CN104837865B - 衍生自髓样细胞触发受体-1(trem-1)trem-样转录物1(tlt-1)的抑制肽及其用途 - Google Patents
衍生自髓样细胞触发受体-1(trem-1)trem-样转录物1(tlt-1)的抑制肽及其用途 Download PDFInfo
- Publication number
- CN104837865B CN104837865B CN201380058170.9A CN201380058170A CN104837865B CN 104837865 B CN104837865 B CN 104837865B CN 201380058170 A CN201380058170 A CN 201380058170A CN 104837865 B CN104837865 B CN 104837865B
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- China
- Prior art keywords
- trem
- tlt
- peptide
- seq
- peptides
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306079 | 2012-09-07 | ||
| EP12306079.0 | 2012-09-07 | ||
| PCT/EP2013/068628 WO2014037565A2 (en) | 2012-09-07 | 2013-09-09 | Inhibiting peptides derived from triggering receptor expressed on myeloid cells-1 (trem-1) trem-like transcript 1 (tlt-1) and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104837865A CN104837865A (zh) | 2015-08-12 |
| CN104837865B true CN104837865B (zh) | 2019-09-24 |
Family
ID=46826397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380058170.9A Active CN104837865B (zh) | 2012-09-07 | 2013-09-09 | 衍生自髓样细胞触发受体-1(trem-1)trem-样转录物1(tlt-1)的抑制肽及其用途 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9657081B2 (enExample) |
| EP (1) | EP2892920B1 (enExample) |
| JP (1) | JP6307080B2 (enExample) |
| KR (1) | KR102181384B1 (enExample) |
| CN (1) | CN104837865B (enExample) |
| AU (1) | AU2013311606B2 (enExample) |
| CA (1) | CA2884121C (enExample) |
| CY (1) | CY1123014T1 (enExample) |
| DK (1) | DK2892920T3 (enExample) |
| ES (1) | ES2797625T3 (enExample) |
| HR (1) | HRP20200875T8 (enExample) |
| HU (1) | HUE051557T2 (enExample) |
| IL (1) | IL237615B (enExample) |
| LT (1) | LT2892920T (enExample) |
| MX (1) | MX385794B (enExample) |
| NZ (1) | NZ705899A (enExample) |
| PL (1) | PL2892920T3 (enExample) |
| PT (1) | PT2892920T (enExample) |
| RS (1) | RS60421B1 (enExample) |
| RU (1) | RU2672341C2 (enExample) |
| SI (1) | SI2892920T1 (enExample) |
| SM (1) | SMT202000309T1 (enExample) |
| WO (1) | WO2014037565A2 (enExample) |
| ZA (1) | ZA201501779B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| KR20180012856A (ko) * | 2015-06-12 | 2018-02-06 | 매카이 메디컬 파운데이션 더 프레즈비티리언 처치 인 타이완 매카이 메모리얼 호스피탈 | 면역반응의 조절을 위한 방법 및 폴리펩타이드 |
| US11472877B2 (en) | 2016-03-04 | 2022-10-18 | Alector Llc | Anti-TREM1 antibodies and methods of use thereof |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| EP3836951A1 (en) | 2018-08-13 | 2021-06-23 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| US20230016187A1 (en) * | 2019-11-25 | 2023-01-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Trem-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease |
| CN116490199A (zh) * | 2020-06-05 | 2023-07-25 | 伊诺特伦公司 | 用于治疗患有冠状病毒感染的受试者的trem-1抑制剂 |
| AU2021296917A1 (en) | 2020-06-26 | 2023-02-02 | Amgen Inc. | IL-10 muteins and fusion proteins thereof |
| WO2022189659A1 (en) | 2021-03-12 | 2022-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Trem-1 inhibitors for the treatment of marfan syndrome |
| US20240279332A1 (en) | 2021-06-25 | 2024-08-22 | Amgen Inc. | Treatment of Cardiovascular Disease with TREM-1 Antigen Binding Proteins |
| WO2025196177A1 (en) | 2024-03-21 | 2025-09-25 | Institut National de la Santé et de la Recherche Médicale | Use of soluble trem-1 as a biomarker for assessing the risk of cardiovascular disease in asymptomatic subjects |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006056492A1 (en) * | 2004-11-29 | 2006-06-01 | Bioxell Spa | Therapeutic peptides comprising sequences derived from cdr2 or cdr3 of trem-1 and uses thereof to inhibit sepsis |
| WO2011124685A1 (en) * | 2010-04-08 | 2011-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| DE69434860T2 (de) | 1993-02-22 | 2007-03-15 | The Rockefeller University | Herstellung von helfer-freien retroviren mit hohem titer mittels transienter transfektion |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| US5882887A (en) | 1994-09-12 | 1999-03-16 | Schering Aktiengesellschaft | Process for manufacture of a modified collagen-induced platelet aggregation inhibitor pallidipin |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| RU2002110275A (ru) * | 2000-08-22 | 2004-03-27 | Дзе Брихэм Энд Уимен'З Хоспитал, Инк. (Us) | Диагностика и лечение сердечно-сосудистых состояний |
| US20040180409A1 (en) | 2003-03-16 | 2004-09-16 | Mcvicar Daniel | TLT-1, a novel platelet-associated receptor and uses therefor |
| US7553936B2 (en) * | 2006-12-04 | 2009-06-30 | The United States of America as represented by Secretary Department of Health and Human Services | Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions |
| WO2009013319A1 (en) | 2007-07-23 | 2009-01-29 | Bioxell Spa | Screening, therapy and diagnosis |
| DE102009018620A1 (de) | 2009-04-27 | 2010-10-28 | Carefusion Germany 234 Gmbh | Ansteuer- und Auswerteschaltung, Messgerät sowie Verfahren zum Messen der Konzentration eines Gases |
| JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
-
2013
- 2013-09-09 DK DK13759234.1T patent/DK2892920T3/da active
- 2013-09-09 JP JP2015530440A patent/JP6307080B2/ja active Active
- 2013-09-09 CA CA2884121A patent/CA2884121C/en active Active
- 2013-09-09 WO PCT/EP2013/068628 patent/WO2014037565A2/en not_active Ceased
- 2013-09-09 ES ES13759234T patent/ES2797625T3/es active Active
- 2013-09-09 KR KR1020157008973A patent/KR102181384B1/ko active Active
- 2013-09-09 HR HRP20200875TT patent/HRP20200875T8/hr unknown
- 2013-09-09 EP EP13759234.1A patent/EP2892920B1/en active Active
- 2013-09-09 SM SM20200309T patent/SMT202000309T1/it unknown
- 2013-09-09 HU HUE13759234A patent/HUE051557T2/hu unknown
- 2013-09-09 NZ NZ705899A patent/NZ705899A/en unknown
- 2013-09-09 PT PT137592341T patent/PT2892920T/pt unknown
- 2013-09-09 RS RS20200634A patent/RS60421B1/sr unknown
- 2013-09-09 LT LTEP13759234.1T patent/LT2892920T/lt unknown
- 2013-09-09 CN CN201380058170.9A patent/CN104837865B/zh active Active
- 2013-09-09 AU AU2013311606A patent/AU2013311606B2/en active Active
- 2013-09-09 US US14/426,562 patent/US9657081B2/en active Active
- 2013-09-09 MX MX2015002994A patent/MX385794B/es unknown
- 2013-09-09 PL PL13759234T patent/PL2892920T3/pl unknown
- 2013-09-09 RU RU2015112625A patent/RU2672341C2/ru not_active Application Discontinuation
- 2013-09-09 SI SI201331729T patent/SI2892920T1/sl unknown
-
2015
- 2015-03-08 IL IL237615A patent/IL237615B/en active IP Right Grant
- 2015-03-16 ZA ZA2015/01779A patent/ZA201501779B/en unknown
-
2020
- 2020-06-02 CY CY20201100521T patent/CY1123014T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006056492A1 (en) * | 2004-11-29 | 2006-06-01 | Bioxell Spa | Therapeutic peptides comprising sequences derived from cdr2 or cdr3 of trem-1 and uses thereof to inhibit sepsis |
| WO2011124685A1 (en) * | 2010-04-08 | 2011-10-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Inhibiting peptides derived from trem-like transcript 1 (tlt-1) and uses thereof |
Non-Patent Citations (4)
| Title |
|---|
| Effects of TREM-1 pathway modulation during mesenteric ischemia-reperfusion in rats.;Gibot s et al;《CRITICAL CARE MEDICINE》;20081231;第36卷(第2期);第505-507页，图1-3 * |
| Soluble trem-like transcript-1 regulates leukocyte activation and controls microbial sepsis;Derive m et al;《The Journal of Immunology》;20120601;第188卷(第11期);5585-5592 * |
| Trem-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans;Washington A et al;《Journal of Clinical Investigation》;20090601;第119卷(第6期);1489-1501 * |
| Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases;Derive M et al;《ImmuneRecognition and signaling》;20100731;第1卷(第3期);225-230 * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |