JP6657195B2 - L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 - Google Patents

L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 Download PDF

Info

Publication number
JP6657195B2
JP6657195B2 JP2017515139A JP2017515139A JP6657195B2 JP 6657195 B2 JP6657195 B2 JP 6657195B2 JP 2017515139 A JP2017515139 A JP 2017515139A JP 2017515139 A JP2017515139 A JP 2017515139A JP 6657195 B2 JP6657195 B2 JP 6657195B2
Authority
JP
Japan
Prior art keywords
cells
amino acid
car
seq
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2017515139A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017534262A (ja
JP2017534262A5 (enExample
Inventor
イー ブラウン,クリスティン
イー ブラウン,クリスティン
ジェイ フォーマン,スティーブン
ジェイ フォーマン,スティーブン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
City of Hope
Original Assignee
City of Hope
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55533940&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP6657195(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by City of Hope filed Critical City of Hope
Publication of JP2017534262A publication Critical patent/JP2017534262A/ja
Publication of JP2017534262A5 publication Critical patent/JP2017534262A5/ja
Priority to JP2020017583A priority Critical patent/JP6986190B2/ja
Application granted granted Critical
Publication of JP6657195B2 publication Critical patent/JP6657195B2/ja
Priority to JP2021169396A priority patent/JP7171871B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/5437IL-13
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/30Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31Chimeric antigen receptors [CAR]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/421Immunoglobulin superfamily
    • A61K40/4211CD19 or B4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/42Cancer antigens
    • A61K40/4202Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214Receptors for cytokines
    • A61K40/4217Receptors for interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/7051T-cell receptor (TcR)-CD3 complex
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70514CD4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70517CD8
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564Selectins, e.g. CD62
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47Brain; Nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/01Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/33Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2017515139A 2014-09-19 2015-09-18 L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞 Active JP6657195B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020017583A JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2021169396A JP7171871B2 (ja) 2014-09-19 2021-10-15 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053068P 2014-09-19 2014-09-19
US62/053,068 2014-09-19
PCT/US2015/051089 WO2016044811A1 (en) 2014-09-19 2015-09-18 COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020017583A Division JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞

Publications (3)

Publication Number Publication Date
JP2017534262A JP2017534262A (ja) 2017-11-24
JP2017534262A5 JP2017534262A5 (enExample) 2018-10-25
JP6657195B2 true JP6657195B2 (ja) 2020-03-04

Family

ID=55533940

Family Applications (7)

Application Number Title Priority Date Filing Date
JP2017515139A Active JP6657195B2 (ja) 2014-09-19 2015-09-18 L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2017515138A Active JP6711819B2 (ja) 2014-09-19 2015-09-21 養子t細胞療法のためのセントラルメモリーt細胞
JP2020017583A Active JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2020093109A Active JP7216045B2 (ja) 2014-09-19 2020-05-28 養子t細胞療法のためのセントラルメモリーt細胞
JP2021169396A Active JP7171871B2 (ja) 2014-09-19 2021-10-15 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞
JP2022176776A Pending JP2023014100A (ja) 2014-09-19 2022-11-02 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2023006410A Ceased JP2023052506A (ja) 2014-09-19 2023-01-19 養子t細胞療法のためのセントラルメモリーt細胞

Family Applications After (6)

Application Number Title Priority Date Filing Date
JP2017515138A Active JP6711819B2 (ja) 2014-09-19 2015-09-21 養子t細胞療法のためのセントラルメモリーt細胞
JP2020017583A Active JP6986190B2 (ja) 2014-09-19 2020-02-05 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2020093109A Active JP7216045B2 (ja) 2014-09-19 2020-05-28 養子t細胞療法のためのセントラルメモリーt細胞
JP2021169396A Active JP7171871B2 (ja) 2014-09-19 2021-10-15 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞
JP2022176776A Pending JP2023014100A (ja) 2014-09-19 2022-11-02 IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞L13Rα2を標的とする共刺激性キメラ抗原レセプターT細胞
JP2023006410A Ceased JP2023052506A (ja) 2014-09-19 2023-01-19 養子t細胞療法のためのセントラルメモリーt細胞

Country Status (14)

Country Link
US (3) US9914909B2 (enExample)
EP (4) EP3194433B1 (enExample)
JP (7) JP6657195B2 (enExample)
KR (3) KR102683584B1 (enExample)
CN (4) CN113789336B (enExample)
AU (4) AU2015317351B2 (enExample)
BR (3) BR112017005631A2 (enExample)
CA (2) CA2961654A1 (enExample)
DK (1) DK3200591T3 (enExample)
ES (2) ES2738705T3 (enExample)
IL (6) IL308324A (enExample)
MX (4) MX387135B (enExample)
RU (2) RU2749922C2 (enExample)
WO (2) WO2016044811A1 (enExample)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN2015KN00329A (enExample) 2012-08-09 2015-07-10 Univ Leland Stanford Junior
US20150320799A1 (en) 2012-12-20 2015-11-12 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
US9657105B2 (en) 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
CA3180148A1 (en) 2013-09-24 2015-04-02 Medicenna Therapeutics, Inc. Interleukin-4 receptor-binding fusion proteins and uses thereof
CN113789336B (zh) * 2014-09-19 2025-12-16 希望之城公司 靶向IL13Rα2的共刺激嵌合抗原受体T细胞
PT3298033T (pt) 2015-05-18 2020-09-22 Tcr2 Therapeutics Inc Composições e utilizações médicas para reprogramação de tcr utilizando proteínas de fusão
CN108348550A (zh) 2015-07-21 2018-07-31 希望之城公司 用于表达嵌合抗原受体和其它受体的t细胞
AU2016301932B2 (en) * 2015-08-05 2020-02-27 CellabMED Inc. Chimeric antigen receptor, and T cells in which chimeric antigen receptor is expressed
SI3436079T1 (sl) 2016-04-01 2022-01-31 Kite Pharma, Inc. Himerni antigen in T celični receptorji ter način uporabe
KR102522622B1 (ko) * 2016-04-01 2023-04-18 카이트 파마 인코포레이티드 Bcma 결합 분자 및 그의 사용 방법
ES2930058T3 (es) 2016-04-01 2022-12-05 Kite Pharma Inc Receptores quiméricos y métodos de uso de los mismos
PH12018502118B1 (en) * 2016-04-01 2024-02-23 Amgen Inc Chimeric receptors to flt3 and methods of use thereof
CA3019835A1 (en) 2016-04-08 2017-10-12 Purdue Research Foundation Methods and compositions for car t cell therapy
WO2017192536A1 (en) 2016-05-02 2017-11-09 University Of Kansas Eliminating mhc restriction from the t cell receptor as a strategy for immunotherapy
AU2017276706B2 (en) * 2016-06-07 2024-08-15 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft Chimeric antigen receptor and CAR-T cells that bind BCMA
CN110191898B (zh) * 2016-06-08 2024-05-10 英特瑞克斯顿股份有限公司 Cd33特异性嵌合抗原受体
CA3032498A1 (en) 2016-08-02 2018-02-08 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20190194619A1 (en) * 2016-09-16 2019-06-27 Baylor College Of Medicine Platform for activation and expansion of virus-specific t-cells
CN109689686B (zh) 2016-10-07 2020-08-25 T细胞受体治疗公司 使用融合蛋白进行t细胞受体重编程的组合物和方法
EP3544996A2 (en) 2016-11-22 2019-10-02 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2018102761A1 (en) 2016-12-02 2018-06-07 City Of Hope Methods for manufacturing and expanding t cells expressing chimeric antigen receptors and other receptors
US20200078401A1 (en) * 2016-12-07 2020-03-12 La Jolla Institute For Allergy And Immunology Compositions for cancer treatment and methods and uses for cancer treatment and prognosis
US12473343B2 (en) 2017-01-10 2025-11-18 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
AU2018219226B2 (en) 2017-02-07 2024-12-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
CN108395481B (zh) * 2017-02-08 2021-02-05 西比曼生物科技(香港)有限公司 一种靶向cd20的car的构建及其工程化t细胞的活性鉴定
US12083148B2 (en) * 2017-02-22 2024-09-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. IL13Ra2-binding chimeric antigen receptors
ES3010559T3 (en) 2017-02-28 2025-04-03 Endocyte Inc Compositions and methods for car t cell therapy
US20210122831A1 (en) * 2017-03-27 2021-04-29 Noile-Immune Biotech, Inc. Chimeric antigen receptor
CN110520524A (zh) 2017-04-14 2019-11-29 综合医院公司 靶向肿瘤微环境的嵌合抗原受体t细胞
AU2018256436B2 (en) * 2017-04-19 2024-12-05 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
CN107267555B (zh) * 2017-05-27 2020-03-20 上海优卡迪生物医药科技有限公司 一种基于octs技术的恶性胶质瘤car-t治疗载体及其构建方法和应用
JP7391831B2 (ja) * 2017-08-11 2023-12-05 シティ・オブ・ホープ Car t細胞標的を発現する腫瘍溶解性ウイルス、及びその使用
AU2018347796B2 (en) 2017-10-10 2025-07-24 Medicenna Therapeutics, Inc. IL-4-fusion formulations for treatment of central nervous system (CNS) tumors
AU2018362014A1 (en) * 2017-11-03 2020-05-28 Sorrento Therapeutics, Inc. CD38-directed chimeric antigen receptor constructs
EP3707246B1 (en) * 2017-11-07 2023-06-07 City of Hope Treatment of cns lymphoma and systemic lymphoma with intracerebroventricularly administered cd19 car
CN109971721B (zh) * 2017-12-28 2023-10-31 上海细胞治疗研究院 自表达cd47抗体的间皮素特异性car-t细胞及其用途
CN109971712B (zh) * 2017-12-28 2023-06-20 上海细胞治疗研究院 特异性靶向cd19抗原且高水平稳定表达pd-1抗体的car-t细胞及用途
AU2019209432B2 (en) 2018-01-22 2026-01-08 Seattle Children's Hospital (dba Seattle Children's Research Institute) Methods of use for CAR T cells
EP3743445A1 (en) * 2018-01-26 2020-12-02 City of Hope Chimeric antigen receptors and methods for reducing off target toxicity
AU2019218729B2 (en) * 2018-02-06 2025-12-04 Seattle Children's Hospital (dba Seattle Children's Research Institute) Fluorescein-specific CARs exhibiting optimal T cell function against FL-PLE labelled tumors
EP3752170A4 (en) * 2018-02-12 2022-03-30 The General Hospital Corporation CHEMERA ANTIGEN RECEPTORS TARGETING THE MICROENVIRONMENT
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
TW202000229A (zh) 2018-02-23 2020-01-01 美商安德賽特公司 Car t細胞療法之順序方法
CA3093810A1 (en) * 2018-03-14 2019-09-19 Seattle Children's Hospital (dba Seattle Children's Research Institute) Il-13 receptor alpha 2 (il13ra2) chimeric antigen receptor for tumor specific t cell immunotherapy
AU2019234580B2 (en) * 2018-03-14 2024-02-01 Seattle Children's Hospital D/B/A Seattle Children's Research Institute IL-13 receptor alpha 2 targeted, zetakine directed T cell immunotherapy
AU2019249215A1 (en) 2018-04-06 2020-10-22 The Regents Of The University Of California Methods of treating EGFRvIII expressing glioblastomas
WO2019195596A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
EP3797164A4 (en) * 2018-05-21 2022-03-02 Biosceptre (Aust) Pty Ltd CHEMERA ANTIGEN RECEPTORS WITH MODIFIED BINDING DOMAINS AND USES THEREOF
WO2019239213A2 (en) 2018-06-01 2019-12-19 Medicenna Therapeutics Inc. Uses and methods for oncolytic virus targeting of il-4/il-13 and fusions thereof
CN118108857A (zh) * 2018-06-01 2024-05-31 利兰斯坦福初级大学董事会 免疫细胞靶向性构建体
US12281151B2 (en) 2018-06-29 2025-04-22 City Of Hope CD6 targeted chimeric antigen receptors for treatment of certain autoimmune disorders
EP3834833A4 (en) * 2018-08-10 2022-05-18 Eutilex Co., Ltd. CANCER ANTIGEN-SPECIFIC CYTOTOXIC T-CELLS
EP3876961A4 (en) * 2018-11-06 2023-01-25 Washington University CHIMERIC ANTIGEN RECEPTOR MEMORY-LIKE (CARML) NK CELLS AND METHODS FOR THEIR PRODUCTION AND USE
US20230065784A1 (en) 2019-03-21 2023-03-02 City Of Hope Composition and method for reducing expression of checkpoint inhibitors in t cells expressing a car or ctl
WO2020205751A1 (en) 2019-03-29 2020-10-08 City Of Hope Methods for manufacturing t cells expressing of chimeric antigen receptors and other receptors
CA3141812A1 (en) * 2019-05-24 2020-12-03 City Of Hope Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies
CN112204135A (zh) * 2019-07-06 2021-01-08 苏州克睿基因生物科技有限公司 一种表达cd3抗体受体复合物的免疫细胞及其用途
WO2021004400A1 (zh) * 2019-07-06 2021-01-14 苏州克睿基因生物科技有限公司 一种表达cd3抗体受体复合物的免疫细胞及其用途
CN114174345B (zh) * 2019-07-24 2024-11-26 瑞泽恩制药公司 具有mage-a4特异性的嵌合抗原受体和其用途
EP3769816A1 (en) * 2019-07-25 2021-01-27 Ospedale Pediatrico Bambino Gesù Car-cd123 vector and uses thereof
WO2021138454A1 (en) 2019-12-30 2021-07-08 City Of Hope Methods of making and using regulatory t cells and effector t cells having chimeric antigen receptors targeted to cd6, cd19, and/or an il-13r for treatment of autoimmune disorders and cancers
JP2023512250A (ja) * 2020-01-31 2023-03-24 シティ・オブ・ホープ IL13Rα2陽性悪性腫瘍の治療のための標的キメラ抗原受容体修飾T細胞
US20230374085A1 (en) * 2020-03-11 2023-11-23 City Of Hope Dual-targeting chimeric antigen receptor modified t cells comprising il-13 and chlorotoxin for cancer treatment
WO2021183960A1 (en) * 2020-03-12 2021-09-16 City Of Hope TARGETED CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS FOR TREATMENT OF IL13RαA2 POSITIVE MALIGNANCIES
JP2023524047A (ja) 2020-04-28 2023-06-08 ライエル・イミュノファーマ・インコーポレイテッド 細胞の培養方法
US20230220419A1 (en) * 2020-05-27 2023-07-13 The Medical College Of Wisconsin, Inc. Improved Lentiviral Vector Transfer Plasmid and Methods of Use
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
AU2021323525A1 (en) * 2020-08-11 2023-04-20 Ichilov Tech Ltd. Veto CAR-T cells
CN116963759A (zh) * 2020-09-10 2023-10-27 野马生物股份有限公司 包含靶向癌症的car-t细胞的组合疗法及使用其治疗癌症的方法
WO2022098797A1 (en) * 2020-11-04 2022-05-12 Fred Hutchinson Cancer Research Center Therapeutic targeting of mesothelin in acute myeloid leukemia with chimeric antigen receptor t cell therapy
US20230364138A1 (en) 2020-11-23 2023-11-16 City Of Hope Engineered t cells for expression of chimeric anitgen receptors
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
KR20230118887A (ko) 2020-12-03 2023-08-14 센츄리 쎄라퓨틱스 인코포레이티드 유전자 조작 세포 및 이의 용도
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
CN114907485B (zh) * 2021-02-08 2024-04-26 浙江大学 一种以内源性蛋白质分子替代单结构域抗体的嵌合抗原受体
AU2022227686A1 (en) 2021-02-25 2023-07-27 Lyell Immunopharma, Inc. Ror1 targeting chimeric antigen receptor
KR20230175198A (ko) * 2021-03-18 2023-12-29 더 위스타 인스티튜트 오브 아나토미 앤드 바이올로지 IL13Rα2를 표적으로 하는 DNA 암호화 이중특이적 항체 및 이를 암 치료에 사용하는 방법
EP4314040A2 (en) 2021-03-30 2024-02-07 City of Hope Car t cell therapy and ifn gamma
US20230190799A1 (en) * 2021-07-21 2023-06-22 City Of Hope Chimeric antigen receptor t cells targeting cea and anti-cea-il2 immunocytokines for cancer therapy
CN113621077B (zh) * 2021-09-02 2023-01-31 山东大学 一种tim-3/cd28融合蛋白及所述融合蛋白修饰的car-t细胞
EP4176895A1 (en) * 2021-11-08 2023-05-10 AvenCell Europe GmbH Targeting modules against il13ra2 or her2 for use in combination with a chimeric antigen receptor
WO2023130462A1 (zh) * 2022-01-10 2023-07-13 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的嵌合抗原受体及其用途
CN115960257B (zh) * 2022-09-29 2023-10-27 卡瑞济(北京)生命科技有限公司 靶向IL13Rα2的经优化的嵌合抗原受体及其用途
EP4588939A1 (en) 2024-01-16 2025-07-23 Universitat de Barcelona Interleukin-13 receptor subunit alpha-2 (il13ralpha2) targeting moieties for the treatment and prevention of il13ralpha2-positive cancer

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992010591A1 (en) 1990-12-14 1992-06-25 Cell Genesys, Inc. Chimeric chains for receptor-associated signal transduction pathways
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
CA2209300C (en) * 1995-02-24 2011-06-28 The General Hospital Corporation Redirection of cellular immunity by receptor chimeras
GB9526131D0 (en) 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Recombinant chimeric receptors
US6576232B1 (en) 1998-04-03 2003-06-10 The Penn State Research Foundation IL13 mutants
CA2338928A1 (en) 1998-07-30 2000-02-10 Hynda K. Kleinman Thymosin .beta.4 promotes wound repair
WO2000023573A2 (en) 1998-10-20 2000-04-27 City Of Hope Cd20-specific redirected t cells and their use in cellular immunotherapy of cd20+ malignancies
CA2404763A1 (en) * 1999-11-11 2001-05-17 Raj K. Puri Mutated il-13 molecules and their uses
US7560280B2 (en) 2000-11-03 2009-07-14 Kourion Therapeutics Gmbh Human cord blood derived unrestricted somatic stem cells (USSC)
US7070995B2 (en) 2001-04-11 2006-07-04 City Of Hope CE7-specific redirected immune cells
US11278594B2 (en) * 2001-04-30 2022-03-22 City Of Hope Chimeric immunoreceptor useful in treating human cancers
JP4448282B2 (ja) 2001-04-30 2010-04-07 シティ・オブ・ホープ ヒト癌を処置するのに有用なキメライムノレセプター
US7514537B2 (en) * 2001-04-30 2009-04-07 City Of Hope Chimeric immunoreceptor useful in treating human gliomas
US20090257994A1 (en) 2001-04-30 2009-10-15 City Of Hope Chimeric immunoreceptor useful in treating human cancers
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
EP1501226B1 (en) 2003-07-24 2007-09-19 Matsushita Electric Industrial Co., Ltd. Method, encoder and communication device for encoding parallel concatenated data
US20050113564A1 (en) 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
US7754441B2 (en) * 2003-11-17 2010-07-13 Genentech, Inc. Compositions and methods for the treatment of tumor of hematopoietic origin
DE102004043271A1 (de) * 2004-09-07 2006-03-09 Linde Ag Verfahren zur Synthese von Zirkoniumcarboxylaten
PL1814580T3 (pl) * 2004-11-24 2017-03-31 Fred Hutchinson Cancer Research Center Metody stosowania il-21 do adoptywnej immunoterapii i identyfikacji antygenów guza
NZ569105A (en) * 2005-12-21 2011-07-29 Sentoclone Internat Ab A method for the expansion of tumor-reactive CD4 positive T-helper and CD positive T-lymphocytes
CA2634072A1 (en) * 2005-12-21 2007-06-28 Universite De Montreal Markers for memory t cells and uses thereof
WO2008095141A2 (en) 2007-01-31 2008-08-07 Yeda Research And Development Co. Ltd. Redirected, genetically-engineered t regulatory cells and their use in suppression of autoimmune and inflammatory disease
ES2622460T3 (es) * 2007-09-26 2017-07-06 Ucb Biopharma Sprl Fusiones de anticuerpos con doble especificidad
HRP20211788T1 (hr) * 2008-08-26 2022-02-18 City Of Hope Postupak i pripravci za poboljšanje anti-tumorskog efektorskog funkcioniranja t stanica
BR112012017164A2 (pt) * 2009-12-22 2019-09-24 Novartis Ag proteína de fusão de região constante de anticorpo-cd47 tetravalente
GB2481983A (en) * 2010-07-12 2012-01-18 Hart Fenton & Co Ltd A ship including a gas tank room
WO2012024203A1 (en) * 2010-08-18 2012-02-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of identifying central memory t cells and obtaining antigen-specific t cell populations
PH12013501201A1 (en) * 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
SG10201602253SA (en) * 2011-03-23 2016-05-30 Hutchinson Fred Cancer Res Method and compositions for cellular immunotherapy
BR112013024574B1 (pt) * 2011-03-29 2022-08-09 Roche Glycart Ag Anticorpo e uso do anticorpo
EP2532740A1 (en) * 2011-06-11 2012-12-12 Michael Schmück Antigen-specific CD4+ and CD8+ central-memory T cell preparations for adoptive T cell therapy
WO2013123061A1 (en) * 2012-02-13 2013-08-22 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
BR112015002816A8 (pt) * 2012-08-20 2023-04-18 Hutchinson Fred Cancer Res Método e composições para imunoterapia celular
US9657105B2 (en) * 2013-03-15 2017-05-23 City Of Hope CD123-specific chimeric antigen receptor redirected T cells and methods of their use
EP3626748A1 (en) * 2014-01-13 2020-03-25 Stephen J. Forman Chimeric antigen receptors (cars) having mutations in the fc spacer region and methods for their use
CN113789336B (zh) 2014-09-19 2025-12-16 希望之城公司 靶向IL13Rα2的共刺激嵌合抗原受体T细胞

Also Published As

Publication number Publication date
EP3200591B2 (en) 2024-09-25
US10676717B2 (en) 2020-06-09
EP3200591A4 (en) 2018-04-04
CN113789336B (zh) 2025-12-16
RU2017111298A (ru) 2018-10-19
ES2876235T5 (en) 2025-02-12
ES2876235T3 (es) 2021-11-12
JP2023014100A (ja) 2023-01-26
EP3194433B1 (en) 2019-05-22
IL308324A (en) 2024-01-01
RU2017111298A3 (enExample) 2019-03-13
MX2017003596A (es) 2017-10-20
MX2021012720A (es) 2022-01-06
KR102683584B1 (ko) 2024-07-10
CN107404881B (zh) 2021-07-09
JP7216045B2 (ja) 2023-01-31
JP2017534262A (ja) 2017-11-24
MX383042B (es) 2025-03-13
CA2961654A1 (en) 2016-03-24
EP3200591A1 (en) 2017-08-09
AU2015317351A1 (en) 2017-04-06
CN107002084A (zh) 2017-08-01
JP6711819B2 (ja) 2020-06-17
WO2016044853A8 (en) 2017-04-06
IL280576B (en) 2022-06-01
RU2017111300A3 (enExample) 2019-09-04
RU2763523C2 (ru) 2021-12-30
EP3587446A1 (en) 2020-01-01
AU2015317351B2 (en) 2020-07-02
AU2020203651A1 (en) 2020-06-25
ES2738705T3 (es) 2020-01-24
US9914909B2 (en) 2018-03-13
JP2020156494A (ja) 2020-10-01
NZ730208A (en) 2024-03-22
MX387135B (es) 2025-03-18
CA2961676A1 (en) 2016-03-24
JP7171871B2 (ja) 2022-11-15
CN113637640A (zh) 2021-11-12
MX2021006400A (es) 2021-07-15
BR112017005631A2 (pt) 2018-06-26
JP6986190B2 (ja) 2021-12-22
BR112017005630A2 (pt) 2018-06-26
EP3194433A1 (en) 2017-07-26
KR20170054509A (ko) 2017-05-17
JP2017529081A (ja) 2017-10-05
IL251196B (en) 2021-02-28
WO2016044853A1 (en) 2016-03-24
US20180265844A1 (en) 2018-09-20
WO2016044811A1 (en) 2016-03-24
CN107002084B (zh) 2021-09-10
AU2024201326A1 (en) 2024-04-11
US20160340649A1 (en) 2016-11-24
IL292650B2 (en) 2024-04-01
BR112017005630B1 (pt) 2023-12-12
JP2023052506A (ja) 2023-04-11
CN113789336A (zh) 2021-12-14
HK1247046A1 (zh) 2018-09-21
CN107404881A (zh) 2017-11-28
IL280576A (en) 2021-03-25
US20200318069A1 (en) 2020-10-08
IL251196A0 (en) 2017-05-29
RU2017111300A (ru) 2018-10-19
BR122024000360A2 (pt) 2024-02-27
JP2020100626A (ja) 2020-07-02
RU2749922C2 (ru) 2021-06-21
IL251188A0 (en) 2017-05-29
KR102610715B1 (ko) 2023-12-08
DK3200591T3 (da) 2021-06-21
KR20170057351A (ko) 2017-05-24
KR20230169455A (ko) 2023-12-15
IL292650A (en) 2022-07-01
MX2017003557A (es) 2017-10-12
IL292650B1 (en) 2023-12-01
EP3916084A1 (en) 2021-12-01
IL292828A (en) 2022-07-01
AU2021277651A1 (en) 2021-12-23
IL251188B (en) 2022-07-01
EP3200591B1 (en) 2021-03-31
JP2022017333A (ja) 2022-01-25

Similar Documents

Publication Publication Date Title
JP7171871B2 (ja) IL13Rα2を標的とする共刺激性キメラ抗原受容体T細胞
US20230348617A1 (en) Chimeric antigen receptors targeted to psca
JP2021192617A (ja) Her2を標的とするキメラ抗原受容体
HK40020210A (en) Costimulatory chimeric antigen receptor t cells targeting il13 r alpha 2
HK40036816A (en) Chimeric antigen receptors targeted to psca
HK40063401A (en) Chimeric antigen receptors containing a chlorotoxin domain
HK1247046B (zh) 用於过继性t细胞疗法的中央记忆t细胞

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180911

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180911

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190806

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191106

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200107

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200205

R150 Certificate of patent or registration of utility model

Ref document number: 6657195

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250