NI201000143A - Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados, de pirazolo[1,5-a] pirimidinas, procedimientos para su preparación y usos de los mismos. - Google Patents

Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados, de pirazolo[1,5-a] pirimidinas, procedimientos para su preparación y usos de los mismos.

Info

Publication number
NI201000143A
NI201000143A NI201000143A NI201000143A NI201000143A NI 201000143 A NI201000143 A NI 201000143A NI 201000143 A NI201000143 A NI 201000143A NI 201000143 A NI201000143 A NI 201000143A NI 201000143 A NI201000143 A NI 201000143A
Authority
NI
Nicaragua
Prior art keywords
spirobicyclic
pyrazolo
pyrimidines
procedures
preparation
Prior art date
Application number
NI201000143A
Other languages
English (en)
Inventor
Maarten Berger Dan
Joseph Di Grandi Martin
Lee Dunnick Alejandro
Dhanjisha Dutia Minu
William Hopper Darrin
Ian Levin Jeremy
Torres Nancy
Wang Xiaolun
Zhang Chunchun
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of NI201000143A publication Critical patent/NI201000143A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen compuestos de fórmula A: y sales farmacéuticamente aceptables de los mismos, que inhiben selectivamente la actividad Raf quinasa y son útiles para tratar trastornos mediados por Raf quinasas.
NI201000143A 2008-02-29 2010-08-27 Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados, de pirazolo[1,5-a] pirimidinas, procedimientos para su preparación y usos de los mismos. NI201000143A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6784308P 2008-02-29 2008-02-29
US11680908P 2008-11-21 2008-11-21

Publications (1)

Publication Number Publication Date
NI201000143A true NI201000143A (es) 2011-03-09

Family

ID=40548843

Family Applications (1)

Application Number Title Priority Date Filing Date
NI201000143A NI201000143A (es) 2008-02-29 2010-08-27 Derivados bicíclicos heterocíclicos o espirobicíclicos heterocíclicos enlazados, de pirazolo[1,5-a] pirimidinas, procedimientos para su preparación y usos de los mismos.

Country Status (24)

Country Link
US (1) US20100029657A1 (es)
EP (1) EP2271649A1 (es)
JP (1) JP2011513334A (es)
KR (1) KR20100123725A (es)
CN (1) CN102083835A (es)
AP (1) AP2010005363A0 (es)
AR (1) AR070728A1 (es)
AU (1) AU2009219175A1 (es)
BR (1) BRPI0908403A2 (es)
CA (1) CA2716499A1 (es)
CO (1) CO6321261A2 (es)
CR (1) CR11650A (es)
DO (1) DOP2010000261A (es)
EA (1) EA201001188A1 (es)
EC (1) ECSP10010429A (es)
IL (1) IL207576A0 (es)
MA (1) MA32110B1 (es)
MX (1) MX2010009458A (es)
NI (1) NI201000143A (es)
PE (1) PE20091833A1 (es)
SV (1) SV2010003654A (es)
TW (1) TW200951134A (es)
WO (1) WO2009108838A1 (es)
ZA (1) ZA201005603B (es)

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JP2007089031A (ja) 2005-09-26 2007-04-05 Fuji Xerox Co Ltd 出力装置
WO2007079078A1 (en) 2005-12-29 2007-07-12 Bayer Schering Pharma Aktiengesellschaft Diamine derivatives as inhibitors of leukotriene a4 hydrolase
AU2010332010A1 (en) 2009-12-14 2012-08-02 Inspire Pharmaceuticals, Inc. Bridged bicyclic Rho kinase inhibitor compounds, composition and use
CA2782601C (en) 2009-12-18 2015-07-21 Mitsubishi Tanabe Pharma Corporation Novel antiplatelet agent
EP2402343A1 (en) * 2010-06-29 2012-01-04 Basf Se Pyrazole-fused bicyclic compounds
EP2734520B1 (en) 2011-07-19 2016-09-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2012325909B2 (en) 2011-10-20 2016-06-09 Glaxosmithkline Llc Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
EP2768833A4 (en) * 2011-10-20 2015-04-15 Sirtris Pharmaceuticals Inc SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS MODULATORS OF SIRTUINS
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
AU2013344716B2 (en) 2012-11-16 2018-03-01 University Health Network Pyrazolopyrimidine compounds
RU2686101C2 (ru) 2013-03-12 2019-04-24 Селтакссис, Инк. Способы ингибирования лейкотриен- а4-гидролазы
WO2014152518A2 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
BR112015022226A2 (pt) 2013-03-14 2017-07-18 Celtaxsys Inc inibidores de leucotrieno a4 hidrolase
CA2906086A1 (en) 2013-03-14 2014-09-25 Celtaxsys, Inc. Inhibitors of leukotriene a4 hydrolase
EA032255B1 (ru) 2014-03-27 2019-04-30 Янссен Фармацевтика Нв ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-a]ПИРАЗИНА И ПРОИЗВОДНЫЕ 5,6,7,8-ТЕТРАГИДРО-4H-ПИРАЗОЛО[1,5-a][1,4]ДИАЗЕПИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Ros1
EA031639B1 (ru) * 2014-03-27 2019-01-31 Янссен Фармацевтика Нв ЗАМЕЩЕННЫЕ 4,5,6,7-ТЕТРАГИДРОПИРАЗОЛО[1,5-а]ПИРИМИДИНОВЫЕ ПРОИЗВОДНЫЕ И 2,3-ДИГИДРО-1H-ИМИДАЗО[1,2-b]ПИРАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ROS1
AR100448A1 (es) 2014-05-21 2016-10-05 Bayer Cropscience Ag 5-(hetero)aril-piridazinonas y su uso como herbicida
AU2017319500C1 (en) 2016-08-31 2022-10-20 Les Laboratoires Servier Inhibitors of cellular metabolic processes
EP3579872A1 (en) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
CN112020500A (zh) 2017-12-22 2020-12-01 拉文纳制药公司 作为磷脂酰肌醇磷酸激酶抑制剂的氨基吡啶衍生物
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
US10898484B2 (en) 2018-05-31 2021-01-26 Celltaxis, Llc Method of reducing pulmonary exacerbations in respiratory disease patients

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US4178449A (en) * 1978-04-17 1979-12-11 American Cyanamid Company Pyrazolo[1,5-a]pyrimidines and imidazo-[1,5-a]pyrimidines
US4236005A (en) * 1979-07-02 1980-11-25 American Cyanamid Company Imidazo[1,5-a]pyrimidines
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
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US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
WO2004052315A2 (en) * 2002-12-11 2004-06-24 Merck & Co., Inc. Tyrosine kinase inhibitors
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
WO2005089443A2 (en) * 2004-03-19 2005-09-29 The Penn State Research Foundation Combinatorial methods and compositions for treatment of melanoma
WO2007109093A2 (en) * 2006-03-17 2007-09-27 Wyeth Pyrazolo[1,5-a]pyrimidine derivatives and methods of use thereof

Also Published As

Publication number Publication date
MA32110B1 (fr) 2011-02-01
SV2010003654A (es) 2011-03-23
JP2011513334A (ja) 2011-04-28
EA201001188A1 (ru) 2011-04-29
TW200951134A (en) 2009-12-16
AP2010005363A0 (en) 2010-08-31
AR070728A1 (es) 2010-04-28
AU2009219175A1 (en) 2009-09-03
WO2009108838A8 (en) 2009-11-12
DOP2010000261A (es) 2010-09-15
EP2271649A1 (en) 2011-01-12
CA2716499A1 (en) 2009-09-03
MX2010009458A (es) 2010-09-24
CR11650A (es) 2010-09-14
ZA201005603B (en) 2011-05-25
US20100029657A1 (en) 2010-02-04
WO2009108838A1 (en) 2009-09-03
PE20091833A1 (es) 2009-11-22
ECSP10010429A (es) 2010-09-30
KR20100123725A (ko) 2010-11-24
CO6321261A2 (es) 2011-09-20
IL207576A0 (en) 2010-12-30
CN102083835A (zh) 2011-06-01
BRPI0908403A2 (pt) 2015-08-11

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