JP2015533791A5 - - Google Patents
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- JP2015533791A5 JP2015533791A5 JP2015530440A JP2015530440A JP2015533791A5 JP 2015533791 A5 JP2015533791 A5 JP 2015533791A5 JP 2015530440 A JP2015530440 A JP 2015530440A JP 2015530440 A JP2015530440 A JP 2015530440A JP 2015533791 A5 JP2015533791 A5 JP 2015533791A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- amino acid
- acid sequence
- sequence number
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims 4
- 239000013604 expression vector Substances 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306079 | 2012-09-07 | ||
| EP12306079.0 | 2012-09-07 | ||
| PCT/EP2013/068628 WO2014037565A2 (en) | 2012-09-07 | 2013-09-09 | Inhibiting peptides derived from triggering receptor expressed on myeloid cells-1 (trem-1) trem-like transcript 1 (tlt-1) and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533791A JP2015533791A (ja) | 2015-11-26 |
| JP2015533791A5 true JP2015533791A5 (enExample) | 2016-06-02 |
| JP6307080B2 JP6307080B2 (ja) | 2018-04-04 |
Family
ID=46826397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530440A Active JP6307080B2 (ja) | 2012-09-07 | 2013-09-09 | 骨髄細胞に発現する誘発性受容体１（ｔｒｅｍ−１）ｔｒｅｍ様転写産物１（ｔｌｔ−１）に由来する阻害ペプチドおよびその使用 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9657081B2 (enExample) |
| EP (1) | EP2892920B1 (enExample) |
| JP (1) | JP6307080B2 (enExample) |
| KR (1) | KR102181384B1 (enExample) |
| CN (1) | CN104837865B (enExample) |
| AU (1) | AU2013311606B2 (enExample) |
| CA (1) | CA2884121C (enExample) |
| CY (1) | CY1123014T1 (enExample) |
| DK (1) | DK2892920T3 (enExample) |
| ES (1) | ES2797625T3 (enExample) |
| HR (1) | HRP20200875T8 (enExample) |
| HU (1) | HUE051557T2 (enExample) |
| IL (1) | IL237615B (enExample) |
| LT (1) | LT2892920T (enExample) |
| MX (1) | MX385794B (enExample) |
| NZ (1) | NZ705899A (enExample) |
| PL (1) | PL2892920T3 (enExample) |
| PT (1) | PT2892920T (enExample) |
| RS (1) | RS60421B1 (enExample) |
| RU (1) | RU2672341C2 (enExample) |
| SI (1) | SI2892920T1 (enExample) |
| SM (1) | SMT202000309T1 (enExample) |
| WO (1) | WO2014037565A2 (enExample) |
| ZA (1) | ZA201501779B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| CN107949571A (zh) * | 2015-06-12 | 2018-04-20 | 台湾基督长老教会马偕医疗财团法人马偕纪念医院 | 调控免疫反应的方法及抗体 |
| WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| WO2020036987A1 (en) | 2018-08-13 | 2020-02-20 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| EP4065152A1 (en) | 2019-11-25 | 2022-10-05 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Trem-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease |
| CN116490199A (zh) * | 2020-06-05 | 2023-07-25 | 伊诺特伦公司 | 用于治疗患有冠状病毒感染的受试者的trem-1抑制剂 |
| US20230265145A1 (en) | 2020-06-26 | 2023-08-24 | Amgen Inc. | Il-10 muteins and fusion proteins thereof |
| WO2022189659A1 (en) | 2021-03-12 | 2022-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Trem-1 inhibitors for the treatment of marfan syndrome |
| US20240279332A1 (en) | 2021-06-25 | 2024-08-22 | Amgen Inc. | Treatment of Cardiovascular Disease with TREM-1 Antigen Binding Proteins |
| WO2025196177A1 (en) | 2024-03-21 | 2025-09-25 | Institut National de la Santé et de la Recherche Médicale | Use of soluble trem-1 as a biomarker for assessing the risk of cardiovascular disease in asymptomatic subjects |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| CA2156725A1 (en) | 1993-02-22 | 1994-09-01 | Warren S. Pear | Production of high titer helper-free retroviruses by transient transfection |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| PL184617B1 (pl) | 1994-09-12 | 2002-11-29 | Schering Ag | Sposób wytwarzania rekombinacyjnego białka Pallidipiny Asp Pallidipiny rekombinacyjne białko Asp Pallidipina kompozycja farmaceutyczna zastosowanie Asp Pallidipiny sposób oczyszczania Asp Pallidipiny rekombinacyjny wektor gospodarz bakteryjny sposób wytwarzania leku i Asp Pallidipina |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| AU8513901A (en) * | 2000-08-22 | 2002-03-04 | Brigham And Women's Hospital | Diagnosis and treatment of cardiovascular conditions |
| US20040180409A1 (en) * | 2003-03-16 | 2004-09-16 | Mcvicar Daniel | TLT-1, a novel platelet-associated receptor and uses therefor |
| GB0426146D0 (en) * | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| US7553936B2 (en) * | 2006-12-04 | 2009-06-30 | The United States of America as represented by Secretary Department of Health and Human Services | Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions |
| EP2174131A1 (en) | 2007-07-23 | 2010-04-14 | Bioxell S.p.a. | Screening, therapy and diagnosis |
| DE102009018620A1 (de) | 2009-04-27 | 2010-10-28 | Carefusion Germany 234 Gmbh | Ansteuer- und Auswerteschaltung, Messgerät sowie Verfahren zum Messen der Konzentration eines Gases |
| JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| EP3741383A1 (en) | 2010-04-08 | 2020-11-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof |
-
2013
- 2013-09-09 LT LTEP13759234.1T patent/LT2892920T/lt unknown
- 2013-09-09 JP JP2015530440A patent/JP6307080B2/ja active Active
- 2013-09-09 HU HUE13759234A patent/HUE051557T2/hu unknown
- 2013-09-09 PL PL13759234T patent/PL2892920T3/pl unknown
- 2013-09-09 NZ NZ705899A patent/NZ705899A/en unknown
- 2013-09-09 CA CA2884121A patent/CA2884121C/en active Active
- 2013-09-09 HR HRP20200875TT patent/HRP20200875T8/hr unknown
- 2013-09-09 RS RS20200634A patent/RS60421B1/sr unknown
- 2013-09-09 EP EP13759234.1A patent/EP2892920B1/en active Active
- 2013-09-09 US US14/426,562 patent/US9657081B2/en active Active
- 2013-09-09 SI SI201331729T patent/SI2892920T1/sl unknown
- 2013-09-09 SM SM20200309T patent/SMT202000309T1/it unknown
- 2013-09-09 MX MX2015002994A patent/MX385794B/es unknown
- 2013-09-09 PT PT137592341T patent/PT2892920T/pt unknown
- 2013-09-09 AU AU2013311606A patent/AU2013311606B2/en not_active Ceased
- 2013-09-09 KR KR1020157008973A patent/KR102181384B1/ko active Active
- 2013-09-09 ES ES13759234T patent/ES2797625T3/es active Active
- 2013-09-09 CN CN201380058170.9A patent/CN104837865B/zh active Active
- 2013-09-09 RU RU2015112625A patent/RU2672341C2/ru not_active Application Discontinuation
- 2013-09-09 DK DK13759234.1T patent/DK2892920T3/da active
- 2013-09-09 WO PCT/EP2013/068628 patent/WO2014037565A2/en not_active Ceased
-
2015
- 2015-03-08 IL IL237615A patent/IL237615B/en active IP Right Grant
- 2015-03-16 ZA ZA2015/01779A patent/ZA201501779B/en unknown
-
2020
- 2020-06-02 CY CY20201100521T patent/CY1123014T1/el unknown