WO2007071688A1 - Composition for dyeing keratin fibres with a tetraazapentamethine cationic direct dye, a particular oxidation base and a coupler - Google Patents

Composition for dyeing keratin fibres with a tetraazapentamethine cationic direct dye, a particular oxidation base and a coupler Download PDF

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Publication number
WO2007071688A1
WO2007071688A1 PCT/EP2006/069934 EP2006069934W WO2007071688A1 WO 2007071688 A1 WO2007071688 A1 WO 2007071688A1 EP 2006069934 W EP2006069934 W EP 2006069934W WO 2007071688 A1 WO2007071688 A1 WO 2007071688A1
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Prior art keywords
formazano
chloride
pyridinylidene
methyl
radical
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PCT/EP2006/069934
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French (fr)
Inventor
Maxime De Boni
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L'oréal
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Priority claimed from FR0554062A external-priority patent/FR2895245B1/en
Application filed by L'oréal filed Critical L'oréal
Publication of WO2007071688A1 publication Critical patent/WO2007071688A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B50/00—Formazane dyes; Tetrazolium dyes
    • C09B50/10—Cationic formazan dyes

Definitions

  • the invention relates to a composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising, in a suitable dyeing medium, at least one tetraazapentamethine cationic direct dye, and which is characterized in that it also contains at least one particular oxidation base and at least one coupler.
  • the invention also relates to the processes and dyeing devices using the said composition.
  • Two types of dyeing may be distinguished in the field of hair dyeing.
  • the first is semi-permanent or temporary dyeing, or direct dyeing, which involves dyes capable of giving the hair's natural coloration a more or less pronounced colour change, which may be resistant to shampoo washing several times.
  • These dyes are known as direct dyes; they may be used with or without an oxidizing agent.
  • the aim is to obtain lightening dyeing.
  • Lightening dyeing is performed by applying to the hair an extemporaneous mixture of a direct dye and an oxidizing agent, and makes it possible especially to obtain, via lightening of the melanin of the hair, an advantageous effect such as a unified colour in the case of grey hair, or to bring out the colour in the case of naturally pigmented hair.
  • the second is permanent dyeing or oxidation dyeing.
  • oxidation dyes comprising oxidation dye precursors and couplers.
  • Oxidation dye precursors commonly known as “oxidation bases” are compounds that are initially colourless or weakly coloured, which develop their dyeing power on the hair in the presence of oxidizing agents added at the time of use, leading to the formation of coloured compounds and dyes.
  • the formation of these coloured compounds and dyes results either from an oxidative condensation of the "oxidation bases” with themselves, or from an oxidative condensation of the "oxidation bases” with coloration modifiers commonly known as “couplers", which are generally present in the dye compositions used in oxidation dyeing.
  • direct dyes may be added thereto.
  • a first subject of the present invention is thus a composition for dyeing keratin fibres and in particular human keratin fibres such as the hair, containing, in a suitable dyeing medium, (i) at least one cationic direct dye whose structure corresponds to formula (I) defined below, characterized in that it also contains (ii) at least one heterocyclic oxidation base comprising in its structure at least one 5- or 6-membered sulfur-free nitrogenous heterocycle optionally fused with not more than one aromatic or heterocyclic ring and (iii) at least one coupler:
  • W 2 represents a heteroaromatic radical of formula (IV) or (V):
  • Z 0 represents a radical CR 2 , a nitrogen atom or a radical NR 2 i,
  • Z 1 represents an oxygen or sulfur atom or a radical NR 9
  • - Z 2 represents a nitrogen atom or a radical CR 1 0,
  • Z 3 represents a nitrogen atom or a radical CRn
  • Z 4 represents a nitrogen atom or a radical CR 12 ,
  • Z 5 represents a nitrogen atom or a radical CR 1 3,
  • Z 6 represents a nitrogen atom or a radical CR 14
  • - Z 7 represents an oxygen or sulfur atom or a radical NR 15 ,
  • Z 8 represents a nitrogen atom or a radical CR 16 ,
  • Z 9 represents a nitrogen atom or a radical CR 17 ,
  • Z 10 represents a nitrogen atom or a radical CR 18 ,
  • Z 11 represents a nitrogen atom or a radical CR 19
  • - Z 12 represents a nitrogen atom or a radical CR 20
  • Z 13 represents a radical CR 6 , a nitrogen atom or a radical NR 22 , it being understood that each of the rings of formulae (II), (III), (IV) and (V) comprise not more than three nitrogen atoms and that two of the three nitrogen atoms may be contiguous, - the bond a of the 5-membered cationic heteroaromatic radical of formula (II) being linked to the nitrogen atom N 1 of formula (I), the bond b of the 6-membered cationic heteroaromatic radical of formula (III) being linked to the nitrogen atom N 1 of formula (I), the double bond a' of the 5-membered heteroaromatic radical of formula (IV) being linked to the nitrogen atom N 2 of formula (I), the double bond b' of the 6-membered heteroaromatic radical of formula (V) being linked to the nitrogen atom N 2 of formula (I), the bond b, linking the cationic heteroaromatic radical of formula (III) to the nitrogen atom N 1 of formula (
  • R 2 , Re, R-io and R 16 represent, independently of each other, a hydrogen atom; a linear or branched C 1 -C 4 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino, C 1 -C 2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino and C 1 -C 2 (di)alkylamino radicals; a carboxyl radical; a sulfonylamino radical, R 1 , R 4 , R 5 , R 7 , Rg, R- 15 , R 21 and R 22 represent, independently of each other,
  • R 0 , R3, Re, R11, R12, Ri3, Ri 4 , Ri7, R18, Ri9 and R 20 represent, independently of each other, a hydrogen atom, a linear or branched C 1 -C 16 hydrocarbon-based chain, this chain possibly being saturated or unsaturated with one to three unsaturations, this chain being unsubstituted or substituted with one to three radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino, C 1 -C 2 (di)alkylamino, carboxyl, sulfonic, sulfonylamino and C 2 -C 4 (poly)hydroxyalkylamino radicals or a halogen atom such as chlorine, fluorine or bromine; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (pol
  • R 2 with R 10 , R 11 with R 12 , R 6 with R 16 , and R 17 with R 18 can form, independently of each other, a 5- or 6-membered carbon-based aromatic ring, which is unsubstituted or substituted with one or two hydroxyl, amino, (di)(CrC 2 )alkylamino, C 1 -C 2 alkoxy or C 2 -C 4 (poly)hydroxyalkylamino radicals, X is an organic or mineral anion.
  • branched hydrocarbon- based chain means a branched hydrocarbon-based chain that may also form one to five 3- to 7-membered carbon-based rings, this chain possibly comprising one to three unsaturations, i.e. one to three double bonds and/or triple bonds.
  • C 2 -C 4 (poly)hydroxyalkoxy means a C 2 -C 4 alkoxy group substituted with 1 or 2 hydroxyl groups.
  • C 2 -C 4 (poly)hydroxyalkylamino means an alkylamino group substituted with 1 or 2 hydroxyl groups.
  • hydrocarbon-based chain may be interrupted with one or more oxygen, nitrogen or sulfur atoms or with an SO 2 radical, or according to which this chain is unsaturated, means that the carbon-based chain may be modified in the following manner:
  • an organic or mineral anion is chosen, for example, from a halide such as chloride, bromide, fluoride or iodide; a hydroxide; a sulfate; a hydrogen sulfate; a (d-C ⁇ Jalkyl sulfate, for instance a methyl sulfate or an ethyl sulfate; an acetate; a tartrate; an oxalate; a (C"rC 6 )alkylsulfonate such as methyl sulfonate; an arylsulfonate, which is unsubstituted or substituted with a CrC 4 alkyl radical, for instance a 4- tolylsulfonate.
  • a halide such as chloride, bromide, fluoride or iodide
  • a hydroxide such as chloride, bromide, fluoride or iodide
  • a hydroxide such as chloride
  • Ro represents a hydrogen atom; a linear or branched C 1 -C 6 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, CrC 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino, C 1 -C 2 (di)alkylamino, C 2 -C 4 (poly)hydroxyalkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino, CrC 2 (di)alkylamino, carboxyl and sulfonic radicals or a halogen atom such as chlorine, fluorine or bromine, an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl, thi
  • R 0 preferably represents a hydrogen atom; a linear or branched C 1 -C 3 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C 1 -C 2 alkoxy, amino, C 1 -C 2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, amino, C 1 -C 2 (di)alkylamino and C 2 -C 4 (poly)hydroxyalkylamino radicals, or an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl and pyridyl radicals.
  • R 0 represents a hydrogen atom; a methyl, ethyl, propyl, butyl, 2-hydroxyethyl, 2-aminoethyl, 1-carboxymethyl, 2-carboxyethyl, 2-sulfonylethyl or 2-methoxyethyl; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from amino, C 1 -C 2 (di)alkylamino and C 2 -C 4 (poly)hydroxyalkylamino radicals, or an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl and pyridyl radicals.
  • R 0 even more preferably represents a hydrogen atom; a methyl, ethyl or 2-methoxyethyl radical; a phenyl radical, which is unsubstituted or substituted with an amino, (di)methylamino or (di)(2-hydroxyethyl)amino radical, or an optionally cationic heteroaryl radical chosen from imidazolyl and pyridyl radicals.
  • R 2 , R 6 , R 1O and R 16 preferably represent a hydrogen atom, a phenyl radical or a C 1 -C 4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, amino, C 1 -C 2 (di)alkylamino and carboxyl radicals.
  • R 2 , R 6 , R 10 and R 16 preferably represent a hydrogen atom, a methyl, phenyl or 2-hydroxymethyl radical, a carboxyl or a phenyl radical.
  • Ri, R 4 , R5, R 7 , Rg, Ri5, R 21 and R 22 preferably represent a CrC 4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C 1 -C 2 alkoxy, amino, CrC 2 (di)alkylamino, carboxyl and sulfonic radicals.
  • R 1 , R 4 , R 5 , R 7 , R 9 , R 15 , R 21 and R 22 preferably represent a methyl, ethyl, 2-hydroxyethyl, 1-carboxymethyl, 2-carboxyethyl or 2- sulfonylethyl radical.
  • R 3 , R 8 , R 11 , R 12 , R 13 , R 14 , R 17 , R 18 , R 1 9 and R 20 preferably represent, independently of each other, a hydrogen atom; a linear or branched C 1 -C 4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino, C 1 -C 2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C 1 -C 2 alkoxy, C 2 -C 4 (poly)hydroxyalkoxy, amino, C 1 -C 2 (di)alkylamino, carboxyl and sulfonic radicals or a halogen atom such as chlorine, fluorine or bromine;
  • R 3 , R 8 , R 11 , R 12 , R 13 , R 14 , R 17 , R 18 , R 19 and R 20 represent a hydrogen atom, a C 1 -C 4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl radicals or a C 1 -C 2 alkoxy radical; an amino radical; a C 1 -C 2 (di)alkylamino radical; a carboxyl radical; a C 2 -C 4 (poly)hydroxyalkylamino radical.
  • R 3 , R 8 , R 11 , R 12 , R 13 , R 14 , R 17 , R 18 , R 19 and R 20 represent, independently of each other, a hydrogen atom, a methyl or 2- hydroxymethyl radical, a carboxyl, a methoxy, ethoxy or 2-hydroxyethyloxy radical, or an amino, methylamino, dimethylamino or 2-hydroxyethylamino radical.
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-pyridinium radical and W 2 is a 2-pyridine radical. Even more preferably, they are the following compounds:
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 4-pyridinium radical and W 2 is a 4-pyridine radical. Even more preferably, they are the following compounds:
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-imidazolium radical and W 2 is a 2-imidazole radical. Even more preferably, they are the following compounds: - 2-[5-(1 ,3-dimethyl-2-imidazolidene)-1-formazano]-1 ,3-dimethylimidazolium chloride
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 5-pyrazolium radical and W 2 is a 5-pyrazole radical. Even more preferably, they are the following compounds:
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-benzimidazolium radical and W 2 is a 2- pyridine radical. Even more preferably, they are the following compounds:
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-benzimidazolium radical and W 2 is a 4- pyridine radical. Even more preferably, they are the following compounds: - 2-[5-(N-methyl-4-pyridinylidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-imidazolium radical and W 2 is a 2-pyridine radical. Even more preferably, they are the following compounds:
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-imidazolium radical and W 2 is a 4-pyridine radical. Even more preferably, they are the following compounds:
  • the compounds of formula I are chosen from the family defined by the compounds for which W 1 is a 2-benzimidazolium radical and W 2 is a 2-benzimidazole radical. Even more preferably, they are the following compounds:
  • the compounds of family A (first variant) will be preferred most particularly.
  • the compound(s) of formula (I) is (are) preferably present in a concentration ranging from 0.001 % to 10%, preferably from 0.005% to 5% and even more preferentially from 0.01 % to 2% by weight relative to the total weight of the composition.
  • the compounds of formula (I) may especially be obtained via a process in which at least two equivalents of at least one hydrazone chosen from the hydrazones of formula A and the hydrazones of formula B:
  • Formula A in which Zi 4 , -_ 15 , -_ 16 ⁇ nu ⁇ 25 have me o ⁇ mc mc ⁇ iiings as Z 7 , Zs, Zi 3 , and R 5 , respectively, of formula IV,
  • Y being an organic or mineral anion
  • x being an integer ranging from 1 to 3
  • Z 17 , Z 18 , Z 19 , Z 20 , R 26 and R 27 have the same meanings as Z 9 , Z 10 , Z 11 , Z 12 , R 8 and R 7 , respectively, of formula V,
  • Y' being an organic or mineral anion, x' being an integer ranging from 1 to 3, are reacted with one equivalent of an aldehyde of formula R 23 CHO, R 23 having the same meaning as R 0 of formula I. Two equivalents of the same hydrazone or of two different hydrazones may thus be reacted.
  • the aldehyde of formula R 23 CHO is generated in the reaction medium from an aldehyde precursor of formula R' 23 CH 2 OH in the presence of an oxidizing system; R' 23 then has the same meaning as R 0 of formula I.
  • This oxidizing system may be a chemical oxidizing agent or a biocatalytic oxidizing agent such as an enzyme.
  • the process for preparing the compound of formula (I) according to the present invention may be performed in the presence of an aldehyde precursor of formula R' 23 CH 2 OH and of at least one enzyme capable of generating an aldehyde from the aldehyde precursor of formula R' 23 CH 2 OH.
  • the process for enzymatically synthesizing the compounds of formula (I) defined above is performed by reacting at least two equivalents of at least one hydrazone chosen from the hydrazones of formula A and the hydrazones of formula B in which Z 14 , Z 15 , Z 16 and R 25 have the same meanings as Z 7 , Z 8 , Z 13 and R 5 , respectively, of formula IV, Y being an organic or mineral anion, x being an integer ranging from 1 to 3,
  • Y' being an organic or mineral anion
  • x' being an integer ranging from 1 to 3, with one equivalent of an aldehyde of formula R 23 CHO, R 23 having the same meaning as R 0 of formula I.
  • the reaction is performed with or without an oxidizing system, with or without a cofactor for the enzyme, and with or without a system for regenerating the cofactor.
  • an oxidizing system means that no oxidizing system other than atmospheric oxygen is used.
  • the reaction is performed in aerobic medium at a pH of between 3 and 11 and at a temperature of between 6°C and 80°C.
  • the aldehyde precursor that may be used to prepare the compound of formula (I) may be chosen from primary alcohols, sarcosine, 4-hydroxymandelate, N6- methyllysine, dimethylglycine, methylglutamate, 2-oxo acids, for example 2-oxo acid pyruvate, benzoylformate, phenylpyruvate or threonine. It will preferably be chosen from primary alcohols.
  • the enzymes capable of generating an aldehyde from this aldehyde precursor may be chosen especially from the alcohol dehydrogenases EC 1.1.1.1 , the alcohol dehydrogenases EC 1.1.1.2, the alcohol dehydrogenases EC 1.1.1.71 , the aromatic alcohol dehydrogenases EC 1.1.1.90, also known as aryl alcohol dehydrogenases, the aromatic alcohol dehydrogenases EC 1.1.1.97, the 3-hydroxybenzyl alcohol dehydrogenases EC 1.1.1.97, the coniferyl alcohol dehydrogenases EC 1.1.1.194, the cinnamyl alcohol dehydrogenases EC 1.1.1.195, the methanol dehydrogenases EC 1.1.1.244, the aromatic alcohol oxidases EC 1.1.3.7, also known as aryl alcohol oxidases, the alcohol oxidases EC 1.1.3.13, the 4- hydroxymandelate oxidases EC 1.1.3.19, the long-chain hydrocarbon alcohol oxid
  • N-methyl L-amino acid oxidase EC 1.5.3.2 N-methyl-L-amino acid
  • trimethylamine dehydrogenase EC 1.5.99.7 trimethylamine
  • dimethylamine dehydrogenase EC 1.5.99.10 dimethylamine
  • nitroethane oxidase EC 1.7.3.1 nitroethane
  • acetoin ribose 5 phosphate transaldolase EC 2.2.1.4 (3-hydroxybutan-2-one), diamine aminotransferase EC 2.6.1.29 (alpha omega diamine + 2- oxogluterate), alkenylglycerophosphocholine hydrolase EC 3.3
  • the enzyme capable of generating an aldehyde from the aldehyde precursor used in the dye composition according to the invention may be derived from an extract of plants, of animals, of microorganisms (bacterium, fungus, yeast or microalga) or from viruses, or from cells that are differentiated or undifferentiated, obtained in vivo or in vitro, which are genetically modified or unmodified, or synthetic (obtained via chemical or biotechnological synthesis).
  • Examples of useful enzymes that may be mentioned in particular are the genera Plectranthus, Pinus, Gastropode, Manduca, Pichia, Candida, Pleurotus, and Pseudomonas, and even more particularly the following species: Plectranthus colloides, Pinus strobus, which is a species of plant origin, Gastropode mollusc and Manduca sexta, which are of animal origin, Pichia pastoris and Candida boidinii, which are yeasts, Pleurotus pulmonarius, which is a fungus, and Pseudomonas pseudoalcaligenes, which is a bacterium.
  • Plectranthus colloides Pinus strobus, which is a species of plant origin
  • Gastropode mollusc and Manduca sexta which are of animal origin
  • Pichia pastoris and Candida boidinii which are yeasts
  • Pleurotus pulmonarius which is a fungus
  • the choice of the enzyme depends on the nature of the aldehyde precursor. For example, when the aldehyde precursor is an alcohol, then the enzyme is chosen from enzymes capable of generating an aldehyde from this alcohol. When the aldehyde precursor is methylglutamate, then the enzyme is a methylglutamate dehydrogenase.
  • the aldehyde precursor is a primary alcohol and the enzyme is an enzyme capable of generating the aldehyde from an alcohol.
  • the primary alcohol is a Ci-C ⁇ aliphatic alcohol
  • the enzyme capable of generating the aldehyde is chosen from alcohol oxidases, alcohol dehydrogenases, methanol dehydrogenases and methanol oxidases.
  • the primary alcohol is benzyl alcohol, 4-tert- butylbenzyl alcohol, 3-hydroxy-4-methoxybenzyl alcohol, veratryl alcohol, 4-methoxybenzyl alcohol, cinnamyl alcohol or 2,4-hexadien-1-ol, aryl alcohol oxidases or aromatic alcohol dehydrogenases may be used as aldehyde precursor.
  • the enzyme dehydrogenases it is essential to include the cofactor(s) required for their activity, more specifically NAD + or NADP + or other molecules capable of acting as electron acceptor.
  • the addition of a system for regenerating the cofactors may be used for reaction purposes or economic purposes. This regeneration system may be enzymatic, chemical or electrochemical.
  • oxidizing agents may be used to perform this process: aqueous hydrogen peroxide solution, organic peracids such as peracetic acid, persalts such as permanganate, perborate and persulfates, chromates or dichromates, hypochlorites, hypobromites, ferricyanides, and peroxides such as manganese dioxide or lead dioxide.
  • Aqueous hydrogen peroxide solution will preferably be used.
  • the concentration of enzyme substrate may be between 0.001 M and 6 M and preferably between 0.1 M and 4 M.
  • the reaction may be performed between pH 3 and pH 1 1 and preferably between pH 5 and pH 9.5.
  • the reaction temperature may be between 10°C and 80°C and preferably between 20°C and
  • the hydrazone concentration of the reaction medium is between 0.01 M and 3 M and preferably between 0.1 M and 1 M.
  • the content of cofactor for said enzymes may be between 0.01 mM and 1 M and preferably between 0.1 mM and 10 mM.
  • the reagents the hydrazone(s), the enzyme(s), the substrate for said enzyme, and/or the cofactor for said enzyme, and the oxidizing agent and/or the system for regenerating the cofactor are mixed together, and the pH and the temperature are adjusted.
  • the compounds of formula I may also be prepared via a process in which a compound of formula (F1 ) or (F2)
  • Formula Fl Formula F2 with Z 14 , Z M , , negligence,tician - - R25 for formula F _ , _,, , , _, rule, Z 2 o, Ro, R24 and R26 for formula F2 having the meanings described above, is reacted in the presence of one equivalent of a hydrazone of formula (A) or (B).
  • the compounds of formula (F1 ) or (F2) may be obtained by reacting a compound of formula R ⁇ sC(OR 24 ) S and a hydrazone of formula (A) or (B) in the presence or absence of a protic solvent whose boiling point ranges between 66°C and 180°C.
  • R" 2 3 has the same meaning as Ro of formula (I) and R 24 represents a radical chosen from methyl and ethyl groups.
  • the reaction is performed in the presence of triethyl orthoformate and trimethyl orthoacetate at a temperature of between 0°C and 150°C for a period of between 30 minutes and 12 hours.
  • the protic solvent is chosen from H 2 O, ethanol and methanol.
  • the dye composition in accordance with the invention contains, in addition to the cationic direct dye(s) (i), one or more heterocyclic oxidation bases comprising in their structure at least one 5- or 6-membered sulfur-free nitrogenous heterocycle optionally fused with at least one aromatic or heterocyclic ring (ii).
  • sulfur-free nitrogenous heterocycle means a heterocycle comprising in the sequence of ring members constituting the said ring at least one nitrogen atom and no sulfur atoms.
  • the heterocyclic bases of the invention may contain on the ring(s) constituting them one or more identical or different substituents. These substituents may or may not comprise one or more heteroatoms, including sulfur.
  • heterocyclic bases in accordance with the invention, mention may be made of pyridines, pyrazoles, fused pyrazolopyrimidines, pyrazolotriazoles, pyrazolotetrazoles, pyrazolopyridazines, pyrazoloimidazoles, pyrazolopyrazoles, aminopyrazolones, aminopyrrolidines, aminopyrazolines, monoaminoquinolines, aminoindazoles, diaminouracils, hydrazones, aminoindolenines, diamino- or triaminoquinolines, pyrazolobenzimidazoles and pyrimidines, alone or as mixtures.
  • pyridine derivatives that may be mentioned more particularly are the compounds described, for example, in patents GB 1 026 978 and GB 1 153 196, such as 2,5-diaminopyridine and 3,4-diaminopyridine, and the addition salts thereof with an acid.
  • pyrazole derivatives that may be mentioned more particularly are the compounds described in patents DE 38 43 892 and DE 41 33 957 and patent applications WO 94/08969, WO 94/08970, FR-A-2 733 749 and DE 195 43 988, for instance 4,5-diamino-1- methylpyrazole, 3,4-diaminopyrazole, 4,5-diamino-1-(4'-chlorobenzyl)pyrazole, 4,5-diamino- 1 ,3-dimethylpyrazole, 4,5-diamino-3-methyl-1-phenylpyrazole, 4,5-diamino-1-methyl-3- phenylpyrazole, 4-amino-1 ,3-dimethyl-5-hydrazinopyrazole, 1-benzyl-4,5-diamino-3-methyl- pyrazole, 4,5-diamino-3-tert-butyl-1 -methylpyrazole,
  • R 2 , R3 and R 4 which may be identical or different, denote a hydrogen atom, a d-C 4 alkyl radical, an aryl radical, a Ci-C 4 hydroxyalkyl radical, a C 2 -C 4 polyhydroxyalkyl radical, a (Ci-C 4 )alkoxy(CrC 4 )alkyl radical, a d-C 4 aminoalkyl radical; a d-C 4 aminoalkyl radical in which the amine is protected with an acetyl, ureido or sulfonyl radical; a (Cr C 4 )alkylamino(Ci-C 4 )alkyl radical; a di[(Ci-C 4 )alkyl]amino(Ci-C 4 )alkyl radical in which the dialkyl radicals can form a 5- or 6-membered aliphatic or heterocyclic ring; a hydroxy(Cr C 4 )al
  • - i is equal to 0, 1 , 2 or 3;
  • - p is equal to 0 or 1 ;
  • pyrazolo[1 ,5-a]pyrimidines described above are known compounds and are especially described in patent application FR-A-2 750 048.
  • Diaminouracils that may be mentioned include the compounds 5,6-diaminouracil, 5,6- diamino-2-thiouracil, 5,6-diamino-3-methyluracil, ⁇ -amino-S-methyl- ⁇ -methylaminouracil, 5- amino-3-methyl-6- ⁇ -hydroxyethylaminouracil, 5-amino-3-methyl-6-benzylaminouracil, 5- amino-3-methyl-6-phenylaminouracil, 5,6-diamino-i-phenyluracil, 5,6-diamino-1 ,3- dimethyluracil, 5-amino-1 ,3-dimethyl-6-methylaminouracil, 5-amino-1 ,3-dimethyl-6- ⁇ - hydroxymethylaminouracil, 5-amino-1 ,3-dimethyl-6-benzylaminouracil, 5-amino-1 ,3-dimethyl- 6-phenylaminouracil and ⁇ -a
  • Aminoindolenines that may be mentioned include the compounds 2-methyl-5- aminoindolenine and 1- ⁇ -hydroxyethyl-2-methyl-5-aminoindolenine. Such compounds are described in document FR 1 602 547.
  • Mono- or diaminotetrahydroquinolines that may be mentioned include the compounds 5- amino-1 ,2,3,4-tetrahydroquinoline, 5-amino-7-chloro-8-piperidino-1 ,2,3,4-tetrahydroquinoline,
  • Diaminoquinolines that may be mentioned include the compounds 5,7-diamino-6-methyl-8- hydroxyquinoline and 5,7-diamino-2-methyl-8-hydroxyquinoline. Such compounds are described in document DE 2 441 598.
  • Triaminoquinolines that may be mentioned include 5,7-diamino-8-methylaminoquinoline, 5,7- diamino-8-dimethylaminoquinoline, 5,7-diamino-8-morpholinoquinoline, 5,7-diamino-8- ⁇ - hydroxyethylaminoquinoline and 5,7,8-triaminoquinoline. Such compounds are described in document DE 2 441 599.
  • Aminopyrazolones that may be mentioned include 1-phenyl-4-aminopyrazolone-3-carbonic acid, 1-phenyl-4-aminopyrazolone-3-carbonic acid amide, ethyl 1-phenyl-4-aminopyrazolone- 3-carbonate and i-phenyl-S-methyM-aminopyrazolone. Such compounds are described in document FR 1 488 169. Mention may also be made of 3-aminopyrazolone, 1-phenyl-3- aminopyrazolone and 1-phenyl-3-hydroxypyrazolone. Such compounds are described in document FR 1 564 999.
  • Pyrazolotriazoles that may be mentioned include the compounds 3-amino-4-methyl-6- methylthio-2-phenylpyrazolo[3,2-c]-s-triazole, 3-amino-2,4,6-trimethylpyrazolo[3,2-c]-s- triazole and 3-amino-4,6-dimethylpyrazolo[3,2-c]-s-triazole. Such compounds are described in document US 5 457 200.
  • Pyrazoloimidazoles that may be mentioned include the compounds 3-amino-4- benzylpyrazolo[1 ,5-a]imidazole, 3-amino-2,4-dimethylpyrazolo[1 ,5-a]imidazole and 3-amino- 4-methylpyrazolo[1 ,5-a]imidazole. Such compounds are described in document US 5 457 200.
  • a pyrazoloquinoline that may be mentioned is the compound 3-amino-2-phenylpyrazolo[1 ,5- a]quinoline. Such compounds are described in document US 5 457 200.
  • a pyrazolopyridazine that may be mentioned is 3-aminopyrazolo[1 ,5-b]pyridazine. Such compounds are described in document US 5 457 200.
  • Hydrazones that may be mentioned include the compounds N-methylpyridone-4-hydrazone, N,N-dimethylbenzimidazolonehydrazone, N-methylpyridone-2-hydrazone, 1 ,2-dimethylinda zolone-3-hydrazone, 1 ,2,6-trimethylpyridone-4-hydrazone, 1 -methylquinolone-2-hydrazone, 1 ,2,6-trimethyl-3-nitropyridone-4-hydrazone, 1 ,2,6-trimethyl-3-aminopyridone-4-hydrazone, 1 ,2,5-trimethylpyrazolone-3-hydrazone, 1 ,2-dimethylindazolone-3-hydrazone, 1 ,2-dimethyl-5- chloroindazolone-3-hydrazone, 1-methyl-2-ethyl-5-nitroindazolone-3-hydrazone and N- methylquinolone-4-hydrazone.
  • Such compounds are described in document FR 1 602
  • Aminopyrazolines that may be mentioned include the compounds 1-(4'-aminophenyl)-3- aminopyrazoline and 1-(4'-hydroxyphenyl)-3-aminopyrazoline. Such compounds are described in document FR 2 018 056.
  • Aminoindazoles that may be mentioned include 4,7-diamino-5-methylindazole, 4,7-diamino- 5,6-dimethylindazole, 6,7-diaminoindazole, 6-hydroxy-7-aminoindazole, 1-ethyl-6-hydroxy-7- aminoindazole, 6-aminoindazole and 5,6-diaminoindazole.
  • Such compounds are described in documents FR 2 315 906 and DE 1 492 166.
  • Pyrazolobenzimidazoles that may be mentioned include the compounds 7-amino-6- methylpyrazolo[1 ,5-a]benzimidazole, 6,7-diaminopyrazolo[1 ,5-a]benzimidazole, 6,7-diamino- 2-methylpyrazolo[1 ,5-a]benzimidazole and 6,7-diamino-2-phenylpyrazolo[1 ,5-a] benzimidazole, which are described, for example, in EP 923 929.
  • Pyrazolotetrazoles that may be mentioned include the compounds 7-amino-6- methylpyrazolo[1 ,5-e]tetrazole, 7-amino-6-phenylpyrazolo[1 ,5-e]tetrazole and 7-amino-6- carboxypyrazolo[1 ,5-e]tetrazole, which are described in EP 923 929.
  • Pyrimidine derivatives that may be mentioned include the compounds described, for example, in patents DE 2 359 399; JP 88-169 571 ; JP 05-63124; EP 0 770 375 or patent application WO 96/15765, for instance 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6- triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopyrimidine and 2,5,6-triaminopyrimidine, and the addition salts thereof with an acid, and the tautomeric forms thereof, when a tautomeric equilibrium exists.
  • the heterocyclic oxidation base(s) according to the invention is (are) chosen from monocyclic pyrazoles and pyrimidines.
  • compositions of the invention may also contain one or more additional oxidation bases.
  • oxidation bases are preferably chosen from the oxidation bases conventionally used for oxidation dyeing, and among which mention may be made especially of para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols and ortho- aminophenols.
  • Ri represents a hydrogen atom, a CrC 4 alkyl radical, a d-C 4 monohydroxyalkyl radical, a C 2 -C 4 polyhydroxyalkyl radical, a (Ci-C 4 )alkoxy(Ci-C 4 )alkyl radical, a CrC 4 alkyl radical substituted with a nitrogenous group, a phenyl group or a 4'-aminophenyl group;
  • R 2 represents a hydrogen atom, a CrC 4 alkyl radical, a CrC 4 monohydroxyalkyl radical, a C 2 -C 4 polyhydroxyalkyl radical, a (Ci-C 4 )alkoxy(CrC 4 )alkyl radical or a CrC 4 alkyl radical substituted with a nitrogenous group; Ri and R 2 may also form with the nitrogen atom that bears them a 5- or 6-membered nitrogenous heterocycle optionally substituted with one or more alkyl, hydroxy or ureido groups;
  • R 3 represents a hydrogen atom, a halogen atom such as a chlorine atom, a CrC 4 alkyl radical, a sulfo radical, a carboxy radical, a CrC 4 monohydroxyalkyl radical, a CrC 4 hydroxyalkoxy radical, an acetylamino(CrC 4 )alkoxy radical, a C 1 -C 4 mesylaminoalkoxy radical or a carbamoylamino(CrC 4 )alkoxy radical,
  • R 4 represents a hydrogen or halogen atom or a C 1 -C 4 alkyl radical.
  • nitrogenous groups of formula (Vl) above mention may be made in particular of amino, mono(Ci-C 4 )alkylamino, di(Ci-C 4 )alkylamino, tri(Ci-C 4 )alkylamino, monohydroxy(d- C 4 )alkylamino, imidazolinium and ammonium radicals.
  • para-phenylenediamines of formula (Vl) above examples include para-phenylenediamine, para-tolylenediamine, 2-chloro-para- phenylenediamine, 2,3-dimethyl-para-phenylenediamine, 2,6-dimethyl-para- phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,5-dimethyl-para-phenylenediamine, N,N-dimethyl-para-phenylenediamine, N,N-diethyl-para-phenylenediamine, N,N-dipropyl- para-phenylenediamine, 4-amino-N,N-diethyl-3-methylaniline, N,N-bis( ⁇ -hydroxyethyl)-para- phenylenediamine, 4-amino-N,N-bis( ⁇ -hydroxyethyl)-2-methylaniline, 4-amino-2-chloro
  • para-phenylenediamines of formula (Vl) above para-phenylenediamine, para- tolylenediamine, 2-isopropyl-para-phenylenediamine, 2- ⁇ -hydroxyethyl-para-phenylene- diamine, 2- ⁇ -hydroxyethyloxy-para-phenylenediamine, 2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,3-dimethyl-para-phenylenediamine, N,N-bis( ⁇ -hydroxy- ethyl)-para-phenylenediamine and 2-chloro-para-phenylenediamine, and the addition salts thereof with an acid are most particularly preferred.
  • double bases is understood to refer to the compounds containing at least two aromatic nucleii bearing amino and/or hydroxyl groups.
  • - Z 1 and Z 2 which may be identical or different, represent a hydroxyl or -NH 2 group that may be substituted with a CrC 4 alkyl radical or with a linker arm Y;
  • the linker arm Y represents a linear or branched alkylene chain containing from 1 to 14 carbon atoms, which may be interrupted by or terminated with one or more nitrogenous groups and/or one or more heteroatoms such as oxygen, sulfur or nitrogen atoms, and optionally substituted with one or more hydroxyl or CrC ⁇ alkoxy radicals;
  • R 5 and R 6 represent a hydrogen or halogen atom, a CrC 4 alkyl radical, a CrC 4 monohydroxyalkyl radical, a C 2 -C 4 polyhydroxyalkyl radical, a CrC 4 aminoalkyl radical or a linker arm Y;
  • R 7 , Rs, Rg, R-io, Rn and Ri 2 which may be identical or different, represent a hydrogen atom, a linker arm Y or a CrC 4 alkyl radical; it being understood that the compounds of formula (VII) contain only one linker arm Y per molecule.
  • nitrogenous groups of formula (VII) above mention may be made in particular of amino, mono(CrC 4 )alkylamino, di(CrC 4 )alkylamino, tri(CrC 4 )alkylamino, monohydroxy(Cr C 4 )alkylamino, imidazolinium and ammonium radicals.
  • N,N'-bis( ⁇ -hydroxyethyl)-N,N'-bis(4'-amino- phenyl)-1 ,3-diaminopropanol and 1 ,8-bis(2,5-diaminophenoxy)-3,5-dioxaoctane, or one of the addition salts thereof with an acid are particularly preferred.
  • para-Aminophenols that may especially be mentioned include those corresponding to formula (VIII) below, and the addition salts thereof with an acid:
  • R- 1 3 represents a hydrogen atom, a halogen atom such as fluorine, a C 1 -C 4 alkyl,
  • Ru represents a hydrogen atom or a halogen atom such as fluorine, a CrC 4 -alkyl, C 1 -C 4 monohydroxyalkyl, C 2 -C 4 polyhydroxyalkyl, CrC 4 aminoalkyl, CrC 4 cyanoalkyl or (C 1 -C 4 )alkoxy(C 1 -C 4 )alkyl radical.
  • para-aminophenols of formula (VIII) mention may be made more particularly of para-aminophenol, 4-amino-3-methylphenol, 4-amino-3-fluorophenol, 4-amino- 3-hydroxymethylphenol, 4-amino-2-methylphenol, 4-amino-2-hydroxymethylphenol, 4-amino- 2-methoxymethylphenol, 4-amino-2-aminomethylphenol and 4-amino-2-
  • the ortho-aminophenols that may be used as oxidation bases in the context of the present invention are chosen especially from 2-aminophenol, 2-amino-1-hydroxy-5- methylbenzene, 2-amino-1-hydroxy-6-methylbenzene and 5-acetamido-2-aminophenol, and the addition salts thereof with an acid.
  • the heterocyclic oxidation base(s) of the invention preferably represent(s) from 0.0005% to 12% by weight approximately relative to the total weight of the dye composition, and even more preferably from 0.005% to 6% by weight approximately relative to this weight.
  • the additional oxidation base(s) preferably represent(s) from 0.0005% to 12% by weight approximately relative to the total weight of the dye composition, and even more preferentially from 0.005% to 6% by weight approximately relative to this weight.
  • compositions of the invention contain at least one coupler.
  • the couplers that may be used in the dye composition according to the invention are those conventionally used in oxidation dye compositions, i.e. meta-aminophenols, meta- phenylenediamines, meta-diphenols, naphthols and heterocyclic couplers, and the addition salts thereof with an acid.
  • additional couplers are more particularly chosen from 2,4-diamino-1-( ⁇ - hydroxyethyloxy)benzene, 2-methyl-5-aminophenol, 5-N-( ⁇ -hydroxyethyl)amino-2-methyl- phenol, 3-aminophenol, 1 ,3-dihydroxybenzene, 1 ,3-dihydroxy-2-methylbenzene, 4-chloro- 1 ,3-dihydroxybenzene, 2-amino-4-( ⁇ -hydroxyethylamino)-1-methoxybenzene, 1 ,3-diamino benzene, 1 ,3-bis(2,4-diaminophenoxy)propane, sesamol, 1-amino-2-methoxy-4,5- methylenedioxybenzene, ⁇ -naphthol, 6-hydroxybenzomorpholine, 2-amino-3- hydroxypyridine, 1-amino-4,5-methylenedioxybenzene and 1-( ⁇ -hydroxyeth
  • the coupler(s) preferably represent(s) from 0.0001 % to 10% by weight approximately relative to the total weight of the dye composition, and even more preferentially from 0.005% to 5% by weight approximately relative to this weight.
  • addition salts with an acid of the oxidation bases and couplers are especially chosen from the hydrochlorides, hydrobromides, sulfates, tartrates, lactates and acetates.
  • the suitable dyeing medium generally consists of water or of a mixture of water and of at least one organic solvent to dissolve the compounds that are not sufficiently water- soluble.
  • organic solvents include CrC 4 lower alkanols, such as ethanol and isopropanol; aromatic alcohols, for instance benzyl alcohol, and also similar products and mixtures thereof.
  • the solvents may be present in proportions preferably between 1 % and 40% by weight approximately and even more preferentially between 5% and 30% by weight approximately relative to the total weight of the dye composition.
  • the pH of the dye composition in accordance with the invention is generally between 2 and 1 1 approximately and preferably between 5 and 10 approximately. It may be adjusted to the desired value by means of acidifying or basifying agents usually used in the dyeing of keratin fibres.
  • acidifying agents examples that may be mentioned include mineral or organic acids, for instance hydrochloric acid, orthophosphoric acid, sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid and lactic acid, and sulfonic acids.
  • mineral or organic acids for instance hydrochloric acid, orthophosphoric acid, sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid and lactic acid, and sulfonic acids.
  • basifying agents examples that may be mentioned include aqueous ammonia, alkali metal carbonates, alkanolamines such as monoethanolamine, diethanolamine and triethanolamine, and also derivatives thereof, sodium hydroxide, potassium hydroxide and the compounds of formula (XV) below:
  • the dye compositions in accordance with the invention may contain one or more other additional direct dyes that may be chosen, for example, from nitrobenzene dyes, anthraquinone dyes, naphthoquinone dyes, triarylmethane dyes, xanthene dyes and non- cationic azo dyes.
  • the dye composition in accordance with the invention may also contain various adjuvants conventionally used in hair dye compositions, such as antioxidants, penetrants, sequestrants, fragrances, buffers, nonionic, anionic or amphoteric polymers, non-silicone cationic polymers, nonionic, cationic or amphoteric surfactants, ceramides, preserving agents, screening agents and opacifiers.
  • adjuvants conventionally used in hair dye compositions such as antioxidants, penetrants, sequestrants, fragrances, buffers, nonionic, anionic or amphoteric polymers, non-silicone cationic polymers, nonionic, cationic or amphoteric surfactants, ceramides, preserving agents, screening agents and opacifiers.
  • the dye composition according to the invention may be in various forms, such as in the form of liquids, shampoos, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and especially human hair. It may be obtained by extemporaneously mixing a composition, optionally a pulverulent composition, containing the cationic direct dye(s) of formula (I) with a composition containing at least one oxidation base and at least one nitrogenous heterocyclic coupler as defined above.
  • the dye composition in accordance with the invention also contains at least one oxidizing agent chosen, for example, from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, and enzymes such as peroxidases, laccases and two-electron oxidoreductases.
  • oxidizing agent chosen, for example, from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, and enzymes such as peroxidases, laccases and two-electron oxidoreductases.
  • the use of hydrogen peroxide or of enzymes is particularly preferred.
  • Another subject of the invention is a process for dyeing keratin fibres, and in particular human keratin fibres such as the hair, using the dye composition as defined above.
  • the dyeing process comprises a preliminary step that consists in separately storing, on the one hand, a composition (A1 ) comprising, in a suitable dyeing medium, at least one cationic direct dye (i) as defined above and, on the other hand, a composition (B1 ) containing, in a suitable dyeing medium, at least one oxidizing agent, and optionally a composition (C1 ) in a suitable dyeing medium, and then in mixing together at the time of use compositions (A1 ) and (B1 ) and optionally (C1 ), followed by applying this mixture to keratin fibres, composition (A1 ) and/or composition (C1 ) containing at least one particular heterocyclic oxidation base and at least one coupler as defined above.
  • a composition (A1 ) comprising, in a suitable dyeing medium, at least one cationic direct dye (i) as defined above and, on the other hand, a composition (B1 ) containing, in a suitable dyeing medium, at least one
  • Another subject of the invention is a multi-compartment device or dyeing "kit” or any other multi-compartment packaging system, of which a first compartment contains composition (A1 ) as defined above, a second compartment contains composition (B1 ), and optionally a third compartment contains composition (C1 ) as defined above.
  • These devices may be equipped with a means for applying the desired mixture to the hair, such as the devices described in patent FR 2 586 913 in the name of the Applicant.
  • the dye composition below was prepared (amounts expressed as grams of active material):
  • this composition is mixed weight for weight with 20-volumes aqueous hydrogen peroxide solution at pH 3.
  • the mixture is applied firstly to locks of natural grey hair containing 90% white hairs, and secondly to locks of permanent-waved grey hair containing 90% white hairs, for 30 minutes at room temperature (20°C).
  • the locks are rinsed, shampooed and then rinsed and dried. They are dyed in a sparingly selective chromatic deep purple-mahogany blond shade.

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Abstract

The invention relates to a composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising, in a suitable dyeing medium, at least one tetraazapentamethine cationic direct dye, and which is characterized in that it also contains at least one particular oxidation base and at least one coupler. The invention also relates to the processes and dyeing devices using the said composition.

Description

COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, A PARTICULAR OXIDATION BASE AND A COUPLER
The invention relates to a composition for dyeing keratin fibres, in particular human keratin fibres such as the hair, comprising, in a suitable dyeing medium, at least one tetraazapentamethine cationic direct dye, and which is characterized in that it also contains at least one particular oxidation base and at least one coupler.
The invention also relates to the processes and dyeing devices using the said composition.
Two types of dyeing may be distinguished in the field of hair dyeing.
The first is semi-permanent or temporary dyeing, or direct dyeing, which involves dyes capable of giving the hair's natural coloration a more or less pronounced colour change, which may be resistant to shampoo washing several times. These dyes are known as direct dyes; they may be used with or without an oxidizing agent. In the presence of an oxidizing agent, the aim is to obtain lightening dyeing. Lightening dyeing is performed by applying to the hair an extemporaneous mixture of a direct dye and an oxidizing agent, and makes it possible especially to obtain, via lightening of the melanin of the hair, an advantageous effect such as a unified colour in the case of grey hair, or to bring out the colour in the case of naturally pigmented hair.
The second is permanent dyeing or oxidation dyeing. This is performed with "oxidation" dyes comprising oxidation dye precursors and couplers. Oxidation dye precursors, commonly known as "oxidation bases", are compounds that are initially colourless or weakly coloured, which develop their dyeing power on the hair in the presence of oxidizing agents added at the time of use, leading to the formation of coloured compounds and dyes. The formation of these coloured compounds and dyes results either from an oxidative condensation of the "oxidation bases" with themselves, or from an oxidative condensation of the "oxidation bases" with coloration modifiers commonly known as "couplers", which are generally present in the dye compositions used in oxidation dyeing.
To vary the shades obtained with the said oxidation dyes, or to enrich them with tints, direct dyes may be added thereto.
Among the already known cationic direct dyes available in the field of dyeing keratin fibres, especially human keratin fibres, are tetraazapentamethine compounds, the structure of which is discussed in the text hereinbelow; however, these dyes lead to colorations which have characteristics that are still insufficient as regards the strength and the homogeneity of the colour distributed along the fibre: the coloration is then said to be too selective, and as regards the staying power in terms of resistance to the various attacking factors to which the hair may be subjected (light, bad weather, shampooing).
Now, after considerable research conducted in this matter, the Applicant has discovered that it is possible to obtain novel compositions for dyeing keratin fibres, which are capable of leading to strong and sparingly selective colorations, but which nevertheless withstand the various attacking factors to which the hair may be subjected, by combining at least one tetraazapentamethine cationic direct dye known in the prior art, at least one particular heterocyclic oxidation base and at least one coupler.
This discovery is the basis of the present invention.
A first subject of the present invention is thus a composition for dyeing keratin fibres and in particular human keratin fibres such as the hair, containing, in a suitable dyeing medium, (i) at least one cationic direct dye whose structure corresponds to formula (I) defined below, characterized in that it also contains (ii) at least one heterocyclic oxidation base comprising in its structure at least one 5- or 6-membered sulfur-free nitrogenous heterocycle optionally fused with not more than one aromatic or heterocyclic ring and (iii) at least one coupler:
Figure imgf000003_0001
in which - W1 represents a cationic heteroaromatic radical of formula (II) or (III):
Figure imgf000003_0002
(H) (in)
W2 represents a heteroaromatic radical of formula (IV) or (V):
Figure imgf000004_0001
(FV) CO in which:
Z0 represents a radical CR2, a nitrogen atom or a radical NR2i,
Z1 represents an oxygen or sulfur atom or a radical NR9, - Z2 represents a nitrogen atom or a radical CR10,
Z3 represents a nitrogen atom or a radical CRn,
Z4 represents a nitrogen atom or a radical CR12,
Z5 represents a nitrogen atom or a radical CR13,
Z6 represents a nitrogen atom or a radical CR14, - Z7 represents an oxygen or sulfur atom or a radical NR15,
Z8 represents a nitrogen atom or a radical CR16,
Z9 represents a nitrogen atom or a radical CR17,
Z10 represents a nitrogen atom or a radical CR18,
Z11 represents a nitrogen atom or a radical CR19, - Z12 represents a nitrogen atom or a radical CR20,
Z13 represents a radical CR6, a nitrogen atom or a radical NR22, it being understood that each of the rings of formulae (II), (III), (IV) and (V) comprise not more than three nitrogen atoms and that two of the three nitrogen atoms may be contiguous, - the bond a of the 5-membered cationic heteroaromatic radical of formula (II) being linked to the nitrogen atom N1 of formula (I), the bond b of the 6-membered cationic heteroaromatic radical of formula (III) being linked to the nitrogen atom N1 of formula (I), the double bond a' of the 5-membered heteroaromatic radical of formula (IV) being linked to the nitrogen atom N2 of formula (I), the double bond b' of the 6-membered heteroaromatic radical of formula (V) being linked to the nitrogen atom N2 of formula (I), the bond b, linking the cationic heteroaromatic radical of formula (III) to the nitrogen atom N1 of formula (I), being in an ortho or para position relative to the nitrogen atom bearing the radical R4 when Z5 represents a radical CR13; the bond b being in an ortho position relative to the nitrogen atom bearing the radical R4 when Z5 represents a nitrogen atom, the bond b', linking the heteroaromatic radical of formula (V) to the nitrogen atom N2 of formula (I), being in an ortho or para position relative to the nitrogen atom bearing the radical R7 when Z11 represents a radical CR19; the bond b' being in an ortho position relative to the nitrogen atom bearing the radical R7 when Z11 represents a nitrogen atom,
R2, Re, R-io and R16 represent, independently of each other, a hydrogen atom; a linear or branched C1-C4 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino and C1-C2 (di)alkylamino radicals; a carboxyl radical; a sulfonylamino radical, R1, R4, R5, R7, Rg, R-15, R21 and R22 represent, independently of each other, a linear or branched C1-C8 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals;
R0, R3, Re, R11, R12, Ri3, Ri4, Ri7, R18, Ri9 and R20 represent, independently of each other, a hydrogen atom, a linear or branched C1-C16 hydrocarbon-based chain, this chain possibly being saturated or unsaturated with one to three unsaturations, this chain being unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl, sulfonic, sulfonylamino and C2-C4 (poly)hydroxyalkylamino radicals or a halogen atom such as chlorine, fluorine or bromine; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl, sulfonic, sulfonylamino and C2-C4 (poly)hydroxyalkylamino radicals or a halogen atom such as chlorine, fluorine or bromine; a heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, triazolyl, pyridyl, pyrimidinyl, triazinyl, pyrazinyl and pyridazinyl radicals; in addition, this hydrocarbon-based chain may be interrupted with one or two oxygen, nitrogen or sulfur atoms or with an SO2 radical, it being understood that R0, R3, Rs, R11, R12, R1S, R14, R17, R1S, R19 and R20 do not comprise a peroxide bond or diazo or nitroso radicals,
R2 with R10, R11 with R12, R6 with R16, and R17 with R18 can form, independently of each other, a 5- or 6-membered carbon-based aromatic ring, which is unsubstituted or substituted with one or two hydroxyl, amino, (di)(CrC2)alkylamino, C1-C2 alkoxy or C2-C4 (poly)hydroxyalkylamino radicals, X is an organic or mineral anion.
For the purposes of the present patent application, the expression "branched hydrocarbon- based chain" means a branched hydrocarbon-based chain that may also form one to five 3- to 7-membered carbon-based rings, this chain possibly comprising one to three unsaturations, i.e. one to three double bonds and/or triple bonds.
The term "C2-C4 (poly)hydroxyalkoxy" means a C2-C4 alkoxy group substituted with 1 or 2 hydroxyl groups.
For the purposes of the present invention, the expression "C2-C4 (poly)hydroxyalkylamino" means an alkylamino group substituted with 1 or 2 hydroxyl groups.
The expression according to which the hydrocarbon-based chain may be interrupted with one or more oxygen, nitrogen or sulfur atoms or with an SO2 radical, or according to which this chain is unsaturated, means that the carbon-based chain may be modified in the following manner:
Figure imgf000006_0001
For the purposes of the present patent application, an organic or mineral anion is chosen, for example, from a halide such as chloride, bromide, fluoride or iodide; a hydroxide; a sulfate; a hydrogen sulfate; a (d-CβJalkyl sulfate, for instance a methyl sulfate or an ethyl sulfate; an acetate; a tartrate; an oxalate; a (C"rC6)alkylsulfonate such as methyl sulfonate; an arylsulfonate, which is unsubstituted or substituted with a CrC4 alkyl radical, for instance a 4- tolylsulfonate. Preferably, Ro represents a hydrogen atom; a linear or branched C1-C6 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, CrC2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, C2-C4 (poly)hydroxyalkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, CrC2 (di)alkylamino, carboxyl and sulfonic radicals or a halogen atom such as chlorine, fluorine or bromine, an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, triazolyl, pyridyl, pyrimidinyl, triazinyl, pyrazinyl and pyridazinyl radicals.
Even more preferably, R0 preferably represents a hydrogen atom; a linear or branched C1-C3 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, amino, C1-C2 (di)alkylamino and C2-C4 (poly)hydroxyalkylamino radicals, or an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl and pyridyl radicals.
According to one particularly preferred embodiment, R0 represents a hydrogen atom; a methyl, ethyl, propyl, butyl, 2-hydroxyethyl, 2-aminoethyl, 1-carboxymethyl, 2-carboxyethyl, 2-sulfonylethyl or 2-methoxyethyl; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from amino, C1-C2 (di)alkylamino and C2-C4 (poly)hydroxyalkylamino radicals, or an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl and pyridyl radicals.
R0 even more preferably represents a hydrogen atom; a methyl, ethyl or 2-methoxyethyl radical; a phenyl radical, which is unsubstituted or substituted with an amino, (di)methylamino or (di)(2-hydroxyethyl)amino radical, or an optionally cationic heteroaryl radical chosen from imidazolyl and pyridyl radicals.
R2, R6, R1O and R16 preferably represent a hydrogen atom, a phenyl radical or a C1-C4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, amino, C1-C2 (di)alkylamino and carboxyl radicals.
According to one particularly preferred embodiment, R2, R6, R10 and R16 preferably represent a hydrogen atom, a methyl, phenyl or 2-hydroxymethyl radical, a carboxyl or a phenyl radical. Ri, R4, R5, R7, Rg, Ri5, R21 and R22 preferably represent a CrC4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, amino, CrC2 (di)alkylamino, carboxyl and sulfonic radicals.
According to one particularly preferred embodiment, R1, R4, R5, R7, R9, R15, R21 and R22 preferably represent a methyl, ethyl, 2-hydroxyethyl, 1-carboxymethyl, 2-carboxyethyl or 2- sulfonylethyl radical.
R3, R8, R11, R12, R13, R14, R17, R18, R19 and R20 preferably represent, independently of each other, a hydrogen atom; a linear or branched C1-C4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals or a halogen atom such as chlorine, fluorine or bromine; a sulfonylamino radical; a C2-C4 (poly)hydroxyalkylamino radical.
More preferably, R3, R8, R11, R12, R13, R14, R17, R18, R19 and R20 represent a hydrogen atom, a C1-C4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl radicals or a C1-C2 alkoxy radical; an amino radical; a C1-C2 (di)alkylamino radical; a carboxyl radical; a C2-C4 (poly)hydroxyalkylamino radical.
According to one particularly preferred embodiment, R3, R8, R11, R12, R13, R14, R17, R18, R19 and R20 represent, independently of each other, a hydrogen atom, a methyl or 2- hydroxymethyl radical, a carboxyl, a methoxy, ethoxy or 2-hydroxyethyloxy radical, or an amino, methylamino, dimethylamino or 2-hydroxyethylamino radical.
A. In a first preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-pyridinium radical and W2 is a 2-pyridine radical. Even more preferably, they are the following compounds:
- 2-[5-(N-methyl-2-pyridinylidene)-1 -formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-methyl-1 -formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-ethyl-1 -formazano]-N-methylpyridinium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-isopropyl-1-formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-phenyl-1 -formazano]-N-methylpyridinium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N-methylpyridinium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-methyl-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-ethyl-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-isopropyl-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride - 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-phenyl-1 -formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-4- pyrrolidino-N-methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-4- pyrrolidino-N-methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1- formazano]-4-pyrrolidino-N-methylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-ethyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-N-hydroxyethylpyridinium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-N-carboxyethylpyridinium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-ethyl-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-isopropyl-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- carboxyethylpyridinium chloride
B. In a second preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 4-pyridinium radical and W2 is a 4-pyridine radical. Even more preferably, they are the following compounds:
- 4-[5-(N-methyl-4-pyridinylidene)-1 -formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-methyl-1 -formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-ethyl-1 -formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-isopropyl-1 -forrnazano]-N-methylpyridinium chloride - 4-[5-(N-methyl-4-pyridinylidene)-3-phenyl-1-formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N-methylpyridinium chloride - 4-[5-(N-methyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- methylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-1-formazano]-N-hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-methyl-1-formazano]-N-hydroxyethylpyridinium chloride - 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-ethyl-1-formazano]-N-hydroxyethylpyridinium chloride - 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-isopropyl-1-formazano]-N-hydroxyethylpyridinium chloride - 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-N- hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-methyl-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-ethyl-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-isopropyl-1-formazano]-N-carboxyethylpyridinium chloride - 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-N- carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- carboxyethylpyridinium chloride
C. In a third preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-imidazolium radical and W2 is a 2-imidazole radical. Even more preferably, they are the following compounds: - 2-[5-(1 ,3-dimethyl-2-imidazolidene)-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-methyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-ethyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-isopropyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-phenyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-1 -formazano]-1 ,3-dihydroxyethylimidazolium chloride - 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-isopropyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,3-dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-1-formazano]-1 ,3-dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-methyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-ethyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-isopropyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,3-dicarboxyethylimidazolium chloride
D. In a fourth preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 5-pyrazolium radical and W2 is a 5-pyrazole radical. Even more preferably, they are the following compounds:
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-1 -formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-methyl-1 -formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-ethyl-1-formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-isopropyl-1-formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-phenyl-1 -formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,2- dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,2- dimethylpyrazolinium chloride - 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,2- dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-1 -formazano]-1 ,2-dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-methyl-1 -formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-ethyl-1 -formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-phenyl-1-formazano]-1 ,2- dihydroxyethylpyrazolinium chloride - 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-isopropyl-1 -formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,2-dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-1 -formazano]-1 ,2-dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-methyl-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-ethyl-1 -formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-phenyl-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride - 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-isopropyl-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,2-dicarboxyethylpyrazolinium chloride
E. In a fifth preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-benzimidazolium radical and W2 is a 2- pyridine radical. Even more preferably, they are the following compounds:
- 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-phenyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-ethyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
F. In a sixth preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-benzimidazolium radical and W2 is a 4- pyridine radical. Even more preferably, they are the following compounds: - 2-[5-(N-methyl-4-pyridinylidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-phenyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-ethyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
G. In a seventh preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-imidazolium radical and W2 is a 2-pyridine radical. Even more preferably, they are the following compounds:
- 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-ethyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
H. In an eighth preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-imidazolium radical and W2 is a 4-pyridine radical. Even more preferably, they are the following compounds:
- 2-[5-(N-methyl-4-pyridinylidene)-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-ethyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene) — 3-phenyl-1-formazano]-1 ,3-dimethylimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-ethyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride I. In a ninth preferred variant, the compounds of formula I are chosen from the family defined by the compounds for which W1 is a 2-benzimidazolium radical and W2 is a 2-benzimidazole radical. Even more preferably, they are the following compounds:
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-methyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-ethyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-isopropyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-phenyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,3-dimethylbenzimidazolium chloride - 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-ethyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-isopropyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1- formazano]-1 ,3-dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-methyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-ethyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-isopropyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1- formazano]-1 ,3-dicarboxyethylbenzimidazolium chloride.
Among all the compounds described above, the compounds of family A (first variant) will be preferred most particularly.
In the compositions of the invention, the compound(s) of formula (I) is (are) preferably present in a concentration ranging from 0.001 % to 10%, preferably from 0.005% to 5% and even more preferentially from 0.01 % to 2% by weight relative to the total weight of the composition.
The compounds of formula (I) may especially be obtained via a process in which at least two equivalents of at least one hydrazone chosen from the hydrazones of formula A and the hydrazones of formula B:
Figure imgf000021_0001
Formula A Formula B in which Zi4, -_15, -_16 αnu ι\25 have me oαmc mcαiiings as Z7, Zs, Zi3, and R5, respectively, of formula IV,
Y being an organic or mineral anion, x being an integer ranging from 1 to 3, Z17, Z18, Z19, Z20, R26 and R27 have the same meanings as Z9, Z10, Z11, Z12, R8 and R7, respectively, of formula V,
Y' being an organic or mineral anion, x' being an integer ranging from 1 to 3, are reacted with one equivalent of an aldehyde of formula R23CHO, R23 having the same meaning as R0 of formula I. Two equivalents of the same hydrazone or of two different hydrazones may thus be reacted.
According to one preferred variant, the aldehyde of formula R23CHO is generated in the reaction medium from an aldehyde precursor of formula R'23CH2OH in the presence of an oxidizing system; R'23 then has the same meaning as R0 of formula I.
This oxidizing system may be a chemical oxidizing agent or a biocatalytic oxidizing agent such as an enzyme.
In particular, the process for preparing the compound of formula (I) according to the present invention may be performed in the presence of an aldehyde precursor of formula R'23CH2OH and of at least one enzyme capable of generating an aldehyde from the aldehyde precursor of formula R'23CH2OH.
The process for enzymatically synthesizing the compounds of formula (I) defined above is performed by reacting at least two equivalents of at least one hydrazone chosen from the hydrazones of formula A and the hydrazones of formula B in which Z14, Z15, Z16 and R25 have the same meanings as Z7, Z8, Z13 and R5, respectively, of formula IV, Y being an organic or mineral anion, x being an integer ranging from 1 to 3,
Z17, Z18, Z19, Z20, R26 and R27 having the same meanings as Z9, Z10, Z11, Z12, R8 and R7, respectively, of formula V,
Y' being an organic or mineral anion, x' being an integer ranging from 1 to 3, with one equivalent of an aldehyde of formula R23CHO, R23 having the same meaning as R0 of formula I.
Depending on the reagents used, the reaction is performed with or without an oxidizing system, with or without a cofactor for the enzyme, and with or without a system for regenerating the cofactor. For the purpose of the present patent application, the term "without an oxidizing system" means that no oxidizing system other than atmospheric oxygen is used.
Preferably, the reaction is performed in aerobic medium at a pH of between 3 and 11 and at a temperature of between 6°C and 80°C.
More generally, the aldehyde precursor that may be used to prepare the compound of formula (I) may be chosen from primary alcohols, sarcosine, 4-hydroxymandelate, N6- methyllysine, dimethylglycine, methylglutamate, 2-oxo acids, for example 2-oxo acid pyruvate, benzoylformate, phenylpyruvate or threonine. It will preferably be chosen from primary alcohols.
The enzymes capable of generating an aldehyde from this aldehyde precursor may be chosen especially from the alcohol dehydrogenases EC 1.1.1.1 , the alcohol dehydrogenases EC 1.1.1.2, the alcohol dehydrogenases EC 1.1.1.71 , the aromatic alcohol dehydrogenases EC 1.1.1.90, also known as aryl alcohol dehydrogenases, the aromatic alcohol dehydrogenases EC 1.1.1.97, the 3-hydroxybenzyl alcohol dehydrogenases EC 1.1.1.97, the coniferyl alcohol dehydrogenases EC 1.1.1.194, the cinnamyl alcohol dehydrogenases EC 1.1.1.195, the methanol dehydrogenases EC 1.1.1.244, the aromatic alcohol oxidases EC 1.1.3.7, also known as aryl alcohol oxidases, the alcohol oxidases EC 1.1.3.13, the 4- hydroxymandelate oxidases EC 1.1.3.19, the long-chain hydrocarbon alcohol oxidases EC 1.1.3.20, the methanol oxidases EC 1.1.3.31 , the alcohol dehydrogenases EC 1.1.99.20, the sarcosine oxidases EC 1.5.3.1 , the N6-methyllysine oxidases EC 1.5.3.4, the dimethylglycine oxidases EC 1.5.3.10, the sarcosine dehydrogenases EC 1.5.99.1 , the dimethylglycine dehydrogenases EC 1.5.99.2, the methylglutamate dehydrogenases
EC 1.5.99.5, the 2-oxo acid decarboxylases EC 4.1.1.1 , the benzoylformate decarboxylases EC 4.1.1.7, the phenylpyruvate decarboxylases EC 4.1.1.43 and the threonine aldolases EC 4.1.2.5.
Mention may also be made of the following enzymes capable of generating an aldehyde, the preferred substrate of which is given in parentheses: N-methyl L-amino acid oxidase EC 1.5.3.2 (N-methyl-L-amino acid), trimethylamine dehydrogenase EC 1.5.99.7 (trimethylamine), dimethylamine dehydrogenase EC 1.5.99.10 (dimethylamine), nitroethane oxidase EC 1.7.3.1 (nitroethane), indole 2,3-dioxigenase EC 1.13.1 1.17 (indole), taurine dioxygenase EC 1.14.1 1.17 (taurine), acetoin ribose 5 phosphate transaldolase EC 2.2.1.4 (3-hydroxybutan-2-one), diamine aminotransferase EC 2.6.1.29 (alpha omega diamine + 2- oxogluterate), alkenylglycerophosphocholine hydrolase EC 3.3.2.2 (alkenylglycero phosphocholine), alkenylglycerophosphoethanolamine hydrolase EC 3.3.2.5 (alkenylglycero phosphocholine), alkylalidase EC 3.8.1.1 (halomethane), phosphonoacetaldehyde hydrolase EC 3.1 1.1.1 (phosphonoacetaldehyde), indolepyruvate decarboxylase EC 4.1.1.74 (3-indol- 3-yl pyruvate) mandelonitrile lyase EC 4.1.2.10 (mandelonitrile), hydroxymandelonitrile lyase EC 4.1.2.11 (hydroxymandelonitrile), ketopantoaldolase EC 4.1.2.12 (2-hydroxy-2- isopropylbutanedioate), dimethylaniline-N-oxide aldolase EC 4.1.2.24 (dimethylaniline-N- oxide), phenylserine aldolase EC 4.1.2.26 (phenylserine), sphinganine-1 -phosphate aldolase EC 4.1.2.27 (sphinganine-1 -phosphate), 17-alpha hydroxyprogesterone aldolase EC 4.1.2.30 (17-alpha hydroxyprogesterone), trimethylamine oxide aldolase EC 4.1.2.23 (trimethylamine oxide), fucosterol epoxide lyase EC 4.1.2.23 (fucosterol epoxide), (3E)-4-(2- carboxyphenyl)-2-oxobut-3-enoate aldolase EC 4.1.2.34 ((3E)-4-(2-carboxyphenyl)-2-oxobut- 3-enoate), lactate aldolase EC 4.1.2.36 (lactate), benzoin aldolase EC 4.1.2.38 (benzoin), octoamine dehydratase EC 4.2.1.87 (1-(4-hydroxyphenyl)-2-aminoethanol), synephrine dehydratase EC 4.2.1.88 (1-(4-hydroxyphenyl)-2-(methylamino)ethanol), ethanolamine phosphate phospholyase EC 4.2.3.2 (ethanolamine phosphate), ethanolamine ammonia lyase EC 4.3.1.7 (ethanolamine), dichloromethane dehalogenase EC 4.5.1.3 (dichloromethane), styrene oxide isomerase EC 5.3.99.7 (styrene oxide).
The enzyme capable of generating an aldehyde from the aldehyde precursor used in the dye composition according to the invention may be derived from an extract of plants, of animals, of microorganisms (bacterium, fungus, yeast or microalga) or from viruses, or from cells that are differentiated or undifferentiated, obtained in vivo or in vitro, which are genetically modified or unmodified, or synthetic (obtained via chemical or biotechnological synthesis).
Examples of useful enzymes that may be mentioned in particular are the genera Plectranthus, Pinus, Gastropode, Manduca, Pichia, Candida, Pleurotus, and Pseudomonas, and even more particularly the following species: Plectranthus colloides, Pinus strobus, which is a species of plant origin, Gastropode mollusc and Manduca sexta, which are of animal origin, Pichia pastoris and Candida boidinii, which are yeasts, Pleurotus pulmonarius, which is a fungus, and Pseudomonas pseudoalcaligenes, which is a bacterium.
The choice of the enzyme depends on the nature of the aldehyde precursor. For example, when the aldehyde precursor is an alcohol, then the enzyme is chosen from enzymes capable of generating an aldehyde from this alcohol. When the aldehyde precursor is methylglutamate, then the enzyme is a methylglutamate dehydrogenase. According to one preferred variant, the aldehyde precursor is a primary alcohol and the enzyme is an enzyme capable of generating the aldehyde from an alcohol. For example, when the primary alcohol is a Ci-Cβ aliphatic alcohol, then the enzyme capable of generating the aldehyde is chosen from alcohol oxidases, alcohol dehydrogenases, methanol dehydrogenases and methanol oxidases. When the primary alcohol is benzyl alcohol, 4-tert- butylbenzyl alcohol, 3-hydroxy-4-methoxybenzyl alcohol, veratryl alcohol, 4-methoxybenzyl alcohol, cinnamyl alcohol or 2,4-hexadien-1-ol, aryl alcohol oxidases or aromatic alcohol dehydrogenases may be used as aldehyde precursor.
For the enzyme dehydrogenases, it is essential to include the cofactor(s) required for their activity, more specifically NAD+ or NADP+ or other molecules capable of acting as electron acceptor. The addition of a system for regenerating the cofactors may be used for reaction purposes or economic purposes. This regeneration system may be enzymatic, chemical or electrochemical.
A very wide variety of oxidizing agents may be used to perform this process: aqueous hydrogen peroxide solution, organic peracids such as peracetic acid, persalts such as permanganate, perborate and persulfates, chromates or dichromates, hypochlorites, hypobromites, ferricyanides, and peroxides such as manganese dioxide or lead dioxide. Aqueous hydrogen peroxide solution will preferably be used.
The concentration of enzyme substrate (aldehyde precursor) may be between 0.001 M and 6 M and preferably between 0.1 M and 4 M.
The reaction may be performed between pH 3 and pH 1 1 and preferably between pH 5 and pH 9.5.
The reaction temperature may be between 10°C and 80°C and preferably between 20°C and
65°C.
The hydrazone concentration of the reaction medium is between 0.01 M and 3 M and preferably between 0.1 M and 1 M.
The content of cofactor for said enzymes may be between 0.01 mM and 1 M and preferably between 0.1 mM and 10 mM.
During the implementation of the synthesis of the compounds of formula (I), the reagents: the hydrazone(s), the enzyme(s), the substrate for said enzyme, and/or the cofactor for said enzyme, and the oxidizing agent and/or the system for regenerating the cofactor are mixed together, and the pH and the temperature are adjusted.
The compounds of formula I may also be prepared via a process in which a compound of formula (F1 ) or (F2)
Figure imgf000026_0001
Formula Fl Formula F2 with Z14, ZM, , „, „ - - R25 for formula F _ , _,, , , _,„, Z2o, Ro, R24 and R26 for formula F2 having the meanings described above, is reacted in the presence of one equivalent of a hydrazone of formula (A) or (B).
According to one preferred variant, the compounds of formula (F1 ) or (F2) may be obtained by reacting a compound of formula R^sC(OR24)S and a hydrazone of formula (A) or (B) in the presence or absence of a protic solvent whose boiling point ranges between 66°C and 180°C. R"23 has the same meaning as Ro of formula (I) and R24 represents a radical chosen from methyl and ethyl groups.
Preferably, the reaction is performed in the presence of triethyl orthoformate and trimethyl orthoacetate at a temperature of between 0°C and 150°C for a period of between 30 minutes and 12 hours.
Preferably, the protic solvent is chosen from H2O, ethanol and methanol.
The dye composition in accordance with the invention contains, in addition to the cationic direct dye(s) (i), one or more heterocyclic oxidation bases comprising in their structure at least one 5- or 6-membered sulfur-free nitrogenous heterocycle optionally fused with at least one aromatic or heterocyclic ring (ii).
For the purposes of the present invention, the term "sulfur-free nitrogenous heterocycle" means a heterocycle comprising in the sequence of ring members constituting the said ring at least one nitrogen atom and no sulfur atoms. The heterocyclic bases of the invention may contain on the ring(s) constituting them one or more identical or different substituents. These substituents may or may not comprise one or more heteroatoms, including sulfur.
Among the heterocyclic bases in accordance with the invention, mention may be made of pyridines, pyrazoles, fused pyrazolopyrimidines, pyrazolotriazoles, pyrazolotetrazoles, pyrazolopyridazines, pyrazoloimidazoles, pyrazolopyrazoles, aminopyrazolones, aminopyrrolidines, aminopyrazolines, monoaminoquinolines, aminoindazoles, diaminouracils, hydrazones, aminoindolenines, diamino- or triaminoquinolines, pyrazolobenzimidazoles and pyrimidines, alone or as mixtures.
Among the pyridine derivatives that may be mentioned more particularly are the compounds described, for example, in patents GB 1 026 978 and GB 1 153 196, such as 2,5-diaminopyridine and 3,4-diaminopyridine, and the addition salts thereof with an acid.
Among the pyrazole derivatives that may be mentioned more particularly are the compounds described in patents DE 38 43 892 and DE 41 33 957 and patent applications WO 94/08969, WO 94/08970, FR-A-2 733 749 and DE 195 43 988, for instance 4,5-diamino-1- methylpyrazole, 3,4-diaminopyrazole, 4,5-diamino-1-(4'-chlorobenzyl)pyrazole, 4,5-diamino- 1 ,3-dimethylpyrazole, 4,5-diamino-3-methyl-1-phenylpyrazole, 4,5-diamino-1-methyl-3- phenylpyrazole, 4-amino-1 ,3-dimethyl-5-hydrazinopyrazole, 1-benzyl-4,5-diamino-3-methyl- pyrazole, 4,5-diamino-3-tert-butyl-1 -methylpyrazole, 4,5-diamino-1 -tert-butyl-3-methyl- pyrazole, 4,5-diamino-1-(β-hydroxyethyl)-3-methylpyrazole, 4,5-diamino-1-(β- hydroxyethyl)pyrazole, 4,5-diamino-1-ethyl-3-methylpyrazole, 4,5-diamino-1-ethyl-3-(4'- methoxyphenyl)pyrazole, 4,5-diamino-1-ethyl-3-hydroxymethylpyrazole, 4,5-diamino-3- hydroxymethyl-1 -methylpyrazole, 4,5-diamino-3-hydroxymethyl-1 -isopropylpyrazole,
4,5-diamino-3-methyl-1 -isopropylpyrazole, 4-amino-5-(2'-aminoethyl)amino-1 ,3-dimethylpyrazole, 3,4,5-triaminopyrazole, 1-methyl-3,4,5-triaminopyrazole, 3,5-diamino-1-methyl- 4-methylaminopyrazole and 3, 5-diamino-4-(β-hydroxyethyl)amino-1 -methylpyrazole, and the addition salts thereof with an acid.
Among the pyrazolo[1 ,5-a]pyrimidines that may be used as oxidation bases in the dye composition in accordance with the invention, mention may be made especially of the compounds having the following formula, and the addition salts thereof with an acid or with a base:
Figure imgf000028_0001
in which:
- Ri, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a d-C4 alkyl radical, an aryl radical, a Ci-C4 hydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a (Ci-C4)alkoxy(CrC4)alkyl radical, a d-C4 aminoalkyl radical; a d-C4 aminoalkyl radical in which the amine is protected with an acetyl, ureido or sulfonyl radical; a (Cr C4)alkylamino(Ci-C4)alkyl radical; a di[(Ci-C4)alkyl]amino(Ci-C4)alkyl radical in which the dialkyl radicals can form a 5- or 6-membered aliphatic or heterocyclic ring; a hydroxy(Cr C4)alkyl- or di[hydroxy-(Ci-C4)alkyl]amino(Ci-C4)alkyl radical; - the radicals X, which may be identical or different, denote a hydrogen atom, a Ci-C4 alkyl radical, an aryl radical, a CrC4 hydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a Ci- C4 aminoalkyl radical, a (Ci-C4)alkylamino(Ci-C4)alkyl radical, a di[(Ci-C4)alkyl]amino(Ci- C4)alkyl radical in which the dialkyl radicals can form a 5- or 6-membered aliphatic or heterocyclic ring; a hydroxy(Ci-C4)alkyl- or di[hydroxy(Ci-C4)alkyl]amino(Ci-C4)alkyl radical, an amino radical, a (Ci-C4)alkyl- or di[(CrC4)alkyl]amino radical; a halogen atom, a carboxylic acid group or a sulfonic acid group;
- i is equal to 0, 1 , 2 or 3;
- p is equal to 0 or 1 ;
- q is equal to 0 or 1 ; - n is equal to 0 or 1 ; with the proviso that:
- (i) the sum p + q is other than 0;
- (ii) when p + q is equal to 2, then n is equal to 0 and the groups NRiR2 and NR3R4 occupy the (2,3); (5,6); (6,7); (3,5) or (3,7) positions; - (iii) when p + q is equal to 1 , then n is equal to 1 and the group NRiR2 (or NR3R4) and the OH group occupy the (2,3); (5,6); (6,7); (3,5) or (3,7) positions.
The pyrazolo[1 ,5-a]pyrimidines described above are known compounds and are especially described in patent application FR-A-2 750 048.
Among the pyrazolo[1 ,5-a]pyrimidines, mention may be made especially of:
- pyrazolo[1 ,5-a]pyrimidine-3,7-diamine, - 2-methylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 2,5-dimethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- pyrazolo[1 ,5-a]pyrimidine-3,5-diamine,
- 2,7-dimethylpyrazolo[1 ,5-a]pyrimidine-3,5-diamine, - 3-aminopyrazolo[1 ,5-a]pyrimidin-7-ol,
- 3-amino-5-methylpyrazolo[1 ,5-a]pyrimidin-7-ol
- 3-aminopyrazolo[1 ,5-a]pyrimidin-5-ol,
- 2-(3-aminopyrazolo[1 ,5-a]pyrimidin-7-ylamino)ethanol,
- 3-amino-7-β-hydroxyethylamino-5-methylpyrazolo[1 ,5-a]pyrimidine, - 2-(7-aminopyrazolo[1 ,5-a]pyπmidin-3-ylamino)ethanol,
- 2-[(3-aminopyrazolo[1 ,5-a]pyrimidin-7-yl)(2-hydroxyethyl)amino]ethanol,
- 2-[(7-aminopyrazolo[1 ,5-a]pyrimidin-3-yl)(2-hydroxyethyl)amino]ethanol,
- 5,6-dimethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 2,6-dimethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine, - 2,5,N7,N7-tetramethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 3-amino-5-methyl-7-imidazolylpropylaminopyrazolo[1 ,5-a]pyrimidine, and the addition salts thereof.
Diaminouracils that may be mentioned include the compounds 5,6-diaminouracil, 5,6- diamino-2-thiouracil, 5,6-diamino-3-methyluracil, δ-amino-S-methyl-δ-methylaminouracil, 5- amino-3-methyl-6-β-hydroxyethylaminouracil, 5-amino-3-methyl-6-benzylaminouracil, 5- amino-3-methyl-6-phenylaminouracil, 5,6-diamino-i-phenyluracil, 5,6-diamino-1 ,3- dimethyluracil, 5-amino-1 ,3-dimethyl-6-methylaminouracil, 5-amino-1 ,3-dimethyl-6-β- hydroxymethylaminouracil, 5-amino-1 ,3-dimethyl-6-benzylaminouracil, 5-amino-1 ,3-dimethyl- 6-phenylaminouracil and δ-amino-I .S-dimethyl-δ-dimethylaminouracil. Such compounds are described in document DE 2 533 629.
Aminoindolenines that may be mentioned include the compounds 2-methyl-5- aminoindolenine and 1-β-hydroxyethyl-2-methyl-5-aminoindolenine. Such compounds are described in document FR 1 602 547.
Mono- or diaminotetrahydroquinolines that may be mentioned include the compounds 5- amino-1 ,2,3,4-tetrahydroquinoline, 5-amino-7-chloro-8-piperidino-1 ,2,3,4-tetrahydroquinoline,
5-amino-7-chloro-8-morpholino-1 ,2,3,4-tetrahydroquinoline, 5,7-diamino-6-methyl-8-hydroxy- 1 ,2,3,4-tetrahydroquinoline, 5-amino-8-methoxy-1 ,2,3,4-tetrahydroquinoline and 5-amino-7- chloro-8-dimethylamino-1 ,2,3,4-tetrahydroquinoline. Such compounds are described in document DE 2 441 895.
Diaminoquinolines that may be mentioned include the compounds 5,7-diamino-6-methyl-8- hydroxyquinoline and 5,7-diamino-2-methyl-8-hydroxyquinoline. Such compounds are described in document DE 2 441 598.
Triaminoquinolines that may be mentioned include 5,7-diamino-8-methylaminoquinoline, 5,7- diamino-8-dimethylaminoquinoline, 5,7-diamino-8-morpholinoquinoline, 5,7-diamino-8-β- hydroxyethylaminoquinoline and 5,7,8-triaminoquinoline. Such compounds are described in document DE 2 441 599.
Aminopyrazolones that may be mentioned include 1-phenyl-4-aminopyrazolone-3-carbonic acid, 1-phenyl-4-aminopyrazolone-3-carbonic acid amide, ethyl 1-phenyl-4-aminopyrazolone- 3-carbonate and i-phenyl-S-methyM-aminopyrazolone. Such compounds are described in document FR 1 488 169. Mention may also be made of 3-aminopyrazolone, 1-phenyl-3- aminopyrazolone and 1-phenyl-3-hydroxypyrazolone. Such compounds are described in document FR 1 564 999.
Pyrazolotriazoles that may be mentioned include the compounds 3-amino-4-methyl-6- methylthio-2-phenylpyrazolo[3,2-c]-s-triazole, 3-amino-2,4,6-trimethylpyrazolo[3,2-c]-s- triazole and 3-amino-4,6-dimethylpyrazolo[3,2-c]-s-triazole. Such compounds are described in document US 5 457 200. Mention may also be made of the compounds 7-amino-2,6- dimethylpyrazolo[1 ,5-b]-1 ,2,4-triazole, 7-amino-3,6-dimethylpyrazolo[3,2-c]-1 ,2,4-triazole, 7- amino-3-methylpyrazolo[3,2-c]-1 ,2,4-triazole, 7-amino-3-methyl-6-carboxypyrazolo[3,2-c]-
1 ,2,4-triazole, 7-amino-2-methylpyrazolo[1 ,5-b]-1 ,2,4-triazole, 7-amino-2-phenylpyrazolo[1 ,5- b]-1 ,2,4-triazole and 7-amino-2-methyl-6-carboxypyrazolo[1 ,5-b]-1 ,2,4-triazole. These compounds are described in EP 923 929.
Pyrazoloimidazoles that may be mentioned include the compounds 3-amino-4- benzylpyrazolo[1 ,5-a]imidazole, 3-amino-2,4-dimethylpyrazolo[1 ,5-a]imidazole and 3-amino- 4-methylpyrazolo[1 ,5-a]imidazole. Such compounds are described in document US 5 457 200. Mention may also be made of the compounds 7-amino-6-methylpyrazolo[1 ,5- a]imidazole, 7-aminopyrazolo[1 ,5-a]imidazole, 7-amino-2-methylpyrazolo[1 ,5-a]imidazole and 7-amino-2-phenylpyrazolo[1 ,5-a]imidazole, which are described in EP 923 929. A pyrazoloquinoline that may be mentioned is the compound 3-amino-2-phenylpyrazolo[1 ,5- a]quinoline. Such compounds are described in document US 5 457 200.
A pyrazolopyridazine that may be mentioned is 3-aminopyrazolo[1 ,5-b]pyridazine. Such compounds are described in document US 5 457 200.
Hydrazones that may be mentioned include the compounds N-methylpyridone-4-hydrazone, N,N-dimethylbenzimidazolonehydrazone, N-methylpyridone-2-hydrazone, 1 ,2-dimethylinda zolone-3-hydrazone, 1 ,2,6-trimethylpyridone-4-hydrazone, 1 -methylquinolone-2-hydrazone, 1 ,2,6-trimethyl-3-nitropyridone-4-hydrazone, 1 ,2,6-trimethyl-3-aminopyridone-4-hydrazone, 1 ,2,5-trimethylpyrazolone-3-hydrazone, 1 ,2-dimethylindazolone-3-hydrazone, 1 ,2-dimethyl-5- chloroindazolone-3-hydrazone, 1-methyl-2-ethyl-5-nitroindazolone-3-hydrazone and N- methylquinolone-4-hydrazone. Such compounds are described in document FR 1 602 547.
Aminopyrazolines that may be mentioned include the compounds 1-(4'-aminophenyl)-3- aminopyrazoline and 1-(4'-hydroxyphenyl)-3-aminopyrazoline. Such compounds are described in document FR 2 018 056.
Aminoindazoles that may be mentioned include 4,7-diamino-5-methylindazole, 4,7-diamino- 5,6-dimethylindazole, 6,7-diaminoindazole, 6-hydroxy-7-aminoindazole, 1-ethyl-6-hydroxy-7- aminoindazole, 6-aminoindazole and 5,6-diaminoindazole. Such compounds are described in documents FR 2 315 906 and DE 1 492 166.
Pyrazolobenzimidazoles that may be mentioned include the compounds 7-amino-6- methylpyrazolo[1 ,5-a]benzimidazole, 6,7-diaminopyrazolo[1 ,5-a]benzimidazole, 6,7-diamino- 2-methylpyrazolo[1 ,5-a]benzimidazole and 6,7-diamino-2-phenylpyrazolo[1 ,5-a] benzimidazole, which are described, for example, in EP 923 929.
Pyrazolotetrazoles that may be mentioned include the compounds 7-amino-6- methylpyrazolo[1 ,5-e]tetrazole, 7-amino-6-phenylpyrazolo[1 ,5-e]tetrazole and 7-amino-6- carboxypyrazolo[1 ,5-e]tetrazole, which are described in EP 923 929.
Pyrimidine derivatives that may be mentioned include the compounds described, for example, in patents DE 2 359 399; JP 88-169 571 ; JP 05-63124; EP 0 770 375 or patent application WO 96/15765, for instance 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6- triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopyrimidine and 2,5,6-triaminopyrimidine, and the addition salts thereof with an acid, and the tautomeric forms thereof, when a tautomeric equilibrium exists.
Preferably, the heterocyclic oxidation base(s) according to the invention is (are) chosen from monocyclic pyrazoles and pyrimidines.
The compositions of the invention may also contain one or more additional oxidation bases.
These additional oxidation bases are preferably chosen from the oxidation bases conventionally used for oxidation dyeing, and among which mention may be made especially of para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols and ortho- aminophenols.
Among these additional oxidation bases, mention may be made most particularly of: - (I) the para-phenylenediamines of formula (Vl) below, and the addition salts thereof with an acid:
Figure imgf000032_0001
in which:
Ri represents a hydrogen atom, a CrC4 alkyl radical, a d-C4 monohydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a (Ci-C4)alkoxy(Ci-C4)alkyl radical, a CrC4 alkyl radical substituted with a nitrogenous group, a phenyl group or a 4'-aminophenyl group;
R2 represents a hydrogen atom, a CrC4 alkyl radical, a CrC4 monohydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a (Ci-C4)alkoxy(CrC4)alkyl radical or a CrC4 alkyl radical substituted with a nitrogenous group; Ri and R2 may also form with the nitrogen atom that bears them a 5- or 6-membered nitrogenous heterocycle optionally substituted with one or more alkyl, hydroxy or ureido groups;
R3 represents a hydrogen atom, a halogen atom such as a chlorine atom, a CrC4 alkyl radical, a sulfo radical, a carboxy radical, a CrC4 monohydroxyalkyl radical, a CrC4 hydroxyalkoxy radical, an acetylamino(CrC4)alkoxy radical, a C1-C4 mesylaminoalkoxy radical or a carbamoylamino(CrC4)alkoxy radical,
R4 represents a hydrogen or halogen atom or a C1-C4 alkyl radical. Among the nitrogenous groups of formula (Vl) above, mention may be made in particular of amino, mono(Ci-C4)alkylamino, di(Ci-C4)alkylamino, tri(Ci-C4)alkylamino, monohydroxy(d- C4)alkylamino, imidazolinium and ammonium radicals.
Examples of para-phenylenediamines of formula (Vl) above that may especially be mentioned include para-phenylenediamine, para-tolylenediamine, 2-chloro-para- phenylenediamine, 2,3-dimethyl-para-phenylenediamine, 2,6-dimethyl-para- phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,5-dimethyl-para-phenylenediamine, N,N-dimethyl-para-phenylenediamine, N,N-diethyl-para-phenylenediamine, N,N-dipropyl- para-phenylenediamine, 4-amino-N,N-diethyl-3-methylaniline, N,N-bis(β-hydroxyethyl)-para- phenylenediamine, 4-amino-N,N-bis(β-hydroxyethyl)-2-methylaniline, 4-amino-2-chloro-N,N- bis(β-hydroxyethyl)aniline, 2-β-hydroxyethyl-para-phenylenediamine, 2-fluoro-para- phenylenediamine, 2-isopropyl-para-phenylenediamine, N-(β-hydroxypropyl)-para- phenylenediamine, 2-hydroxymethyl-para-phenylenediamine, N,N-dimethyl-3-methyl-para- phenylenediamine, N,N-(ethyl-β-hydroxyethyl)-para-phenylenediamine, N-(β,γ-dihydroxy propyl)-para-phenylenediamine, N-(4'-aminophenyl)-para-phenylenediamine, N-phenyl-para- phenylenediamine, 2-β-hydroxyethyloxy-para-phenylenediamine, 2-β-acetylaminoethyloxy- para-phenylenediamine, N-(β-methoxyethyl)-para-phenylenediamine, 2-methyl-1-N-β- hydroxyethyl-para-phenylenediamine, and the addition salts thereof with an acid.
Among the para-phenylenediamines of formula (Vl) above, para-phenylenediamine, para- tolylenediamine, 2-isopropyl-para-phenylenediamine, 2-β-hydroxyethyl-para-phenylene- diamine, 2-β-hydroxyethyloxy-para-phenylenediamine, 2,6-dimethyl-para-phenylenediamine, 2,6-diethyl-para-phenylenediamine, 2,3-dimethyl-para-phenylenediamine, N,N-bis(β-hydroxy- ethyl)-para-phenylenediamine and 2-chloro-para-phenylenediamine, and the addition salts thereof with an acid are most particularly preferred.
- (II) According to the invention, the term double bases is understood to refer to the compounds containing at least two aromatic nucleii bearing amino and/or hydroxyl groups.
Among the double bases that may be used as oxidation bases in the dye compositions in accordance with the invention, mention may be made in particular of the compounds corresponding to formula (VII) below, and the addition salts thereof with an acid:
Figure imgf000034_0001
in which
- Z1 and Z2, which may be identical or different, represent a hydroxyl or -NH2 group that may be substituted with a CrC4 alkyl radical or with a linker arm Y;
- the linker arm Y represents a linear or branched alkylene chain containing from 1 to 14 carbon atoms, which may be interrupted by or terminated with one or more nitrogenous groups and/or one or more heteroatoms such as oxygen, sulfur or nitrogen atoms, and optionally substituted with one or more hydroxyl or CrCβ alkoxy radicals;
- R5 and R6 represent a hydrogen or halogen atom, a CrC4 alkyl radical, a CrC4 monohydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a CrC4 aminoalkyl radical or a linker arm Y;
- R7, Rs, Rg, R-io, Rn and Ri2, which may be identical or different, represent a hydrogen atom, a linker arm Y or a CrC4 alkyl radical; it being understood that the compounds of formula (VII) contain only one linker arm Y per molecule.
Among the nitrogenous groups of formula (VII) above, mention may be made in particular of amino, mono(CrC4)alkylamino, di(CrC4)alkylamino, tri(CrC4)alkylamino, monohydroxy(Cr C4)alkylamino, imidazolinium and ammonium radicals.
Among the double bases of formula (VII) above, mention may be made more particularly of N,N'-bis(β-hydroxyethyl)-N,N'-bis(4'-aminophenyl)-1 ,3-diaminopropanol, N,N'-bis(β- hydroxyethyl)-N,N'-bis(4'-aminophenyl)ethylenediamine, N,N'-bis(4-aminophenyl)- tetramethylenediamine, N,N'-bis(β-hydroxyethyl)-N,N'-bis(4-aminophenyl)- tetramethylenediamine, N,N'-bis(4-methylaminophenyl)tetramethylenediamine, N,N'-bis- (ethyl)-N,N'-bis(4'-amino-3'-methylphenyl)ethylenediamine and 1 ,8-bis(2,5-diaminophenoxy)- 3,5-dioxaoctane, and the addition salts thereof with an acid.
Among these double bases of formula (VII), N,N'-bis(β-hydroxyethyl)-N,N'-bis(4'-amino- phenyl)-1 ,3-diaminopropanol and 1 ,8-bis(2,5-diaminophenoxy)-3,5-dioxaoctane, or one of the addition salts thereof with an acid, are particularly preferred. - (Ill) para-Aminophenols that may especially be mentioned include those corresponding to formula (VIII) below, and the addition salts thereof with an acid:
Figure imgf000035_0001
NH2 in which: R-13 represents a hydrogen atom, a halogen atom such as fluorine, a C1-C4 alkyl,
Ci-C4 monohydroxyalkyl, (Ci-C4)alkoxy(Ci-C4)alkyl, d-C4 aminoalkyl or hydroxy(Ci-C4)alkylamino(Ci-C4)alkyl radical,
Ru represents a hydrogen atom or a halogen atom such as fluorine, a CrC4-alkyl, C1-C4 monohydroxyalkyl, C2-C4 polyhydroxyalkyl, CrC4 aminoalkyl, CrC4 cyanoalkyl or (C1-C4)alkoxy(C1-C4)alkyl radical.
Among the para-aminophenols of formula (VIII) above, mention may be made more particularly of para-aminophenol, 4-amino-3-methylphenol, 4-amino-3-fluorophenol, 4-amino- 3-hydroxymethylphenol, 4-amino-2-methylphenol, 4-amino-2-hydroxymethylphenol, 4-amino- 2-methoxymethylphenol, 4-amino-2-aminomethylphenol and 4-amino-2-
(β-hydroxyethylaminomethyl)phenol, and the addition salts thereof with an acid.
- (IV) The ortho-aminophenols that may be used as oxidation bases in the context of the present invention are chosen especially from 2-aminophenol, 2-amino-1-hydroxy-5- methylbenzene, 2-amino-1-hydroxy-6-methylbenzene and 5-acetamido-2-aminophenol, and the addition salts thereof with an acid.
The heterocyclic oxidation base(s) of the invention preferably represent(s) from 0.0005% to 12% by weight approximately relative to the total weight of the dye composition, and even more preferably from 0.005% to 6% by weight approximately relative to this weight.
The additional oxidation base(s) preferably represent(s) from 0.0005% to 12% by weight approximately relative to the total weight of the dye composition, and even more preferentially from 0.005% to 6% by weight approximately relative to this weight.
The compositions of the invention contain at least one coupler. The couplers that may be used in the dye composition according to the invention are those conventionally used in oxidation dye compositions, i.e. meta-aminophenols, meta- phenylenediamines, meta-diphenols, naphthols and heterocyclic couplers, and the addition salts thereof with an acid.
These additional couplers are more particularly chosen from 2,4-diamino-1-(β- hydroxyethyloxy)benzene, 2-methyl-5-aminophenol, 5-N-(β-hydroxyethyl)amino-2-methyl- phenol, 3-aminophenol, 1 ,3-dihydroxybenzene, 1 ,3-dihydroxy-2-methylbenzene, 4-chloro- 1 ,3-dihydroxybenzene, 2-amino-4-(β-hydroxyethylamino)-1-methoxybenzene, 1 ,3-diamino benzene, 1 ,3-bis(2,4-diaminophenoxy)propane, sesamol, 1-amino-2-methoxy-4,5- methylenedioxybenzene, α-naphthol, 6-hydroxybenzomorpholine, 2-amino-3- hydroxypyridine, 1-amino-4,5-methylenedioxybenzene and 1-(β-hydroxyethylamino)-4,5- methylenedioxybenzene, and the addition salts thereof with an acid.
The coupler(s) preferably represent(s) from 0.0001 % to 10% by weight approximately relative to the total weight of the dye composition, and even more preferentially from 0.005% to 5% by weight approximately relative to this weight.
In general, the addition salts with an acid of the oxidation bases and couplers are especially chosen from the hydrochlorides, hydrobromides, sulfates, tartrates, lactates and acetates.
The suitable dyeing medium (or support) generally consists of water or of a mixture of water and of at least one organic solvent to dissolve the compounds that are not sufficiently water- soluble. Examples of organic solvents that may be mentioned include CrC4 lower alkanols, such as ethanol and isopropanol; aromatic alcohols, for instance benzyl alcohol, and also similar products and mixtures thereof.
The solvents may be present in proportions preferably between 1 % and 40% by weight approximately and even more preferentially between 5% and 30% by weight approximately relative to the total weight of the dye composition.
The pH of the dye composition in accordance with the invention is generally between 2 and 1 1 approximately and preferably between 5 and 10 approximately. It may be adjusted to the desired value by means of acidifying or basifying agents usually used in the dyeing of keratin fibres.
Among the acidifying agents, examples that may be mentioned include mineral or organic acids, for instance hydrochloric acid, orthophosphoric acid, sulfuric acid, carboxylic acids, for instance acetic acid, tartaric acid, citric acid and lactic acid, and sulfonic acids.
Among the basifying agents, examples that may be mentioned include aqueous ammonia, alkali metal carbonates, alkanolamines such as monoethanolamine, diethanolamine and triethanolamine, and also derivatives thereof, sodium hydroxide, potassium hydroxide and the compounds of formula (XV) below:
*'' V in which w is a propylene residue optionally substituted with a hydroxyl group or a CrCβ alkyl radical; R3, R4, R5 and R6, which may be identical or different, represent a hydrogen atom or a C-i-Cδ alkyl or CrCβ hydroxyalkyl radical. In addition to the direct dye(s) of the invention defined above, the dye compositions in accordance with the invention may contain one or more other additional direct dyes that may be chosen, for example, from nitrobenzene dyes, anthraquinone dyes, naphthoquinone dyes, triarylmethane dyes, xanthene dyes and non- cationic azo dyes.
The dye composition in accordance with the invention may also contain various adjuvants conventionally used in hair dye compositions, such as antioxidants, penetrants, sequestrants, fragrances, buffers, nonionic, anionic or amphoteric polymers, non-silicone cationic polymers, nonionic, cationic or amphoteric surfactants, ceramides, preserving agents, screening agents and opacifiers.
Needless to say, a person skilled in the art will take care to select the optional additional compound(s) such that the advantageous properties intrinsically associated with the dye composition in accordance with the invention are not, or are not substantially, adversely affected by the envisaged addition(s).
The dye composition according to the invention may be in various forms, such as in the form of liquids, shampoos, creams or gels, or in any other form that is suitable for dyeing keratin fibres, and especially human hair. It may be obtained by extemporaneously mixing a composition, optionally a pulverulent composition, containing the cationic direct dye(s) of formula (I) with a composition containing at least one oxidation base and at least one nitrogenous heterocyclic coupler as defined above. When it is ready-to-use, the dye composition in accordance with the invention also contains at least one oxidizing agent chosen, for example, from hydrogen peroxide, urea peroxide, alkali metal bromates, persalts such as perborates and persulfates, and enzymes such as peroxidases, laccases and two-electron oxidoreductases. The use of hydrogen peroxide or of enzymes is particularly preferred.
Another subject of the invention is a process for dyeing keratin fibres, and in particular human keratin fibres such as the hair, using the dye composition as defined above.
According to one particular embodiment, the dyeing process comprises a preliminary step that consists in separately storing, on the one hand, a composition (A1 ) comprising, in a suitable dyeing medium, at least one cationic direct dye (i) as defined above and, on the other hand, a composition (B1 ) containing, in a suitable dyeing medium, at least one oxidizing agent, and optionally a composition (C1 ) in a suitable dyeing medium, and then in mixing together at the time of use compositions (A1 ) and (B1 ) and optionally (C1 ), followed by applying this mixture to keratin fibres, composition (A1 ) and/or composition (C1 ) containing at least one particular heterocyclic oxidation base and at least one coupler as defined above.
Another subject of the invention is a multi-compartment device or dyeing "kit" or any other multi-compartment packaging system, of which a first compartment contains composition (A1 ) as defined above, a second compartment contains composition (B1 ), and optionally a third compartment contains composition (C1 ) as defined above. These devices may be equipped with a means for applying the desired mixture to the hair, such as the devices described in patent FR 2 586 913 in the name of the Applicant.
The examples that follow are intended to illustrate the invention without, however, limiting its scope.
EXAMPLES
Figure imgf000039_0001
Application Examples Example 1
The dye composition below was prepared (amounts expressed as grams of active material):
Figure imgf000039_0002
At the time of use, this composition is mixed weight for weight with 20-volumes aqueous hydrogen peroxide solution at pH 3. The mixture is applied firstly to locks of natural grey hair containing 90% white hairs, and secondly to locks of permanent-waved grey hair containing 90% white hairs, for 30 minutes at room temperature (20°C).
After the action time, the locks are rinsed, shampooed and then rinsed and dried. They are dyed in a sparingly selective chromatic deep purple-mahogany blond shade.
Example 2
If dye 1 is replaced weight for weight with dye 2 and the oxidation base 4,5-diamino-1-(β- hydroxyethyl)pyrazole sulfate with 2,4,5,6-tetraaminopyrimidine sulfate, a sparingly selective chromatic violet-red blond shade is finally obtained.

Claims

1. Composition for dyeing keratin fibres, comprising, in a suitable dyeing medium, at least one heterocyclic oxidation base comprising in its structure at least one 5- or 6- membered sulfur-free nitrogenous heterocycle optionally fused with not more than one aromatic or heterocyclic ring, at least one coupler, and at least one tetraazapentamethine compound of formula I
Figure imgf000040_0001
in which - W1 represents a cationic heteroaromatic radical of formula (II) or (III):
Figure imgf000040_0002
(DD (III)
W2 represents a heteroaromatic radical of formula (IV) or (V):
Figure imgf000040_0003
in which: - Z0 represents a radical CR2, a nitrogen atom or a radical NR21,
Z1 represents an oxygen or sulfur atom or a radical NR9, Z2 represents a nitrogen atom or a radical CR1O, Z3 represents a nitrogen atom or a radical CR11, Z4 represents a nitrogen atom or a radical CR12, - Z5 represents a nitrogen atom or a radical CR13,
Z6 represents a nitrogen atom or a radical CR14, Z7 represents an oxygen or sulfur atom or a radical NR15, Z8 represents a nitrogen atom or a radical CR-iβ, Zg represents a nitrogen atom or a radical CR17,
Z10 represents a nitrogen atom or a radical CRi8,
Z11 represents a nitrogen atom or a radical CR-19,
Z12 represents a nitrogen atom or a radical CR2O, - Z13 represents a radical CR6, a nitrogen atom or a radical NR22, it being understood that each of the rings of formulae (II), (III), (IV) and (V) comprise not more than three nitrogen atoms and that two of the three nitrogen atoms may be contiguous, the bond a of the 5-membered cationic heteroaromatic radical of formula (II) being linked to the nitrogen atom N1 of formula (I), the bond b of the 6-membered cationic heteroaromatic radical of formula (III) being linked to the nitrogen atom N1 of formula (I), the double bond a' of the 5-membered heteroaromatic radical of formula (IV) being linked to the nitrogen atom N2 of formula (I), - the double bond b' of the 6-membered heteroaromatic radical of formula (V) being linked to the nitrogen atom N2 of formula (I), the bond b, linking the cationic heteroaromatic radical of formula (III) to the nitrogen atom N1 of formula (I), being in an ortho or para position relative to the nitrogen atom bearing the radical R4 when Z5 represents a radical CR13; the bond b being in an ortho position relative to the nitrogen atom bearing the radical R4 when Z5 represents a nitrogen atom, the bond b', linking the heteroaromatic radical of formula (V) to the nitrogen atom N2 of formula (I), being in an ortho or para position relative to the nitrogen atom bearing the radical R7 when Z11 represents a radical CRig; the bond b' being in an ortho position relative to the nitrogen atom bearing the radical R7 when Z11 represents a nitrogen atom,
R2, R6, R1O and R16 represent, independently of each other, a hydrogen atom; a linear or branched C1-C4 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino and C1-C2 (di)alkylamino radicals; a carboxyl radical; a sulfonylamino radical,
R1, R4, R5, R7, R9, R15, R21 and R22 represent, independently of each other, a linear or branched C1-C8 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals;
R0, R3, Rs, R11, R12, Ri3, Ri4, Ri7, R18, Ri9 and R2o represent, independently of each other, a hydrogen atom, a linear or branched C1-C16 hydrocarbon-based chain, this chain possibly being saturated or unsaturated with one to three unsaturations, this chain being unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl, sulfonic, sulfonylamino and C2-C4 (poly)hydroxyalkylamino radicals or a halogen atom such as chlorine, fluorine or bromine; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl, sulfonic, sulfonylamino and C2-C4 (poly)hydroxyalkylamino radicals or a halogen atom such as chlorine, fluorine or bromine; a heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, triazolyl, pyridyl, pyrimidinyl, triazinyl, pyrazinyl and pyridazinyl radicals; in addition, this hydrocarbon-based chain may be interrupted with one or two oxygen, nitrogen or sulfur atoms or with an SO2 radical, it being understood that R0, R3, Re, Rn, R12, R13, Ri4, R17, R18, R19 and R20 do not comprise a peroxide bond or diazo or nitroso radicals,
R2 with R10, R11 with R12, R6 with R16, and R17 with R18 can form, independently of each other, a 5- or 6-membered carbon-based aromatic ring, which is unsubstituted or substituted with one or two hydroxyl, amino, (di)(CrC2)alkylamino, C1-C2 alkoxy or
C2-C4 (poly)hydroxyalkylamino radicals, X is an organic or mineral anion.
2. Composition according to Claim 1 , characterized in that, in formula I, Z1 represents an oxygen atom or a radical NR9 and Z7 represents an oxygen atom or a radical NR15.
3. Composition according to Claims 1 and 2, in which R0 represents a hydrogen atom; a linear or branched C1-C6 alkyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, C2-C4 (poly)hydroxyalkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one to three radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals or a halogen atom such as chlorine, fluorine or bromine; an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl, thiazolyl, oxazolyl, triazolyl, pyridyl, pyrimidinyl, triazinyl, pyrazinyl and pyridazinyl radicals.
4. Composition according to any one of the preceding claims, in which R0 represents a hydrogen atom; a methyl, ethyl or 2-methoxyethyl radical; a phenyl radical, which is unsubstituted or substituted with an amino, (di)methylamino or (di)(2-hydroxyethyl)amino radical, or an optionally cationic heteroaryl radical chosen from pyrazolyl, pyrrolyl, imidazolyl and pyridyl radicals.
5. Composition according to any one of the preceding claims, in which R2, R6, Rio and R16 represent a hydrogen atom, a C1-C4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, amino, C1-C2 (di)alkylamino and carboxyl radicals, or a phenyl radical.
6. Composition according to any one of the preceding claims, in which R2, R6, R10 and R16 represent a hydrogen atom, a methyl, phenyl or 2-hydroxymethyl radical or a carboxyl.
7. Composition according to any one of the preceding claims, in which R1, R4, R5, R7, R9, R15, R21 and R22 represent a C1-C4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals.
8. Composition according to any one of the preceding claims, in which R1, R4, R5, R7, Rg, R15, R21 and R22 represent a methyl, ethyl, 2-hydroxyethyl, 1-carboxymethyl, 2- carboxyethyl or 2-sulfonylethyl radical.
9. Composition according to any one of the preceding claims, in which R3, R8, R11, R12, R-I3, Ri4. R-17. R-18. R-19 and R20 represent, independently of each other, a hydrogen atom; a linear or branched C1-C4 alkyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals; a phenyl radical, which is unsubstituted or substituted with one or two radicals chosen from hydroxyl, C1-C2 alkoxy, C2-C4 (poly)hydroxyalkoxy, amino, C1-C2 (di)alkylamino, carboxyl and sulfonic radicals or a halogen atom such as chlorine, fluorine or bromine; a sulfonylamino radical; a C2-C4
(poly)hydroxyalkylamino radical.
10. Composition according to any one of the preceding claims, in which R3, R8, R11, R12, Ri3, Ri4, Ri7, Ri8, Ri9 and R20 represent, independently of each other, a hydrogen atom, a methyl or 2-hydroxymethyl radical, a carboxyl, a methoxy, ethoxy or 2-hydroxyethyloxy radical, or an amino, methylamino, dimethylamino or 2-hydroxyethylamino radical.
1 1. Composition according to any one of the preceding claims, in which W1 is a 2- pyridinium radical and W2 is a 2-pyridine radical.
12. Composition according to Claim 11 , in which the compound of formula (I) is chosen from the following compounds:
- 2-[5-(N-methyl-2-pyridinylidene)-1 -formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-methyl-1 -formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-ethyl-1 -formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-isopropyl-1 -forrnazano]-N-methylpyridinium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-phenyl-1-formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N-methylpyridinium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N-methylpyridinium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-methyl-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-ethyl-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-isopropyl-1-formazano]-4-pyrrolidino-N- methylpyridinium chloride - 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-phenyl-1 -formazano]-4-pyrrolidino-N- methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-4- pyrrolidino-N-methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-4- pyrrolidino-N-methylpyridinium chloride
- 2-[5-(4-pyrrolidino-N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1- formazano]-4-pyrrolidino-N-methylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-ethyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-isopropyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-N-carboxyethylpyridinium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-ethyl-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-isopropyl-1-formazano]-N-carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- carboxyethylpyridinium chloride.
13. Composition according to any one of Claims 1 to 10, in which W1 is a 4-pyridinium radical and W2 is a 4-pyridine radical.
14. Composition according to Claim 13, in which the compound of formula (I) is chosen from the following compounds:
- 4-[5-(N-methyl-4-pyridinylidene)-1 -formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-methyl-1 -formazano]-N-methylpyridinium chloride - 4-[5-(N-methyl-4-pyridinylidene)-3-ethyl-1-formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-N-methylpyridinium chloride - 4-[5-(N-methyl-4-pyridinylidene)-3-phenyl-1 -formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N-methylpyridinium chloride
- 4-[5-(N-methyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- methylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-1-formazano]-N-hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-methyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-ethyl-1-formazano]-N-hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-N-hydroxyethylpyridinium chloride - 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-N-hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 4-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- hydroxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-methyl-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-ethyl-1-formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-N-carboxyethylpyridinium chloride - 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-N-carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-N- carboxyethylpyridinium chloride
- 4-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-N- carboxyethylpyridinium chloride.
15. Composition according to any one of Claims 1 to 10, in which W1 is a 2-imidazolium radical and W2 is a 2-imidazole radical.
16. Composition according to Claim 15, in which the compound of formula (I) is chosen from the following compounds:
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-methyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-ethyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-isopropyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-phenyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride - 2-[5-(1 ,3-dimethyl-2-imidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-1 -formazano]-1 ,3-dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-isopropyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-imidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,3-dihydroxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-1-formazano]-1 ,3-dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-methyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-ethyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-isopropyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-imidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,3-dicarboxyethylimidazolium chloride.
17. Composition according to any one of Claims 1 to 10, in which W1 is a 5-pyrazolium radical and W2 is a 5-pyrazole radical.
18. Composition according to Claim 17, in which the compound of formula (I) is chosen from the following compounds:
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-1 -formazano]-1 ,2-dimethylpyrazolinium chloride - 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-methyl-1 -formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-ethyl-1-formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-isopropyl-1-formazano]-1 ,2-dimethylpyrazolinium chloride - 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-phenyl-1 -formazano]-1 ,2-dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,2- dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,2- dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dimethyl-5-pyrazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,2- dimethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-1 -formazano]-1 ,2-dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-methyl-1 -formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-ethyl-1 -formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-phenyl-1-formazano]-1 ,2- dihydroxyethylpyrazolinium chloride - 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-isopropyl-1 -formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,2- dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dihydroxyethyl-5-pyrazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,2-dihydroxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-1 -formazano]-1 ,2-dicarboxyethylpyrazolinium chloride - 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-methyl-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-ethyl-1 -formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-phenyl-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-isopropyl-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride - 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,2- dicarboxyethylpyrazolinium chloride
- 5-[5-(1 ,2-dicarboxyethyl-5-pyrazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,2-dicarboxyethylpyrazolinium chloride.
19. Composition according to any one of Claims 1 to 10, in which W1 is a 2- benzimidazolium radical and W2 is a 2-pyridine radical.
20. Composition according to Claim 19, in which the compound of formula (I) is chosen from the following compounds:
- 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride - 2-[5-(N-methyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride.
21. Composition according to any one of Claims 1 to 10, in which W1 is a 2- benzimidazolium radical and W2 is a 4-pyridine radical.
22. Composition according to Claim 21 , in which the compound of formula (I) is chosen from the following compounds: - 2-[5-(N-methyl-4-pyridinylidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-phenyl-1 -formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(N-carboxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride.
23. Composition according to any one of Claims 1 to 10, in which W1 is a 2-imidazolium radical and W2 is a 2-pyridine radical.
24. Composition according to Claim 23, in which the compound of formula (I) is chosen from the following compounds: - 2-[5-(N-methyl-2-pyridinylidene)-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-ethyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-methyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-isopropyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-2-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride.
25. Composition according to any one of Claims 1 to 10, in which W1 is a 2-imidazolium radical and W2 is a 4-pyridine radical.
26. Composition according to Claim 25, in which the compound of formula (I) is chosen from the following compounds: - 2-[5-(N-methyl-4-pyridinylidene)-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-ethyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3-dimethylimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3-dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylimidazolium chloride - 2-[5-(N-methyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dimethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride - 2-[5-(N-hydroxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dihydroxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-1 -formazano]-1 ,3-dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-methyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-ethyl-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride - 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-isopropyl-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride
- 2-[5-(N-carboxyethyl-4-pyridinylidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]-1 ,3- dicarboxyethylimidazolium chloride.
27. Composition according to any one of Claims 1 to 10, in which W1 is a 2- benzimidazolium radical and W2 is a 2-benzimidazole radical.
28. Composition according to Claim 27, in which the compound of formula (I) is chosen from the following compounds:
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-1-formazano]-1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-methyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-ethyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-isopropyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-phenyl-1-formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-(4'-methoxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride - 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dimethyl-2-benzimidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1-formazano]- 1 ,3-dimethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-methyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-ethyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride - 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-phenyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-isopropyl-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-(4'-hydroxyphenyl)-1 -formazano]-1 ,3- dihydroxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dihydroxyethyl-2-benzimidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1- formazano]-1 ,3-dihydroxyethylbenzimidazolium chloride - 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-1 -formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-methyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-ethyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-phenyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-isopropyl-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-(4'-methoxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride - 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-(4'-hydroxyphenyl)-1-formazano]-1 ,3- dicarboxyethylbenzimidazolium chloride
- 2-[5-(1 ,3-dicarboxyethyl-2-benzimidazolidene)-3-(4'-N,N-dimethylaminophenyl)-1- formazano]-1 ,3-dicarboxyethylbenzimidazolium chloride.
29. Composition according to any one of the preceding claims, characterized in that the compound(s) of formula I is (are) present in a concentration ranging from 0.001 % to 5% and preferably from 0.05% to 2% by weight relative to the total weight of the composition.
30. Composition according to any one of the preceding claims, characterized in that the heterocyclic oxidation base(s) is (are) chosen from pyridines, pyrazoles, fused pyrazolopyrimidines, pyrazolotriazoles, pyrazolotetrazoles, pyrazolopyridazines, pyrazolo- imidazoles, pyrazolopyrazoles, aminopyrazolones, aminopyrrolidines, aminopyrazolines, monoaminoquinolines, aminoindazoles, diaminouracils, hydrazones, aminoindolenines, diamino- or triaminoquinolines, pyrazolobenzimidazoles and pyrimidines, alone or as mixtures.
31. Composition according to Claim 30, characterized in that the pyridine heterocyclic oxidation base(s) is (are) chosen from 2,5-diaminopyridine and 3,4-diaminopyridine, and the addition salts thereof with an acid.
32. Composition according to Claim 30, characterized in that the pyrazole heterocyclic oxidation base(s) is (are) chosen from 4,5-diamino-1-methylpyrazole, 3,4-diaminopyrazole, 4,5-diamino-1-(4'-chlorobenzyl)pyrazole, 4,5-diamino-1 ,3-dimethylpyrazole, 4,5-diamino-3- methyl-1-phenylpyrazole, 4,5-diamino-1-methyl-3-phenylpyrazole, 4-amino-1 ,3-dimethyl-
5-hydrazinopyrazole, 1 -benzyl-4,5-diamino-3-methylpyrazole, 4,5-diamino-3-tert-butyl- 1-methylpyrazole, 4,5-diamino-1-tert-butyl-3-methylpyrazole, 4,5-diamino-1-(β-hydroxyethyl)- 3-methylpyrazole, 4,5-diamino-1-(β-hydroxyethyl)pyrazole, 4,5-diamino-1-ethyl-3- methylpyrazole, 4,5-diamino-1-ethyl-3-(4'-methoxyphenyl)pyrazole, 4,5-diamino-1-ethyl-3- hydroxymethylpyrazole, 4,5-diamino-3-hydroxymethyl-1-methylpyrazole, 4,5-diamino-3- hydroxymethyl-1-isopropylpyrazole, 4,5-diamino-3-methyl-1-isopropylpyrazole, 4-amino- 5-(2'-aminoethyl)amino-1 ,3-dimethylpyrazole, 3,4,5-triaminopyrazole, 1-methyl-3,4,5- triaminopyrazole, 3,5-diamino-1-methyl-4-methylaminopyrazole and 3,5-diamino-4- (β-hydroxyethyl)amino-i-methylpyrazole, and the addition salts thereof with an acid.
33. Composition according to Claim 30, characterized in that the pyrazolopyrimidine heterocyclic oxidation base(s) is (are) chosen from the pyrazolo[1 ,5-a]pyrimidines having the following formula, and the addition salts thereof with an acid or with a base:
Figure imgf000058_0001
in which:
- R-i, R2, R3 and R4, which may be identical or different, denote a hydrogen atom, a C1-C4 alkyl radical, an aryl radical, a d-C4 hydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a (Ci-C4)alkoxy(Ci-C4)alkyl radical, a CrC4 aminoalkyl radical; a C1-C4 aminoalkyl radical in which the amine is protected with an acetyl, ureido or sulfonyl radical; a (C1- C4)alkylamino(Ci-C4)alkyl radical; a di[(Ci-C4)alkyl]amino(Ci-C4)alkyl radical in which the dialkyl radicals can form a 5- or 6-membered aliphatic or heterocyclic ring; a hydroxy(Ci- C4)alkyl- or di[hydroxy-(Ci-C4)alkyl]amino(Ci-C4)alkyl radical;
- the radicals X, which may be identical or different, denote a hydrogen atom, a CrC4 alkyl radical, an aryl radical, a CrC4 hydroxyalkyl radical, a C2-C4 polyhydroxyalkyl radical, a C1- C4 aminoalkyl radical, a (Ci-C4)alkylamino(Ci-C4)alkyl radical, a di[(Ci-C4)alkyl]amino(Ci- C4)alkyl radical in which the dialkyl radicals can form a 5- or 6-membered aliphatic or heterocyclic ring; a hydroxy(CrC4)alkyl- or di[hydroxy(Ci-C4)alkyl]amino(Ci-C4)alkyl radical, an amino radical, a (Ci-C4)alkyl- or di[(Ci-C4)alkyl]amino radical; a halogen atom, a carboxylic acid group or a sulfonic acid group; - i is equal to 0, 1 , 2 or 3;
- p is equal to 0 or 1 ;
- q is equal to 0 or 1 ;
- n is equal to 0 or 1 ; with the proviso that: - (i) the sum p + q is other than 0;
- (ii) when p + q is equal to 2, then n is equal to 0 and the groups NR1R2 and NR3R4 occupy the (2,3); (5,6); (6,7); (3,5) or (3,7) positions;
- (iii) when p + q is equal to 1 , then n is equal to 1 and the group NR1R2 (or NR3R4) and the OH group occupy the (2,3); (5,6); (6,7); (3,5) or (3,7) positions.
34. Composition according to the preceding claim, characterized in that the pyrazolo[1 ,5- a]pyrimidine heterocyclic oxidation base(s) is (are) chosen from: - pyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 2-methylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 2,5-dimethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- pyrazolo[1 ,5-a]pyrimidine-3,5-diamine, - 2,7-dimethylpyrazolo[1 ,5-a]pyrimidine-3,5-diamine,
- 3-aminopyrazolo[1 ,5-a]pyrimidin-7-ol,
- 3-amino-5-methylpyrazolo[1 ,5-a]pyrimidin-7-ol
- 3-aminopyrazolo[1 ,5-a]pyrimidin-5-ol,
- 2-(3-aminopyrazolo[1 ,5-a]pyrimidin-7-ylamino)ethanol, - 3-amino-7-β-hydroxyethylamino-5-methylpyrazolo[1 ,5-a]pyrimidine,
- 2-(7-aminopyrazolo[1 ,5-a]pyrimidin-3-ylamino)ethanol,
- 2-[(3-aminopyrazolo[1 ,5-a]pyrimidin-7-yl)(2-hydroxyethyl)amino]ethanol,
- 2-[(7-aminopyrazolo[1 ,5-a]pyrimidin-3-yl)(2-hydroxyethyl)amino]ethanol,
- 5,6-dimethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine, - 2,6-dimethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 2,5,N7,N7-tetramethylpyrazolo[1 ,5-a]pyrimidine-3,7-diamine,
- 3-amino-5-methyl-7-imidazolylpropylaminopyrazolo[1 ,5-a]pyrimidine, and the addition salts thereof.
35. Composition according to Claim 30, characterized in that the diaminouracil heterocyclic oxidation base(s) is (are) chosen from 5,6-diaminouracil, 5,6-diamino-2- thiouracil, 5,6-diamino-3-methyluracil, δ-amino-S-methyl-δ-methylaminouracil, 5-amino-3- methyl-6-β-hydroxyethylaminouracil, 5-amino-3-methyl-6-benzylaminouracil, 5-amino-3- methyl-6-phenylaminouracil, 5,6-diamino-1-phenyluracil, 5,6-diamino-1 ,3-dimethyluracil, 5- amino-1 ,3-dimethyl-6-methylaminouracil, 5-amino-1 ,3-dimethyl-6-β- hydroxymethylaminouracil, 5-amino-1 ,3-dimethyl-6-benzylaminouracil, 5-amino-1 ,3-dimethyl- 6-phenylaminouracil and 5-amino-1 ,3-dimethyl-6-dimethylaminouracil.
36. Composition according to Claim 30, characterized in that the aminoindolenine heterocyclic oxidation base(s) is (are) chosen from the compounds 2-methyl-5- aminoindolenine and 1 -β-hydroxyethyl-2-methyl-5-aminoindolenine.
37. Composition according to Claim 30, characterized in that the mono- or diaminotetrahydroquinoline heterocyclic oxidation base(s) is (are) chosen from the compounds 5-amino-1 ,2,3,4-tetrahydroquinoline, 5-amino-7-chloro-8-piperidino-1 , 2,3,4- tetrahydroquinoline, 5-amino-7-chloro-8-morpholino-1 ,2,3,4-tetrahydroquinoline, 5,7-diamino- 6-methyl-8-hydroxy-1 ,2,3,4-tetrahydroquinoline, 5-amino-8-methoxy-1 ,2,3,4-tetrahydro- quinoline and 5-amino-7-chloro-8-dimethylamino-1 ,2,3,4-tetrahydroquinoline.
38. Composition according to Claim 30, characterized in that the diaminoquinoline heterocyclic oxidation base(s) is (are) chosen from the compounds 5,7-diamino-6-methyl-8- hydroxyquinoline and 5,7-diamino-2-methyl-8-hydroxyquinoline.
39. Composition according to Claim 30, characterized in that the triaminoquinoline heterocyclic oxidation base(s) is (are) chosen from the compounds 5,7-diamino-8- methylaminoquinoline, 5,7-diamino-8-dimethylaminoquinoline, 5,7-diamino-8- morpholinoquinoline, 5,7-diamino-8-β-hydroxyethylaminoquinoline and 5,7,8-triamino- quinoline.
40. Composition according to Claim 30, characterized in that the aminopyrazolone heterocyclic oxidation base(s) is (are) chosen from 1-phenyl-4-aminopyrazolone-3-carbonic acid, 1-phenyl-4-aminopyrazolone-3-carbonic acid amide, ethyl 1-phenyl-4-aminopyrazolone- 3-carbonate, 1-phenyl-3-methyl-4-aminopyrazolone, 3-aminopyrazolone, 1-phenyl-3- aminopyrazolone and 1-phenyl-3-hydroxypyrazolone.
41. Composition according to Claim 30, characterized in that the pyrazolotriazole heterocyclic oxidation base(s) is (are) chosen from the compounds 3-amino-4-methyl-6- methylthio-2-phenylpyrazolo[3,2-c]-s-triazole, 3-amino-2,4,6-trimethylpyrazolo[3,2-c]-s- triazole, 3-amino-4,6-dimethylpyrazolo[3,2-c]-s-triazole, 7-amino-2,6-dimethylpyrazolo[1 ,5-b]- 1 ,2,4-triazole, 7-amino-3,6-dimethylpyrazolo[3,2-c]-1 ,2,4-triazole, 7-amino-3- methylpyrazolo[3,2-c]-1 ,2,4-triazole, 7-amino-3-methyl-6-carboxypyrazolo[3,2-c]-1 ,2,4- triazole, 7-amino-2-methylpyrazolo[1 ,5-b]-1 ,2,4-triazole, 7-amino-2-phenylpyrazolo[1 ,5-b]- 1 ,2,4-triazole and 7-amino-2-methyl-6-carboxypyrazolo[1 ,5-b]-1 ,2,4-triazole.
42. Composition according to Claim 30, characterized in that the pyrazoloimidazole heterocyclic oxidation base(s) is (are) chosen from the compounds 3-amino-4- benzylpyrazolo[1 ,5-a]imidazole, 3-amino-2,4-dimethylpyrazolo[1 ,5-a]imidazole, 3-amino-4- methylpyrazolo[1 ,5-a]imidazole, 7-amino-6-methylpyrazolo[1 ,5-a]imidazole, 7- aminopyrazolo[1 ,5-a]imidazole, 7-amino-2-methylpyrazolo[1 ,5-a]imidazole and 7-amino-2- phenylpyrazolo[1 ,5-a]imidazole.
43. Composition according to Claim 30, characterized in that the pyrazoloquinoline heterocyclic oxidation base(s) is (are) chosen from the compound 3-amino-2- phenylpyrazolo[1 ,5-a]quinoline.
44. Composition according to Claim 30, characterized in that the pyrazolopyridazine heterocyclic oxidation base is 3-aminopyrazolo[1 ,5-b]pyridazine.
45. Composition according to Claim 30, characterized in that the hydrazone heterocyclic oxidation base(s) is (are) chosen from the compounds N-methylpyridone-4-hydrazone, N1N- dimethylbenzimidazolonehydrazone, N-methylpyridone-2-hydrazone, 1 ,2- dimethylindazolone-3-hydrazone, 1 ,2,6-trimethylpyridone-4-hydrazone, 1-methylquinolone-2- hydrazone, 1 ,2,6-trimethyl-3-nitropyridone-4-hydrazone, 1 ,2,6-trimethyl-3-aminopyridone-4- hydrazone, 1 ,2,5-trimethylpyrazolone-3-hydrazone, 1 ,2-dimethylindazolone-3-hydrazone, 1 ^-dimethyl-δ-chloroindazolone-S-hydrazone, 1 -methyl^-ethyl-δ-nitroindazolone-S- hydrazone and N-methylquinolone-4-hydrazone.
46. Composition according to Claim 30, characterized in that the aminopyrazoline oxidation base(s) is (are) chosen from the compounds 1-(4'-aminophenyl)-3-aminopyrazoline and 1 -(4'-hydroxyphenyl)-3-aminopyrazoline.
47. Composition according to Claim 30, characterized in that the aminoindazole heterocyclic oxidation base(s) is (are) chosen from 4,7-diamino-5-methylindazole, 4,7- diamino-5,6-dimethylindazole, 6,7-diaminoindazole, 6-hydroxy-7-aminoindazole, 1-ethyl-6- hydroxy-7-aminoindazole, 6-aminoindazole and 5,6-diaminoindazole.
48. Composition according to Claim 30, characterized in that the pyrazolobenzimidazole heterocyclic oxidation base(s) is (are) chosen from 7-amino-6-methylpyrazolo[1 ,5- a]benzimidazole, 6,7-diaminopyrazolo[1 ,5-a]benzimidazole, 6,7-diamino-2-methylpyrazolo- [1 ,5-a]benzimidazole and 6,7-diamino-2-phenylpyrazolo[1 ,5-a]benzimidazole.
49. Composition according to Claim 30, characterized in that the pyrazolotetrazole heterocyclic oxidation base(s) is (are) chosen from the compounds 7-amino-6- methylpyrazolo[1 ,5-e]tetrazole, 7-amino-6-phenylpyrazolo[1 ,5-e]tetrazole and 7-amino-6- carboxypyrazolo[1 ,5-e]tetrazole.
50. Composition according to Claim 30, characterized in that the pyrimidine heterocyclic oxidation base(s) is (are) chosen from 2,4,5,6-tetraaminopyrimidine, 4-hydroxy-2,5,6- triaminopyrimidine, 2-hydroxy-4,5,6-triaminopyrimidine, 2,4-dihydroxy-5,6-diaminopyrimidine and 2,5,6-triaminopyrimidine, and the addition salts thereof with an acid, and the tautomeric forms thereof, when a tautomeric equilibrium exists.
51. Composition according to any one of the preceding claims, characterized in that the heterocyclic oxidation base(s) according to the invention are chosen from monocyclic pyrazoles and pyrimidines.
52. Composition according to any one of the preceding claims, characterized in that the heterocyclic oxidation base(s) of the invention preferably represent(s) from 0.0005% to 12% by weight approximately relative to the total weight of the dye composition, and even more preferentially from 0.005% to 6% by weight approximately relative to this weight.
53. Composition according to any one of the preceding claims, characterized in that it contains one or more additional oxidation bases chosen from para-phenylenediamines, bis(phenyl)alkylenediamines, para-aminophenols and ortho-aminophenols.
54. Composition according to any one of the preceding claims, characterized in that the coupler(s) according to the invention is (are) chosen from meta-aminophenols, meta- phenylenediamines, meta-diphenols, naphthols and heterocyclic couplers, and the addition salts thereof with an acid.
55. Composition according to the preceding claim, characterized in that the coupler(s) according to the invention is (are) chosen from 2,4-diamino-1-(β-hydroxyethyloxy)benzene, 2-methyl-5-aminophenol, 5-N-(β-hydroxyethyl)amino-2-methylphenol, 3-aminophenol, 1 ,3- dihydroxybenzene, 1 ,3-dihydroxy-2-methylbenzene, 4-chloro-1 ,3-dihydroxybenzene, 2- amino-4-(β-hydroxyethylamino)-1-methoxybenzene, 1 ,3-diaminobenzene, 1 ,3-bis(2,4- diaminophenoxy)propane, sesamol, 1-amino-2-methoxy-4,5-methylenedioxybenzene, α- naphthol, 6-hydroxybenzomorpholine, 2-amino-3-hydroxypyridine, 1-amino-4,5- methylenedioxybenzene and 1-(β-hydroxyethylamino)-4,5-methylenedioxybenzene, and the addition salts thereof with an acid.
56. Composition according to any one of the preceding claims, characterized in that the coupler(s) preferably represent(s) from 0.0001 % to 10% by weight approximately relative to the total weight of the dye composition and even more preferentially from 0.005% to 5% by weight approximately relative to this weight.
57. Composition according to any one of the preceding claims, characterized in that it comprises at least one additional direct dye other than the direct dyes of the invention.
58. Composition according to any one of the preceding claims, characterized in that it also comprises an oxidizing agent.
59. Dyeing process comprising the step of applying on keratin fibers the composition as defined in any of the preceding claims for a time sufficient to obtain the desired colour.
60. Multi-compartment device or dyeing "kit" or any other multi-compartment packaging system, of which a first compartment contains composition comprising the cationic direct dye, the oxidation base and the coupler as defined in any of the preceding claims, a second compartment comprising an oxidizing agent.
PCT/EP2006/069934 2005-12-22 2006-12-19 Composition for dyeing keratin fibres with a tetraazapentamethine cationic direct dye, a particular oxidation base and a coupler WO2007071688A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0554062A FR2895245B1 (en) 2005-12-22 2005-12-22 DYEING COMPOSITION FOR KERATINIC FIBERS WITH A CATIONIC TETRAAZAPENTA-METHINIC DIRECT COLORANT, A SPECIAL OXIDATION BASE AND A COUPLER
FR0554062 2005-12-22
US76174706P 2006-01-25 2006-01-25
US60/761,747 2006-01-25

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Publication number Priority date Publication date Assignee Title
US10800782B2 (en) 2016-08-31 2020-10-13 Agios Pharmaceutical, Inc. Inhibitors of cellular metabolic processes
US11325914B1 (en) 2016-08-31 2022-05-10 Servier Pharmaceuticals Llc Inhibitors of cellular metabolic processes
USRE49934E1 (en) 2016-08-31 2024-04-23 Servier Pharmaceuticals Llc Inhibitors of cellular metabolic processes

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