CN106998692B - Mk2抑制剂和其用途 - Google Patents

Mk2抑制剂和其用途 Download PDF

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Publication number
CN106998692B
CN106998692B CN201580058026.4A CN201580058026A CN106998692B CN 106998692 B CN106998692 B CN 106998692B CN 201580058026 A CN201580058026 A CN 201580058026A CN 106998692 B CN106998692 B CN 106998692B
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disease
disorder
mmol
certain embodiments
compound
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Chinese (zh)
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CN106998692A (zh
Inventor
马修·戴维·亚历山大
克劳迪奥·丘瓦基
约翰·马罗那
约瑟夫·约翰·麦克唐纳
易科·尼
牛德强
拉塞尔·C·彼得
尤斯温德·辛格
基塔里·帕巴
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Bristol Myers Squibb Co
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Celgene CAR LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201580058026.4A 2014-09-17 2015-09-16 Mk2抑制剂和其用途 Active CN106998692B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462051788P 2014-09-17 2014-09-17
US62/051,788 2014-09-17
US201562199927P 2015-07-31 2015-07-31
US62/199,927 2015-07-31
PCT/US2015/050495 WO2016044463A2 (en) 2014-09-17 2015-09-16 Mk2 inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
CN106998692A CN106998692A (zh) 2017-08-01
CN106998692B true CN106998692B (zh) 2020-09-08

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CN (1) CN106998692B (enExample)
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SG (2) SG10201902326XA (enExample)
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CN114364681A (zh) * 2019-05-17 2022-04-15 西建卡尔有限责任公司 治疗mk2介导的病症的方法
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EP4244341A4 (en) * 2020-11-12 2025-01-15 Akttyva Therapeutics, Inc. Mk2 activating compounds for use in treating vascular leak and endothelial barrier disorders
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TW202328141A (zh) * 2021-08-27 2023-07-16 大陸商瑞石生物醫藥有限公司 喹啉并呋喃衍生物及其用途
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WO2024044731A1 (en) * 2022-08-26 2024-02-29 Matchpoint Therapeutics Inc. Diazepino-thieno-quinoxaline compounds and their use in therapy
WO2024092115A2 (en) * 2022-10-27 2024-05-02 Bristol-Myers Squibb Company Mk2 inhibitors and uses thereof
CN120676947A (zh) * 2023-02-07 2025-09-19 细胞基因公司 可用作mk2激酶降解剂的化合物和组合物
WO2024229401A2 (en) * 2023-05-04 2024-11-07 Matchpoint Therapeutics Inc. Diazepino-thieno-quinoxaline compounds and their use in therapy
WO2025002076A1 (zh) * 2023-06-26 2025-01-02 深圳信立泰药业股份有限公司 一种mk2抑制剂在制备预防和/或治疗疾病药物中的应用

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JP2022078315A (ja) 2022-05-24
US20160075720A1 (en) 2016-03-17
CO2017003279A2 (es) 2017-09-29
MX2017003359A (es) 2017-11-22
US20210053984A1 (en) 2021-02-25
RS62017B1 (sr) 2021-07-30
US9790235B2 (en) 2017-10-17
MX373341B (es) 2020-05-26
CA2961607C (en) 2023-03-28
PL3193611T3 (pl) 2021-10-04
WO2016044463A3 (en) 2016-09-01
NZ730603A (en) 2024-02-23
SG10201902326XA (en) 2019-04-29
TW201617351A (zh) 2016-05-16
IL251051B (en) 2019-11-28
KR20170063734A (ko) 2017-06-08
DK3193611T3 (da) 2021-05-10
EA037299B1 (ru) 2021-03-05
HUE054347T2 (hu) 2021-08-30
ES2874561T3 (es) 2021-11-05
HRP20210529T1 (hr) 2021-08-06
JP2019194236A (ja) 2019-11-07
MA40534B1 (fr) 2021-04-30
CA2961607A1 (en) 2016-03-24
AU2015317741B2 (en) 2020-01-16
EP3193611A2 (en) 2017-07-26
EP3193611A4 (en) 2018-02-28
US11584757B2 (en) 2023-02-21
ECSP17023281A (es) 2017-06-30
SA517381115B1 (ar) 2021-03-09
BR112017005266A2 (pt) 2017-12-12
EP3912981A1 (en) 2021-11-24
US9458175B2 (en) 2016-10-04
SG11201701861RA (en) 2017-04-27
MX2020005213A (es) 2020-08-20
LT3193611T (lt) 2021-08-25
CY1124215T1 (el) 2022-05-27
AU2015317741A1 (en) 2017-04-20
WO2016044463A2 (en) 2016-03-24
IL251051A0 (en) 2017-04-30
TWI744217B (zh) 2021-11-01
PT3193611T (pt) 2021-05-28
CL2017000576A1 (es) 2017-12-01
BR112017005266B1 (pt) 2022-11-01
KR102457848B1 (ko) 2022-10-25
MA40534A (fr) 2016-03-24
SI3193611T1 (sl) 2021-08-31
EA201790380A1 (ru) 2017-08-31
SMT202100311T1 (it) 2021-07-12
US10577380B2 (en) 2020-03-03
US20190375762A1 (en) 2019-12-12
US10253040B1 (en) 2019-04-09
EP3193611B1 (en) 2021-03-24
CN106998692A (zh) 2017-08-01
JP7375072B2 (ja) 2023-11-07
JP2017529367A (ja) 2017-10-05
JP6556225B2 (ja) 2019-08-07
US20170114073A1 (en) 2017-04-27

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