ECSP088121A - Derivados de pirrolo [2,3-b] piridina comoinhibidores de proteina cinasa - Google Patents

Derivados de pirrolo [2,3-b] piridina comoinhibidores de proteina cinasa

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Publication number
ECSP088121A
ECSP088121A EC2008008121A ECSP088121A ECSP088121A EC SP088121 A ECSP088121 A EC SP088121A EC 2008008121 A EC2008008121 A EC 2008008121A EC SP088121 A ECSP088121 A EC SP088121A EC SP088121 A ECSP088121 A EC SP088121A
Authority
EC
Ecuador
Prior art keywords
pyridine
protein kinase
kinase inhibitors
pirrolo
derivatives
Prior art date
Application number
EC2008008121A
Other languages
English (en)
Inventor
Dean R Artis
Prabha N Ibrahim
Guoxian Wu
Chao Zhang
Jiazhong Zhang
Ryan Bremer
Wayne Spevak
Hongyao Zhu
Shumeye Mamo
Marika Nespi
Yong-Liang Zhu
James Tsai
Klaus Peter Hirth
Gideon Bollag
Hanna Cho
Samuel J Gillette
Shenghua Shi
Original Assignee
Plexxikon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37033831&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088121(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Plexxikon Inc filed Critical Plexxikon Inc
Publication of ECSP088121A publication Critical patent/ECSP088121A/es

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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

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Abstract

Se describen compuestos de la fórmula III los cuales son activos sobre proteínas cinasas, así como también métodos para usar tales compuestos para tratar enfermedades y padecimientos asociados con la actividad aberrante de las proteínas cinasas.
EC2008008121A 2005-06-22 2008-01-18 Derivados de pirrolo [2,3-b] piridina comoinhibidores de proteina cinasa ECSP088121A (es)

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