BR112019003914A2 - inibidores de processos metabólicos celulares - Google Patents

inibidores de processos metabólicos celulares

Info

Publication number
BR112019003914A2
BR112019003914A2 BR112019003914A BR112019003914A BR112019003914A2 BR 112019003914 A2 BR112019003914 A2 BR 112019003914A2 BR 112019003914 A BR112019003914 A BR 112019003914A BR 112019003914 A BR112019003914 A BR 112019003914A BR 112019003914 A2 BR112019003914 A2 BR 112019003914A2
Authority
BR
Brazil
Prior art keywords
inhibitors
metabolic processes
cellular metabolic
compounds
cellular
Prior art date
Application number
BR112019003914A
Other languages
English (en)
Inventor
M Travins Jeremy
D Konteatis Zenon
Sui Zhihua
Ye Zhixiong
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/097524 external-priority patent/WO2018039972A1/en
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of BR112019003914A2 publication Critical patent/BR112019003914A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)

Abstract

a presente divulgação fornece compostos inibidores de mat2a que são úteis como agentes terapêuticos para o tratamento de malignidades, e caracterizado por os compostos estarem em conformidade com a fórmula geral (ia) caracterizado por: ra, rb, rc, rd e re serem definidos neste documento.
BR112019003914A 2016-08-31 2017-08-30 inibidores de processos metabólicos celulares BR112019003914A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/CN2016/097524 WO2018039972A1 (en) 2016-08-31 2016-08-31 Inhibitors of cellular metabolic processes
US201762548738P 2017-08-22 2017-08-22
PCT/US2017/049439 WO2018045071A1 (en) 2016-08-31 2017-08-30 Inhibitors of cellular metabolic processes

Publications (1)

Publication Number Publication Date
BR112019003914A2 true BR112019003914A2 (pt) 2019-05-28

Family

ID=59846695

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019003914A BR112019003914A2 (pt) 2016-08-31 2017-08-30 inibidores de processos metabólicos celulares

Country Status (20)

Country Link
US (4) US10329298B2 (pt)
EP (1) EP3507290A1 (pt)
JP (2) JP6832430B2 (pt)
KR (1) KR102411150B1 (pt)
CN (1) CN109890822B (pt)
AU (2) AU2017319500C1 (pt)
BR (1) BR112019003914A2 (pt)
CA (1) CA3034705C (pt)
CL (1) CL2019000511A1 (pt)
CO (1) CO2019002237A2 (pt)
CR (1) CR20190157A (pt)
IL (1) IL265115B (pt)
MA (1) MA46092A (pt)
MX (1) MX2019002303A (pt)
NI (1) NI201900019A (pt)
PE (1) PE20190761A1 (pt)
SG (1) SG11201901747VA (pt)
TW (1) TWI762505B (pt)
UA (1) UA125852C2 (pt)
WO (1) WO2018045071A1 (pt)

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WO2021158792A1 (en) * 2020-02-04 2021-08-12 Agios Pharmaceuticals, Inc. Methods of treating autoimmune or inflammatory diseases or disorders
WO2021254529A1 (zh) * 2020-07-14 2021-12-23 江苏先声药业有限公司 双环类化合物
CN113999232A (zh) * 2020-07-28 2022-02-01 南京正大天晴制药有限公司 Mat2a抑制剂
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CN115960099A (zh) * 2020-09-24 2023-04-14 上海凌达生物医药有限公司 一类芳环或芳基杂环并吡啶酮类化合物、药物组合物及其应用
WO2022078403A1 (zh) * 2020-10-15 2022-04-21 江苏先声药业有限公司 取代的吡啶酮化合物及应用
WO2022115521A1 (en) * 2020-11-25 2022-06-02 Servier Pharmaceuticals, Llc (heteo)aryl substituted pyrrolo-, pyrazolo- and triazolopyridazine derivates as mat2a inhibitors
US20240124454A1 (en) 2020-12-31 2024-04-18 Nanjing Zaiming Pharmaceutical Co., Ltd. Tricyclic compound and use thereof
WO2022189379A1 (en) 2021-03-08 2022-09-15 Technische Universität München Treatment of coronavirus infections using sam cycle inhibitors
CN117396480A (zh) * 2021-03-26 2024-01-12 奥弗恩制药公司 吡唑并嘧啶酮化合物
JP2024116429A (ja) * 2021-07-06 2024-08-28 国立研究開発法人産業技術総合研究所 組織の老化を予防または治療するための組成物
CN115716831B (zh) * 2021-08-25 2024-07-02 中国科学院分子细胞科学卓越创新中心 一种mat2a抑制剂及其在抗病毒中的应用
WO2023083210A1 (zh) * 2021-11-09 2023-05-19 上海海雁医药科技有限公司 取代的萘啶酮衍生物、其药物组合物及应用
WO2023086934A1 (en) * 2021-11-12 2023-05-19 Ideaya Biosciences, Inc. Combination therapy comprising a mat2a inhibitor and a taxane
CN116283994A (zh) * 2021-12-20 2023-06-23 艾立康药业股份有限公司 作为mat2a抑制剂的杂环化合物
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GB202204913D0 (en) 2022-04-04 2022-05-18 Cambridge Entpr Ltd antiviral therapy
TW202415370A (zh) 2022-10-13 2024-04-16 南韓商韓美藥品股份有限公司 新穎三環衍生物化合物以及其應用
WO2024105553A1 (en) * 2022-11-16 2024-05-23 Novartis Ag Bicyclic heterocycles and their use as wrn inhibitors
CN116425721B (zh) * 2022-12-19 2024-02-02 艾立康药业股份有限公司 作为mat2a抑制剂的双环类化合物
WO2024153244A1 (zh) * 2023-01-20 2024-07-25 南京再明医药有限公司 含氮类化合物

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