AR071873A1 - Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida, un hidrato de la sal, un metodo de preparacion del compuesto, una composicion que lo comprende, un metodo para inhibir la actividad de la tirosina quinasa, un metodo para tratar una enfermedad y un proc - Google Patents

Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida, un hidrato de la sal, un metodo de preparacion del compuesto, una composicion que lo comprende, un metodo para inhibir la actividad de la tirosina quinasa, un metodo para tratar una enfermedad y un proc

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Publication number
AR071873A1
AR071873A1 ARP090101835A ARP090101835A AR071873A1 AR 071873 A1 AR071873 A1 AR 071873A1 AR P090101835 A ARP090101835 A AR P090101835A AR P090101835 A ARP090101835 A AR P090101835A AR 071873 A1 AR071873 A1 AR 071873A1
Authority
AR
Argentina
Prior art keywords
methyl
fluoro
triazin
quinolin
imidazo
Prior art date
Application number
ARP090101835A
Other languages
English (en)
Inventor
Pingli Liu
Lingkai Weng
Jiacheng Zhou
Lei Qiao
Yongchun Pan
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41058602&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR071873(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of AR071873A1 publication Critical patent/AR071873A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Abstract

La presente se relaciona una sal diclorh¡drica de 2-fluoro-N-metil-4-[7-(quinolin-6-ilmetil)-imidazol[1,2-b][1,2,4]triazin-2-il]benzamida estos compuestos son utiles en el tratamiento de c ncer y otras enfermedades relacionadas con la desregulacion de Ias v¡as de la quinasa. La presente invencion tambien se relaciona con los procesos e intermediarios para preparar 2- fluoro-N-metil-4-[7-(quinoIin-6-iIimetil)imidazo[1,2-b][1,2,4]triazin-2-il] benzamida y sus sales.
ARP090101835A 2008-05-21 2009-05-21 Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida, un hidrato de la sal, un metodo de preparacion del compuesto, una composicion que lo comprende, un metodo para inhibir la actividad de la tirosina quinasa, un metodo para tratar una enfermedad y un proc AR071873A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5499508P 2008-05-21 2008-05-21

Publications (1)

Publication Number Publication Date
AR071873A1 true AR071873A1 (es) 2010-07-21

Family

ID=41058602

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP090101835A AR071873A1 (es) 2008-05-21 2009-05-21 Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida, un hidrato de la sal, un metodo de preparacion del compuesto, una composicion que lo comprende, un metodo para inhibir la actividad de la tirosina quinasa, un metodo para tratar una enfermedad y un proc
ARP180101072A AR111428A2 (es) 2008-05-21 2018-04-26 Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida y procesos relacionados con la preparación de las mismas
ARP210102275A AR123240A2 (es) 2008-05-21 2021-08-12 SAL DICLORHÍDRICA O DIBENCENSULFÓNICA DE 2-FLUORO-N-METIL-4-[7-(QUINOLIN-6-ILMETIL)IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-IL]BENZAMIDA, O HIDRATOS O SOLVATOS DE LAS MISMAS; COMPOSICIÓN; MÉTODOS PARA INHIBIR LA ACTIVIDAD DE UNA TIROSINA QUINASA RECEPTORA, LA VÍA DE SEÑALIZACIÓN DE QUINASA HGF / c-MET EN CÉLULAS, LA ACTIVIDAD PROLIFERATIVA DE CÉLULAS, EL CRECIMIENTO TUMORAL EN PACIENTES, LA METÁSTASIS TUMORAL EN UN PACIENTE; MÉTODO PARA TRATAR UNA ENFERMEDAD ASOCIADA CON LA DESREGULACIÓN DE LA VÍA DE SEÑALIZACIÓN DE HGF / c-MET EN PACIENTES, CÁNCER EN PACIENTES; PROCESO PARA PREPARAR DICHOS HIDRATOS Y DICHAS SALES; Y COMPUESTOS RELACIONADOS

Family Applications After (2)

Application Number Title Priority Date Filing Date
ARP180101072A AR111428A2 (es) 2008-05-21 2018-04-26 Sales de 2-fluoro-n-metil-4-[7-(quinolin-6-il-metil)-imidazo[1,2-b][1,2,4]triazin-2-il]benzamida y procesos relacionados con la preparación de las mismas
ARP210102275A AR123240A2 (es) 2008-05-21 2021-08-12 SAL DICLORHÍDRICA O DIBENCENSULFÓNICA DE 2-FLUORO-N-METIL-4-[7-(QUINOLIN-6-ILMETIL)IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-IL]BENZAMIDA, O HIDRATOS O SOLVATOS DE LAS MISMAS; COMPOSICIÓN; MÉTODOS PARA INHIBIR LA ACTIVIDAD DE UNA TIROSINA QUINASA RECEPTORA, LA VÍA DE SEÑALIZACIÓN DE QUINASA HGF / c-MET EN CÉLULAS, LA ACTIVIDAD PROLIFERATIVA DE CÉLULAS, EL CRECIMIENTO TUMORAL EN PACIENTES, LA METÁSTASIS TUMORAL EN UN PACIENTE; MÉTODO PARA TRATAR UNA ENFERMEDAD ASOCIADA CON LA DESREGULACIÓN DE LA VÍA DE SEÑALIZACIÓN DE HGF / c-MET EN PACIENTES, CÁNCER EN PACIENTES; PROCESO PARA PREPARAR DICHOS HIDRATOS Y DICHAS SALES; Y COMPUESTOS RELACIONADOS

Country Status (30)

Country Link
US (7) US8420645B2 (es)
EP (2) EP2300455B1 (es)
JP (2) JP6022158B2 (es)
KR (1) KR101706784B1 (es)
CN (4) CN102083814B (es)
AR (3) AR071873A1 (es)
BR (1) BRPI0912882A2 (es)
CA (1) CA2724742C (es)
CL (1) CL2009001250A1 (es)
CO (1) CO6300934A2 (es)
CY (1) CY1119813T1 (es)
DK (1) DK2300455T3 (es)
EA (1) EA021364B1 (es)
EC (1) ECSP10010685A (es)
ES (1) ES2643363T3 (es)
HK (1) HK1251568A1 (es)
HR (1) HRP20171528T1 (es)
HU (1) HUE034716T2 (es)
IL (3) IL209229A (es)
LT (1) LT2300455T (es)
MA (1) MA32405B1 (es)
MX (3) MX368802B (es)
MY (2) MY155565A (es)
NZ (2) NZ589622A (es)
PL (1) PL2300455T3 (es)
PT (1) PT2300455T (es)
SI (1) SI2300455T1 (es)
TW (1) TWI472529B (es)
WO (1) WO2009143211A2 (es)
ZA (1) ZA201008212B (es)

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