JP2017534262A5 - - Google Patents

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JP2017534262A5
JP2017534262A5 JP2017515139A JP2017515139A JP2017534262A5 JP 2017534262 A5 JP2017534262 A5 JP 2017534262A5 JP 2017515139 A JP2017515139 A JP 2017515139A JP 2017515139 A JP2017515139 A JP 2017515139A JP 2017534262 A5 JP2017534262 A5 JP 2017534262A5
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JP6657195B2 (ja
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JP2017515139A 2014-09-19 2015-09-18 L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 Active JP6657195B2 (ja)

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Application Number Priority Date Filing Date Title
JP2020017583A JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2021169396A JP7171871B2 (ja) 2014-09-19 2021-10-15 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞

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US201462053068P 2014-09-19 2014-09-19
US62/053,068 2014-09-19
PCT/US2015/051089 WO2016044811A1 (en) 2014-09-19 2015-09-18 COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2

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JP2020017583A Division JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞

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JP2017534262A JP2017534262A (ja) 2017-11-24
JP2017534262A5 true JP2017534262A5 (enExample) 2018-10-25
JP6657195B2 JP6657195B2 (ja) 2020-03-04

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JP2017515139A Active JP6657195B2 (ja) 2014-09-19 2015-09-18 L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2017515138A Active JP6711819B2 (ja) 2014-09-19 2015-09-21 養子t細胞療法のためのセントラルメモリーt細胞
JP2020017583A Active JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2020093109A Active JP7216045B2 (ja) 2014-09-19 2020-05-28 養子t細胞療法のためのセントラルメモリーt細胞
JP2021169396A Active JP7171871B2 (ja) 2014-09-19 2021-10-15 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞
JP2022176776A Pending JP2023014100A (ja) 2014-09-19 2022-11-02 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2023006410A Ceased JP2023052506A (ja) 2014-09-19 2023-01-19 養子t細胞療法のためのセントラルメモリーt細胞

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JP2017515138A Active JP6711819B2 (ja) 2014-09-19 2015-09-21 養子t細胞療法のためのセントラルメモリーt細胞
JP2020017583A Active JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2020093109A Active JP7216045B2 (ja) 2014-09-19 2020-05-28 養子t細胞療法のためのセントラルメモリーt細胞
JP2021169396A Active JP7171871B2 (ja) 2014-09-19 2021-10-15 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞
JP2022176776A Pending JP2023014100A (ja) 2014-09-19 2022-11-02 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2023006410A Ceased JP2023052506A (ja) 2014-09-19 2023-01-19 養子t細胞療法のためのセントラルメモリーt細胞

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US (3) US9914909B2 (enExample)
EP (4) EP3587446A1 (enExample)
JP (7) JP6657195B2 (enExample)
KR (3) KR102683584B1 (enExample)
CN (4) CN113789336B (enExample)
AU (4) AU2015317351B2 (enExample)
BR (3) BR122024000360A2 (enExample)
CA (2) CA2961654A1 (enExample)
DK (1) DK3200591T3 (enExample)
ES (2) ES2738705T3 (enExample)
IL (6) IL308324A (enExample)
MX (4) MX387135B (enExample)
RU (2) RU2749922C2 (enExample)
WO (2) WO2016044811A1 (enExample)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9738696B2 (en) 2012-08-09 2017-08-22 The Board Of Trustees Of The Leland Stanford Junior University Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities
EP2934532B1 (en) 2012-12-20 2019-10-23 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
JP6936934B2 (ja) 2013-09-24 2021-09-22 メディシナ セラピューティクス インコーポレイテッド インターロイキン−4受容体結合融合タンパク質及びその使用
CN113307880B (zh) 2014-01-13 2025-07-04 希望之城公司 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法
IL308324A (en) 2014-09-19 2024-01-01 Hope City IL13RA2-targeted chimeric antigen receptor T cells
EA202090931A3 (ru) 2015-05-18 2020-10-30 Тср2 Терапьютикс Инк. Композиции и способы перепрограммирования tcr с помощью гибридных белков
US12115189B2 (en) 2015-07-21 2024-10-15 City Of Hope T cells for expression of chimeric antigen receptors and other receptors
RU2724738C2 (ru) * 2015-08-05 2020-06-25 СеллабМЕД ИНК. Химерный антигенный рецептор и т-клетки, в которых экспрессируется химерный антигенный рецептор
IL261941B2 (en) 2016-04-01 2023-11-01 Kite Pharma Inc Chimeric antigen and T cell receptors and methods of use
US20190183931A1 (en) * 2016-04-01 2019-06-20 Amgen Inc. Chimeric receptors to flt3 and methods of use thereof
SI3436030T1 (sl) 2016-04-01 2023-01-31 Kite Pharma, Inc. Himerni receptorji in načini njihove uporabe
TWI761831B (zh) * 2016-04-01 2022-04-21 美商凱特製藥公司 嵌合抗原受體(car)和t細胞受體(tcr)及彼等之用途
US12144850B2 (en) 2016-04-08 2024-11-19 Purdue Research Foundation Methods and compositions for car T cell therapy
WO2017192536A1 (en) 2016-05-02 2017-11-09 University Of Kansas Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy
CA3026778A1 (en) * 2016-06-07 2017-12-14 Max-Delbruck-Centrum Fur Molekulare Medizin In Der Helmholtz-Gemeinschaft Chimeric antigen receptor and car-t cells that bind bcma
CA3025667A1 (en) * 2016-06-08 2017-12-14 Intrexon Corporation Cd33 specific chimeric antigen receptors
JP7109789B2 (ja) 2016-08-02 2022-08-01 ティーシーアール2 セラピューティクス インク. 融合タンパク質を使用したtcrの再プログラム化のための組成物及び方法
CN110177558B (zh) * 2016-09-16 2025-02-28 贝勒医学院 用于病毒特异性t细胞的活化和扩增的平台
CN112280796A (zh) 2016-10-07 2021-01-29 T细胞受体治疗公司 使用融合蛋白进行t细胞受体重编程的组合物和方法
CA3044593A1 (en) 2016-11-22 2018-05-31 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018102761A1 (en) 2016-12-02 2018-06-07 City Of Hope Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors
WO2018106972A1 (en) * 2016-12-07 2018-06-14 La Jolla Institute For Allergy And Immunology Compositions for cancer treatment and methods and uses for cancer treatment and prognosis
WO2018132427A1 (en) 2017-01-10 2018-07-19 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
EP3579870A4 (en) 2017-02-07 2020-12-30 Seattle Children's Hospital (DBA Seattle Children's Research Institute) PHOSPHOLIPID ETHER (PLE) T CAR-LYMPHOCYTE TUMOR (CTCT) TARGETING AGENTS
CN108395481B (zh) * 2017-02-08 2021-02-05 西比曼生物科技(香港)有限公司 一种靶向cd20的car的构建及其工程化t细胞的活性鉴定
US12083148B2 (en) * 2017-02-22 2024-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. IL13Ra2-binding chimeric antigen receptors
US11850262B2 (en) 2017-02-28 2023-12-26 Purdue Research Foundation Compositions and methods for CAR T cell therapy
EP3604344A4 (en) * 2017-03-27 2021-01-06 Noile-Immune Biotech, Inc. CHEMICAL ANTIGENIC RECEPTOR
WO2018191748A1 (en) 2017-04-14 2018-10-18 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
EP3612210A4 (en) 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System MANIPULATED ANTIGEN RECEPTORS EXPRESSING IMMUNE CELLS
CN107267555B (zh) * 2017-05-27 2020-03-20 上海优卡迪生物医药科技有限公司 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用
JP7391831B2 (ja) * 2017-08-11 2023-12-05 シティ・オブ・ホープ Car t細胞標的を発現する腫瘍溶解性ウイルス、及びその使用
EP3694558B1 (en) 2017-10-10 2024-04-10 Medicenna Therapeutics Inc. Il-4-fusion formulations for treatment of central nervous system (cns) tumors
AU2018362014A1 (en) * 2017-11-03 2020-05-28 Sorrento Therapeutics, Inc. CD38-directed chimeric antigen receptor constructs
WO2019094498A1 (en) * 2017-11-07 2019-05-16 City Of Hope Treatment of cns lymphoma and systemic lymphoma with intracerebroventricularly administered cd19 car
CN109971721B (zh) * 2017-12-28 2023-10-31 上海细胞治疗研究院 自表达cd47抗体的间皮素特异性car-t细胞及其用途
CN109971712B (zh) * 2017-12-28 2023-06-20 上海细胞治疗研究院 特异性靶向cd19抗原且高水平稳定表达pd-1抗体的car-t细胞及用途
CA3089051A1 (en) 2018-01-22 2019-07-25 Endocyte, Inc. Methods of use for car t cells
EP3743445A1 (en) * 2018-01-26 2020-12-02 City of Hope Chimeric antigen receptors and methods for reducing off target toxicity
EP3749695A4 (en) * 2018-02-06 2021-12-29 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
WO2019157533A1 (en) * 2018-02-12 2019-08-15 The General Hospital Corporation Chimeric antigen receptors targeting the tumor microenvironment
CN111918661A (zh) 2018-02-21 2020-11-10 得克萨斯大学体系董事会 用于活化和扩增自然杀伤细胞的方法及其用途
AU2019225174B2 (en) 2018-02-23 2025-11-20 Endocyte, Inc. Sequencing method for CAR T cell therapy
EA202091984A1 (ru) * 2018-03-14 2021-02-18 Сиэтл Чилдрен'С Хоспитал (Дба Сиэтл Чилдрен'С Ресёрч Инститьют) Направленная дзетакинами т-клеточная иммунотерапия, нацеленная на рецептор il-13 альфа 2
CA3093810A1 (en) * 2018-03-14 2019-09-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Il-13 receptor alpha 2 (il13ra2) chimeric antigen receptor for tumor specific t cell immunotherapy
AU2019249215A1 (en) 2018-04-06 2020-10-22 The Regents Of The University Of California Methods of treating EGFRvIII expressing glioblastomas
US12090170B2 (en) 2018-04-06 2024-09-17 The Regents Of The University Of California Methods of treating glioblastomas
KR20210013691A (ko) * 2018-05-21 2021-02-05 바이오셉터 (유케이) 리미티드 수정된 링커 도메인을 갖는 키메라 항원 수용체 및 그 용도
CA3102097A1 (en) * 2018-06-01 2019-12-05 The Board Of Trustees Of The Leland Stanford Junior Unversity Il-13/il-4 superkines: immune cell targeting constructs and methods of use thereof
WO2019239213A2 (en) 2018-06-01 2019-12-19 Medicenna Therapeutics Inc. Uses and methods for oncolytic virus targeting of il-4/il-13 and fusions thereof
US12281151B2 (en) 2018-06-29 2025-04-22 City Of Hope CD6 targeted chimeric antigen receptors for treatment of certain autoimmune disorders
CN113260369B (zh) * 2018-08-10 2024-08-23 优特力克斯有限公司 癌抗原特异性细胞毒性t细胞
SG11202104287RA (en) * 2018-11-06 2021-05-28 Univ Washington Chimeric antigen receptor memory-like (carml) nk cells and methods of making and using same
WO2020191336A1 (en) 2019-03-21 2020-09-24 Yamaguchi, Yukiko Composition and method for reducing expression of checkpoint inhibitors in t cells expressing a car or ctl
US20220145252A1 (en) 2019-03-29 2022-05-12 City Of Hope Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors
JP2022533247A (ja) * 2019-05-24 2022-07-21 シティ・オブ・ホープ Ccr4陽性悪性腫瘍治療用ccr4標的化キメラ抗原受容体修飾t細胞
WO2021004400A1 (zh) * 2019-07-06 2021-01-14 苏州克睿基因生物科技有限公司 一种表达cd3抗体受体复合物的免疫细胞及其用途
CN112204135A (zh) * 2019-07-06 2021-01-08 苏州克睿基因生物科技有限公司 一种表达cd3抗体受体复合物的免疫细胞及其用途
KR20220038397A (ko) * 2019-07-24 2022-03-28 리제너론 파아마슈티컬스, 인크. Mage-a4 특이성을 갖는 키메라 항원 수용체 및 이들의 용도
EP3769816A1 (en) * 2019-07-25 2021-01-27 Ospedale Pediatrico Bambino Gesù Car-cd123 vector and uses thereof
WO2021138454A1 (en) 2019-12-30 2021-07-08 City Of Hope Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers
WO2021154543A2 (en) 2020-01-31 2021-08-05 City Of Hope TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF IL13Rα2 POSITIVE MALIGNANCIES
WO2021183755A1 (en) * 2020-03-11 2021-09-16 City Of Hope Dual-targeting chimeric antigen receptor modified t cells comprising il-13 and chlorotoxin for cancer treatment
EP4118106A1 (en) * 2020-03-12 2023-01-18 City of Hope TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF IL13Ralpha2 POSITIVE MALIGNANCIES
EP4143300A1 (en) 2020-04-28 2023-03-08 Lyell Immunopharma, Inc. Methods for culturing cells
CA3184784A1 (en) * 2020-05-27 2021-12-02 The Medical College Of Wisconsin, Inc. Improved lentiviral vector transfer plasmid and methods of use
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
MX2023001771A (es) * 2020-08-11 2023-04-25 Yeda Res & Dev Celulas car-t de veto.
IL301233A (en) * 2020-09-10 2023-05-01 Mustang Bio Inc Combination therapy comprising cancer-targeted car-t cells and a method of using same for a treatment for cancer
US20240009239A1 (en) * 2020-11-04 2024-01-11 Fred Hutchinson Cancer Center Therapeutic targeting of mesothelin in acute myeloid leukemia with chimeric antigen receptor t cell therapy
WO2022109498A1 (en) 2020-11-23 2022-05-27 City Of Hope Engineered t cells for expression of chimeric anitgen receptors
WO2022120334A1 (en) 2020-12-03 2022-06-09 Century Therapeutics, Inc. Genetically engineered cells and uses thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
AU2021401052A1 (en) 2020-12-18 2023-06-22 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN118146395A (zh) * 2021-02-08 2024-06-07 浙江大学 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体
CA3172530A1 (en) 2021-02-25 2022-09-01 Spencer PARK Ror1 targeting chimeric antigen receptor
WO2022198027A1 (en) * 2021-03-18 2022-09-22 The Wistar Institute Of Anatomy And Biology DNA-ENCODED BISPECIFIC ANTIBODIES TARGETING IL13Rα2 AND METHODS OF USE IN CANCER THERAPEUTICS
CN117242090A (zh) 2021-03-30 2023-12-15 希望之城公司 CAR T细胞疗法和IFNγ
US20230190799A1 (en) * 2021-07-21 2023-06-22 City Of Hope Chimeric antigen receptor t cells targeting cea and anti-cea-il2 immunocytokines for cancer therapy
CN113621077B (zh) * 2021-09-02 2023-01-31 山东大学 一种tim-3/cd28融合蛋白及所述融合蛋白修饰的car-t细胞
EP4176895A1 (en) * 2021-11-08 2023-05-10 AvenCell Europe GmbH Targeting modules against il13ra2 or her2 for use in combination with a chimeric antigen receptor
WO2023130462A1 (zh) * 2022-01-10 2023-07-13 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的嵌合抗原受体及其用途
CN115960257B (zh) * 2022-09-29 2023-10-27 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的经优化的嵌合抗原受体及其用途
EP4588939A1 (en) 2024-01-16 2025-07-23 Universitat de Barcelona Interleukin-13 receptor subunit alpha-2 (il13ralpha2) targeting moieties for the treatment and prevention of il13ralpha2-positive cancer

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0517895B1 (en) 1990-12-14 1996-11-20 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
RU2167676C2 (ru) * 1995-02-24 2001-05-27 Дзе Дженерал Хоспитал Корпорейшн Перенаправление клеточного иммунитета посредством химерных рецепторов
GB9526131D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Recombinant chimeric receptors
US6576232B1 (en) 1998-04-03 2003-06-10 The Penn State Research Foundation IL13 mutants
ATE292473T1 (de) 1998-07-30 2005-04-15 Us Gov Health & Human Serv Thymosin beta 4 stimuliert wundheilung
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
EP1263785A2 (en) * 1999-11-11 2002-12-11 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Mutated il-13 molecules and their uses
US7560280B2 (en) 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US7514537B2 (en) 2001-04-30 2009-04-07 City Of Hope Chimeric immunoreceptor useful in treating human gliomas
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US11278594B2 (en) * 2001-04-30 2022-03-22 City Of Hope Chimeric immunoreceptor useful in treating human cancers
AU2002256390B2 (en) 2001-04-30 2007-08-30 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
ATE373904T1 (de) 2003-07-24 2007-10-15 Matsushita Electric Industrial Co Ltd Verfahren, kodierer und kommunikationsvorrichtung zur kodierung von parallel verketteten daten
US20050113564A1 (en) 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
US7754441B2 (en) * 2003-11-17 2010-07-13 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
DE102004043271A1 (de) * 2004-09-07 2006-03-09 Linde Ag Verfahren zur Synthese von Zirkoniumcarboxylaten
US20060269973A1 (en) * 2004-11-24 2006-11-30 Cassian Yee Methods of using IL-21 for adoptive immunotherapy and identification of tumor antigens
CN101346463B (zh) * 2005-12-21 2012-06-13 江苏太瑞生诺生物医药科技有限公司 用于癌患者免疫治疗的瘤反应性t-淋巴细胞扩增的改善方法
US20080293070A1 (en) 2005-12-21 2008-11-27 Rafick-Pierre Sekaly Markers for Memory T Cells and Uses Thereof
PL2126054T3 (pl) 2007-01-31 2017-01-31 Yeda Research And Development Company Limited Przekierowane, genetycznie modyfikowane regulatorowe komórki T i ich zastosowanie w hamowaniu choroby autoimmunologicznej i zapalnej
CN101842387B (zh) * 2007-09-26 2014-05-07 Ucb医药有限公司 双特异性抗体融合物
ES2553421T3 (es) * 2008-08-26 2015-12-09 City Of Hope Método y composiciones para el funcionamiento potenciado del efector antitumoral de células T
US20130011401A1 (en) * 2009-12-22 2013-01-10 Novartis Ag Soluble proteins for use as therapeutics
GB2481983A (en) * 2010-07-12 2012-01-18 Hart Fenton & Co Ltd A ship including a gas tank room
US20130164272A1 (en) 2010-08-18 2013-06-27 Udai S. Kammula Methods of identifying central memory t cells and obtaining antigen-specific t cell populations
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
SG193591A1 (en) * 2011-03-23 2013-10-30 Hutchinson Fred Cancer Res Method and compositions for cellular immunotherapy
BR112013024574B1 (pt) * 2011-03-29 2022-08-09 Roche Glycart Ag Anticorpo e uso do anticorpo
EP2532740A1 (en) 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
CA2861491C (en) * 2012-02-13 2020-08-25 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
KR102264290B1 (ko) * 2012-08-20 2021-06-10 프레드 헛친슨 켄서 리서치 센터 세포 면역요법을 위한 방법 및 조성물
US9657105B2 (en) * 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
CN113307880B (zh) * 2014-01-13 2025-07-04 希望之城公司 在Fc间隔物区中具有突变的嵌合抗原受体(CAR)及其使用方法
IL308324A (en) 2014-09-19 2024-01-01 Hope City IL13RA2-targeted chimeric antigen receptor T cells

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