SA517381115B1 - مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها - Google Patents

مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها Download PDF

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Publication number
SA517381115B1
SA517381115B1 SA517381115A SA517381115A SA517381115B1 SA 517381115 B1 SA517381115 B1 SA 517381115B1 SA 517381115 A SA517381115 A SA 517381115A SA 517381115 A SA517381115 A SA 517381115A SA 517381115 B1 SA517381115 B1 SA 517381115B1
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Saudi Arabia
Prior art keywords
compound
aliphatic
atoms
certain embodiments
pharmaceutically acceptable
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SA517381115A
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Arabic (ar)
English (en)
Inventor
ماثيو ديفيد اليكسندر
شيتارى بابا
روسيل سى بيتير
جوسويندير سينج
كلاوديو شواكوى
جون مالونا
جوزيف جون مكدونالد
يك نى
ديكياانج نيو
Original Assignee
كيلجين افيلوميكز ريسيرش، انك.
كيلجين كار ال ال سى
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Application filed by كيلجين افيلوميكز ريسيرش، انك., كيلجين كار ال ال سى filed Critical كيلجين افيلوميكز ريسيرش، انك.
Publication of SA517381115B1 publication Critical patent/SA517381115B1/ar

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Enzymes And Modification Thereof (AREA)
SA517381115A 2014-09-17 2017-03-16 مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها SA517381115B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462051788P 2014-09-17 2014-09-17
US201562199927P 2015-07-31 2015-07-31
PCT/US2015/050495 WO2016044463A2 (en) 2014-09-17 2015-09-16 Mk2 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
SA517381115B1 true SA517381115B1 (ar) 2021-03-09

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SA517381115A SA517381115B1 (ar) 2014-09-17 2017-03-16 مثبطات كيناز بروتين 2 منشط بكيناز بروتين منشط بميتوجين واستخداماتها

Country Status (30)

Country Link
US (5) US9458175B2 (enExample)
EP (2) EP3193611B1 (enExample)
JP (3) JP6556225B2 (enExample)
KR (1) KR102457848B1 (enExample)
CN (1) CN106998692B (enExample)
AU (1) AU2015317741B2 (enExample)
BR (1) BR112017005266B1 (enExample)
CA (1) CA2961607C (enExample)
CL (1) CL2017000576A1 (enExample)
CO (1) CO2017003279A2 (enExample)
CY (1) CY1124215T1 (enExample)
DK (1) DK3193611T3 (enExample)
EA (1) EA037299B1 (enExample)
EC (1) ECSP17023281A (enExample)
ES (1) ES2874561T3 (enExample)
HR (1) HRP20210529T1 (enExample)
HU (1) HUE054347T2 (enExample)
IL (1) IL251051B (enExample)
LT (1) LT3193611T (enExample)
MA (1) MA40534B1 (enExample)
MX (2) MX373341B (enExample)
PL (1) PL3193611T3 (enExample)
PT (1) PT3193611T (enExample)
RS (1) RS62017B1 (enExample)
SA (1) SA517381115B1 (enExample)
SG (2) SG10201902326XA (enExample)
SI (1) SI3193611T1 (enExample)
SM (1) SMT202100311T1 (enExample)
TW (1) TWI744217B (enExample)
WO (1) WO2016044463A2 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150133172A (ko) 2013-03-15 2015-11-27 셀진 아빌로믹스 리서치, 인코포레이티드 Mk2 억제제 및 이의 용도
SG10201902326XA (en) 2014-09-17 2019-04-29 Celgene Car Llc Mk2 inhibitors and uses thereof
CN106632077B (zh) * 2016-10-10 2019-01-22 上海再启生物技术有限公司 一种2-氨基-4-溴嘧啶的制备方法
JP2020511468A (ja) * 2017-03-16 2020-04-16 セルジーン シーエーアール エルエルシー Mk2阻害剤の重水素化アナログおよびその使用
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
CA3054826A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Mk2 inhibitors, synthesis thereof, and intermediates thereto
CN110678178B (zh) * 2017-03-16 2023-10-03 百时美施贵宝公司 Mk2抑制剂的形式和组合物
JP2020514361A (ja) * 2017-03-16 2020-05-21 セルジーン シーエーアール エルエルシー 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用
CN107058259A (zh) * 2017-05-18 2017-08-18 南京中医药大学 分子标志物mk2基因及其应用
AU2019351912B2 (en) * 2018-10-02 2025-07-31 Disc Medicine, Inc. Matriptase 2 inhibitors and uses thereof
WO2020236636A1 (en) * 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
WO2021163633A1 (en) * 2020-02-14 2021-08-19 Salk Institute For Biological Studies Mono and combination therapies with ulk1/2 inhibitors
EP4114411A4 (en) * 2020-03-02 2024-04-24 Washington University Compositions and methods for the treatment of pancreatic cancer
KR20230044446A (ko) * 2020-07-24 2023-04-04 브리스톨-마이어스 스큅 컴퍼니 급성 호흡기 장애의 치료 방법
CA3201774A1 (en) * 2020-11-12 2022-05-19 Akttyva Therapeutics, Inc. Mk2 activating compounds for use in treating vascular leak and endothelial barrier disorders
EP4284805A1 (en) * 2021-02-01 2023-12-06 Celgene Corporation Mk2 inhibitors, the synthesis thereof, and intermediates thereto
EP4079855A1 (en) * 2021-04-20 2022-10-26 Eberhard Karls Universität Tübingen Medizinische Fakultät Compound and method for the prophylaxis and treatment of leukemia
CN117940433A (zh) * 2021-08-27 2024-04-26 瑞石生物医药有限公司 喹啉并呋喃衍生物及其用途
AU2023207395A1 (en) 2022-01-14 2024-07-11 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Pyridine-containing polycyclic derivative, and preparation method therefor and use thereof
WO2024044731A1 (en) * 2022-08-26 2024-02-29 Matchpoint Therapeutics Inc. Diazepino-thieno-quinoxaline compounds and their use in therapy
EP4608401A2 (en) * 2022-10-27 2025-09-03 Bristol-Myers Squibb Company Mk2 inhibitors and uses thereof
EP4661875A1 (en) * 2023-02-07 2025-12-17 Celgene Corporation Compounds and compositions useful as degraders of mk2 kinase
WO2024229401A2 (en) * 2023-05-04 2024-11-07 Matchpoint Therapeutics Inc. Diazepino-thieno-quinoxaline compounds and their use in therapy
WO2025002076A1 (zh) * 2023-06-26 2025-01-02 深圳信立泰药业股份有限公司 一种mk2抑制剂在制备预防和/或治疗疾病药物中的应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015778A (en) 1989-12-18 1991-05-14 The Dow Chemical Company Catalytic method to produce hydroxy substituted arylophenones
JP3696884B2 (ja) 1994-03-25 2005-09-21 アイソテクニカ、インコーポレーテッド ジュウテリウム化による薬物の効能の増強
US5441946A (en) 1994-04-14 1995-08-15 Rhone-Poulenc-Rorer Pharmaceuticals, Inc. Phosphonate derivatives of lipophilic amines
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
US6861440B2 (en) * 2001-10-26 2005-03-01 Hoffmann-La Roche Inc. DPP IV inhibitors
TW200413273A (en) 2002-11-15 2004-08-01 Wako Pure Chem Ind Ltd Heavy hydrogenation method of heterocyclic rings
AU2003301226A1 (en) 2002-12-20 2004-07-22 Pharmacia Corp Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2
JP5010917B2 (ja) 2003-08-29 2012-08-29 エグゼリクシス, インコーポレイテッド c−Kit調節因子および使用方法
WO2005105814A1 (en) 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
MY158077A (en) 2005-02-04 2016-08-30 Senomyx Inc Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers tastants and taste enhancers for comestible compositions
EP1849781A1 (en) 2006-04-28 2007-10-31 Laboratorios del Dr. Esteve S.A. Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments
EP2223925A1 (en) 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
CN101687869A (zh) 2007-07-16 2010-03-31 诺瓦提斯公司 作为mk2抑制剂的四环内酰胺衍生物
AU2008317057B8 (en) 2007-10-22 2014-02-13 Merck Sharp & Dohme Corp. Bicyclic Heterocycle Derivatives and their use as modulators of the activity of GPR119
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
EP2361248B1 (en) 2008-06-27 2018-09-19 Celgene CAR LLC Heteroaryl compounds and uses thereof
WO2010048149A2 (en) 2008-10-20 2010-04-29 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
US20110269744A1 (en) * 2010-03-12 2011-11-03 Astellas Pharma Inc. Benzazepine Compound
WO2011153553A2 (en) * 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
EP2508511A1 (en) * 2011-04-07 2012-10-10 Laboratoire Biodim Inhibitors of viral replication, their process of preparation and their therapeutical uses
EP2511273B8 (en) * 2011-04-15 2019-06-26 Hivih Inhibitors of viral replication, their process of preparation and their therapeutical uses
CN104136576B (zh) 2012-02-22 2020-10-16 默克专利股份有限公司 液晶介质
WO2013146963A1 (ja) * 2012-03-28 2013-10-03 武田薬品工業株式会社 複素環化合物
TW201406758A (zh) * 2012-06-28 2014-02-16 Daiichi Sankyo Co Ltd 三環性化合物
EP2872144A4 (en) * 2012-07-11 2015-12-02 Nimbus Iris Inc IRAQ INHIBITOR AND USES THEREOF
MA38030B1 (fr) * 2012-09-24 2019-11-29 Claremont Speede Accès à des données contrôlé par un expéditeur mobile, et procédé et système de suppression de données
WO2014050779A1 (ja) * 2012-09-25 2014-04-03 第一三共株式会社 Gsk3阻害剤と抗dr5抗体の組み合わせ
WO2014139144A1 (en) 2013-03-15 2014-09-18 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
KR20150133172A (ko) * 2013-03-15 2015-11-27 셀진 아빌로믹스 리서치, 인코포레이티드 Mk2 억제제 및 이의 용도
WO2015050957A2 (en) 2013-10-02 2015-04-09 Treatments For Systemic Lupus Erythematosus Treatments for systemic lupus erythematosus
WO2016032882A1 (en) 2014-08-25 2016-03-03 Stc.Unm Inhibition of mk2 in the treatment of cancer
SG10201902326XA (en) 2014-09-17 2019-04-29 Celgene Car Llc Mk2 inhibitors and uses thereof
MX2017008994A (es) 2015-01-08 2018-09-18 Moerae Matrix Inc Formulacion de peptidos inhibidores mk2.
CA3054826A1 (en) 2017-03-16 2018-09-20 Celgene Car Llc Mk2 inhibitors, synthesis thereof, and intermediates thereto
JP2020511468A (ja) 2017-03-16 2020-04-16 セルジーン シーエーアール エルエルシー Mk2阻害剤の重水素化アナログおよびその使用
US11124525B2 (en) 2017-03-16 2021-09-21 Celgene Car Llc Heteroaryl compounds useful as MK2 inhibitors
CN110678178B (zh) 2017-03-16 2023-10-03 百时美施贵宝公司 Mk2抑制剂的形式和组合物
JP2020514361A (ja) 2017-03-16 2020-05-21 セルジーン シーエーアール エルエルシー 9,10,11,12−テトラヒドロ−8h−[1,4]ジアゼピノ[5’,6’:4,5]チエノ[3,2−f]キノリン−8−オン化合物およびその使用
WO2020236636A1 (en) 2019-05-17 2020-11-26 Celgene Car Llc Methods of treating a mk2-mediated disorder
KR20230044446A (ko) 2020-07-24 2023-04-04 브리스톨-마이어스 스큅 컴퍼니 급성 호흡기 장애의 치료 방법

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Publication number Publication date
AU2015317741B2 (en) 2020-01-16
KR102457848B1 (ko) 2022-10-25
US10577380B2 (en) 2020-03-03
SI3193611T1 (sl) 2021-08-31
CL2017000576A1 (es) 2017-12-01
NZ730603A (en) 2024-02-23
RS62017B1 (sr) 2021-07-30
SG11201701861RA (en) 2017-04-27
BR112017005266A2 (pt) 2017-12-12
US20190375762A1 (en) 2019-12-12
JP7375072B2 (ja) 2023-11-07
US11584757B2 (en) 2023-02-21
SMT202100311T1 (it) 2021-07-12
US20210053984A1 (en) 2021-02-25
SG10201902326XA (en) 2019-04-29
US9458175B2 (en) 2016-10-04
CN106998692B (zh) 2020-09-08
WO2016044463A3 (en) 2016-09-01
MA40534B1 (fr) 2021-04-30
US20160075720A1 (en) 2016-03-17
EP3193611A4 (en) 2018-02-28
PT3193611T (pt) 2021-05-28
ECSP17023281A (es) 2017-06-30
CY1124215T1 (el) 2022-05-27
WO2016044463A2 (en) 2016-03-24
JP2022078315A (ja) 2022-05-24
BR112017005266B1 (pt) 2022-11-01
IL251051A0 (en) 2017-04-30
CA2961607A1 (en) 2016-03-24
CO2017003279A2 (es) 2017-09-29
EP3193611A2 (en) 2017-07-26
CN106998692A (zh) 2017-08-01
AU2015317741A1 (en) 2017-04-20
LT3193611T (lt) 2021-08-25
EP3193611B1 (en) 2021-03-24
HUE054347T2 (hu) 2021-08-30
US9790235B2 (en) 2017-10-17
TWI744217B (zh) 2021-11-01
CA2961607C (en) 2023-03-28
US10253040B1 (en) 2019-04-09
MX2017003359A (es) 2017-11-22
MA40534A (fr) 2016-03-24
KR20170063734A (ko) 2017-06-08
PL3193611T3 (pl) 2021-10-04
MX2020005213A (es) 2020-08-20
US20170114073A1 (en) 2017-04-27
JP6556225B2 (ja) 2019-08-07
JP2017529367A (ja) 2017-10-05
EA037299B1 (ru) 2021-03-05
DK3193611T3 (da) 2021-05-10
JP2019194236A (ja) 2019-11-07
IL251051B (en) 2019-11-28
TW201617351A (zh) 2016-05-16
MX373341B (es) 2020-05-26
EP3912981A1 (en) 2021-11-24
ES2874561T3 (es) 2021-11-05
HRP20210529T1 (hr) 2021-08-06
EA201790380A1 (ru) 2017-08-31

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