DOP2020000051A - Compuestos que contienen pirazolopirimidinona y sus usos - Google Patents
Compuestos que contienen pirazolopirimidinona y sus usosInfo
- Publication number
- DOP2020000051A DOP2020000051A DO2020000051A DO2020000051A DOP2020000051A DO P2020000051 A DOP2020000051 A DO P2020000051A DO 2020000051 A DO2020000051 A DO 2020000051A DO 2020000051 A DO2020000051 A DO 2020000051A DO P2020000051 A DOP2020000051 A DO P2020000051A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- compounds
- compounds containing
- relates
- present
- pyrazolopyrimidinone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención se refiere a compuestos de pirazolopirimidinona. La presente invención también se refiere a composiciones farmacéuticas que contienen estos compuestos y a métodos para tratar enfermedades autoinmunitarias, inflamatorias y neurodegenerativas mediante la administración de estos compuestos y composiciones farmacéuticas a sujetos que los necesitan. La presente invención también se refiere al uso de tales compuestos para investigación u otros fines no terapéuticos.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762559482P | 2017-09-15 | 2017-09-15 | |
US201862633248P | 2018-02-21 | 2018-02-21 | |
US201862687769P | 2018-06-20 | 2018-06-20 | |
PCT/US2018/051014 WO2019055750A1 (en) | 2017-09-15 | 2018-09-14 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2020000051A true DOP2020000051A (es) | 2020-08-15 |
Family
ID=65723108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2020000051A DOP2020000051A (es) | 2017-09-15 | 2020-03-02 | Compuestos que contienen pirazolopirimidinona y sus usos |
Country Status (22)
Country | Link |
---|---|
US (1) | US10738056B2 (es) |
EP (1) | EP3681888A4 (es) |
JP (1) | JP2020533376A (es) |
KR (1) | KR20200032751A (es) |
CN (1) | CN111212839A (es) |
AU (1) | AU2018331456B2 (es) |
BR (1) | BR112020003676A2 (es) |
CA (1) | CA3075751A1 (es) |
CL (1) | CL2020000544A1 (es) |
CO (1) | CO2020002107A2 (es) |
CR (1) | CR20200114A (es) |
DO (1) | DOP2020000051A (es) |
EC (1) | ECSP20018586A (es) |
IL (1) | IL273236A (es) |
JO (1) | JOP20200055A1 (es) |
MA (1) | MA50256A (es) |
MX (1) | MX2020002869A (es) |
PE (1) | PE20210340A1 (es) |
PH (1) | PH12020500500A1 (es) |
SG (1) | SG11202002218VA (es) |
TW (1) | TW201920185A (es) |
WO (1) | WO2019055750A1 (es) |
Families Citing this family (20)
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CA3034705C (en) | 2016-08-31 | 2021-08-03 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
WO2019092660A1 (en) | 2017-11-10 | 2019-05-16 | Takeda Pharmaceutical Company Limited | Sting modulator compounds, and methods of making and using |
WO2019123340A1 (en) | 2017-12-20 | 2019-06-27 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
US11203610B2 (en) | 2017-12-20 | 2021-12-21 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2′3′ cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
CA3093888A1 (en) | 2018-04-06 | 2019-10-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides |
TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
MX2022002152A (es) * | 2019-08-21 | 2022-05-18 | Scripps Research Inst | Agonistas biciclicos del estimulador de genes de interferon sting. |
CN110724143B (zh) * | 2019-10-09 | 2021-03-23 | 清华大学 | 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用 |
CN110627725B (zh) * | 2019-10-14 | 2022-10-18 | 遵义医科大学 | 一种4-取代5-二氟甲基-3-硝基-1h-吡唑类化合物及其制备方法与应用 |
KR20230154292A (ko) | 2019-11-25 | 2023-11-07 | 암젠 인크 | 델타-5 불포화효소 억제제로서의 헤테로시클릭 화합물 및 사용 방법 |
CN113248491B (zh) * | 2020-02-11 | 2022-02-25 | 中国科学院上海药物研究所 | 一类取代的吲哚脲衍生物、合成方法及其用途 |
WO2021233851A1 (en) * | 2020-05-20 | 2021-11-25 | F. Hoffmann-La Roche Ag | New malonitrile derivatives |
JP2023525908A (ja) * | 2020-05-20 | 2023-06-19 | エフ. ホフマン-ラ ロシュ アーゲー | Cgas阻害トリアゾロピリミドン誘導体 |
CN115551837A (zh) * | 2020-05-20 | 2022-12-30 | 豪夫迈·罗氏有限公司 | 新型丙二腈衍生物 |
MX2023005381A (es) | 2020-11-09 | 2023-05-23 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
CN114644633A (zh) * | 2020-12-18 | 2022-06-21 | 北京诺诚健华医药科技有限公司 | 杂环类jak抑制剂 |
WO2022137082A1 (en) * | 2020-12-22 | 2022-06-30 | Novartis Ag | Pyrrolo[3,2-b]pyridine derivatives useful in treating conditions associated with cgas |
WO2022221188A1 (en) * | 2021-04-13 | 2022-10-20 | University Of Washington | Designed constitutively active cyclic gmp-amp synthase as a genetically encoded stimulant of interferons |
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EP3394032A4 (en) | 2015-12-21 | 2019-09-18 | The University of Chicago | COMPOUNDS AND METHODS OF TREATMENT, DETECTION AND IDENTIFICATION OF COMPOUNDS FOR THE TREATMENT OF PARASITIC ILLNESSES BY APICOMPLEXA |
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US20200317674A1 (en) | 2016-06-03 | 2020-10-08 | An2H Discovery Limited | Pyrazolopyrimidine derivatives and the compositions and methods of treatment regarding the same |
WO2018039972A1 (en) | 2016-08-31 | 2018-03-08 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
CA3034705C (en) | 2016-08-31 | 2021-08-03 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
WO2018229683A1 (en) | 2017-06-15 | 2018-12-20 | Novartis Ag | 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases |
KR20200134203A (ko) * | 2017-08-21 | 2020-12-01 | 나비젠, 인코포레이티드 | Arf6 억제제 및 관련 방법 |
-
2018
- 2018-09-14 PE PE2020000341A patent/PE20210340A1/es unknown
- 2018-09-14 CR CR20200114A patent/CR20200114A/es unknown
- 2018-09-14 CN CN201880059704.2A patent/CN111212839A/zh active Pending
- 2018-09-14 CA CA3075751A patent/CA3075751A1/en not_active Abandoned
- 2018-09-14 EP EP18857356.2A patent/EP3681888A4/en not_active Withdrawn
- 2018-09-14 JP JP2020515108A patent/JP2020533376A/ja not_active Withdrawn
- 2018-09-14 WO PCT/US2018/051014 patent/WO2019055750A1/en unknown
- 2018-09-14 MA MA050256A patent/MA50256A/fr unknown
- 2018-09-14 KR KR1020207007178A patent/KR20200032751A/ko not_active Application Discontinuation
- 2018-09-14 JO JOP/2020/0055A patent/JOP20200055A1/ar unknown
- 2018-09-14 MX MX2020002869A patent/MX2020002869A/es unknown
- 2018-09-14 BR BR112020003676-5A patent/BR112020003676A2/pt not_active Application Discontinuation
- 2018-09-14 AU AU2018331456A patent/AU2018331456B2/en not_active Ceased
- 2018-09-14 SG SG11202002218VA patent/SG11202002218VA/en unknown
- 2018-09-14 US US16/131,221 patent/US10738056B2/en active Active
- 2018-09-14 TW TW107132537A patent/TW201920185A/zh unknown
-
2020
- 2020-02-27 CO CONC2020/0002107A patent/CO2020002107A2/es unknown
- 2020-03-02 DO DO2020000051A patent/DOP2020000051A/es unknown
- 2020-03-04 CL CL2020000544A patent/CL2020000544A1/es unknown
- 2020-03-11 IL IL273236A patent/IL273236A/en unknown
- 2020-03-12 PH PH12020500500A patent/PH12020500500A1/en unknown
- 2020-03-13 EC ECSENADI202018586A patent/ECSP20018586A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL273236A (en) | 2020-04-30 |
EP3681888A1 (en) | 2020-07-22 |
US20190119285A1 (en) | 2019-04-25 |
JP2020533376A (ja) | 2020-11-19 |
MX2020002869A (es) | 2020-07-24 |
WO2019055750A1 (en) | 2019-03-21 |
CO2020002107A2 (es) | 2020-05-29 |
CR20200114A (es) | 2020-06-01 |
CL2020000544A1 (es) | 2020-10-02 |
US10738056B2 (en) | 2020-08-11 |
CN111212839A (zh) | 2020-05-29 |
CA3075751A1 (en) | 2019-03-21 |
PH12020500500A1 (en) | 2021-03-01 |
TW201920185A (zh) | 2019-06-01 |
EP3681888A4 (en) | 2021-07-07 |
JOP20200055A1 (ar) | 2020-03-10 |
AU2018331456B2 (en) | 2020-10-08 |
AU2018331456A1 (en) | 2020-03-05 |
KR20200032751A (ko) | 2020-03-26 |
SG11202002218VA (en) | 2020-04-29 |
PE20210340A1 (es) | 2021-02-22 |
MA50256A (fr) | 2020-07-22 |
ECSP20018586A (es) | 2020-06-30 |
BR112020003676A2 (pt) | 2020-09-01 |
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