PE20081140A1 - Agentes terapeuticos a base de peptidos derivados de toxinas - Google Patents
Agentes terapeuticos a base de peptidos derivados de toxinasInfo
- Publication number
- PE20081140A1 PE20081140A1 PE2007001455A PE2007001455A PE20081140A1 PE 20081140 A1 PE20081140 A1 PE 20081140A1 PE 2007001455 A PE2007001455 A PE 2007001455A PE 2007001455 A PE2007001455 A PE 2007001455A PE 20081140 A1 PE20081140 A1 PE 20081140A1
- Authority
- PE
- Peru
- Prior art keywords
- toxins
- therapeutic agents
- peptides derived
- agents based
- refers
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 239000003053 toxin Substances 0.000 title abstract 3
- 231100000765 toxin Toxicity 0.000 title abstract 3
- 108700012359 toxins Proteins 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 101100242312 Oryza sativa subsp. japonica OSK1 gene Proteins 0.000 abstract 1
- 101100533605 Oryza sativa subsp. japonica SKP1 gene Proteins 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE REFIERE A UNA COMPOSICION DE MATERIA DE FORMULA I, DONDE: F1 Y F2 SON FRACCIONES QUE PROLONGAN LA SEMIVIDA, COMO POLIETILENGLICOL DE 5kDa Y 20 kDa, PROPILENGLICOL, CARBOXIMETILCELULOSA, ACIDO GRASO, UN DOMINIO Fc DE LA Ig G HUMANA O UNA PARTE DE ESTE Y COMPRENDE UNA SECUENCIA SEQ ID NOS: 2,470,71,72,74,75,76,1340,1341,1342 Y 1359 A 1363; d Y e SON CADA UNO 0-1; X1, X2 Y X3 SON CADA UNO -(L)f-P-(L)g-; f Y g SON CADA UNO 0-1; P ES UN PEPTIDO DERIVADO DE TOXINAS, DE PREFERENCIA ANALOGO DEL PEPTIDO DE LA TOXINA OSK1; L ES UN LIGADOR; a, b Y c SON CADA UNO 0-1, DONDE AL MENOS 1 DE a , b O c SEA 1. TAMBIEN SE REFIERE A UNA SECUENCIA DE ADN UN VECTOR DE EXPRESION Y CELULAS HOSPEDANTES. DICHA COMPOSICION FARMACEUTICA ES UTIL PARA EL TRATAMIENTO DE TRANSTORNOS AUTOINMUNES COMO LA ESCLEROSIS MULTIPLE, DIABETES TIPO I, ESCLERODERMIA, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85467406P | 2006-10-25 | 2006-10-25 | |
US99537007P | 2007-09-25 | 2007-09-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081140A1 true PE20081140A1 (es) | 2008-09-22 |
Family
ID=39636515
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001455A PE20081140A1 (es) | 2006-10-25 | 2007-10-25 | Agentes terapeuticos a base de peptidos derivados de toxinas |
Country Status (8)
Country | Link |
---|---|
US (6) | US7825093B2 (es) |
EP (1) | EP2081602A2 (es) |
AR (1) | AR063384A1 (es) |
AU (1) | AU2007343796A1 (es) |
CA (1) | CA2667678A1 (es) |
PE (1) | PE20081140A1 (es) |
TW (1) | TW200833840A (es) |
WO (1) | WO2008088422A2 (es) |
Families Citing this family (78)
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US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
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US8188220B2 (en) * | 2006-12-06 | 2012-05-29 | Sanford-Burnham Medical Research Institute | Methods and compositions related to targeting wounds, regenerating tissue, and tumors |
CA2840407A1 (en) | 2007-05-22 | 2008-12-18 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
US8598311B2 (en) * | 2007-11-21 | 2013-12-03 | The University Of The Sciences In Philadelphia | Complexation of fatty acid-conjugated molecules with albumin |
US8716437B2 (en) * | 2007-12-07 | 2014-05-06 | Steven A. Goldstein | Identification of toxin ligands |
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US20120121591A1 (en) | 2009-03-20 | 2012-05-17 | Amgen Inc. | SELECTIVE AND POTENT PEPTIDE INHIBITORS OF Kv1.3 |
US8765677B2 (en) | 2009-09-21 | 2014-07-01 | The University Of Queensland | Omega conotoxin peptides |
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EP2569330B1 (en) | 2010-05-11 | 2016-09-28 | Fred Hutchinson Cancer Research Center | Chlorotoxin variants, conjugates, and methods for their use |
EA201370030A1 (ru) | 2010-08-10 | 2013-06-28 | Амген Инк. | Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням |
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JP2014509859A (ja) | 2011-03-16 | 2014-04-24 | アムジエン・インコーポレーテツド | 17nav1.3およびnav1.7の強力かつ選択的阻害剤 |
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EP3973981A1 (en) | 2012-05-18 | 2022-03-30 | Janssen Biotech, Inc. | Huwentoxin-iv variants and methods of use |
US10414808B2 (en) | 2012-05-18 | 2019-09-17 | Janssen Biotech, Inc. | Huwentoxin-IV variants and methods of use |
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US9283241B2 (en) * | 2012-07-10 | 2016-03-15 | Clemson University | Treatment to render implants resistant to diabetes |
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JP2019513711A (ja) | 2016-04-01 | 2019-05-30 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | アルカリホスファターゼによって筋力低下を治療すること |
KR102462084B1 (ko) | 2016-05-23 | 2022-11-02 | 모멘타 파머슈티컬스 인코포레이티드 | 유전자 조작 Fc 작제물에 관한 조성물 및 방법 |
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MX2021004296A (es) | 2018-10-16 | 2021-08-05 | Glo Pharma Inc | Composiciones de conotoxina del antagonista del peptido receptor nicotinico de acetilcolina y metodos relacionados. |
CN109106943B (zh) * | 2018-11-05 | 2021-04-20 | 中国科学院上海有机化学研究所 | 抗癫痫的毒素Martentoxin及其应用 |
JP2020080784A (ja) * | 2018-11-29 | 2020-06-04 | シスメックス株式会社 | 融合ポリペプチド、融合ポリペプチドの製造方法、及び融合ポリペプチドをコードするdna |
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WO2022066767A2 (en) | 2020-09-23 | 2022-03-31 | Aldevron, Llc | Potent and selective inhibitors of nav1.7 |
WO2022200374A1 (en) | 2021-03-23 | 2022-09-29 | Zealand Pharma A/S | Kv1.3 blockers |
CN113930462A (zh) * | 2021-10-19 | 2022-01-14 | 江南大学 | 高丝氨酸内酯信号分子促进碳链延长微生物合成己酸的方法 |
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2007
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- 2007-10-25 CA CA002667678A patent/CA2667678A1/en not_active Abandoned
- 2007-10-25 WO PCT/US2007/022831 patent/WO2008088422A2/en active Search and Examination
- 2007-10-25 US US11/978,076 patent/US7820623B2/en not_active Expired - Fee Related
- 2007-10-25 US US11/978,111 patent/US7910102B2/en not_active Expired - Fee Related
- 2007-10-25 TW TW096139989A patent/TW200833840A/zh unknown
- 2007-10-25 US US11/978,105 patent/US7834164B2/en not_active Expired - Fee Related
- 2007-10-25 AU AU2007343796A patent/AU2007343796A1/en not_active Abandoned
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US7834164B2 (en) | 2010-11-16 |
EP2081602A2 (en) | 2009-07-29 |
US20090291885A1 (en) | 2009-11-26 |
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US7825093B2 (en) | 2010-11-02 |
AR063384A1 (es) | 2009-01-28 |
WO2008088422A3 (en) | 2009-02-19 |
US20090305399A1 (en) | 2009-12-10 |
US20090297520A1 (en) | 2009-12-03 |
CA2667678A1 (en) | 2008-07-24 |
TW200833840A (en) | 2008-08-16 |
US20090281028A1 (en) | 2009-11-12 |
WO2008088422A2 (en) | 2008-07-24 |
US8043829B2 (en) | 2011-10-25 |
AU2007343796A1 (en) | 2008-07-24 |
US7910102B2 (en) | 2011-03-22 |
US7803769B2 (en) | 2010-09-28 |
US20090299044A1 (en) | 2009-12-03 |
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