JP2010065037A5 - - Google Patents
Info
- Publication number
- JP2010065037A5 JP2010065037A5 JP2009233816A JP2009233816A JP2010065037A5 JP 2010065037 A5 JP2010065037 A5 JP 2010065037A5 JP 2009233816 A JP2009233816 A JP 2009233816A JP 2009233816 A JP2009233816 A JP 2009233816A JP 2010065037 A5 JP2010065037 A5 JP 2010065037A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- sequence
- apo
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 2
- 108700012411 TNFSF10 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102220056661 rs730880421 Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39105002P | 2002-06-24 | 2002-06-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Division JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010065037A JP2010065037A (ja) | 2010-03-25 |
| JP2010065037A5 true JP2010065037A5 (enExample) | 2010-12-09 |
Family
ID=30000661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Expired - Lifetime JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
| JP2009233816A Pending JP2010065037A (ja) | 2002-06-24 | 2009-10-07 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Expired - Lifetime JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20060141561A1 (enExample) |
| EP (2) | EP2500032A1 (enExample) |
| JP (2) | JP4574350B2 (enExample) |
| AU (2) | AU2003247609A1 (enExample) |
| CA (1) | CA2489348A1 (enExample) |
| IL (1) | IL165777A0 (enExample) |
| WO (1) | WO2004001009A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2461292A1 (en) * | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
| GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| CA2560742A1 (en) | 2004-03-23 | 2005-10-06 | Biogen Idec Ma Inc. | Receptor coupling agents and therapeutic uses thereof |
| KR20070050950A (ko) * | 2004-09-08 | 2007-05-16 | 제넨테크, 인크. | 사멸 수용체 리간드 및 ｃｄ20 항체의 사용 방법 |
| GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
| KR100886783B1 (ko) | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
| US8008261B2 (en) * | 2006-08-04 | 2011-08-30 | Mayo Foundation For Medical Education And Research | Methods of reducing trail-induced apoptosis by trail isoforms |
| EP2205282A2 (en) | 2007-09-24 | 2010-07-14 | Bar-Ilan University | Polymer nanoparticles coated by magnetic metal oxide and uses thereof |
| JP2011501951A (ja) * | 2007-10-31 | 2011-01-20 | メディミューン，エルエルシー | タンパク質足場 |
| WO2011079293A1 (en) * | 2009-12-23 | 2011-06-30 | Ambrx, Inc | Tumor necrosis factor-related apoptosis inducing ligand polypeptides and their uses |
| CN102834114A (zh) | 2010-04-13 | 2012-12-19 | 米迪缪尼有限公司 | 基于纤连蛋白iii型结构域的多聚体支架 |
| PT2771022T (pt) | 2011-10-11 | 2020-09-14 | Viela Bio Inc | Suportes derivados de tn3 específicos para cd40l e métodos de uso dos mesmos |
| US20150056204A1 (en) | 2012-03-28 | 2015-02-26 | Amgen Inc. | Dr5 receptor agonist combinations |
| CN107318267B (zh) | 2013-08-12 | 2021-08-17 | 豪夫迈·罗氏有限公司 | 用于治疗补体相关的病症的组合物和方法 |
| WO2015138638A1 (en) | 2014-03-11 | 2015-09-17 | Theraly Pharmaceuticals, Inc. | Long acting trail receptor agonists for treatment of autoimmune diseases |
| PE20161440A1 (es) | 2014-05-01 | 2017-01-26 | Genentech Inc | Variantes del anticuerpo anti-factor d y sus usos |
| KR20150133576A (ko) * | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
| WO2017075173A2 (en) | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibodies and conjugates |
| JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック， インコーポレイテッド | 抗ｄ因子抗体変異体コンジュゲート及びその使用 |
| ES3013312T3 (en) | 2015-12-17 | 2025-04-11 | Univ Johns Hopkins | Ameliorating systemic sclerosis with death receptor agonists |
| EP3439687A1 (en) | 2016-04-07 | 2019-02-13 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
| US12344645B2 (en) | 2017-03-29 | 2025-07-01 | Polaris Group | Protein conjugates |
| IT201900024622A1 (it) * | 2019-12-18 | 2021-06-18 | Univ Degli Studi G Dannunzio Chieti Pescara | Pegilazione innovativa del killer tnf-apoptosis induced ligand (killer-trail) |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| DE3779221D1 (de) | 1986-08-19 | 1992-06-25 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und -zytokinen. |
| KR0154872B1 (ko) | 1987-12-21 | 1998-10-15 | 로버트 에이. 아미테이지 | 발아하는 식물종자의 아크로박테리움 매개된 형질전환 |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| DK168302B1 (da) | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
| EP0939121B2 (de) | 1989-09-12 | 2007-12-26 | AHP Manufacturing B.V. | TFN-bindende Proteine |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| WO1992003478A1 (en) | 1990-08-17 | 1992-03-05 | Genentech, Inc. | Metal ion mediated receptor binding of polypeptide hormones |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| WO1992017200A2 (en) | 1991-03-28 | 1992-10-15 | Genentech, Inc. | Stable growth hormone metal ion formulations |
| AU2147192A (en) | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| JPH08506095A (ja) | 1992-11-25 | 1996-07-02 | アムジェン ボールダー インコーポレイテッド | 改変インシュリン様成長因子 |
| JPH08508296A (ja) | 1993-04-07 | 1996-09-03 | アムジエン・ブルダー・インコーポレーテッド | インシュリン様成長因子結合タンパク質の使用方法 |
| JPH09504174A (ja) * | 1993-10-29 | 1997-04-28 | インサイト ファーマシューティカルズ，インク． | プロテアーゼネキシン１変異体を含むキメラ蛋白 |
| US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| ES2253753T3 (es) | 1995-06-29 | 2006-06-01 | Immunex Corporation | Citocina que induce apoptosis. |
| CA2658039A1 (en) | 1995-09-21 | 1997-03-27 | Genentech, Inc. | Human growth hormone variants |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| EP1577391A1 (en) | 1996-10-25 | 2005-09-21 | Human Genome Sciences, Inc. | Neutrokine alpha |
| US6242213B1 (en) | 1996-12-23 | 2001-06-05 | Immunex Corporation | Isolated DNA molecules encoding RANK-L |
| EP1012274B2 (en) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l) |
| WO1998035026A1 (en) | 1997-02-06 | 1998-08-13 | Novo Nordisk A/S | Polypeptide-polymer conjugates having added and/or removed attachment groups |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
| JP4330180B2 (ja) | 1997-03-17 | 2009-09-16 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | 死ドメイン含有レセプター５ |
| EP1007562A4 (en) | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR |
| HU230547B1 (hu) | 1997-04-16 | 2016-11-28 | Amgen Inc. | Osteoprotegerin-kötő fehérjék és receptorok |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| ATE516354T1 (de) | 1997-05-15 | 2011-07-15 | Genentech Inc | Apo-2-rezeptor |
| WO1999002653A1 (en) | 1997-07-11 | 1999-01-21 | Trustees Of The University Of Pennsylvania | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
| EP1881005B1 (en) | 1997-07-14 | 2013-04-03 | Bolder Biotechnology, Inc. | Derivatives of G-CSF and related proteins |
| WO1999009165A1 (en) | 1997-08-15 | 1999-02-25 | Idun Pharmaceuticals, Inc. | Trail receptors, nucleic acids encoding the same, and methods of use thereof |
| ATE443761T1 (de) | 1997-08-26 | 2009-10-15 | Genentech Inc | Rtd receptor |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| PT1045906E (pt) * | 1998-01-15 | 2009-01-27 | Genentech Inc | Ligando apo-2 |
| CA2318405C (en) | 1998-01-26 | 2014-01-07 | Genentech, Inc. | Antibodies to death receptor 4(dr4) and uses thereof |
| AU5596500A (en) | 1999-06-09 | 2000-12-28 | Genentech Inc. | Apo-2l receptor agonist and cpt-11 synergism |
| US6318934B1 (en) * | 1999-06-24 | 2001-11-20 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
| MXPA01013236A (es) * | 1999-06-28 | 2002-06-21 | Genentech Inc | Metodos para hacer ligando apo-2 mediante el uso de iones metalicos divalentes. |
| DK1303293T3 (da) | 2000-07-27 | 2009-03-30 | Genentech Inc | Sekventiel indgivelse af CPT-11 og APO-2L-polypeptid |
| CA2461292A1 (en) * | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
-
2003
- 2003-06-23 CA CA002489348A patent/CA2489348A1/en not_active Abandoned
- 2003-06-23 EP EP11183690A patent/EP2500032A1/en not_active Withdrawn
- 2003-06-23 EP EP03761262A patent/EP1556076A4/en not_active Withdrawn
- 2003-06-23 US US10/519,647 patent/US20060141561A1/en not_active Abandoned
- 2003-06-23 AU AU2003247609A patent/AU2003247609A1/en not_active Abandoned
- 2003-06-23 WO PCT/US2003/019750 patent/WO2004001009A2/en not_active Ceased
- 2003-06-23 JP JP2004516142A patent/JP4574350B2/ja not_active Expired - Lifetime
-
2004
- 2004-12-15 IL IL16577704A patent/IL165777A0/xx unknown
-
2006
- 2006-10-02 US US11/541,821 patent/US20070098681A1/en not_active Abandoned
-
2009
- 2009-08-26 AU AU2009212834A patent/AU2009212834A1/en not_active Abandoned
- 2009-10-07 JP JP2009233816A patent/JP2010065037A/ja active Pending
-
2011
- 2011-06-06 US US13/153,710 patent/US20120165267A1/en not_active Abandoned
-
2012
- 2012-04-06 US US13/441,682 patent/US20130165383A1/en not_active Abandoned