MA46092A - Inhibiteurs de processus métaboliques cellulaires - Google Patents

Inhibiteurs de processus métaboliques cellulaires

Info

Publication number
MA46092A
MA46092A MA046092A MA46092A MA46092A MA 46092 A MA46092 A MA 46092A MA 046092 A MA046092 A MA 046092A MA 46092 A MA46092 A MA 46092A MA 46092 A MA46092 A MA 46092A
Authority
MA
Morocco
Prior art keywords
metabolic process
cellular metabolic
process inhibitors
inhibitors
cellular
Prior art date
Application number
MA046092A
Other languages
English (en)
Inventor
Zenon D Konteatis
Zhihua Sui
Jeremy M Travins
Zhixiong Ye
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2016/097524 external-priority patent/WO2018039972A1/fr
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of MA46092A publication Critical patent/MA46092A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/141—Esters of phosphorous acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Preparation (AREA)
MA046092A 2016-08-31 2017-08-30 Inhibiteurs de processus métaboliques cellulaires MA46092A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2016/097524 WO2018039972A1 (fr) 2016-08-31 2016-08-31 Inhibiteurs de processus métaboliques cellulaires
US201762548738P 2017-08-22 2017-08-22

Publications (1)

Publication Number Publication Date
MA46092A true MA46092A (fr) 2021-04-21

Family

ID=59846695

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046092A MA46092A (fr) 2016-08-31 2017-08-30 Inhibiteurs de processus métaboliques cellulaires

Country Status (20)

Country Link
US (4) US10329298B2 (fr)
EP (1) EP3507290A1 (fr)
JP (2) JP6832430B2 (fr)
KR (1) KR102411150B1 (fr)
CN (1) CN109890822B (fr)
AU (2) AU2017319500C1 (fr)
BR (1) BR112019003914A2 (fr)
CA (1) CA3034705C (fr)
CL (1) CL2019000511A1 (fr)
CO (1) CO2019002237A2 (fr)
CR (1) CR20190157A (fr)
IL (1) IL265115B (fr)
MA (1) MA46092A (fr)
MX (1) MX2019002303A (fr)
NI (1) NI201900019A (fr)
PE (1) PE20190761A1 (fr)
SG (1) SG11201901747VA (fr)
TW (1) TWI762505B (fr)
UA (1) UA125852C2 (fr)
WO (1) WO2018045071A1 (fr)

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CA3034705C (fr) 2016-08-31 2021-08-03 Agios Pharmaceuticals, Inc. Inhibiteurs de processus metaboliques cellulaires
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PE20210340A1 (es) 2017-09-15 2021-02-22 Aduro Biotech Inc Compuestos que contienen pirazolopirimidinona y sus usos
BR112020020104A2 (pt) * 2018-03-30 2021-01-26 Agios Pharmaceuticals, Inc. inibidores heterobicíclicos de mat2a e métodos de uso para o tratamento de câncer
AU2019395338A1 (en) * 2018-12-10 2021-07-29 Ideaya Biosciences, Inc. 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
MA54609A (fr) * 2018-12-27 2022-04-06 Les Laboratoires Servier Sas Inhibiteurs aza-hétérobicycliques de mat2a et procédés d'utilisation pour le traitement du cancer
EP3902803B1 (fr) * 2018-12-27 2023-02-01 Les Laboratoires Servier Inhibiteurs aza-hétérobicycliques de mat2a et procédés d'utilisation pour le traitement du cancer
WO2020167952A1 (fr) * 2019-02-12 2020-08-20 Mirati Therapeutics, Inc. Inhibiteurs de mat2a
JOP20210221A1 (ar) 2019-02-13 2023-01-30 Les Laboratoires Servier Sas علاجات مشتركة لاستخدامها في علاج السرطان
WO2021023609A1 (fr) 2019-08-02 2021-02-11 Glaxosmithkline Intellectual Property Development Limited Combinaison d'un inhibiteur de la protéine arginine n-méthyltransférase de type i (prmt1) et d'un inhibiteur de la méthionine adénosyltransférase ii alpha (mat2a)
KR20230154292A (ko) 2019-11-25 2023-11-07 암젠 인크 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법
WO2021139775A1 (fr) * 2020-01-10 2021-07-15 江苏先声药业有限公司 Composé de pyridone et son application
WO2021158792A1 (fr) * 2020-02-04 2021-08-12 Agios Pharmaceuticals, Inc. Méthodes de traitement de maladies ou de troubles auto-immuns ou inflammatoires
WO2021254529A1 (fr) * 2020-07-14 2021-12-23 江苏先声药业有限公司 Composé bicyclique
CN113999232A (zh) * 2020-07-28 2022-02-01 南京正大天晴制药有限公司 Mat2a抑制剂
AR123228A1 (es) 2020-08-12 2022-11-09 Servier Pharmaceuticals Llc Formas en estado sólido de un compuesto orgánico
WO2022036067A1 (fr) * 2020-08-12 2022-02-17 Servier Pharmaceuticals, Llc Polythérapies destinées à être utilisées dans le traitement du cancer
CN115960099A (zh) * 2020-09-24 2023-04-14 上海凌达生物医药有限公司 一类芳环或芳基杂环并吡啶酮类化合物、药物组合物及其应用
CN116782903A (zh) * 2020-10-15 2023-09-19 南京再明医药有限公司 取代的吡啶酮化合物及应用
TW202237610A (zh) * 2020-11-25 2022-10-01 法商施維雅藥廠 新穎有機化合物
CN116670144A (zh) 2020-12-31 2023-08-29 南京再明医药有限公司 三环类化合物及用途
EP4304573A1 (fr) 2021-03-08 2024-01-17 Technische Universität München Traitement d'infections à coronavirus au moyen d'inhibiteurs de cycle sam
CN117396480A (zh) * 2021-03-26 2024-01-12 奥弗恩制药公司 吡唑并嘧啶酮化合物
WO2023282145A1 (fr) * 2021-07-06 2023-01-12 国立研究開発法人産業技術総合研究所 Composition pour prévenir ou traiter le vieillissement des tissus
CN115716831A (zh) * 2021-08-25 2023-02-28 中国科学院分子细胞科学卓越创新中心 一种mat2a抑制剂及其在抗病毒中的应用
WO2023083210A1 (fr) * 2021-11-09 2023-05-19 上海海雁医药科技有限公司 Dérivé de naphtyridinone substitué, composition pharmaceutique de celui-ci et utilisation de celui-ci
WO2023086934A1 (fr) * 2021-11-12 2023-05-19 Ideaya Biosciences, Inc. Polythérapie comprenant un inhibiteur de mat2a et un taxane
GB202204913D0 (en) 2022-04-04 2022-05-18 Cambridge Entpr Ltd antiviral therapy
KR20240051860A (ko) 2022-10-13 2024-04-22 한미약품 주식회사 신규한 트리사이클 유도체 화합물 및 이의 용도
WO2024105553A1 (fr) * 2022-11-16 2024-05-23 Novartis Ag Hétérocycles bicycliques et leur utilisation en tant qu'inhibiteurs de wrn
CN116425721B (zh) * 2022-12-19 2024-02-02 艾立康药业股份有限公司 作为mat2a抑制剂的双环类化合物

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