JP2011136981A5 - - Google Patents
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- JP2011136981A5 JP2011136981A5 JP2010264759A JP2010264759A JP2011136981A5 JP 2011136981 A5 JP2011136981 A5 JP 2011136981A5 JP 2010264759 A JP2010264759 A JP 2010264759A JP 2010264759 A JP2010264759 A JP 2010264759A JP 2011136981 A5 JP2011136981 A5 JP 2011136981A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- acid sequence
- seq
- set forth
- ttr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/117,109 US20030191056A1 (en) | 2002-04-04 | 2002-04-04 | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| US10/117,109 | 2002-04-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583462A Division JP4738743B2 (ja) | 2002-04-04 | 2003-04-03 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011136981A JP2011136981A (ja) | 2011-07-14 |
| JP2011136981A5 true JP2011136981A5 (enExample) | 2012-03-08 |
Family
ID=28674128
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583462A Expired - Fee Related JP4738743B2 (ja) | 2002-04-04 | 2003-04-03 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
| JP2010264759A Withdrawn JP2011136981A (ja) | 2002-04-04 | 2010-11-29 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583462A Expired - Fee Related JP4738743B2 (ja) | 2002-04-04 | 2003-04-03 | 薬理学的活性ペプチド／タンパク質の血清中半減期を上昇させるためのトランスサイレチンペプチド／タンパク質融合物の使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US20030191056A1 (enExample) |
| EP (2) | EP1496926B1 (enExample) |
| JP (2) | JP4738743B2 (enExample) |
| AU (1) | AU2003224844B2 (enExample) |
| CA (1) | CA2480883A1 (enExample) |
| ES (1) | ES2400341T3 (enExample) |
| MX (1) | MXPA04009680A (enExample) |
| PL (1) | PL372849A1 (enExample) |
| WO (1) | WO2003086444A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261244A3 (en) | 2003-04-15 | 2011-02-23 | Glaxosmithkline LLC | Human il-18 substitution mutants and their conjugates |
| JP2007531513A (ja) * | 2003-11-13 | 2007-11-08 | ハンミ ファーム．インダストリー カンパニー リミテッド | 薬物のキャリアとして有用なＩｇＧＦｃ断片およびその製造方法 |
| US8263084B2 (en) * | 2003-11-13 | 2012-09-11 | Hanmi Science Co., Ltd | Pharmaceutical composition for treating obesity-related disease comprising insulinotropic peptide conjugate |
| US20090238838A1 (en) * | 2003-11-13 | 2009-09-24 | Hanmi Pharm. Ind. Co. Ltd. | Insulinotropic peptide conjugate using an immunoglobulin fc |
| WO2005074460A2 (en) * | 2003-12-05 | 2005-08-18 | Becton Dickinson And Company | Methods of enhancing immune response in the intradermal compartment and compounds useful in the methods |
| AU2004298424A1 (en) | 2003-12-18 | 2005-06-30 | Novo Nordisk A/S | Novel GLP-1 compounds |
| WO2005077976A2 (en) * | 2004-02-13 | 2005-08-25 | Avidis Sa | Coiled-coil domains from c4b-binding protein |
| CA2572765C (en) * | 2004-07-08 | 2013-05-21 | Amgen Inc. | Compound having improved bioefficiency when administered in a multidose regimen |
| CN100344323C (zh) * | 2004-09-30 | 2007-10-24 | 华东师范大学 | 一种人胰高血糖素样肽－1的复合物及其制备方法 |
| GB0426146D0 (en) | 2004-11-29 | 2004-12-29 | Bioxell Spa | Therapeutic peptides and method |
| MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
| BRPI0519393A2 (pt) * | 2004-12-22 | 2009-01-20 | Lilly Co Eli | formulaÇço em soluÇço estÁvel |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| PT1767545E (pt) | 2005-09-22 | 2010-02-05 | Biocompatibles Uk Ltd | Polipéptidos de fusão glp-1 (péptido 1 do tipo glucagom) com resistência aumentada à peptidase |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Ｇｌｐ−１のポリマ複合体 |
| EP1854455B1 (en) * | 2006-05-10 | 2009-10-07 | Biocompatibles UK Limited | Spherical microcapsules comprising GLP-1 peptides, their production and use |
| PE20081140A1 (es) * | 2006-10-25 | 2008-09-22 | Amgen Inc | Agentes terapeuticos a base de peptidos derivados de toxinas |
| EP1972349A1 (en) * | 2007-03-21 | 2008-09-24 | Biocompatibles UK Limited | GLP-1 fusion peptides conjugated to polymer(s), their production and use |
| EP1975176A1 (en) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Novel glp-1 fusion peptides, their production and use |
| JP5591691B2 (ja) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
| US20090054332A1 (en) * | 2007-06-21 | 2009-02-26 | Conjuchem Biotechnologies, Inc. | Thombopoietin peptide conjugates |
| CL2008001887A1 (es) | 2007-06-29 | 2008-10-03 | Amgen Inc | Proteinas de union a antigeno que se unen al receptor activado por proteasas 2 (par-2); acido nucleico que las codifica; vector y celula huesped; metodo de produccion; y composicion que las comprende. |
| EP2163243A1 (en) * | 2008-09-12 | 2010-03-17 | Biocompatibles UK Limited | Treatment of acute myocardial infarction (AMI) using encapsulated cells encoding and secreting GLP-1 peptides or analogs thereof |
| SG10201809460SA (en) | 2008-10-20 | 2018-11-29 | Alnylam Pharmaceuticals Inc | Compositions and methods for inhibiting expression of transthyretin |
| AU2010206840B2 (en) | 2009-01-21 | 2015-02-05 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| WO2010091253A1 (en) | 2009-02-06 | 2010-08-12 | Women & Infants' Hospital Of Rhode Island | Compositions, formulations and methods of treating preeclampsia-type disorders of pregnancy |
| WO2010108154A2 (en) | 2009-03-20 | 2010-09-23 | Amgen Inc. | Selective and potent peptide inhibitors of kv1.3 |
| EP2408816B1 (en) | 2009-03-20 | 2019-09-04 | Amgen Inc. | Alpha-4-beta-7 heterodimer specific antagonist antibody |
| MX2012001283A (es) | 2009-07-31 | 2012-06-12 | Amgen Inc | Polipeptidos que se enlazan al inhibidor de tejidos de metaloproteinasa tipo tres (timp-3) composiciones y metodos. |
| SG187867A1 (en) | 2010-08-16 | 2013-03-28 | Amgen Inc | Antibodies that bind myostatin, compositions and methods |
| CN103339145A (zh) | 2010-09-22 | 2013-10-02 | 安姆根有限公司 | 运载体免疫球蛋白及其用途 |
| US20140037642A1 (en) | 2011-02-02 | 2014-02-06 | Amgen Inc. | Methods and compositions relating to inhibition of igf-1r |
| EP2681238A2 (en) | 2011-02-28 | 2014-01-08 | Istituto di Ricovero E Cura A Carattere Scientifico Materno-Infantile Burlo Garofolo- Ospedale di Alta Specializzazione E di Rilievo | Apoptosis-inducing molecules and uses therefor |
| SG10201601789TA (en) | 2011-03-16 | 2016-04-28 | Amgen Inc | Potent And Selective Inhibitors Of Nav1.3 And Nav1.7 |
| JP2014132832A (ja) * | 2011-05-10 | 2014-07-24 | Sekisui Chem Co Ltd | 医薬、機能性食品、目的蛋白質の安定化方法、融合蛋白質、核酸、並びに、組換え体 |
| WO2013075035A1 (en) | 2011-11-18 | 2013-05-23 | Alnylam Pharmaceuticals | Rnai agents, compositions and methods of use thereof for treating transthyretin (ttr) associated diseases |
| HK1201328A1 (en) * | 2011-11-18 | 2015-08-28 | Alnylam Pharmaceuticals, Inc. | Quantification of transthyretin and its isoforms |
| US9309318B2 (en) | 2012-10-17 | 2016-04-12 | Amgen, Inc. | Compositions relating to anti-IL-21 receptor antibodies |
| US20160067347A1 (en) | 2012-12-20 | 2016-03-10 | Amgen Inc. | Apj receptor agonists and uses thereof |
| US10344060B2 (en) | 2013-03-12 | 2019-07-09 | Amgen Inc. | Potent and selective inhibitors of Nav1.7 |
| JP6469644B2 (ja) | 2013-03-15 | 2019-02-13 | アムジエン・インコーポレーテツド | 抗ｃｃｒ７抗原結合タンパク質に関係する方法および組成物 |
| CA2935903A1 (en) | 2014-01-09 | 2015-07-16 | Hadasit Medical Research Services And Development Ltd. | Improved cell compositions and methods for cancer therapy |
| AU2015274574B2 (en) | 2014-06-10 | 2019-10-10 | Amgen Inc. | Apelin polypeptides |
| US20160045609A1 (en) | 2014-08-14 | 2016-02-18 | Mamoun M. Alhamadsheh | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
| AR101942A1 (es) | 2014-08-27 | 2017-01-25 | Amgen Inc | Variantes de inhibidor de tejido de metaloproteinasa tipo tres (timp-3), composiciones y métodos |
| IL283764B2 (en) | 2015-04-10 | 2024-01-01 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| PL3329002T3 (pl) | 2015-07-31 | 2021-04-19 | Alnylam Pharmaceuticals, Inc. | Kompozycje irna transtyretyny (ttr) i sposoby ich zastosowania do leczenia lub zapobiegania chorobom związanym z ttr |
| WO2017155981A1 (en) * | 2016-03-07 | 2017-09-14 | Massachusetts Institute Of Technology | Protein-chaperoned t-cell vaccines |
| EP3568411B1 (en) | 2017-01-13 | 2024-03-06 | Pietro P. Sanna | Methods and compositions for treating hpa hyperactivity |
| CN108623690A (zh) * | 2017-03-16 | 2018-10-09 | 兰州大学 | 一种促血小板生成素的融合蛋白及其制备方法和应用 |
| CN106977609B (zh) * | 2017-04-19 | 2020-07-28 | 刘崇东 | 一种融合蛋白、制备方法及其应用 |
| MA68842B1 (fr) | 2017-08-04 | 2025-01-31 | Amgen Inc. | Procédé de conjugaison de cys-mabs |
| BR112020005230A2 (pt) | 2017-09-19 | 2020-09-24 | Alnylam Pharmaceuticals, Inc. | composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr) |
| CA3076630A1 (en) | 2017-10-04 | 2019-04-11 | Amgen Inc. | Transthyretin immunoglobulin fusions |
| KR20220029545A (ko) | 2019-03-22 | 2022-03-08 | 리플렉시온 파마슈티컬스, 인크. | Vegf에 대한 d-펩티드성 화합물 |
| WO2020198075A2 (en) | 2019-03-22 | 2020-10-01 | Reflexion Pharmaceuticals, Inc. | Multivalent d-peptidic compounds for target proteins |
| JP7360142B2 (ja) * | 2019-05-21 | 2023-10-12 | 国立大学法人 熊本大学 | アミロイドーシス治療薬の新規スクリーニング方法 |
| IL267614A (en) | 2019-06-24 | 2019-09-26 | Lotem Michal | Nucleic acids to modulate SLAMF6 isoforms |
| WO2021007150A1 (en) | 2019-07-08 | 2021-01-14 | Amgen Inc. | Multispecific transthyretin immunoglobulin fusions |
| PH12022550165A1 (en) | 2019-07-26 | 2023-05-08 | Visterra Inc | Interleukin-2 agents and uses thereof |
| CN112043820B (zh) * | 2020-09-16 | 2022-06-21 | 易舟(上海)生物医药有限公司 | 一种眼用制剂及其制备方法和应用 |
| WO2021120937A1 (zh) * | 2019-12-17 | 2021-06-24 | 童妍(上海)医疗器械有限公司 | 转甲状腺素蛋白进入眼内以及在制备滴剂中的应用 |
| CN110960687A (zh) * | 2019-12-17 | 2020-04-07 | 上海卡序生物医药科技有限公司 | 转甲状腺素蛋白转运融合蛋白进入眼内的应用 |
| EP4208474A2 (en) | 2020-09-01 | 2023-07-12 | Takeda Pharmaceutical Company Limited | Interleukin-2 muteins and uses thereof |
| MX2023006599A (es) | 2020-12-04 | 2023-06-19 | Visterra Inc | Metodos de uso de agentes de interleucina-2. |
| CA3227852A1 (en) | 2021-08-03 | 2023-02-09 | Alnylam Pharmaceuticals, Inc. | Transthyretin (ttr) irna compositions and methods of use thereof |
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-
2002
- 2002-04-04 US US10/117,109 patent/US20030191056A1/en not_active Abandoned
-
2003
- 2003-04-03 CA CA002480883A patent/CA2480883A1/en not_active Abandoned
- 2003-04-03 PL PL03372849A patent/PL372849A1/xx unknown
- 2003-04-03 JP JP2003583462A patent/JP4738743B2/ja not_active Expired - Fee Related
- 2003-04-03 ES ES03721538T patent/ES2400341T3/es not_active Expired - Lifetime
- 2003-04-03 MX MXPA04009680A patent/MXPA04009680A/es active IP Right Grant
- 2003-04-03 EP EP03721538A patent/EP1496926B1/en not_active Expired - Lifetime
- 2003-04-03 US US10/407,078 patent/US20030195154A1/en not_active Abandoned
- 2003-04-03 AU AU2003224844A patent/AU2003224844B2/en not_active Ceased
- 2003-04-03 EP EP10178081A patent/EP2298331A3/en not_active Withdrawn
- 2003-04-03 WO PCT/US2003/010443 patent/WO2003086444A1/en not_active Ceased
-
2009
- 2009-02-26 US US12/380,451 patent/US8633153B2/en not_active Expired - Fee Related
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2010
- 2010-11-29 JP JP2010264759A patent/JP2011136981A/ja not_active Withdrawn
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2014
- 2014-01-16 US US14/157,325 patent/US20140234945A1/en not_active Abandoned