CO2020002107A2 - Compuestos que contienen pirazolopirimidinona y sus usos - Google Patents

Compuestos que contienen pirazolopirimidinona y sus usos

Info

Publication number
CO2020002107A2
CO2020002107A2 CONC2020/0002107A CO2020002107A CO2020002107A2 CO 2020002107 A2 CO2020002107 A2 CO 2020002107A2 CO 2020002107 A CO2020002107 A CO 2020002107A CO 2020002107 A2 CO2020002107 A2 CO 2020002107A2
Authority
CO
Colombia
Prior art keywords
compounds
pyrazolopyrimidinone
relates
present
containing compounds
Prior art date
Application number
CONC2020/0002107A
Other languages
English (en)
Inventor
Chudi Obioma Ndubaku
George Edwin Katibah
Tucker Curran Roberts
Leonard Sung
Stephane Ciblat
Franck Raeppel
Vu Linh Ly
Yeeman K Ramtohul
Taras Rybak
Mariam Zaky
Laura Gillard
Hossein Ismaili
Original Assignee
Aduro Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aduro Biotech Inc filed Critical Aduro Biotech Inc
Publication of CO2020002107A2 publication Critical patent/CO2020002107A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a compuestos de pirazolopirimidinona. La presente invención también se refiere a composiciones farmacéuticas que contienen estos compuestos y a métodos para tratar enfermedades autoinmunitarias, inflamatorias y neurodegenerativas mediante la administración de estos compuestos y composiciones farmacéuticas a sujetos que los necesitan. La presente invención también se refiere al uso de tales compuestos para investigación u otros fines no terapéuticos.
CONC2020/0002107A 2017-09-15 2020-02-27 Compuestos que contienen pirazolopirimidinona y sus usos CO2020002107A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201762559482P 2017-09-15 2017-09-15
US201862633248P 2018-02-21 2018-02-21
US201862687769P 2018-06-20 2018-06-20
PCT/US2018/051014 WO2019055750A1 (en) 2017-09-15 2018-09-14 PYRAZOLOPYRIMIDINONE COMPOUNDS AND USES THEREOF

Publications (1)

Publication Number Publication Date
CO2020002107A2 true CO2020002107A2 (es) 2020-05-29

Family

ID=65723108

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0002107A CO2020002107A2 (es) 2017-09-15 2020-02-27 Compuestos que contienen pirazolopirimidinona y sus usos

Country Status (22)

Country Link
US (1) US10738056B2 (es)
EP (1) EP3681888A4 (es)
JP (1) JP2020533376A (es)
KR (1) KR20200032751A (es)
CN (1) CN111212839A (es)
AU (1) AU2018331456B2 (es)
BR (1) BR112020003676A2 (es)
CA (1) CA3075751A1 (es)
CL (1) CL2020000544A1 (es)
CO (1) CO2020002107A2 (es)
CR (1) CR20200114A (es)
DO (1) DOP2020000051A (es)
EC (1) ECSP20018586A (es)
IL (1) IL273236A (es)
JO (1) JOP20200055A1 (es)
MA (1) MA50256A (es)
MX (1) MX2020002869A (es)
PE (1) PE20210340A1 (es)
PH (1) PH12020500500A1 (es)
SG (1) SG11202002218VA (es)
TW (1) TW201920185A (es)
WO (1) WO2019055750A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018045071A1 (en) 2016-08-31 2018-03-08 Agios Pharmaceuticals, Inc. Inhibitors of cellular metabolic processes
JOP20170192A1 (ar) 2016-12-01 2019-01-30 Takeda Pharmaceuticals Co داي نوكليوتيد حلقي
BR112020009126A2 (pt) 2017-11-10 2020-10-20 Takeda Pharmaceutical Company Limited compostos do modulador sting e métodos de fabricação e uso
AU2018392213B2 (en) 2017-12-20 2021-03-04 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
CN111511754B (zh) 2017-12-20 2023-09-12 捷克共和国有机化学与生物化学研究所 活化sting转接蛋白的具有膦酸酯键的2’3’环状二核苷酸
TWI833744B (zh) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-環二核苷酸
TWI818007B (zh) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-環二核苷酸
WO2020227159A2 (en) 2019-05-03 2020-11-12 Flagship Pioneering Innovations V, Inc. Methods of modulating immune activity
EP4017593A1 (en) * 2019-08-21 2022-06-29 The Scripps Research Institute Bicyclic agonists of stimulator of interferon genes sting
CN110724143B (zh) * 2019-10-09 2021-03-23 清华大学 一种靶向btk蛋白降解化合物的制备及其在治疗自身免疫系统疾病与肿瘤中的应用
CN110627725B (zh) * 2019-10-14 2022-10-18 遵义医科大学 一种4-取代5-二氟甲基-3-硝基-1h-吡唑类化合物及其制备方法与应用
MX2022006281A (es) 2019-11-25 2022-06-08 Amgen Inc Compuestos heterociclicos como inhibidores de delta-5 desaturasa y metodos de uso.
CN113248491B (zh) * 2020-02-11 2022-02-25 中国科学院上海药物研究所 一类取代的吲哚脲衍生物、合成方法及其用途
CN115666721A (zh) * 2020-05-20 2023-01-31 豪夫迈·罗氏有限公司 新型丙二腈衍生物
WO2021233854A1 (en) * 2020-05-20 2021-11-25 F. Hoffmann-La Roche Ag New malonitrile derivatives
JP2023525908A (ja) * 2020-05-20 2023-06-19 エフ． ホフマン－ラ ロシュ アーゲー Ｃｇａｓ阻害トリアゾロピリミドン誘導体
IL302390A (en) 2020-11-09 2023-06-01 Takeda Pharmaceuticals Co Drug antibody conjugates
CN114644633A (zh) * 2020-12-18 2022-06-21 北京诺诚健华医药科技有限公司 杂环类jak抑制剂
WO2022137082A1 (en) * 2020-12-22 2022-06-30 Novartis Ag Pyrrolo[3,2-b]pyridine derivatives useful in treating conditions associated with cgas
US20240252598A1 (en) * 2021-04-13 2024-08-01 University Of Washington Designed constitutively active cyclic gmp-amp synthase as a genetically encoded stimulant of interferons
US20240270740A1 (en) * 2022-12-20 2024-08-15 Ventus Therapeutics U.S., Inc. Inhibitors of cyclic gmp-amp synthase and uses thereof

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JPS625362A (ja) 1985-06-30 1987-01-12 菊地　真 ハイパ−サ−ミア用加温装置
JPH02131235A (ja) 1988-11-12 1990-05-21 Fuji Photo Film Co Ltd 新規なカプラーを含有するハロゲン化銀写真感光材料
WO1992006096A1 (en) 1990-10-09 1992-04-16 Otsuka Pharmaceutical Co., Ltd. Pyrimidine derivative, production thereof, and androgen inhibitor
ES2126573T3 (es) * 1991-04-22 1999-04-01 Otsuka Pharma Co Ltd Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.
WO1997011946A1 (fr) 1995-09-28 1997-04-03 Otsuka Pharmaceutical Factory, Inc. Analgesiques
US5763263A (en) 1995-11-27 1998-06-09 Dehlinger; Peter J. Method and apparatus for producing position addressable combinatorial libraries
FR2746309B1 (fr) 1996-03-22 1998-04-17 Oreal Composition de teinture des fibres keratiniques contenant des pyrazolopyrimidineoxo ; leur utilisation pour la teinture comme coupleurs, procedes de teinture
US6060478A (en) 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
AU731838B2 (en) 1997-03-14 2001-04-05 Otsuka Pharmaceutical Co., Ltd. Novel pyrimidine derivative
JP3625362B2 (ja) 1997-09-08 2005-03-02 コニカミノルタホールディングス株式会社 感熱転写記録材料及び感熱転写記録方法
US6245759B1 (en) 1999-03-11 2001-06-12 Merck & Co., Inc. Tyrosine kinase inhibitors
AU2002367953C1 (en) 2001-05-04 2009-02-19 Paratek Pharmaceuticals, Inc Transcription factor modulating compounds and methods of use thereof
US7405235B2 (en) 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CA2487211C (en) 2002-06-04 2010-09-14 Neogenesis Pharmaceuticals, Inc. Pyrazolo(1,5a) pyrimidine compounds as antiviral agents
US7449488B2 (en) 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
CA2504448C (en) 2002-11-01 2012-06-19 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
JP2005008581A (ja) * 2003-06-20 2005-01-13 Kissei Pharmaceut Co Ltd 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途
DE10356579A1 (de) 2003-12-04 2005-07-07 Merck Patent Gmbh Aminderivate
AU2005324492B2 (en) 2004-04-23 2012-06-07 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
CL2008002398A1 (es) 2007-08-14 2009-07-31 Bayer Ip Gmbh Compuestos derivados de 6-(fenil piperidina) pirimidinas fusionadas con imidazol, triazol o pirozol, inhibidores de la via pi3k/akt; composicion farmaceutica; combinacion farmaceutica; y uso de los compuestos para el tratamiento de la neoplasia benigna y/o maligna y para el cancer.
WO2009039323A1 (en) 2007-09-19 2009-03-26 Smithkline Beecham Corporation Prolyl hydroxylase inhibitors
WO2009071705A1 (en) * 2007-12-07 2009-06-11 Galapagos Nv Pyrazolepyrimidine compounds useful for the treatment of degenerative & inflammatory diseases
MX2010006378A (es) * 2007-12-11 2010-09-07 Schering Corp Moduladores de gamma secretasa.
JP5637859B2 (ja) 2007-12-13 2014-12-10 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜コンダクタンスレギュレーターのモジュレーター
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
CN101906105B (zh) 2009-06-08 2013-01-16 河北医科大学 吡唑并[1，5-a]嘧啶酮衍生物及其药物组合物以及其用途
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
CN103052639B (zh) * 2010-08-12 2016-02-17 贝林格尔.英格海姆国际有限公司 6-环烷基-1,5-二氢-吡唑并[3,4-d]嘧啶-4-酮衍生物及其作为PDE9A抑制剂的用途
JP2013538838A (ja) 2010-09-27 2013-10-17 プロクシマゲン リミテッド ７−ヒドロキシ−ピラゾロ［１，５−ａ］ピリミジン化合物およびｃｃｒ２レセプターアンタゴニストとしてのその使用
WO2012149157A2 (en) * 2011-04-26 2012-11-01 Bioenergenix Heterocyclic compounds for the inhibition of pask
EP2518070A1 (en) * 2011-04-29 2012-10-31 Almirall, S.A. Pyrrolotriazinone derivatives as PI3K inhibitors
RU2014143250A (ru) 2012-05-23 2016-07-20 Савира Фармасьютикалз Гмбх Производные 7-оксо-тиазолопиридин карбоновой кислоты и их применение при лечении, облегчении или профилактике вирусного заболевания
EP2861232A1 (en) 2012-05-23 2015-04-22 Savira Pharmaceuticals GmbH 7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease
KR20150039832A (ko) 2012-08-06 2015-04-13 사피라 파르마슈티칼즈 게엠베하 디하이드록시피리미딘 탄산 유도체 및 바이러스성 질환의 치료, 개선 또는 예방에서의 이의 용도
JP6660182B2 (ja) 2013-03-13 2020-03-11 ジェネンテック， インコーポレイテッド ピラゾロ化合物及びその使用
US9505767B2 (en) * 2013-09-05 2016-11-29 Genentech, Inc. Pyrazolo[1,5-A]pyrimidin-7(4H)-onehistone demethylase inhibitors
WO2015135094A1 (en) 2014-03-13 2015-09-17 Genentech, Inc. Therapeutic compounds and uses thereof
WO2015183989A1 (en) 2014-05-27 2015-12-03 Navigen, Inc. Arf6 inhibitors and methods of synthesis and use thereof
CN106146508A (zh) * 2015-03-19 2016-11-23 浙江导明医药科技有限公司 优化的联合用药及其治疗癌症和自身免疫疾病的用途
EP3366684B1 (en) 2015-10-23 2020-09-02 Takeda Pharmaceutical Company Limited Heterocyclic compound
US11414385B2 (en) 2015-12-21 2022-08-16 The University Of Chicago Compounds and methods for treating, detecting, and identifying compounds to treat apicomplexan parasitic diseases
CN109071545B (zh) 2016-04-15 2021-08-03 拜耳动物保健有限责任公司 新的吡唑并嘧啶衍生物
US20200317674A1 (en) 2016-06-03 2020-10-08 An2H Discovery Limited Pyrazolopyrimidine derivatives and the compositions and methods of treatment regarding the same
WO2018045071A1 (en) 2016-08-31 2018-03-08 Agios Pharmaceuticals, Inc. Inhibitors of cellular metabolic processes
WO2018039972A1 (en) 2016-08-31 2018-03-08 Agios Pharmaceuticals, Inc. Inhibitors of cellular metabolic processes
WO2018229683A1 (en) 2017-06-15 2018-12-20 Novartis Ag 5,6-fused-bicyclic compounds and compositions for the treatment of parasitic diseases
EP3672597A4 (en) 2017-08-21 2021-09-22 Navigen, Inc. ARF6 INHIBITORS AND RELATED PROCEDURES

Also Published As

Publication number Publication date
PH12020500500A1 (en) 2021-03-01
CL2020000544A1 (es) 2020-10-02
WO2019055750A1 (en) 2019-03-21
KR20200032751A (ko) 2020-03-26
CR20200114A (es) 2020-06-01
AU2018331456B2 (en) 2020-10-08
EP3681888A1 (en) 2020-07-22
US10738056B2 (en) 2020-08-11
AU2018331456A1 (en) 2020-03-05
PE20210340A1 (es) 2021-02-22
BR112020003676A2 (pt) 2020-09-01
EP3681888A4 (en) 2021-07-07
US20190119285A1 (en) 2019-04-25
DOP2020000051A (es) 2020-08-15
SG11202002218VA (en) 2020-04-29
CN111212839A (zh) 2020-05-29
MA50256A (fr) 2020-07-22
JOP20200055A1 (ar) 2020-03-10
ECSP20018586A (es) 2020-06-30
IL273236A (en) 2020-04-30
TW201920185A (zh) 2019-06-01
JP2020533376A (ja) 2020-11-19
CA3075751A1 (en) 2019-03-21
MX2020002869A (es) 2020-07-24

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