PE20210340A1 - Compuestos que contienen pirazolopirimidinona y sus usos - Google Patents

Compuestos que contienen pirazolopirimidinona y sus usos

Info

Publication number
PE20210340A1
PE20210340A1 PE2020000341A PE2020000341A PE20210340A1 PE 20210340 A1 PE20210340 A1 PE 20210340A1 PE 2020000341 A PE2020000341 A PE 2020000341A PE 2020000341 A PE2020000341 A PE 2020000341A PE 20210340 A1 PE20210340 A1 PE 20210340A1
Authority
PE
Peru
Prior art keywords
unsubstituted
methyl
halo
cyano
compound
Prior art date
Application number
PE2020000341A
Other languages
English (en)
Inventor
Chudi Obioma Ndubaku
George Edwin Katibah
Tucker Curran Roberts
Leonard Sung
Stephane Ciblat
Franck Raeppel
Vu Linh Ly
Yeeman K Ramtohul
Taras Rybak
Mariam Zaky
Laura Gillard
Hossein Ismaili
Original Assignee
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aduro Biotech Inc filed Critical Aduro Biotech Inc
Publication of PE20210340A1 publication Critical patent/PE20210340A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de formula (I) donde Y es -CR3= o -N=; R1 es Q1-T1-(X1)n; Q1 es un enlace o alquilenoC1-3; T1 es C3-8cialoalquil, C6-10aril, entre otros; X1 es halo, ciano, oxo, entre otros; R2 es Q2-T2-(X2)p donde Q2 es enlace o C1-3alquileno; T2 es H, halo, ciano, C1-6alquil, entre otros; X2 es halo, ciano, oxo, entre otros; R3 es C1-3alquil, C1-3haloalquil, C2-3alquenil, entre otros; R4 es C1-6alquil, C1-6haloalquil, C0-3alquileno-C3-8cicloalquil, entre otros; n y p son 0-5; T2 es H, p es 0; m es 0-2; con la provision para el compuesto donde Y es -CR3=; a) cuando R1 es fenilo insustituido, R2 es metil y R3 es metil, R4 no es etil, fenil insustituido o piridina insustituido; b)cuando R1 es ciclohexil insustituido, R2 es metil y R3 es metil, R4 no es piridina insustituido; c) cuando R1 es ciclopentil insustituido, R2 es metil y R3 es metil, R4 no es etil o piridina insustituido; entre otros. Con la provision para compuestos donde Y es -N=, donde el compuesto no es R1 es fenil insustituido, R2 es H y R4 es 2-fluoro-fenil. Utiles en el tratamiento de enfermedades autoinmunes, inflamatorias y neurodegenerativas.
PE2020000341A 2017-09-15 2018-09-14 Compuestos que contienen pirazolopirimidinona y sus usos PE20210340A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762559482P 2017-09-15 2017-09-15
US201862633248P 2018-02-21 2018-02-21
US201862687769P 2018-06-20 2018-06-20
PCT/US2018/051014 WO2019055750A1 (en) 2017-09-15 2018-09-14 PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF

Publications (1)

Publication Number Publication Date
PE20210340A1 true PE20210340A1 (es) 2021-02-22

Family

ID=65723108

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020000341A PE20210340A1 (es) 2017-09-15 2018-09-14 Compuestos que contienen pirazolopirimidinona y sus usos

Country Status (22)

Country Link
US (1) US10738056B2 (es)
EP (1) EP3681888A4 (es)
JP (1) JP2020533376A (es)
KR (1) KR20200032751A (es)
CN (1) CN111212839A (es)
AU (1) AU2018331456B2 (es)
BR (1) BR112020003676A2 (es)
CA (1) CA3075751A1 (es)
CL (1) CL2020000544A1 (es)
CO (1) CO2020002107A2 (es)
CR (1) CR20200114A (es)
DO (1) DOP2020000051A (es)
EC (1) ECSP20018586A (es)
IL (1) IL273236A (es)
JO (1) JOP20200055A1 (es)
MA (1) MA50256A (es)
MX (1) MX2020002869A (es)
PE (1) PE20210340A1 (es)
PH (1) PH12020500500A1 (es)
SG (1) SG11202002218VA (es)
TW (1) TW201920185A (es)
WO (1) WO2019055750A1 (es)

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Also Published As

Publication number Publication date
PH12020500500A1 (en) 2021-03-01
CL2020000544A1 (es) 2020-10-02
CO2020002107A2 (es) 2020-05-29
WO2019055750A1 (en) 2019-03-21
KR20200032751A (ko) 2020-03-26
CR20200114A (es) 2020-06-01
AU2018331456B2 (en) 2020-10-08
EP3681888A1 (en) 2020-07-22
US10738056B2 (en) 2020-08-11
AU2018331456A1 (en) 2020-03-05
BR112020003676A2 (pt) 2020-09-01
EP3681888A4 (en) 2021-07-07
US20190119285A1 (en) 2019-04-25
DOP2020000051A (es) 2020-08-15
SG11202002218VA (en) 2020-04-29
CN111212839A (zh) 2020-05-29
MA50256A (fr) 2020-07-22
JOP20200055A1 (ar) 2020-03-10
ECSP20018586A (es) 2020-06-30
IL273236A (en) 2020-04-30
TW201920185A (zh) 2019-06-01
JP2020533376A (ja) 2020-11-19
CA3075751A1 (en) 2019-03-21
MX2020002869A (es) 2020-07-24

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