AU2015317351B2 - Costimulatory chimeric antigen receptor T cells targeting IL3Ra2 - Google Patents

Costimulatory chimeric antigen receptor T cells targeting IL3Ra2 Download PDF

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AU2015317351B2
AU2015317351B2 AU2015317351A AU2015317351A AU2015317351B2 AU 2015317351 B2 AU2015317351 B2 AU 2015317351B2 AU 2015317351 A AU2015317351 A AU 2015317351A AU 2015317351 A AU2015317351 A AU 2015317351A AU 2015317351 B2 AU2015317351 B2 AU 2015317351B2
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cells
amino acid
seq
sequence
car
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AU2015317351A1 (en
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Christine E. BROWN
Stephen J. Forman
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City of Hope
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City of Hope
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/5437—IL-13
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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AU2015317351A 2014-09-19 2015-09-18 Costimulatory chimeric antigen receptor T cells targeting IL3Ra2 Active AU2015317351B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020203651A AU2020203651A1 (en) 2014-09-19 2020-06-03 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2
AU2021277651A AU2021277651A1 (en) 2014-09-19 2021-11-30 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2
AU2024201326A AU2024201326A1 (en) 2014-09-19 2024-02-28 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053068P 2014-09-19 2014-09-19
US62/053,068 2014-09-19
PCT/US2015/051089 WO2016044811A1 (en) 2014-09-19 2015-09-18 COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2

Related Child Applications (1)

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AU2020203651A Division AU2020203651A1 (en) 2014-09-19 2020-06-03 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2

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AU2015317351A1 AU2015317351A1 (en) 2017-04-06
AU2015317351B2 true AU2015317351B2 (en) 2020-07-02

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Application Number Title Priority Date Filing Date
AU2015317351A Active AU2015317351B2 (en) 2014-09-19 2015-09-18 Costimulatory chimeric antigen receptor T cells targeting IL3Ra2
AU2020203651A Abandoned AU2020203651A1 (en) 2014-09-19 2020-06-03 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2
AU2021277651A Abandoned AU2021277651A1 (en) 2014-09-19 2021-11-30 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2
AU2024201326A Abandoned AU2024201326A1 (en) 2014-09-19 2024-02-28 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2020203651A Abandoned AU2020203651A1 (en) 2014-09-19 2020-06-03 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2
AU2021277651A Abandoned AU2021277651A1 (en) 2014-09-19 2021-11-30 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2
AU2024201326A Abandoned AU2024201326A1 (en) 2014-09-19 2024-02-28 Costimulatory Chimeric Antigen Receptor T Cells Targeting IL13Ra2

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US (3) US9914909B2 (enExample)
EP (4) EP3587446A1 (enExample)
JP (7) JP6657195B2 (enExample)
KR (3) KR102683584B1 (enExample)
CN (4) CN113789336B (enExample)
AU (4) AU2015317351B2 (enExample)
BR (3) BR112017005631A2 (enExample)
CA (2) CA2961654A1 (enExample)
DK (1) DK3200591T3 (enExample)
ES (2) ES2738705T3 (enExample)
IL (6) IL292650B2 (enExample)
MX (4) MX387135B (enExample)
RU (2) RU2749922C2 (enExample)
WO (2) WO2016044811A1 (enExample)

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