonas y su uso como herbicida
CA3034705C (en) 2016-08-31 2021-08-03 Agios Pharmaceuticals, Inc. Inhibitors of cellular metabolic processes
WO2018146253A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
CA3085366A1 (en) 2017-12-22 2019-06-27 Petra Pharma Corporation Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors
CA3086765A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
CA3102077A1 (en) 2018-05-31 2019-12-05 Sanjeev AHUJA Method of reducing pulmonary exacerbations in respiratory disease patients

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US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4900836A (en) * 1983-06-23 1990-02-13 American Cyanamid Company (3-amino-1H-pyrazol-4-yl) (aryl)methanones
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
AU2003299651A1 (en) * 2002-12-11 2004-06-30 Merck And Co., Inc. Tyrosine kinase inhibitors
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US20050267060A1 (en) * 2004-03-19 2005-12-01 The Penn State Research Foundation Combinatorial methods and compositions for treatment of melanoma
CA2643968A1 (en) * 2006-03-17 2007-09-27 Wyeth Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof

Also Published As

Publication number Publication date
ZA201005603B (en) 2011-05-25
TW200951134A (en) 2009-12-16
PE20091833A1 (es) 2009-11-22
DOP2010000261A (es) 2010-09-15
IL207576A0 (en) 2010-12-30
CR11650A (es) 2010-09-14
US20100029657A1 (en) 2010-02-04
CO6321261A2 (es) 2011-09-20
EP2271649A1 (en) 2011-01-12
EA201001188A1 (ru) 2011-04-29
MA32110B1 (fr) 2011-02-01
BRPI0908403A2 (pt) 2015-08-11
KR20100123725A (ko) 2010-11-24
JP2011513334A (ja) 2011-04-28
AP2010005363A0 (en) 2010-08-31
CN102083835A (zh) 2011-06-01
NI201000143A (es) 2011-03-09
AR070728A1 (es) 2010-04-28
AU2009219175A1 (en) 2009-09-03
SV2010003654A (es) 2011-03-23
ECSP10010429A (es) 2010-09-30
WO2009108838A8 (en) 2009-11-12
CA2716499A1 (en) 2009-09-03
WO2009108838A1 (en) 2009-09-03

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