JP2010065037A5 - - Google Patents
Info
- Publication number
- JP2010065037A5 JP2010065037A5 JP2009233816A JP2009233816A JP2010065037A5 JP 2010065037 A5 JP2010065037 A5 JP 2010065037A5 JP 2009233816 A JP2009233816 A JP 2009233816A JP 2009233816 A JP2009233816 A JP 2009233816A JP 2010065037 A5 JP2010065037 A5 JP 2010065037A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- sequence
- apo
- ligand
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000046283 TNF-Related Apoptosis-Inducing Ligand Human genes 0.000 claims 2
- 108700012411 TNFSF10 Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102220056661 rs730880421 Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39105002P | 2002-06-24 | 2002-06-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Division JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010065037A JP2010065037A (ja) | 2010-03-25 |
| JP2010065037A5 true JP2010065037A5 (enExample) | 2010-12-09 |
Family
ID=30000661
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Expired - Lifetime JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
| JP2009233816A Pending JP2010065037A (ja) | 2002-06-24 | 2009-10-07 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004516142A Expired - Lifetime JP4574350B2 (ja) | 2002-06-24 | 2003-06-23 | Ａｐｏ−２リガンド／ｔｒａｉｌ変異体とその使用法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US20060141561A1 (enExample) |
| EP (2) | EP2500032A1 (enExample) |
| JP (2) | JP4574350B2 (enExample) |
| AU (2) | AU2003247609A1 (enExample) |
| CA (1) | CA2489348A1 (enExample) |
| IL (1) | IL165777A0 (enExample) |
| WO (1) | WO2004001009A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003029420A2 (en) * | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
| GB0328261D0 (en) * | 2003-12-05 | 2004-01-07 | Univ Groningen | Improved cytokine design |
| BRPI0509201A (pt) | 2004-03-23 | 2007-08-28 | Biogen Idec Inc | agentes de acoplamento de receptor e usos terapêuticos destes |
| JP2008513367A (ja) * | 2004-09-08 | 2008-05-01 | ジェネンテック・インコーポレーテッド | デスレセプターリガンド及びｃｄ２０抗体の使用方法 |
| GB0524316D0 (en) * | 2005-11-29 | 2006-01-04 | Medical Res Council | Tumour necrosis factor-related apoptosis-inducing ligands (TRAILs) |
| KR100886783B1 (ko) | 2006-06-12 | 2009-03-04 | 성균관대학교산학협력단 | N-말단이 수식된 peg-trail 결합체, 이의 제조방법 및 이의 용도 |
| WO2008088582A2 (en) * | 2006-08-04 | 2008-07-24 | Mayo Foundation For Medical Education And Research | Methods and materials related to trail isoforms |
| EP2399610A3 (en) | 2007-09-24 | 2012-09-05 | Bar-Ilan University | Polymer nanoparticles coated by magnetic metal oxide and uses thereof |
| RU2010121967A (ru) * | 2007-10-31 | 2011-12-10 | Медиммун, Ллк (Us) | Белковые каркасные структуры |
| WO2011079293A1 (en) * | 2009-12-23 | 2011-06-30 | Ambrx, Inc | Tumor necrosis factor-related apoptosis inducing ligand polypeptides and their uses |
| CA2796010C (en) | 2010-04-13 | 2020-05-12 | Medimmune, Llc | Trail r2-specific multimeric scaffolds |
| KR20220116585A (ko) | 2011-10-11 | 2022-08-23 | 비엘라 바이오, 인크. | Cd40l 특이적 tn3 유래 스카폴드 및 이의 사용 방법 |
| MX350202B (es) | 2012-03-28 | 2017-08-30 | Amgen Inc | Combinaciones de agonistas de receptores de muerte 5 (dr5). |
| CR20160132A (es) | 2013-08-12 | 2016-08-25 | Genentech Inc | Composiciones y método para tratar condiciones asociadas con el complemento |
| US11299528B2 (en) | 2014-03-11 | 2022-04-12 | D&D Pharmatech Inc. | Long acting TRAIL receptor agonists for treatment of autoimmune diseases |
| KR20160147855A (ko) | 2014-05-01 | 2016-12-23 | 제넨테크, 인크. | 항-인자 d 항체 변이체 및 이의 용도 |
| KR20150133576A (ko) * | 2014-05-20 | 2015-11-30 | 삼성전자주식회사 | 화학적 개질된 표적화 단백질 및 그의 이용 |
| EP3368074A2 (en) | 2015-10-30 | 2018-09-05 | Hoffmann-La Roche AG | Anti-factor d antibodies and conjugates |
| HK1257422A1 (zh) | 2015-10-30 | 2019-10-18 | 豪夫迈‧罗氏有限公司 | 抗-因子d抗体变体缀合物及其用途 |
| US11007251B2 (en) | 2015-12-17 | 2021-05-18 | The Johns Hopkins University | Ameliorating systemic sclerosis with death receptor agonists |
| AU2017248264B2 (en) | 2016-04-07 | 2020-01-30 | The Johns Hopkins University | Compositions and methods for treating pancreatitis and pain with death receptor agonists |
| WO2018183671A1 (en) | 2017-03-29 | 2018-10-04 | Tdw Group | Protein conjugates |
| IT201900024622A1 (it) | 2019-12-18 | 2021-06-18 | Univ Degli Studi G Dannunzio Chieti Pescara | Pegilazione innovativa del killer tnf-apoptosis induced ligand (killer-trail) |
Family Cites Families (52)
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|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4657760A (en) | 1979-03-20 | 1987-04-14 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human T cells |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| US4713339A (en) | 1983-01-19 | 1987-12-15 | Genentech, Inc. | Polycistronic expression vector construction |
| AU2353384A (en) | 1983-01-19 | 1984-07-26 | Genentech Inc. | Amplification in eukaryotic host cells |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| GB8430252D0 (en) | 1984-11-30 | 1985-01-09 | Beecham Group Plc | Compounds |
| US5206344A (en) | 1985-06-26 | 1993-04-27 | Cetus Oncology Corporation | Interleukin-2 muteins and polymer conjugation thereof |
| ES2032831T5 (es) | 1986-08-19 | 2001-02-16 | Genentech Inc | Dispositivo y dispersion para suministro intrapulmonar de factores de crecimiento polipeptidos y citoquinas. |
| KR0154872B1 (ko) | 1987-12-21 | 1998-10-15 | 로버트 에이. 아미테이지 | 발아하는 식물종자의 아크로박테리움 매개된 형질전환 |
| US5166322A (en) | 1989-04-21 | 1992-11-24 | Genetics Institute | Cysteine added variants of interleukin-3 and chemical modifications thereof |
| DK168302B1 (da) | 1989-06-29 | 1994-03-07 | Danisco | Fremgangsmåde til indføring af molekyler, især genetisk materiale i planteceller |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| US5225212A (en) | 1989-10-20 | 1993-07-06 | Liposome Technology, Inc. | Microreservoir liposome composition and method |
| CA2087267A1 (en) | 1990-08-17 | 1992-02-18 | Steven H. Bass | Metal ion mediated receptor binding of polypeptide hormones |
| US5206161A (en) | 1991-02-01 | 1993-04-27 | Genentech, Inc. | Human plasma carboxypeptidase B |
| AU1757092A (en) | 1991-03-28 | 1992-11-02 | Genentech Inc. | Stable growth hormone metal ion formulations |
| WO1993000109A1 (en) | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
| EP0679095A1 (en) | 1992-11-25 | 1995-11-02 | Amgen Boulder Inc. | Modified insulin-like growth factors |
| CN1134111A (zh) | 1993-04-07 | 1996-10-23 | 赛纳根公司 | 使用胰岛素样生长因子结合蛋白质的方法 |
| EP0730660A4 (en) * | 1993-10-29 | 1998-02-25 | Incyte Pharma Inc | CHIMEAN PROTEINE PROTEASE NEXIN-1 CONTAINING VARIANTS |
| KR100510234B1 (ko) | 1995-06-29 | 2005-11-25 | 임뮤넥스 코포레이션 | 세포소멸을 유도하는 시토킨 |
| US6284236B1 (en) | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| AU718439B2 (en) | 1995-09-21 | 2000-04-13 | Genentech Inc. | Human growth hormone variants |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| DK0939804T4 (da) | 1996-10-25 | 2011-07-18 | Human Genome Sciences Inc | Neutrokin-alpha |
| PT951551E (pt) | 1996-12-23 | 2008-10-28 | Immunex Corp | Ligando para receptor activador de nf-kb, ligando membro da superfamília de tnf |
| EP1012274B2 (en) | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l) |
| JP2001511162A (ja) | 1997-02-06 | 2001-08-07 | ノボ ノルディスク アクティーゼルスカブ | 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体 |
| US6072047A (en) | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
| DE69836956T2 (de) | 1997-03-17 | 2007-10-31 | Human Genome Sciences, Inc. | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält |
| SI0975754T2 (sl) | 1997-04-16 | 2016-04-29 | Amgen Inc., | Vezivni proteini in receptorji osteoprotegerina |
| EP1007562A4 (en) | 1997-04-16 | 2000-09-27 | Millennium Pharm Inc | TANGO-63d AND TANGO-63e PROTEINS RELATED TO THE TUMOR NECROSIS FACTOR RECEPTOR |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| EP1860187B1 (en) | 1997-05-15 | 2011-07-13 | Genentech, Inc. | Apo-2 receptor |
| WO1999002653A1 (en) | 1997-07-11 | 1999-01-21 | Trustees Of The University Of Pennsylvania | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
| CN1269805A (zh) | 1997-07-14 | 2000-10-11 | 博尔德生物技术公司 | 生长激素和相关蛋白的衍生物 |
| AU8784498A (en) | 1997-08-15 | 1999-03-08 | Idun Pharmaceuticals, Inc. | Trail receptors, nucleic acids encoding the same, and methods of use thereof |
| DK1009817T3 (da) | 1997-08-26 | 2010-01-18 | Genentech Inc | RTD-receptor |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| EP1045906B1 (en) * | 1998-01-15 | 2008-10-15 | Genentech, Inc. | Apo-2 ligand |
| PT1053256E (pt) | 1998-01-26 | 2011-09-28 | Genentech Inc | Anticorpos para o receptor de morte 4 (dr4) e utilizações destes |
| ZA200002867B (en) | 1999-06-09 | 2001-12-07 | Pfizer Prod Inc | Process for preparing sertraline from chiral tetralone. |
| US6318934B1 (en) * | 1999-06-24 | 2001-11-20 | Anchor Wall Systems, Inc. | Segmental retaining wall system |
| JP5118796B2 (ja) | 1999-06-28 | 2013-01-16 | ジェネンテック， インコーポレイテッド | 二価の金属イオンを利用したＡｐｏ−２リガンドの製造方法 |
| ATE415978T1 (de) | 2000-07-27 | 2008-12-15 | Genentech Inc | Sequentielle verabreichung von cpt-11 und apo-2l polypeptid |
| WO2003029420A2 (en) * | 2001-10-02 | 2003-04-10 | Genentech, Inc. | Apo-2 ligand variants and uses thereof |
-
2003
- 2003-06-23 EP EP11183690A patent/EP2500032A1/en not_active Withdrawn
- 2003-06-23 EP EP03761262A patent/EP1556076A4/en not_active Withdrawn
- 2003-06-23 CA CA002489348A patent/CA2489348A1/en not_active Abandoned
- 2003-06-23 US US10/519,647 patent/US20060141561A1/en not_active Abandoned
- 2003-06-23 AU AU2003247609A patent/AU2003247609A1/en not_active Abandoned
- 2003-06-23 WO PCT/US2003/019750 patent/WO2004001009A2/en not_active Ceased
- 2003-06-23 JP JP2004516142A patent/JP4574350B2/ja not_active Expired - Lifetime
-
2004
- 2004-12-15 IL IL16577704A patent/IL165777A0/xx unknown
-
2006
- 2006-10-02 US US11/541,821 patent/US20070098681A1/en not_active Abandoned
-
2009
- 2009-08-26 AU AU2009212834A patent/AU2009212834A1/en not_active Abandoned
- 2009-10-07 JP JP2009233816A patent/JP2010065037A/ja active Pending
-
2011
- 2011-06-06 US US13/153,710 patent/US20120165267A1/en not_active Abandoned
-
2012
- 2012-04-06 US US13/441,682 patent/US20130165383A1/en not_active Abandoned