SG10201912699RA - Colony stimulating factor-1 receptor (csf-1r) inhibitors - Google Patents

Colony stimulating factor-1 receptor (csf-1r) inhibitors

Info

Publication number
SG10201912699RA
SG10201912699RA SG10201912699RA SG10201912699RA SG10201912699RA SG 10201912699R A SG10201912699R A SG 10201912699RA SG 10201912699R A SG10201912699R A SG 10201912699RA SG 10201912699R A SG10201912699R A SG 10201912699RA SG 10201912699R A SG10201912699R A SG 10201912699RA
Authority
SG
Singapore
Prior art keywords
csf
inhibitors
receptor
stimulating factor
colony stimulating
Prior art date
Application number
SG10201912699RA
Inventor
John Kane
Claude Barberis
Mark Czekaj
Paul Erdman
Barret Giese
Michael Kothe
Tieu-Binh Le
Jinyu Liu
Liang Ma
Markus Metz
Vinod Patel
Andrew Scholte
Patrick Shum
Limli Wei
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of SG10201912699RA publication Critical patent/SG10201912699RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
SG10201912699RA 2015-07-20 2016-07-19 Colony stimulating factor-1 receptor (csf-1r) inhibitors SG10201912699RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562194619P 2015-07-20 2015-07-20

Publications (1)

Publication Number Publication Date
SG10201912699RA true SG10201912699RA (en) 2020-02-27

Family

ID=56551024

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10201912699RA SG10201912699RA (en) 2015-07-20 2016-07-19 Colony stimulating factor-1 receptor (csf-1r) inhibitors

Country Status (28)

Country Link
US (3) US11274108B2 (en)
EP (1) EP3325471A1 (en)
JP (3) JP6898914B2 (en)
KR (1) KR102665765B1 (en)
CN (1) CN107922396B (en)
AR (1) AR105392A1 (en)
AU (3) AU2016297558B2 (en)
BR (1) BR112018001017B1 (en)
CA (2) CA2993018A1 (en)
CL (1) CL2018000140A1 (en)
CO (1) CO2018001621A2 (en)
CR (1) CR20180109A (en)
DO (1) DOP2018000008A (en)
EC (1) ECSP18012103A (en)
GT (1) GT201800020A (en)
IL (3) IL276292B2 (en)
MA (1) MA42023B2 (en)
MX (2) MX2018000880A (en)
MY (1) MY186368A (en)
NZ (1) NZ739951A (en)
PE (1) PE20180573A1 (en)
PH (1) PH12018500140A1 (en)
RU (1) RU2748884C2 (en)
SG (1) SG10201912699RA (en)
TN (1) TN2018000020A1 (en)
TW (1) TWI734693B (en)
WO (1) WO2017015267A1 (en)
ZA (1) ZA201800082B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI572599B (en) 2011-03-28 2017-03-01 Ｍｅｉ製藥公司 (alpha-substituted aralkylamino and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions thereof, and their use in treating proliferative diseases
CA3063976A1 (en) 2017-05-23 2018-11-29 Mei Pharma, Inc. Combination therapy
WO2019028440A1 (en) 2017-08-04 2019-02-07 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
SG11202001258UA (en) 2017-08-14 2020-03-30 Mei Pharma Inc Combination therapy
WO2020163405A1 (en) 2019-02-05 2020-08-13 Skyhawk Therapeutics, Inc. Methods and compositions for modulating splicing
CN113677344A (en) 2019-02-06 2021-11-19 斯基霍克疗法公司 Methods and compositions for modulating splicing
MX2021011923A (en) * 2019-03-29 2021-11-03 Kowa Co Novel azaindole derivative.
TW202216720A (en) 2020-07-20 2022-05-01 美商尼道生物科學公司 Indole compounds as androgen receptor modulators
JP2023542041A (en) * 2020-09-21 2023-10-04 ハチソン メディファルマ リミテッド Heteroaromatic compounds and their uses
TW202241888A (en) 2020-12-23 2022-11-01 美商健臻公司 Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors
JP2024500919A (en) * 2020-12-23 2024-01-10 ジェンザイム・コーポレーション Deuterated colony stimulating factor-1 receptor (CSF-1R) inhibitor
WO2023249989A1 (en) 2022-06-22 2023-12-28 Genzyme Corporation Solid forms of deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4612323A (en) 1983-06-27 1986-09-16 Sumitomo Chemical Company, Limited Insecticidal and acaricidal derivatives of 1-benzylbenzimidazole
JPS61151176A (en) * 1984-12-24 1986-07-09 Sumitomo Chem Co Ltd Benzimidazole derivative, production thereof, insecticide and acaricide comprising same as active ingredient
US5187159A (en) * 1991-10-07 1993-02-16 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole
AU4348593A (en) * 1992-06-25 1994-01-24 Zeneca Limited Chromanderivatives as angiotensin ii antagonists
FR2693197B1 (en) * 1992-07-03 1994-09-23 Synthelabo New quinoline derivatives, their preparation process and their therapeutic application.
JP2895961B2 (en) * 1992-12-17 1999-05-31 フアイザー・インコーポレイテツド Pyrrolopyrimidines as CRF antagonists
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
JPH09202774A (en) * 1996-01-25 1997-08-05 Green Cross Corp:The 2-arylquinoline and its production
JPH101471A (en) * 1996-06-13 1998-01-06 Green Cross Corp:The Crystal of n-((quinolin-2-yl)phenyl)sulfonamides and its production
US6060480A (en) * 1996-08-30 2000-05-09 Yoshitomi Pharmaceutical Industries, Ltd. Preventives/remedies for muscle tissue degenerations
KR20010014183A (en) * 1997-06-27 2001-02-26 Fujisawa Pharmaceutical Co Sulfonamide compounds and medicinal use thereof
JP2002507996A (en) * 1997-07-03 2002-03-12 デュポン ファーマシューティカルズ カンパニー Imidazopyrimidines and imidazopyridines for treating neurological disorders
US6130333A (en) * 1998-11-27 2000-10-10 Monsanto Company Bicyclic imidazolyl derivatives as phosphodiesterase inhibitors, pharmaceutical compositions and method of use
KR20030010589A (en) 2000-03-09 2003-02-05 오노 야꾸힝 고교 가부시키가이샤 Indole derivatives, process for preparation of the same and use thereof
US7135495B2 (en) 2000-03-09 2006-11-14 Ono Pharmaceutical Co., Ltd. Indole derivatives
PA8535601A1 (en) 2000-12-21 2002-11-28 Pfizer BENZIMIDAZOL AND PIRIDILIMIDAZOL DERIVATIVES AS LIGANDOS FOR GABAA
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
CA2483084A1 (en) * 2002-05-02 2003-11-13 Merck & Co., Inc. Tyrosine kinase inhibitors
CN1742007A (en) * 2003-01-22 2006-03-01 伊莱利利公司 Indole-derivative modulators of steroid hormone nuclear receptors
DE10342503A1 (en) * 2003-09-12 2005-04-14 Merck Patent Gmbh Benzyl-Benzimidazolylderivate
US7138401B2 (en) 2003-09-18 2006-11-21 Conforma Therapeutics Corporation 2-aminopurine analogs having HSP90-inhibiting activity
CA2553724A1 (en) * 2004-02-03 2005-08-18 Abbott Laboratories Aminobenzoxazoles as therapeutic agents
TW200616632A (en) * 2004-06-17 2006-06-01 Plexxikon Inc Compounds modulating c-kit activity and uses therefor
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
KR100946220B1 (en) * 2004-09-03 2010-03-08 주식회사유한양행 Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
TWI278682B (en) 2004-11-23 2007-04-11 Ind Tech Res Inst Fiber optic interferometric position sensor and measuring method thereof
KR20070086865A (en) 2004-12-01 2007-08-27 오에스아이 파마슈티컬스, 인코포레이티드 N-substituted benzimidazolyl c-kit inhibitors and combinatorial benzimidazole library
FR2883286B1 (en) * 2005-03-16 2008-10-03 Sanofi Aventis Sa NOVEL IMIDAZO [1,5-a] PYRIDINE DERIVATIVES, INHIBITORS OF FGFs, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
CN102127078A (en) * 2005-07-14 2011-07-20 安斯泰来制药株式会社 Heterocyclic janus kinase 3 inhibitors
NL2000613C2 (en) * 2006-05-11 2007-11-20 Pfizer Prod Inc Triazole pyrazine derivatives.
PE20080403A1 (en) 2006-07-14 2008-04-25 Amgen Inc FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE
AU2007309237B2 (en) 2006-10-23 2012-03-22 Sgx Pharmaceuticals, Inc. Triazolo-pyridazine protein kinase modulators
CN101558070A (en) 2006-10-23 2009-10-14 Sgx药品公司 Triazolo-pyridazine protein kinase modulators
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008064199A1 (en) * 2006-11-22 2008-05-29 Johnson Controls Technology Company Multichannel evaporator with flow separating manifold
BRPI0720695A2 (en) 2006-12-21 2014-02-18 Plexxikon Inc COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS FOR THESE
WO2008130951A1 (en) 2007-04-17 2008-10-30 Bristol-Myers Squibb Company Fused heterocyclic 11-beta-hydroxysteroid dehydrogenase type i inhibitors
US20090274698A1 (en) * 2007-07-06 2009-11-05 Shripad Bhagwat Combination anti-cancer therapy
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
CN101917999A (en) 2007-11-07 2010-12-15 弗尔德里克斯制药股份有限公司 Modulation of protein trafficking
US8158636B2 (en) * 2008-05-19 2012-04-17 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
RU2011147200A (en) * 2009-04-22 2013-05-27 Янссен Фармацевтика Нв ASETIDINYLDIAMIDES AS MONOACYGLYCERINE LIPASE INHIBITORS
EP2571878B1 (en) * 2010-05-17 2018-10-17 Incozen Therapeutics Pvt. Ltd. Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b]pyridine compounds as modulators of protein kinases
WO2011156632A2 (en) * 2010-06-09 2011-12-15 Georgetown University Compositions and methods of treatment for tumors in the nervous system
CN103380112A (en) * 2010-11-24 2013-10-30 阿勒根公司 Indole derivatives as modulators of S1P receptors
EP2673277A1 (en) 2011-02-10 2013-12-18 Novartis AG [1, 2, 4]triazolo [4, 3 -b]pyridazine compounds as inhibitors of the c-met tyrosine kinase
US8748435B2 (en) * 2011-04-01 2014-06-10 Novartis Ag Pyrazolo pyrimidine derivatives
WO2012160464A1 (en) 2011-05-26 2012-11-29 Daiichi Sankyo Company, Limited Heterocyclic compounds as protein kinase inhibitors
US8609653B2 (en) * 2011-07-15 2013-12-17 Glaxosmithkline Llc Azaindole compounds and methods for treating HIV
JP6162130B2 (en) * 2011-10-14 2017-07-12 アムビト ビオスシエンセス コルポラチオン Heterocyclic compounds and modulators thereof as modulators of type III receptor tyrosine kinases
RU2610262C2 (en) * 2011-11-03 2017-02-08 Мерк Шарп И Доум Корп. QUINOLINE CARBOXAMIDE AND QUINOLINE CARBONITRILE DERIVATIVES AS mGluR2 NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS AND USE THEREOF
WO2013116182A1 (en) * 2012-01-31 2013-08-08 Boehringer Ingelheim International Gmbh Heterocyclic compounds as inhibitors of leukotriene production
US9358235B2 (en) 2012-03-19 2016-06-07 Plexxikon Inc. Kinase modulation, and indications therefor
WO2013144737A2 (en) * 2012-03-30 2013-10-03 Rhizen Pharmaceuticals Sa Novel 3,5-disubstitued-3h-imidazo[4,5-b]pyridine and 3,5- disubstitued -3h-[1,2,3]triazolo[4,5-b] pyridine compounds as modulators of c-met protein kinases
EP2922852A4 (en) 2012-11-20 2016-05-25 Discoverybiomed Inc Small molecule cftr correctors
US9067914B1 (en) * 2013-12-10 2015-06-30 Genzyme Corporation Tropomyosin-related kinase (TRK) inhibitors
WO2015103137A1 (en) * 2013-12-30 2015-07-09 Array Biopharma Inc. Serine/threonine kinase inhibitors
MX362341B (en) * 2014-05-01 2019-01-11 Novartis Ag Compounds and compositions as toll-like receptor 7 agonists.

Also Published As

Publication number Publication date
PH12018500140A1 (en) 2018-07-23
CL2018000140A1 (en) 2018-08-17
TW201716393A (en) 2017-05-16
BR112018001017B1 (en) 2024-02-15
RU2748884C2 (en) 2021-06-01
RU2018106060A3 (en) 2019-12-13
TN2018000020A1 (en) 2019-07-08
MY186368A (en) 2021-07-16
IL256964A (en) 2018-03-29
IL276292B2 (en) 2024-02-01
EP3325471A1 (en) 2018-05-30
JP6898914B2 (en) 2021-07-07
MA42023B2 (en) 2022-01-31
AR105392A1 (en) 2017-09-27
MX2018000880A (en) 2018-08-24
IL276292B1 (en) 2023-10-01
RU2018106060A (en) 2019-08-20
PE20180573A1 (en) 2018-04-04
US20240217991A1 (en) 2024-07-04
JP2018524381A (en) 2018-08-30
JP2021107414A (en) 2021-07-29
CN107922396A (en) 2018-04-17
AU2023201013A1 (en) 2023-03-23
CR20180109A (en) 2018-05-03
CN107922396B (en) 2022-08-05
KR20180030199A (en) 2018-03-21
AU2021204116B2 (en) 2022-12-01
KR102665765B1 (en) 2024-05-10
CO2018001621A2 (en) 2018-02-28
US11274108B2 (en) 2022-03-15
NZ739951A (en) 2024-02-23
IL256964B (en) 2021-10-31
GT201800020A (en) 2019-10-21
US20220396588A1 (en) 2022-12-15
ECSP18012103A (en) 2018-04-30
AU2016297558B2 (en) 2021-03-25
AU2021204116A1 (en) 2021-07-15
US20190016707A1 (en) 2019-01-17
CA2993018A1 (en) 2017-01-26
TWI734693B (en) 2021-08-01
IL305843A (en) 2023-11-01
IL276292A (en) 2020-09-30
JP2024028845A (en) 2024-03-05
BR112018001017A2 (en) 2018-09-18
WO2017015267A1 (en) 2017-01-26
ZA201800082B (en) 2018-12-19
CA3217238A1 (en) 2017-01-26
MX2021015102A (en) 2022-02-21
JP7401482B2 (en) 2023-12-19
AU2016297558A1 (en) 2018-03-08
DOP2018000008A (en) 2018-05-15

Similar Documents

Publication Publication Date Title
IL276292A (en) Colony stimulating factor-1 receptor (csf-1r) inhibitors
IL287113A (en) Smyd inhibitors
IL247018A0 (en) Heterocyclic compound
AP2016009496A0 (en) Substituted spirocydic inhibitors of autotaxin
IL248991A0 (en) Substituted dihydroisoquinolinone compounds
HUE049921T2 (en) Herbicidal propynyl-phenyl compounds
IL248895A0 (en) Phosphatidylinositol -kinase inhibitors
EP3183255C0 (en) Spiropyrrolidines as mdm2 inhibitors
IL285105A (en) Heterocyclic compound
GB201419826D0 (en) Herbicidal compounds
GB201412735D0 (en) Herbicidal compounds
GB201419822D0 (en) Herbicidal compounds
SG10201504959UA (en) Plating method
HUE037519T2 (en) Maximum away duration
GB201419829D0 (en) Herbicidal compounds
GB201419828D0 (en) Herbicidal compounds
GB201419827D0 (en) Herbicidal compounds
PT3151658T (en) Horseshoe
IL248999A0 (en) Method of geolocation
GB201405349D0 (en) Oviposition attractant
GB201407798D0 (en) Dispersant
GB201703217D0 (en) Catch
GB201418154D0 (en) Inhibitors
GB201417980D0 (en) Herbicidal compounds
GB201416462D0 (en) Compound for use