SA517381115B1 - مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها - Google Patents

مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها Download PDF

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Publication number
SA517381115B1
SA517381115B1 SA517381115A SA517381115A SA517381115B1 SA 517381115 B1 SA517381115 B1 SA 517381115B1 SA 517381115 A SA517381115 A SA 517381115A SA 517381115 A SA517381115 A SA 517381115A SA 517381115 B1 SA517381115 B1 SA 517381115B1
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Saudi Arabia
Prior art keywords
compound
aliphatic
atoms
certain embodiments
pharmaceutically acceptable
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SA517381115A
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Arabic (ar)
English (en)
Inventor
ماثيو ديفيد اليكسندر
شيتارى بابا
روسيل سى بيتير
جوسويندير سينج
كلاوديو شواكوى
جون مالونا
جوزيف جون مكدونالد
يك نى
ديكياانج نيو
Original Assignee
كيلجين افيلوميكز ريسيرش، انك.
كيلجين كار ال ال سى
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Application filed by كيلجين افيلوميكز ريسيرش، انك., كيلجين كار ال ال سى filed Critical كيلجين افيلوميكز ريسيرش، انك.
Publication of SA517381115B1 publication Critical patent/SA517381115B1/ar

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
SA517381115A 2014-09-17 2017-03-16 مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها SA517381115B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051788P 2014-09-17 2014-09-17
US201562199927P 2015-07-31 2015-07-31
PCT/US2015/050495 WO2016044463A2 (en) 2014-09-17 2015-09-16 Mk2 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
SA517381115B1 true SA517381115B1 (ar) 2021-03-09

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SA517381115A SA517381115B1 (ar) 2014-09-17 2017-03-16 مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها

Country Status (30)

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US (5) US9458175B2 (enExample)
EP (2) EP3912981A1 (enExample)
JP (3) JP6556225B2 (enExample)
KR (1) KR102457848B1 (enExample)
CN (1) CN106998692B (enExample)
AU (1) AU2015317741B2 (enExample)
BR (1) BR112017005266B1 (enExample)
CA (1) CA2961607C (enExample)
CL (1) CL2017000576A1 (enExample)
CO (1) CO2017003279A2 (enExample)
CY (1) CY1124215T1 (enExample)
DK (1) DK3193611T3 (enExample)
EA (1) EA037299B1 (enExample)
EC (1) ECSP17023281A (enExample)
ES (1) ES2874561T3 (enExample)
HR (1) HRP20210529T1 (enExample)
HU (1) HUE054347T2 (enExample)
IL (1) IL251051B (enExample)
LT (1) LT3193611T (enExample)
MA (1) MA40534B1 (enExample)
MX (2) MX373341B (enExample)
PL (1) PL3193611T3 (enExample)
PT (1) PT3193611T (enExample)
RS (1) RS62017B1 (enExample)
SA (1) SA517381115B1 (enExample)
SG (2) SG10201902326XA (enExample)
SI (1) SI3193611T1 (enExample)
SM (1) SMT202100311T1 (enExample)
TW (1) TWI744217B (enExample)
WO (1) WO2016044463A2 (enExample)

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EP3193611A2 (en) 2017-07-26
DK3193611T3 (da) 2021-05-10
MA40534A (fr) 2016-03-24
SI3193611T1 (sl) 2021-08-31
CN106998692A (zh) 2017-08-01
EP3193611B1 (en) 2021-03-24
US20160075720A1 (en) 2016-03-17
RS62017B1 (sr) 2021-07-30
JP7375072B2 (ja) 2023-11-07
PL3193611T3 (pl) 2021-10-04
KR20170063734A (ko) 2017-06-08
US9458175B2 (en) 2016-10-04
IL251051B (en) 2019-11-28
US20210053984A1 (en) 2021-02-25
EA201790380A1 (ru) 2017-08-31
LT3193611T (lt) 2021-08-25
KR102457848B1 (ko) 2022-10-25
CA2961607A1 (en) 2016-03-24
US20170114073A1 (en) 2017-04-27
SG10201902326XA (en) 2019-04-29
EA037299B1 (ru) 2021-03-05
JP2022078315A (ja) 2022-05-24
NZ730603A (en) 2024-02-23
JP2017529367A (ja) 2017-10-05
US20190375762A1 (en) 2019-12-12
TW201617351A (zh) 2016-05-16
CO2017003279A2 (es) 2017-09-29
TWI744217B (zh) 2021-11-01
SG11201701861RA (en) 2017-04-27
ECSP17023281A (es) 2017-06-30
CL2017000576A1 (es) 2017-12-01
IL251051A0 (en) 2017-04-30
JP6556225B2 (ja) 2019-08-07
MA40534B1 (fr) 2021-04-30
CY1124215T1 (el) 2022-05-27
SMT202100311T1 (it) 2021-07-12
US10253040B1 (en) 2019-04-09
PT3193611T (pt) 2021-05-28
EP3193611A4 (en) 2018-02-28
WO2016044463A3 (en) 2016-09-01
HUE054347T2 (hu) 2021-08-30
MX2017003359A (es) 2017-11-22
AU2015317741B2 (en) 2020-01-16
JP2019194236A (ja) 2019-11-07
WO2016044463A2 (en) 2016-03-24
ES2874561T3 (es) 2021-11-05
HRP20210529T1 (hr) 2021-08-06
MX373341B (es) 2020-05-26
US9790235B2 (en) 2017-10-17
US10577380B2 (en) 2020-03-03
BR112017005266A2 (pt) 2017-12-12
US11584757B2 (en) 2023-02-21
BR112017005266B1 (pt) 2022-11-01
AU2015317741A1 (en) 2017-04-20
MX2020005213A (es) 2020-08-20
CN106998692B (zh) 2020-09-08
EP3912981A1 (en) 2021-11-24
CA2961607C (en) 2023-03-28

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