IL273236A - Pyrazolopyrimidine compounds and their uses - Google Patents
Pyrazolopyrimidine compounds and their usesInfo
- Publication number
- IL273236A IL273236A IL273236A IL27323620A IL273236A IL 273236 A IL273236 A IL 273236A IL 273236 A IL273236 A IL 273236A IL 27323620 A IL27323620 A IL 27323620A IL 273236 A IL273236 A IL 273236A
- Authority
- IL
- Israel
- Prior art keywords
- pyrazolopyrimidinone compounds
- pyrazolopyrimidinone
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762559482P | 2017-09-15 | 2017-09-15 | |
| US201862633248P | 2018-02-21 | 2018-02-21 | |
| US201862687769P | 2018-06-20 | 2018-06-20 | |
| PCT/US2018/051014 WO2019055750A1 (en) | 2017-09-15 | 2018-09-14 | PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL273236A true IL273236A (en) | 2020-04-30 |
Family
ID=65723108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL273236A IL273236A (en) | 2017-09-15 | 2020-03-11 | Pyrazolopyrimidine compounds and their uses |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US10738056B2 (es) |
| EP (1) | EP3681888A4 (es) |
| JP (1) | JP2020533376A (es) |
| KR (1) | KR20200032751A (es) |
| CN (1) | CN111212839A (es) |
| AU (1) | AU2018331456B2 (es) |
| BR (1) | BR112020003676A2 (es) |
| CA (1) | CA3075751A1 (es) |
| CL (1) | CL2020000544A1 (es) |
| CO (1) | CO2020002107A2 (es) |
| CR (1) | CR20200114A (es) |
| DO (1) | DOP2020000051A (es) |
| EC (1) | ECSP20018586A (es) |
| IL (1) | IL273236A (es) |
| JO (1) | JOP20200055A1 (es) |
| MA (1) | MA50256A (es) |
| MX (1) | MX2020002869A (es) |
| PE (1) | PE20210340A1 (es) |
| PH (1) | PH12020500500A1 (es) |
| SG (1) | SG11202002218VA (es) |
| TW (1) | TW201920185A (es) |
| WO (1) | WO2019055750A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3034705C (en) | 2016-08-31 | 2021-08-03 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| CA3082351A1 (en) | 2017-11-10 | 2019-05-16 | Takeda Pharmaceutical Company Limited | Sting modulator compounds, and methods of making and using |
| JP7098748B2 (ja) | 2017-12-20 | 2022-07-11 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する２’３’環状ジヌクレオチド |
| AU2018392213B2 (en) | 2017-12-20 | 2021-03-04 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
| AU2020333990B2 (en) * | 2019-08-21 | 2024-05-23 | The Scripps Research Institute | Bicyclic agonists of stimulator of interferon genes sting |
| CN110724143B (zh) * | 2019-10-09 | 2021-03-23 | 清华大学 | 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用 |
| CN110627725B (zh) * | 2019-10-14 | 2022-10-18 | 遵义医科大学 | 一种4-取代5-二氟甲基-3-硝基-1h-吡唑类化合物及其制备方法与应用 |
| BR112022010054A2 (pt) | 2019-11-25 | 2022-08-16 | Amgen Inc | Compostos heterocíclicos como inibidores de delta-5 dessaturase e métodos de uso |
| CN113248491B (zh) * | 2020-02-11 | 2022-02-25 | 中国科学院上海药物研究所 | 一类取代的吲哚脲衍生物、合成方法及其用途 |
| JP2023525908A (ja) * | 2020-05-20 | 2023-06-19 | エフ． ホフマン－ラ ロシュ アーゲー | Ｃｇａｓ阻害トリアゾロピリミドン誘導体 |
| US20230242520A1 (en) * | 2020-05-20 | 2023-08-03 | Hoffmann-La Roche Inc. | Malonitrile derivatives |
| WO2021233854A1 (en) * | 2020-05-20 | 2021-11-25 | F. Hoffmann-La Roche Ag | New malonitrile derivatives |
| JP7397996B2 (ja) | 2020-11-09 | 2023-12-13 | 武田薬品工業株式会社 | 抗体薬物コンジュゲート |
| CN114644633A (zh) * | 2020-12-18 | 2022-06-21 | 北京诺诚健华医药科技有限公司 | 杂环类jak抑制剂 |
| WO2022137082A1 (en) * | 2020-12-22 | 2022-06-30 | Novartis Ag | Pyrrolo[3,2-b]pyridine derivatives useful in treating conditions associated with cgas |
| WO2022221188A1 (en) * | 2021-04-13 | 2022-10-20 | University Of Washington | Designed constitutively active cyclic gmp-amp synthase as a genetically encoded stimulant of interferons |
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| JPH02131235A (ja) | 1988-11-12 | 1990-05-21 | Fuji Photo Film Co Ltd | 新規なカプラーを含有するハロゲン化銀写真感光材料 |
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| DK0591528T3 (da) * | 1991-04-22 | 1999-08-23 | Otsuka Pharma Co Ltd | Pyrazolo[1,5-a]pyrimidinderivat og antiinflammatorisk middel, der indeholder dette |
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| FR2746309B1 (fr) | 1996-03-22 | 1998-04-17 | Oreal | Composition de teinture des fibres keratiniques contenant des pyrazolopyrimidineoxo ; leur utilisation pour la teinture comme coupleurs, procedes de teinture |
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| RS52559B (en) | 2007-08-14 | 2013-04-30 | Bayer Intellectual Property Gmbh | FUSIONED BICYCLIC PYRIMIDINES |
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| JP5756176B2 (ja) * | 2010-08-12 | 2015-07-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ６−シクロアルキル−１，５−ジヒドロ−ピラゾロ（３，４−ｄ）ピリミジ−４−オン誘導体及びｐｄｅ９ａ阻害剤としてのその使用 |
| CA2811934A1 (en) | 2010-09-27 | 2012-04-05 | Proximagen Ltd | 7-hydroxy-pyrazolo[1,5-a] pyrimidine compounds and their use as ccr2 receptor antagonists |
| WO2012149157A2 (en) | 2011-04-26 | 2012-11-01 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
| EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| BR112014029016A8 (pt) | 2012-05-23 | 2018-01-09 | European Molecular Biology Laboratory | derivados de ácido 7-oxo-tiazolopiridina carbônico e seu uso no tratamento, melhora ou prevenção de uma doença viral |
| KR20150014506A (ko) | 2012-05-23 | 2015-02-06 | 사피라 파르마슈티칼즈 게엠베하 | 바이러스성 질환의 치료, 개선 또는 예방에서 유용한 7-옥소-4,7-디하이드로-피라졸로[1,5-a]피리미딘 유도체 |
| JP2015524457A (ja) | 2012-08-06 | 2015-08-24 | ザヴィラ ファーマシューティカルズ ゲーエムベーハー | ジヒドロキシピリミジン炭酸誘導体及びウイルス性疾患の治療、改善又は予防における使用 |
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| JP2017516860A (ja) | 2014-05-27 | 2017-06-22 | ナビゲン，インコーポレーテッド | Ａｒｆ６阻害剤並びにそれらの合成方法及び使用 |
| CN106146508A (zh) * | 2015-03-19 | 2016-11-23 | 浙江导明医药科技有限公司 | 优化的联合用药及其治疗癌症和自身免疫疾病的用途 |
| US10787462B2 (en) | 2015-10-23 | 2020-09-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US11414385B2 (en) | 2015-12-21 | 2022-08-16 | The University Of Chicago | Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases |
| WO2017178416A1 (en) | 2016-04-15 | 2017-10-19 | Bayer Animal Health Gmbh | Pyrazolopyrimidine derivatives |
| US20200317674A1 (en) | 2016-06-03 | 2020-10-08 | An2H Discovery Limited | Pyrazolopyrimidine derivatives and the compositions and methods of treatment regarding the same |
| CA3034705C (en) | 2016-08-31 | 2021-08-03 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
| WO2018039972A1 (en) | 2016-08-31 | 2018-03-08 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
| WO2018229683A1 (en) | 2017-06-15 | 2018-12-20 | Novartis Ag | 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases |
| EP3672597A4 (en) * | 2017-08-21 | 2021-09-22 | Navigen, Inc. | ARF6 INHIBITORS AND RELATED PROCEDURES |
-
2018
- 2018-09-14 SG SG11202002218VA patent/SG11202002218VA/en unknown
- 2018-09-14 JP JP2020515108A patent/JP2020533376A/ja not_active Withdrawn
- 2018-09-14 US US16/131,221 patent/US10738056B2/en active Active
- 2018-09-14 AU AU2018331456A patent/AU2018331456B2/en not_active Ceased
- 2018-09-14 PE PE2020000341A patent/PE20210340A1/es unknown
- 2018-09-14 MA MA050256A patent/MA50256A/fr unknown
- 2018-09-14 TW TW107132537A patent/TW201920185A/zh unknown
- 2018-09-14 WO PCT/US2018/051014 patent/WO2019055750A1/en unknown
- 2018-09-14 CA CA3075751A patent/CA3075751A1/en not_active Abandoned
- 2018-09-14 KR KR1020207007178A patent/KR20200032751A/ko not_active Application Discontinuation
- 2018-09-14 EP EP18857356.2A patent/EP3681888A4/en not_active Withdrawn
- 2018-09-14 JO JOP/2020/0055A patent/JOP20200055A1/ar unknown
- 2018-09-14 CN CN201880059704.2A patent/CN111212839A/zh active Pending
- 2018-09-14 CR CR20200114A patent/CR20200114A/es unknown
- 2018-09-14 BR BR112020003676-5A patent/BR112020003676A2/pt not_active Application Discontinuation
- 2018-09-14 MX MX2020002869A patent/MX2020002869A/es unknown
-
2020
- 2020-02-27 CO CONC2020/0002107A patent/CO2020002107A2/es unknown
- 2020-03-02 DO DO2020000051A patent/DOP2020000051A/es unknown
- 2020-03-04 CL CL2020000544A patent/CL2020000544A1/es unknown
- 2020-03-11 IL IL273236A patent/IL273236A/en unknown
- 2020-03-12 PH PH12020500500A patent/PH12020500500A1/en unknown
- 2020-03-13 EC ECSENADI202018586A patent/ECSP20018586A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2020002869A (es) | 2020-07-24 |
| BR112020003676A2 (pt) | 2020-09-01 |
| PE20210340A1 (es) | 2021-02-22 |
| TW201920185A (zh) | 2019-06-01 |
| CN111212839A (zh) | 2020-05-29 |
| AU2018331456B2 (en) | 2020-10-08 |
| ECSP20018586A (es) | 2020-06-30 |
| US20190119285A1 (en) | 2019-04-25 |
| EP3681888A4 (en) | 2021-07-07 |
| DOP2020000051A (es) | 2020-08-15 |
| CL2020000544A1 (es) | 2020-10-02 |
| WO2019055750A1 (en) | 2019-03-21 |
| CR20200114A (es) | 2020-06-01 |
| EP3681888A1 (en) | 2020-07-22 |
| US10738056B2 (en) | 2020-08-11 |
| JOP20200055A1 (ar) | 2020-03-10 |
| JP2020533376A (ja) | 2020-11-19 |
| CA3075751A1 (en) | 2019-03-21 |
| SG11202002218VA (en) | 2020-04-29 |
| AU2018331456A1 (en) | 2020-03-05 |
| KR20200032751A (ko) | 2020-03-26 |
| MA50256A (fr) | 2020-07-22 |
| PH12020500500A1 (en) | 2021-03-01 |
| CO2020002107A2 (es) | 2020-05-29 |
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