CY1123014T1 - Αναστολη των πεπτιδιων που προερχονται απο τον υποδοχεα ενεργοποιησης που εκφραζεται σε μυελοειδη κυτταρα-1 (trem-1) και το μεταγραφο τυπου trem 1 (tlt-1) και χρησεις αυτων - Google Patents
Αναστολη των πεπτιδιων που προερχονται απο τον υποδοχεα ενεργοποιησης που εκφραζεται σε μυελοειδη κυτταρα-1 (trem-1) και το μεταγραφο τυπου trem 1 (tlt-1) και χρησεις αυτωνInfo
- Publication number
- CY1123014T1 CY1123014T1 CY20201100521T CY201100521T CY1123014T1 CY 1123014 T1 CY1123014 T1 CY 1123014T1 CY 20201100521 T CY20201100521 T CY 20201100521T CY 201100521 T CY201100521 T CY 201100521T CY 1123014 T1 CY1123014 T1 CY 1123014T1
- Authority
- CY
- Cyprus
- Prior art keywords
- trem
- tlt
- myeloid
- transcript
- inhibition
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102100032885 Trem-like transcript 1 protein Human genes 0.000 title 1
- 101710095056 Trem-like transcript 1 protein Proteins 0.000 title 1
- 102000018368 Triggering Receptor Expressed on Myeloid Cells-1 Human genes 0.000 title 1
- 108010066451 Triggering Receptor Expressed on Myeloid Cells-1 Proteins 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306079 | 2012-09-07 | ||
| PCT/EP2013/068628 WO2014037565A2 (en) | 2012-09-07 | 2013-09-09 | Inhibiting peptides derived from triggering receptor expressed on myeloid cells-1 (trem-1) trem-like transcript 1 (tlt-1) and uses thereof |
| EP13759234.1A EP2892920B1 (en) | 2012-09-07 | 2013-09-09 | Inhibiting peptides derived from triggering receptor expressed on myeloid cells-1 (trem-1) trem-like transcript 1 (tlt-1) and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1123014T1 true CY1123014T1 (el) | 2021-10-29 |
Family
ID=46826397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100521T CY1123014T1 (el) | 2012-09-07 | 2020-06-02 | Αναστολη των πεπτιδιων που προερχονται απο τον υποδοχεα ενεργοποιησης που εκφραζεται σε μυελοειδη κυτταρα-1 (trem-1) και το μεταγραφο τυπου trem 1 (tlt-1) και χρησεις αυτων |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9657081B2 (enExample) |
| EP (1) | EP2892920B1 (enExample) |
| JP (1) | JP6307080B2 (enExample) |
| KR (1) | KR102181384B1 (enExample) |
| CN (1) | CN104837865B (enExample) |
| AU (1) | AU2013311606B2 (enExample) |
| CA (1) | CA2884121C (enExample) |
| CY (1) | CY1123014T1 (enExample) |
| DK (1) | DK2892920T3 (enExample) |
| ES (1) | ES2797625T3 (enExample) |
| HR (1) | HRP20200875T8 (enExample) |
| HU (1) | HUE051557T2 (enExample) |
| IL (1) | IL237615B (enExample) |
| LT (1) | LT2892920T (enExample) |
| MX (1) | MX385794B (enExample) |
| NZ (1) | NZ705899A (enExample) |
| PL (1) | PL2892920T3 (enExample) |
| PT (1) | PT2892920T (enExample) |
| RS (1) | RS60421B1 (enExample) |
| RU (1) | RU2672341C2 (enExample) |
| SI (1) | SI2892920T1 (enExample) |
| SM (1) | SMT202000309T1 (enExample) |
| WO (1) | WO2014037565A2 (enExample) |
| ZA (1) | ZA201501779B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12419839B2 (en) | 2009-10-09 | 2025-09-23 | Signablok, Inc. | Methods and compositions for targeted delivery of protein fragments |
| RU2757489C2 (ru) * | 2015-06-12 | 2021-10-18 | Маккэй Медикл Фаундэйшн Зе Пресбайтериэн Чёч Ин Тайвэнь Маккэй Мемориал Хоспитэл | Способы и антитела для модуляции иммунного ответа |
| JP7023853B2 (ja) | 2016-03-04 | 2022-02-22 | アレクトル エルエルシー | 抗ｔｒｅｍ１抗体及びその使用方法 |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| WO2020036987A1 (en) | 2018-08-13 | 2020-02-20 | Signablok, Inc. | Peptides and compositions for targeted treatment and imaging |
| WO2021105137A1 (en) * | 2019-11-25 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Trem-1 inhibitors for the treatment of vaso-occlusions and tissue injuries in patients suffering from sickle cell disease |
| US20230201301A1 (en) * | 2020-06-05 | 2023-06-29 | Inotrem | Trem-1 inhibitor for use in the treatment of a subject suffering from a coronavirus infection |
| IL330191A (en) | 2020-06-26 | 2026-08-01 | Amgen Inc | IL-10 mutants and their fusion proteins |
| US20240173376A1 (en) | 2021-03-12 | 2024-05-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Trem-1 inhibitors for the treatment of marfan syndrome |
| MX2023015442A (es) | 2021-06-25 | 2024-03-12 | Amgen Inc | Tratamiento de la enfermedad cardiovascular con proteínas de unión a antígeno trem-1. |
| WO2025196177A1 (en) | 2024-03-21 | 2025-09-25 | Institut National de la Santé et de la Recherche Médicale | Use of soluble trem-1 as a biomarker for assessing the risk of cardiovascular disease in asymptomatic subjects |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
| US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| JP3866760B2 (ja) | 1993-02-22 | 2007-01-10 | ザ ロックフェラー ユニバーシティ | 一過性トランスフェクションによる高力価のヘルパーフリーのレトロウイルスの生産 |
| FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
| SK29297A3 (en) | 1994-09-12 | 1997-10-08 | Schering Ag | Process for manufacture of pallidipin, a modified collagen-induced platelet inhibitor, a pharmaceutical composition, use, a recombinant vector |
| IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| RU2002110275A (ru) * | 2000-08-22 | 2004-03-27 | Дзе Брихэм Энд Уимен'З Хоспитал, Инк. (Us) | Диагностика и лечение сердечно-сосудистых состояний |
| US20040180409A1 (en) * | 2003-03-16 | 2004-09-16 | Mcvicar Daniel | TLT-1, a novel platelet-associated receptor and uses therefor |
| GB0426146D0 (en) * | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| US7553936B2 (en) | 2006-12-04 | 2009-06-30 | The United States of America as represented by Secretary Department of Health and Human Services | Anti-TREM-like transcript-1 (TLT-1) antibodies and compositions |
| US20100306863A1 (en) | 2007-07-23 | 2010-12-02 | Bioxell S.P.A. | Screening, therapy and diagnosis |
| DE102009018620A1 (de) | 2009-04-27 | 2010-10-28 | Carefusion Germany 234 Gmbh | Ansteuer- und Auswerteschaltung, Messgerät sowie Verfahren zum Messen der Konzentration eines Gases |
| JP5467313B2 (ja) * | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| CN103153327B (zh) | 2010-04-08 | 2016-01-20 | 国家健康与医学研究院 | 衍生自trem样转录1(tlt-1)的抑制肽和其用途 |
-
2013
- 2013-09-09 MX MX2015002994A patent/MX385794B/es unknown
- 2013-09-09 RS RS20200634A patent/RS60421B1/sr unknown
- 2013-09-09 JP JP2015530440A patent/JP6307080B2/ja active Active
- 2013-09-09 WO PCT/EP2013/068628 patent/WO2014037565A2/en not_active Ceased
- 2013-09-09 US US14/426,562 patent/US9657081B2/en active Active
- 2013-09-09 NZ NZ705899A patent/NZ705899A/en not_active IP Right Cessation
- 2013-09-09 CN CN201380058170.9A patent/CN104837865B/zh active Active
- 2013-09-09 CA CA2884121A patent/CA2884121C/en active Active
- 2013-09-09 SM SM20200309T patent/SMT202000309T1/it unknown
- 2013-09-09 DK DK13759234.1T patent/DK2892920T3/da active
- 2013-09-09 PT PT137592341T patent/PT2892920T/pt unknown
- 2013-09-09 ES ES13759234T patent/ES2797625T3/es active Active
- 2013-09-09 PL PL13759234T patent/PL2892920T3/pl unknown
- 2013-09-09 KR KR1020157008973A patent/KR102181384B1/ko active Active
- 2013-09-09 EP EP13759234.1A patent/EP2892920B1/en active Active
- 2013-09-09 HU HUE13759234A patent/HUE051557T2/hu unknown
- 2013-09-09 HR HRP20200875TT patent/HRP20200875T8/hr unknown
- 2013-09-09 AU AU2013311606A patent/AU2013311606B2/en not_active Ceased
- 2013-09-09 RU RU2015112625A patent/RU2672341C2/ru not_active Application Discontinuation
- 2013-09-09 SI SI201331729T patent/SI2892920T1/sl unknown
- 2013-09-09 LT LTEP13759234.1T patent/LT2892920T/lt unknown
-
2015
- 2015-03-08 IL IL237615A patent/IL237615B/en active IP Right Grant
- 2015-03-16 ZA ZA2015/01779A patent/ZA201501779B/en unknown
-
2020
- 2020-06-02 CY CY20201100521T patent/CY1123014T1/el unknown
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