JP2011520976A5 - - Google Patents
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- Publication number
- JP2011520976A5 JP2011520976A5 JP2011510669A JP2011510669A JP2011520976A5 JP 2011520976 A5 JP2011520976 A5 JP 2011520976A5 JP 2011510669 A JP2011510669 A JP 2011510669A JP 2011510669 A JP2011510669 A JP 2011510669A JP 2011520976 A5 JP2011520976 A5 JP 2011520976A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrate
- melting point
- melting
- point
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5499508P | 2008-05-21 | 2008-05-21 | |
| US61/054,995 | 2008-05-21 | ||
| PCT/US2009/044622 WO2009143211A2 (en) | 2008-05-21 | 2009-05-20 | Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015040617A Division JP6105653B2 (ja) | 2008-05-21 | 2015-03-02 | 2−フルオロ−N−メチル−4−[7−(キノリン−6−イル−メチル)−イミダゾ[1,2−b][1,2,4]トリアジン−2−イル]ベンズアミドの塩及びそれを調製することに関する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520976A JP2011520976A (ja) | 2011-07-21 |
| JP2011520976A5 true JP2011520976A5 (enExample) | 2014-05-29 |
| JP6022158B2 JP6022158B2 (ja) | 2016-11-09 |
Family
ID=41058602
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510669A Active JP6022158B2 (ja) | 2008-05-21 | 2009-05-20 | 2−フルオロ−N−メチル−4−[7−(キノリン−6−イル−メチル)−イミダゾ[1,2−b][1,2,4]トリアジン−2−イル]ベンズアミドの塩及びそれを調製することに関する方法 |
| JP2015040617A Active JP6105653B2 (ja) | 2008-05-21 | 2015-03-02 | 2−フルオロ−N−メチル−4−[7−(キノリン−6−イル−メチル)−イミダゾ[1,2−b][1,2,4]トリアジン−2−イル]ベンズアミドの塩及びそれを調製することに関する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015040617A Active JP6105653B2 (ja) | 2008-05-21 | 2015-03-02 | 2−フルオロ−N−メチル−4−[7−(キノリン−6−イル−メチル)−イミダゾ[1,2−b][1,2,4]トリアジン−2−イル]ベンズアミドの塩及びそれを調製することに関する方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US8420645B2 (enExample) |
| EP (2) | EP2300455B1 (enExample) |
| JP (2) | JP6022158B2 (enExample) |
| KR (1) | KR101706784B1 (enExample) |
| CN (4) | CN103936743B (enExample) |
| AR (3) | AR071873A1 (enExample) |
| BR (1) | BRPI0912882A2 (enExample) |
| CA (1) | CA2724742C (enExample) |
| CL (1) | CL2009001250A1 (enExample) |
| CO (1) | CO6300934A2 (enExample) |
| CY (1) | CY1119813T1 (enExample) |
| DK (1) | DK2300455T3 (enExample) |
| EA (1) | EA021364B1 (enExample) |
| EC (1) | ECSP10010685A (enExample) |
| ES (1) | ES2643363T3 (enExample) |
| HK (1) | HK1251568A1 (enExample) |
| HR (1) | HRP20171528T1 (enExample) |
| HU (1) | HUE034716T2 (enExample) |
| IL (3) | IL209229A (enExample) |
| LT (1) | LT2300455T (enExample) |
| MA (1) | MA32405B1 (enExample) |
| MX (3) | MX393622B (enExample) |
| MY (3) | MY155565A (enExample) |
| NZ (2) | NZ602791A (enExample) |
| PL (1) | PL2300455T3 (enExample) |
| PT (1) | PT2300455T (enExample) |
| SI (1) | SI2300455T1 (enExample) |
| TW (1) | TWI472529B (enExample) |
| WO (1) | WO2009143211A2 (enExample) |
| ZA (1) | ZA201008212B (enExample) |
Families Citing this family (47)
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| CA2724742C (en) | 2008-05-21 | 2016-07-19 | Incyte Corporation | Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same |
| ES2608329T3 (es) * | 2010-02-03 | 2017-04-07 | Incyte Holdings Corporation | Imidazo[1,2-b][1,2,4]triazinas como inhibidores de c-Met |
| AU2012310168B2 (en) | 2011-09-15 | 2015-07-16 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
| DE102013100596B4 (de) | 2012-01-27 | 2023-09-07 | Samsung Electronics Co. Ltd. | Nichtflüchtiges Speichersystem mit Programmier- und Löschverfahren und Blockverwaltungsverfahren |
| KR102115047B1 (ko) * | 2012-04-03 | 2020-05-26 | 노파르티스 아게 | 티로신 키나제 억제제들을 갖는 조합 제품 및 그의 용도 |
| AU2013302702A1 (en) * | 2012-08-16 | 2015-02-19 | Novartis Ag | Combination of Pl3K inhibitor and c-Met inhibitor |
| CA2907704C (en) * | 2013-03-21 | 2023-01-10 | Giordano Caponigro | Combination therapy for reversing b-raf inhibitor resistance comprising a second inhibitor based on genetic alterations |
| WO2014174478A1 (en) | 2013-04-26 | 2014-10-30 | Novartis Ag | Pharmaceutical combinations of a pkc inhibitor and a c-met receptor tyrosine kinase inhibitor |
| JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
| JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
| KR20240110004A (ko) | 2014-03-14 | 2024-07-12 | 노파르티스 아게 | Lag-3에 대한 항체 분자 및 그의 용도 |
| CA2954840A1 (en) * | 2014-07-25 | 2016-01-28 | Novartis Ag | Tablet formulation of 2-fluoro-n-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide |
| WO2016011658A1 (en) * | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
| WO2016016822A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
| MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
| US9988452B2 (en) | 2014-10-14 | 2018-06-05 | Novartis Ag | Antibody molecules to PD-L1 and uses thereof |
| JP6692826B2 (ja) | 2015-03-10 | 2020-05-13 | アドゥロ バイオテック,インク. | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達の活性化のための組成物及び方法 |
| CN108025051B (zh) | 2015-07-29 | 2021-12-24 | 诺华股份有限公司 | 包含抗pd-1抗体分子的联合疗法 |
| WO2017019894A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to lag-3 |
| EP3878465A1 (en) | 2015-07-29 | 2021-09-15 | Novartis AG | Combination therapies comprising antibody molecules to tim-3 |
| CA3007671A1 (en) | 2015-12-17 | 2017-06-22 | Novartis Ag | Antibody molecules to pd-1 and uses thereof |
| CA3012791C (en) | 2016-01-27 | 2024-01-23 | Universitat Zurich | Use of gabaa receptor modulators for treatment of itch |
| US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
| CN106496000A (zh) * | 2016-10-19 | 2017-03-15 | 蚌埠学院 | 一种3‑氟‑4‑溴‑苯乙酮的合成方法 |
| UY37695A (es) | 2017-04-28 | 2018-11-30 | Novartis Ag | Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo |
| WO2018237173A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| EP3641812A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
| KR20250057112A (ko) * | 2018-04-18 | 2025-04-28 | 뉴로사이클 테라퓨틱스, 인크. | Gabaa 양성 알로스테릭 조절제 화합물, 이의 제조 방법 및 용도 |
| CN110526916B (zh) * | 2018-05-23 | 2021-07-13 | 海创药业股份有限公司 | 氘代Capmatinib化合物及其用途 |
| AR126019A1 (es) | 2018-05-30 | 2023-09-06 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
| WO2019232244A2 (en) | 2018-05-31 | 2019-12-05 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| EP4031578A1 (en) | 2019-09-18 | 2022-07-27 | Novartis AG | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| WO2021165818A1 (en) * | 2020-02-17 | 2021-08-26 | Novartis Ag | Process and intermediates for the preparation of 2-fluoro-n-methyl-4-[7-quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2yl]benzamide |
| US20230263795A1 (en) * | 2020-06-02 | 2023-08-24 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Combined pharmaceutical composition of c-met kinase inhibitor and anti-pd-l1 antibody |
| CN111825678A (zh) * | 2020-06-05 | 2020-10-27 | 连庆泉 | 一种卡马替尼的制备方法 |
| WO2022007752A1 (zh) * | 2020-07-06 | 2022-01-13 | 苏州晶云药物科技股份有限公司 | 苯甲酰胺类化合物及其二盐酸盐的新晶型及其制备方法 |
| WO2022063869A2 (en) * | 2020-09-24 | 2022-03-31 | Merck Patent Gmbh | Compounds for the treatment of viral infections |
| CN112480017A (zh) * | 2020-11-13 | 2021-03-12 | 金仓(上海)医药生物科技有限公司 | 一种3-氨基-1,2,4-三嗪的制备方法 |
| CN114853762A (zh) * | 2021-02-03 | 2022-08-05 | 四川科伦药物研究院有限公司 | 一种咪唑并三嗪类化合物的固体形式及其制备方法和用途 |
| EP4395769A1 (en) | 2021-09-01 | 2024-07-10 | Novartis AG | Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers |
| CN113896732B (zh) * | 2021-10-13 | 2023-09-12 | 沈阳红旗制药有限公司 | 抗癌药物卡马替尼的制备方法及其应用 |
| WO2023249994A1 (en) * | 2022-06-22 | 2023-12-28 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| CN119775203B (zh) * | 2024-11-29 | 2025-11-14 | 河北科技大学 | 一种卡马替尼中间体6-(3,3-二乙氧基丙基)喹啉的合成方法 |
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