MA32110B1 - Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations - Google Patents
Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisationsInfo
- Publication number
- MA32110B1 MA32110B1 MA33124A MA33124A MA32110B1 MA 32110 B1 MA32110 B1 MA 32110B1 MA 33124 A MA33124 A MA 33124A MA 33124 A MA33124 A MA 33124A MA 32110 B1 MA32110 B1 MA 32110B1
- Authority
- MA
- Morocco
- Prior art keywords
- heterocyclic derivatives
- bicyclic
- pyrazolo
- pyrimidines
- spiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
L'invention concerne des composés de formule a et des composés de qualité pharmaceutique de ceux-ci, qui inhibent sélectivement l'activité de raf kinase et qui sont utiles pour traiter des troubles à médiation par des raf kinases.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6784308P | 2008-02-29 | 2008-02-29 | |
US11680908P | 2008-11-21 | 2008-11-21 | |
PCT/US2009/035422 WO2009108838A1 (fr) | 2008-02-29 | 2009-02-27 | Dérivés hétérocycliques bicycliques pontés ou hétérocycliques bicycliques spiro de pyrazolo[1,5-a]pyrimidines, leurs procédés de préparation et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32110B1 true MA32110B1 (fr) | 2011-02-01 |
Family
ID=40548843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33124A MA32110B1 (fr) | 2008-02-29 | 2010-08-26 | Derives heterocycliques bicycliques pontes ou derives heterocyclique spiro-bicycliques de pyrazolo [1,5-a] pyrimidines, procedes pour leur preparation et leurs utilisations |
Country Status (24)
Country | Link |
---|---|
US (1) | US20100029657A1 (fr) |
EP (1) | EP2271649A1 (fr) |
JP (1) | JP2011513334A (fr) |
KR (1) | KR20100123725A (fr) |
CN (1) | CN102083835A (fr) |
AP (1) | AP2010005363A0 (fr) |
AR (1) | AR070728A1 (fr) |
AU (1) | AU2009219175A1 (fr) |
BR (1) | BRPI0908403A2 (fr) |
CA (1) | CA2716499A1 (fr) |
CO (1) | CO6321261A2 (fr) |
CR (1) | CR11650A (fr) |
DO (1) | DOP2010000261A (fr) |
EA (1) | EA201001188A1 (fr) |
EC (1) | ECSP10010429A (fr) |
IL (1) | IL207576A0 (fr) |
MA (1) | MA32110B1 (fr) |
MX (1) | MX2010009458A (fr) |
NI (1) | NI201000143A (fr) |
PE (1) | PE20091833A1 (fr) |
SV (1) | SV2010003654A (fr) |
TW (1) | TW200951134A (fr) |
WO (1) | WO2009108838A1 (fr) |
ZA (1) | ZA201005603B (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2007089031A (ja) | 2005-09-26 | 2007-04-05 | Fuji Xerox Co Ltd | 出力装置 |
DK1976828T3 (en) | 2005-12-29 | 2017-03-06 | Celtaxsys Inc | DIAMINE DERIVATIVES AS INhibitors of Leukotriene A4 HYDROLASE |
CA2781390A1 (fr) | 2009-12-14 | 2011-06-23 | Inspire Pharmaceuticals, Inc. | Inhibiteurs de la rho-kinase bicycliques pontes, composition et utilisation |
US8703760B2 (en) | 2009-12-18 | 2014-04-22 | Mitsubishi Tanabe Pharma Corporation | Antiplatelet agent |
EP2402343A1 (fr) * | 2010-06-29 | 2012-01-04 | Basf Se | Composés pyrazoliques bicycliques condenses |
EP2734520B1 (fr) | 2011-07-19 | 2016-09-14 | Infinity Pharmaceuticals, Inc. | Composés hétérocycliques et leurs utilisations |
KR20140077965A (ko) * | 2011-10-20 | 2014-06-24 | 글락소스미스클라인 엘엘씨 | 시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체 |
CA2852936A1 (fr) | 2011-10-20 | 2013-04-25 | Glaxosmithkline Llc | Azaheterocycles bicycliques substitues et analogues comme modulateurs de la sirtuine |
US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
JP6377068B2 (ja) | 2012-11-16 | 2018-08-22 | ユニバーシティ・ヘルス・ネットワーク | ピラゾロピリミジン化合物 |
CA2905340C (fr) | 2013-03-12 | 2022-05-31 | Celtaxsys, Inc. | Formulations orales a faible dose d'acebilustat |
WO2014152536A2 (fr) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibiteurs de la leucotriène a4 hydrolase |
AU2014240042C1 (en) | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
WO2014152518A2 (fr) | 2013-03-14 | 2014-09-25 | Celtaxsys, Inc. | Inhibiteurs de la leucotriène a4 hydrolase |
MX367913B (es) * | 2014-03-27 | 2019-09-11 | Janssen Pharmaceutica Nv | Derivados de 4,5,6,7-tetrahidro-pirazolo[1,5-a]pirimidina y 2,3-dihidro-1h-imidazo[1,2-b]pirazol sustituidos como inhibidores de ros1. |
EA032255B1 (ru) | 2014-03-27 | 2019-04-30 | Янссен Фармацевтика Нв | ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИНА И ПРОИЗВОДНЫЕ 5,6,7,8-ТЕТРАГИДРО-4H-ПИРАЗОЛО[1,5-a][1,4]ДИАЗЕПИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Ros1 |
AR100448A1 (es) | 2014-05-21 | 2016-10-05 | Bayer Cropscience Ag | 5-(hetero)aril-piridazinonas y su uso como herbicida |
EA035049B1 (ru) * | 2015-07-16 | 2020-04-22 | Аррэй Байофарма Инк. | СОЕДИНЕНИЯ ЗАМЕЩЕННОГО ПИРАЗОЛО[1,5-a]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ RET КИНАЗЫ |
BR112019003914A2 (pt) | 2016-08-31 | 2019-05-28 | Agios Pharmaceuticals Inc | inibidores de processos metabólicos celulares |
EP3579872A1 (fr) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés et compositions pharmaceutiques pour le traitement de cancers associés à l'activation de la voie mapk |
JP2021506978A (ja) | 2017-12-22 | 2021-02-22 | ラヴェンナ ファーマシューティカルズ,インコーポレイテッド | ホスファチジルイノシトールリン酸キナーゼ阻害剤としてのアミノピリジン誘導体 |
CA3086765A1 (fr) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Systemes de culture de cellules souches pour cellules souches epitheliales colonnaires, et leurs utilisations |
EP3801559A4 (fr) | 2018-05-31 | 2022-03-02 | Celltaxis, LLC | Procédé de réduction d'exacerbations pulmonaires chez des patients atteints d'une maladie respiratoire |
US20220054469A1 (en) * | 2018-09-18 | 2022-02-24 | Metacrine, Inc. | Farnesoid x receptor agonists and uses thereof |
TW202112767A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4178449A (en) * | 1978-04-17 | 1979-12-11 | American Cyanamid Company | Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines |
US4236005A (en) * | 1979-07-02 | 1980-11-25 | American Cyanamid Company | Imidazo[1,5-a]pyrimidines |
US4281000A (en) * | 1979-07-09 | 1981-07-28 | American Cyanamid Company | Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents |
US4521422A (en) * | 1983-06-23 | 1985-06-04 | American Cyanamid Company | Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
US4626538A (en) * | 1983-06-23 | 1986-12-02 | American Cyanamid Company | [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines |
US4900836A (en) * | 1983-06-23 | 1990-02-13 | American Cyanamid Company | (3-amino-1H-pyrazol-4-yl) (aryl)methanones |
US4654347A (en) * | 1983-06-23 | 1987-03-31 | American Cyanamid Company | Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones |
US7550470B2 (en) * | 2002-12-11 | 2009-06-23 | Merck & Co. Inc. | Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors |
US7176210B2 (en) * | 2003-02-10 | 2007-02-13 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
AU2005223649A1 (en) * | 2004-03-19 | 2005-09-29 | The Penn State Research Foundation | Combinatorial methods and compositions for treatment of melanoma |
CN101405289A (zh) * | 2006-03-17 | 2009-04-08 | 惠氏公司 | 吡唑并[1,5-a]嘧啶衍生物和其使用方法 |
-
2009
- 2009-02-26 US US12/393,565 patent/US20100029657A1/en not_active Abandoned
- 2009-02-27 KR KR1020107020750A patent/KR20100123725A/ko not_active Application Discontinuation
- 2009-02-27 MX MX2010009458A patent/MX2010009458A/es not_active Application Discontinuation
- 2009-02-27 TW TW098106566A patent/TW200951134A/zh unknown
- 2009-02-27 AP AP2010005363A patent/AP2010005363A0/en unknown
- 2009-02-27 PE PE2009000313A patent/PE20091833A1/es not_active Application Discontinuation
- 2009-02-27 EP EP09713876A patent/EP2271649A1/fr not_active Withdrawn
- 2009-02-27 CN CN2009801153285A patent/CN102083835A/zh active Pending
- 2009-02-27 EA EA201001188A patent/EA201001188A1/ru unknown
- 2009-02-27 JP JP2010548895A patent/JP2011513334A/ja not_active Withdrawn
- 2009-02-27 AR ARP090100723A patent/AR070728A1/es not_active Application Discontinuation
- 2009-02-27 AU AU2009219175A patent/AU2009219175A1/en not_active Abandoned
- 2009-02-27 WO PCT/US2009/035422 patent/WO2009108838A1/fr active Application Filing
- 2009-02-27 BR BRPI0908403-7A patent/BRPI0908403A2/pt not_active IP Right Cessation
- 2009-02-27 CA CA2716499A patent/CA2716499A1/fr not_active Abandoned
-
2010
- 2010-08-05 ZA ZA2010/05603A patent/ZA201005603B/en unknown
- 2010-08-12 IL IL207576A patent/IL207576A0/en unknown
- 2010-08-24 CO CO10104173A patent/CO6321261A2/es not_active Application Discontinuation
- 2010-08-25 CR CR11650A patent/CR11650A/es not_active Application Discontinuation
- 2010-08-26 MA MA33124A patent/MA32110B1/fr unknown
- 2010-08-27 DO DO2010000261A patent/DOP2010000261A/es unknown
- 2010-08-27 SV SV2010003654A patent/SV2010003654A/es not_active Application Discontinuation
- 2010-08-27 NI NI201000143A patent/NI201000143A/es unknown
- 2010-08-27 EC EC2010010429A patent/ECSP10010429A/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20091833A1 (es) | 2009-11-22 |
US20100029657A1 (en) | 2010-02-04 |
SV2010003654A (es) | 2011-03-23 |
WO2009108838A8 (fr) | 2009-11-12 |
EP2271649A1 (fr) | 2011-01-12 |
MX2010009458A (es) | 2010-09-24 |
TW200951134A (en) | 2009-12-16 |
CO6321261A2 (es) | 2011-09-20 |
NI201000143A (es) | 2011-03-09 |
KR20100123725A (ko) | 2010-11-24 |
AR070728A1 (es) | 2010-04-28 |
AU2009219175A1 (en) | 2009-09-03 |
CR11650A (es) | 2010-09-14 |
WO2009108838A1 (fr) | 2009-09-03 |
IL207576A0 (en) | 2010-12-30 |
JP2011513334A (ja) | 2011-04-28 |
EA201001188A1 (ru) | 2011-04-29 |
ECSP10010429A (es) | 2010-09-30 |
DOP2010000261A (es) | 2010-09-15 |
ZA201005603B (en) | 2011-05-25 |
BRPI0908403A2 (pt) | 2015-08-11 |
CA2716499A1 (fr) | 2009-09-03 |
CN102083835A (zh) | 2011-06-01 |
AP2010005363A0 (en) | 2010-08-31 |
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