JP2016539168A5 - - Google Patents
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- Publication number
- JP2016539168A5 JP2016539168A5 JP2016536746A JP2016536746A JP2016539168A5 JP 2016539168 A5 JP2016539168 A5 JP 2016539168A5 JP 2016536746 A JP2016536746 A JP 2016536746A JP 2016536746 A JP2016536746 A JP 2016536746A JP 2016539168 A5 JP2016539168 A5 JP 2016539168A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
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- following
- synthesizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 4
- 230000002194 synthesizing effect Effects 0.000 claims 3
- 239000000543 intermediate Substances 0.000 claims 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 claims 1
- 0 CCCc(cc1C*C)ccc1N Chemical compound CCCc(cc1C*C)ccc1N 0.000 description 2
- WUTVUNYCKGJXHV-UHFFFAOYSA-N Cc(cc1C=O)ccc1N Chemical compound Cc(cc1C=O)ccc1N WUTVUNYCKGJXHV-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13195864 | 2013-12-05 | ||
| EP13195864.7 | 2013-12-05 | ||
| PCT/EP2014/076041 WO2015082370A1 (en) | 2013-12-05 | 2014-12-01 | Synthesis of trans-8-chloro-5-methyl-1 -[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulene and crytalline forms thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016539168A JP2016539168A (ja) | 2016-12-15 |
| JP2016539168A5 true JP2016539168A5 (enExample) | 2018-08-09 |
| JP6454707B2 JP6454707B2 (ja) | 2019-01-16 |
Family
ID=49726573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016536746A Active JP6454707B2 (ja) | 2013-12-05 | 2014-12-01 | ｔｒａｎｓ−８−クロロ−５−メチル−１−［４−（ピリジン−２−イルオキシ）−シクロヘキシル］−５，６−ジヒドロ−４Ｈ−２，３，５，１０ｂ−テトラアザ−ベンゾ［ｅ］アズレン及びその結晶形態の合成 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US10246460B2 (enExample) |
| EP (1) | EP3077396B1 (enExample) |
| JP (1) | JP6454707B2 (enExample) |
| KR (3) | KR102384608B1 (enExample) |
| CN (1) | CN105793263B (enExample) |
| AR (1) | AR098592A1 (enExample) |
| AU (2) | AU2014359409A1 (enExample) |
| CA (2) | CA3142754C (enExample) |
| ES (1) | ES2875411T3 (enExample) |
| HR (1) | HRP20210966T1 (enExample) |
| IL (2) | IL245450A0 (enExample) |
| MX (1) | MX372971B (enExample) |
| MY (1) | MY175464A (enExample) |
| NZ (1) | NZ720340A (enExample) |
| PL (1) | PL3077396T3 (enExample) |
| SG (1) | SG11201604502SA (enExample) |
| SI (1) | SI3077396T1 (enExample) |
| WO (1) | WO2015082370A1 (enExample) |
| ZA (1) | ZA201603304B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105793263B (zh) | 2013-12-05 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 一种苯并[e]薁化合物及其晶型的合成 |
| WO2017191117A1 (en) | 2016-05-03 | 2017-11-09 | Bayer Pharma Aktiengesellschaft | V1a receptor antagonists for use in the treatment of renal diseases |
| PL3720424T3 (pl) | 2017-12-08 | 2022-12-27 | F. Hoffmann-La Roche Ag | Preparat farmaceutyczny |
| WO2020139670A1 (en) | 2018-12-27 | 2020-07-02 | Teva Pharmaceuticals International Gmbh | Solid state forms of balovaptan |
| US20240154207A1 (en) | 2021-10-06 | 2024-05-09 | Lg Energy Solution, Ltd. | Battery module |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1197242A (en) * | 1983-03-02 | 1985-11-26 | Jean A. Gauthier | Pyrimido¬1,2-a|pyrrolo¬2,1-c|¬1, 4|benzodiazepine-3-carboxylic acid derivatives |
| GB0303852D0 (en) | 2003-02-19 | 2003-03-26 | Pfizer Ltd | Triazole compounds useful in therapy |
| ES2277237T3 (es) * | 2003-02-19 | 2007-07-01 | Pfizer Inc. | Compuestos de triazol utiles en terapia. |
| GB0400700D0 (en) | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| JP2008510789A (ja) | 2004-08-25 | 2008-04-10 | ファイザー・インク | トリアゾロベンゾジアゼピン及びバゾプレシンアンタゴニストとしてのそれらの使用 |
| US7601715B2 (en) | 2005-06-22 | 2009-10-13 | Bristol-Myers Squibb Company | Process for preparing triazole substituted azaindoleoxoacetic piperazine derivatives and novel salt forms produced therein |
| PL2358714T3 (pl) * | 2008-11-18 | 2012-12-31 | Hoffmann La Roche | Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu |
| DK2370441T3 (da) * | 2008-11-28 | 2013-10-21 | Hoffmann La Roche | Arylcyclohexylethere af dihydrotetraazabenzoazulener til anvendelse som vasopressin v1a-receptorantagonister |
| US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
| MX2016001940A (es) | 2013-08-19 | 2016-06-02 | Hoffmann La Roche | Antagonistas de v1a para tratar trastornos del sueño por cambio de fase. |
| CN105793263B (zh) | 2013-12-05 | 2019-08-23 | 豪夫迈·罗氏有限公司 | 一种苯并[e]薁化合物及其晶型的合成 |
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2014
- 2014-12-01 CN CN201480065960.4A patent/CN105793263B/zh active Active
- 2014-12-01 MY MYPI2016000870A patent/MY175464A/en unknown
- 2014-12-01 CA CA3142754A patent/CA3142754C/en active Active
- 2014-12-01 WO PCT/EP2014/076041 patent/WO2015082370A1/en not_active Ceased
- 2014-12-01 CA CA2931016A patent/CA2931016C/en active Active
- 2014-12-01 MX MX2016006558A patent/MX372971B/es active IP Right Grant
- 2014-12-01 SI SI201431838T patent/SI3077396T1/sl unknown
- 2014-12-01 ES ES14805290T patent/ES2875411T3/es active Active
- 2014-12-01 AU AU2014359409A patent/AU2014359409A1/en not_active Abandoned
- 2014-12-01 KR KR1020167017925A patent/KR102384608B1/ko active Active
- 2014-12-01 NZ NZ720340A patent/NZ720340A/en unknown
- 2014-12-01 SG SG11201604502SA patent/SG11201604502SA/en unknown
- 2014-12-01 KR KR1020217034768A patent/KR102384629B1/ko active Active
- 2014-12-01 KR KR1020217034765A patent/KR102384630B1/ko active Active
- 2014-12-01 JP JP2016536746A patent/JP6454707B2/ja active Active
- 2014-12-01 PL PL14805290T patent/PL3077396T3/pl unknown
- 2014-12-01 EP EP14805290.5A patent/EP3077396B1/en active Active
- 2014-12-01 HR HRP20210966TT patent/HRP20210966T1/hr unknown
- 2014-12-03 AR ARP140104488A patent/AR098592A1/es unknown
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2016
- 2016-05-03 IL IL245450A patent/IL245450A0/en unknown
- 2016-05-16 ZA ZA2016/03304A patent/ZA201603304B/en unknown
- 2016-06-03 US US15/172,542 patent/US10246460B2/en active Active
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2019
- 2019-02-18 IL IL264891A patent/IL264891B/en active IP Right Grant
- 2019-02-20 AU AU2019201183A patent/AU2019201183B2/en active Active
- 2019-03-04 US US16/291,887 patent/US11040977B2/en active Active
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2021
- 2021-06-03 US US17/337,547 patent/US12459947B2/en active Active