LT2531206T - Chlorotoksino polipeptidai ir konjugatai ir jų naudojimas - Google Patents
Chlorotoksino polipeptidai ir konjugatai ir jų naudojimasInfo
- Publication number
- LT2531206T LT2531206T LTEP11740464.0T LT11740464T LT2531206T LT 2531206 T LT2531206 T LT 2531206T LT 11740464 T LT11740464 T LT 11740464T LT 2531206 T LT2531206 T LT 2531206T
- Authority
- LT
- Lithuania
- Prior art keywords
- conjugates
- chlorotoxin polypeptides
- chlorotoxin
- polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43522—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from scorpions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57415—Specifically defined cancers of breast
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57434—Specifically defined cancers of prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30161510P | 2010-02-04 | 2010-02-04 | |
PCT/US2011/023823 WO2011097533A1 (en) | 2010-02-04 | 2011-02-04 | Chlorotoxin polypeptides and conjugates and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2531206T true LT2531206T (lt) | 2017-09-25 |
Family
ID=44355816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP11740464.0T LT2531206T (lt) | 2010-02-04 | 2011-02-04 | Chlorotoksino polipeptidai ir konjugatai ir jų naudojimas |
Country Status (19)
Country | Link |
---|---|
US (4) | US9018347B2 (lt) |
EP (2) | EP2531206B1 (lt) |
JP (3) | JP5858932B2 (lt) |
KR (1) | KR101923235B1 (lt) |
CN (2) | CN102844044B (lt) |
AU (1) | AU2011213678B2 (lt) |
CA (1) | CA2788824C (lt) |
CY (1) | CY1119276T1 (lt) |
DK (1) | DK2531206T3 (lt) |
ES (1) | ES2638871T3 (lt) |
HR (1) | HRP20171291T1 (lt) |
HU (1) | HUE034119T2 (lt) |
IL (1) | IL221278B (lt) |
LT (1) | LT2531206T (lt) |
PL (1) | PL2531206T3 (lt) |
PT (1) | PT2531206T (lt) |
RS (1) | RS56231B1 (lt) |
SI (1) | SI2531206T1 (lt) |
WO (1) | WO2011097533A1 (lt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602006020710D1 (de) | 2005-04-22 | 2011-04-28 | Fred Hutchinson Cancer Res Foundation | Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs |
US8227439B2 (en) | 2008-05-15 | 2012-07-24 | Morphotek, Inc. | Treatment of metastatic tumors |
KR101923235B1 (ko) | 2010-02-04 | 2018-11-28 | 에이자이 아이엔씨. | 클로로톡신 폴리펩티드 및 그의 접합체 및 용도 |
AU2011253424B2 (en) * | 2010-05-11 | 2016-02-04 | Fred Hutchinson Cancer Center | Chlorotoxin variants, conjugates, and methods for their use |
AU2013204119B2 (en) * | 2010-05-11 | 2016-03-31 | Fred Hutchinson Cancer Center | Chlorotoxin variants, conjugates, and methods for their use |
ES2609859T3 (es) | 2011-08-04 | 2017-04-24 | Toray Industries, Inc. | Composición de fármaco para el tratamiento y/o la prevención del cáncer |
CA2913127A1 (en) | 2012-12-10 | 2014-06-19 | Fred Hutchinson Cancer Research Center | Methods for screening |
US9784730B2 (en) | 2013-03-21 | 2017-10-10 | University Of Washington Through Its Center For Commercialization | Nanoparticle for targeting brain tumors and delivery of O6-benzylguanine |
US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
CN105813648A (zh) * | 2013-09-17 | 2016-07-27 | 光明之火生物科学公司 | 氯毒素缀合物及其使用方法 |
WO2018170480A1 (en) | 2017-03-16 | 2018-09-20 | Blaze Bioscience, Inc. | Cartilage-homing peptide conjugates and methods of use thereof |
CN105801706B (zh) * | 2014-12-31 | 2019-10-22 | 深圳先进技术研究院 | 蝎氯毒素多肽-铁蛋白重链融合蛋白、自组装蛋白质纳米笼及其制备方法和应用 |
CN104877016A (zh) * | 2015-04-30 | 2015-09-02 | 温州生物材料与工程研究所 | 折叠氯代毒素、氯代毒素变异体与折叠氯代毒素变异体及其制备工艺 |
JP2018521994A (ja) * | 2015-06-26 | 2018-08-09 | フレッド ハッチンソン キャンサー リサーチ センター | 治療用ペプチドおよびそれらの使用方法 |
EP3347035A4 (en) | 2015-09-09 | 2019-05-01 | Fred Hutchinson Cancer Research Center | CARTON PEPTIDES |
CA3001833A1 (en) | 2015-10-13 | 2017-04-20 | City Of Hope | Chimeric antigen receptors containing a chlorotoxin domain |
WO2017136769A1 (en) | 2016-02-04 | 2017-08-10 | Eisai R&D Management Co., Ltd. | Peptide drug conjugates |
WO2017181149A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
EP3442555A4 (en) * | 2016-04-15 | 2020-04-01 | Blaze Bioscience, Inc. | METHODS OF TREATING BREAST CANCER |
KR101678393B1 (ko) * | 2016-08-25 | 2016-12-06 | (주)넥스젠바이오텍 | 피부 세포 증식 효과가 증가한 전갈독 융합단백질 및 이를 유효성분으로 함유하는 피부 주름 개선, 피부 탄력 증대 및 항노화 화장료 조성물 |
CA3044393A1 (en) * | 2016-12-09 | 2018-06-14 | The Uab Research Foundation | Chimeric chlorotoxin receptors |
AU2018210157B2 (en) | 2017-01-18 | 2022-10-06 | Fred Hutchinson Cancer Center | Peptide compositions and methods of use thereof for disrupting TEAD interactions |
CA3064436A1 (en) | 2017-06-15 | 2018-12-20 | Blaze Bioscience, Inc. | Renal-homing peptide conjugates and methods of use thereof |
EP3681540A4 (en) | 2017-09-15 | 2021-05-19 | Eisai, Inc. | CHLOROTOXIN AGENT AND USES THEREOF |
WO2019126240A1 (en) | 2017-12-19 | 2019-06-27 | Blaze Bioscience, Inc. | Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof |
US20220233694A1 (en) * | 2019-05-31 | 2022-07-28 | The Cleveland Clinic Foundation | Functionalized fullerene gel tumor treatment |
CN113092609B (zh) * | 2021-03-31 | 2022-03-29 | 中国海洋大学 | 一种Gymnodimine毒素标准物质的制备方法 |
CN113527416A (zh) * | 2021-08-11 | 2021-10-22 | 南开大学 | 一种硝基还原酶响应氨基酸及肿瘤乏氧荧光探针的制备方法 |
KR20240015030A (ko) * | 2022-07-25 | 2024-02-02 | 충남대학교산학협력단 | E5의 분비를 위한 재조합 발현 벡터 및 이로 형질전환된약독화 살모넬라 균주 |
Family Cites Families (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444744A (en) | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
DE3407582A1 (de) | 1984-03-01 | 1985-09-05 | Dornier System Gmbh, 7990 Friedrichshafen | Schaltungsanordnung fuer einen regelkreis |
EP0282581A4 (en) | 1986-09-19 | 1988-11-02 | Scripps Clinic Res | MONOCLONAL PARATOPIC MOLECULE ACTING AGAINST HUMAN GANGLIOSIDE GD2. |
US5171749A (en) | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
US5591829A (en) | 1987-05-29 | 1997-01-07 | Matsushita; Shuzo | Antibodies modified with toxic substance |
US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
US5051364A (en) | 1989-02-16 | 1991-09-24 | The Salk Institute For Biological Studies | Anti-lipocortin-I and anti-lipocortin-II monoclonal antibodies |
DE3909799A1 (de) | 1989-03-24 | 1990-09-27 | Behringwerke Ag | Monoklonale antikoerper (mak) gegen tumorassoziierte antigene, ihre herstellung und verwendung |
US5173504A (en) | 1989-04-21 | 1992-12-22 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
US5171741A (en) | 1989-04-21 | 1992-12-15 | Health Research, Inc. | Bacteriochlorophyll-a derivatives useful in photodynamic therapy |
US5308608A (en) | 1989-06-07 | 1994-05-03 | University Of British Columbia | Photosensitizing Diels-Alder porphyrin derivatives |
CA2066428C (en) | 1989-09-08 | 2000-11-28 | Bert Vogelstein | Structural alterations of the egf receptor gene in human gliomas |
US5223253A (en) | 1989-09-28 | 1993-06-29 | American Home Products Corporation | Bovine vaccine compositions and method for preventing trichomonas infections using same |
GB2250993B (en) | 1990-11-21 | 1995-02-15 | Inst Nat Sante Rech Med | Stromelysin-3 and its application in the diagnosis and treatment of malignant breast cancer |
US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
EP0610254B1 (en) | 1991-09-20 | 2004-09-01 | Amgen Inc. | Glial derived neurotrophic factor |
US5314992A (en) | 1991-11-25 | 1994-05-24 | Trustees Of Dartmouth College | Lipocortin-1 receptor protein and its uses |
AU4373993A (en) | 1992-05-14 | 1993-12-13 | Ohio State University Research Foundation, The | Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors |
US5726304A (en) | 1992-10-30 | 1998-03-10 | The University Of British Columbia | Porphocyanine and CNC-expanded porphyrins |
US5405957A (en) | 1992-10-30 | 1995-04-11 | The University Of British Columbia | Wavelength-specific photosensitive compounds and expanded porphyrin-like compounds and methods of use |
EP0679086A1 (en) | 1993-01-14 | 1995-11-02 | Cancer Research Campaign Technology Limited | Potentiation of temozolomide in human tumour cells |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
US5688773A (en) | 1994-08-17 | 1997-11-18 | The General Hospital Corporation | Method of selectively destroying neoplastic cells |
US5648485A (en) | 1994-10-26 | 1997-07-15 | University Of British Columbia | β, β-dihydroxy meso-substituted chlorins, isobacteriochlorins, and bacteriochlorins |
US5985822A (en) | 1994-12-09 | 1999-11-16 | The Scripps Research Institute | Inhibition of glial cell proliferation with N-CAM homophilic peptides |
US5756340A (en) | 1995-05-08 | 1998-05-26 | The Regents Of The University Of California | Insect control with multiple toxins |
JP3809502B2 (ja) | 1995-05-30 | 2006-08-16 | 二郎 有川 | ハンタウィルス抗原蛋白質およびモノクローナル抗体 |
JPH0971559A (ja) | 1995-06-29 | 1997-03-18 | Nippon Nohyaku Co Ltd | ヒドロキシルアミン誘導体及び該化合物を含有する殺菌剤 |
JPH0971599A (ja) | 1995-09-06 | 1997-03-18 | Nippon Seibutsu Kagaku Kenkyusho | 鶏貧血ウイルス(cav)感染鶏血清と高い反応性を示すポリペプチド及びこのポリペプチドに対する抗体、鶏貧血ウイルス感染の診断法及びワクチン |
US5905027A (en) | 1995-12-27 | 1999-05-18 | Uab Research Foundation | Method of diagnosing and treating gliomas |
US6667156B2 (en) | 1995-12-27 | 2003-12-23 | Uab Research Foundation | Diagnosis and treatment of neuroectodermal tumors |
US6541212B2 (en) | 1997-03-10 | 2003-04-01 | The Regents Of The University Of California | Methods for detecting prostate stem cell antigen protein |
DK0983273T3 (da) | 1997-05-07 | 2002-04-22 | Univ British Columbia | Ethylenglycolestere af monohydrobenzoporphyrinderivater som fotoaktive midler |
US5880145A (en) | 1997-05-07 | 1999-03-09 | The University Of British Columbia | Class of benzoporphyrin derivative photoactive compounds |
US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
AU748250B2 (en) | 1997-12-05 | 2002-05-30 | Kyogo Itoh | Tumor antigen peptide derivatives |
US6403625B1 (en) | 1998-08-12 | 2002-06-11 | Daiichi Pure Chemicals Co., Ltd. | Fluorescent labeling reagents |
US6703381B1 (en) * | 1998-08-14 | 2004-03-09 | Nobex Corporation | Methods for delivery therapeutic compounds across the blood-brain barrier |
US6214986B1 (en) | 1998-10-07 | 2001-04-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of bcl-x expression |
SE9901387D0 (sv) | 1999-04-19 | 1999-04-19 | Astra Ab | New pharmaceutical foromaulations |
US6849714B1 (en) | 1999-05-17 | 2005-02-01 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
EP1216060A2 (de) | 1999-09-14 | 2002-06-26 | Biomedical Apherese Systeme GmbH | Magnetische nanoteilchen mit biochemischer wirksamkeit und verfahren zu ihrer herstellung sowie ihre verwendung |
US6623936B1 (en) | 1999-09-24 | 2003-09-23 | Imgenex | Compositions and methods for improved detection and classification of neoplasms |
AU4305101A (en) | 1999-11-22 | 2001-06-04 | Research Foundation Of The State University Of New York, The | Magnetic nanoparticles for selective therapy |
DE10020376A1 (de) | 2000-04-26 | 2001-11-08 | Inst Zelltechnologie E V | Dynamische Marker |
AU2002220265A1 (en) | 2000-11-03 | 2002-05-15 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
WO2002069896A2 (en) | 2001-03-01 | 2002-09-12 | Northwest Hospital | Connexin enhances chemotherapy-induced apoptosis in human cancer cells inhibiting tumor cell proliferation |
WO2003008583A2 (en) | 2001-03-02 | 2003-01-30 | Sagres Discovery | Novel compositions and methods for cancer |
US20030021810A1 (en) | 2001-06-26 | 2003-01-30 | Sontheimer Harald W. | Chlorotoxin inhibition of cell invasion, cancer metastasis, angiogenesis and tissue remodeling |
WO2003010475A1 (en) | 2001-07-16 | 2003-02-06 | Maytag Corporation | Method and system for refrigerator with integrated presentation mode |
WO2003029462A1 (en) | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
US6972326B2 (en) | 2001-12-03 | 2005-12-06 | Molecular Probes, Inc. | Labeling of immobilized proteins using dipyrrometheneboron difluoride dyes |
EP1480665A2 (en) | 2002-02-04 | 2004-12-01 | Auburn University | Peptides for recognition and targeting of glial cell tumors |
US20030232013A1 (en) | 2002-02-22 | 2003-12-18 | Gary Sieckman | Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides |
MXPA04011871A (es) | 2002-05-31 | 2005-07-26 | Transmolecular Inc | Quimioterapia en combinacion con clorotoxina. |
US20060088899A1 (en) | 2002-05-31 | 2006-04-27 | Alvarez Vernon L | Combination chemotherapy with chlorotoxin |
US7560160B2 (en) | 2002-11-25 | 2009-07-14 | Materials Modification, Inc. | Multifunctional particulate material, fluid, and composition |
US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
EP2481814A3 (en) | 2003-06-09 | 2012-10-10 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing cancer |
DE10328251A1 (de) | 2003-06-24 | 2005-01-13 | Toximed Gmbh | Pharmazeutischer Wirkstoff |
WO2005053611A2 (en) | 2003-11-26 | 2005-06-16 | Transmolecular, Inc. | Treatment of phosphatidylinositol phospholipid disorders |
US20080153746A1 (en) | 2004-04-06 | 2008-06-26 | Transmolecular, Inc. | Diagnosis and Treatment of Myeloid and Lymphoid Cell Cancers |
JP2007532879A (ja) | 2004-04-06 | 2007-11-15 | トランスモレキュラー, インコーポレイテッド | 骨髄およびリンパ系細胞癌の診断および処置 |
CA2565701A1 (en) | 2004-05-06 | 2005-11-17 | Jonathan M. Barasch | Ngal for reduction and amelioration of ischemic and nephrotoxic injuries |
AU2005327906B2 (en) | 2004-07-21 | 2010-05-13 | Ambrx, Inc. | Biosynthetic polypeptides utilizing non-naturally encoded amino acids |
GB0422901D0 (en) | 2004-10-14 | 2004-11-17 | Ares Trading Sa | Lipocalin protein |
KR100681763B1 (ko) | 2005-02-28 | 2007-02-15 | 재단법인 목암생명공학연구소 | 인간 리포칼린 2를 유효성분으로 포함하는 암 전이 억제용약학적 조성물, 이를 이용한 암 전이 억제 방법 |
GB0504767D0 (en) | 2005-03-08 | 2005-04-13 | Ares Trading Sa | Lipocalin protein |
US7462446B2 (en) | 2005-03-18 | 2008-12-09 | University Of Washington | Magnetic nanoparticle compositions and methods |
US20070037232A1 (en) | 2005-03-31 | 2007-02-15 | Barasch Jonathan M | Detection of NGAL in chronic renal disease |
AU2006235258A1 (en) | 2005-04-07 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | Cancer-related genes |
WO2006110582A1 (en) | 2005-04-08 | 2006-10-19 | Xcyte Therapies, Inc. | Compositions and methods for the treatment of burns and sepsis |
DE602006020710D1 (de) | 2005-04-22 | 2011-04-28 | Fred Hutchinson Cancer Res Foundation | Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs |
CN101232903A (zh) * | 2005-04-22 | 2008-07-30 | 安姆根有限公司 | 具有延长的血液半衰期的毒素肽 |
US7833979B2 (en) | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
CN103103238B (zh) | 2005-08-18 | 2016-08-10 | Ambrx公司 | 一种在细胞中制造在特定位置处具有所选氨基酸的抗体或抗体片段多肽的方法 |
US20070084929A1 (en) | 2005-10-17 | 2007-04-19 | Hitoshi Watanabe | Barcode reader with a music player |
CA2647907A1 (en) | 2006-03-31 | 2007-10-18 | Transmolecular, Inc. | Use of tm-601 for the diagnosis and treatment of tumors |
EP2029157A4 (en) | 2006-05-19 | 2009-11-18 | Georgia Tech Res Inst | LIGAND OF CARRIERS ABC |
CN101003788A (zh) | 2006-09-21 | 2007-07-25 | 武汉大学 | 一种蝎抗肿瘤转移肽及其制备方法和应用 |
CN100564517C (zh) | 2006-09-21 | 2009-12-02 | 武汉大学 | 一种蝎抗神经胶质瘤肽及其制备方法和应用 |
US7825093B2 (en) * | 2006-10-25 | 2010-11-02 | Amgen Inc. | Methods of using OSK1 peptide analogs |
PT2173890E (pt) | 2007-06-21 | 2011-05-06 | Tech Universit T M Nchen | Prote?nas biologicamente activas com estabilidade in vivo e/ou in vitro aumentada |
US20090004105A1 (en) * | 2007-06-27 | 2009-01-01 | Zhen Cheng | Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin |
CA2696303A1 (en) | 2007-08-07 | 2009-02-12 | Transmolecular, Inc. | Chlorotoxins as drug carriers |
EP3023876A1 (en) | 2007-08-31 | 2016-05-25 | Phase Change Software LLC | Quality assurance tools for use with source code and a semantic model |
US20100215575A1 (en) | 2007-10-12 | 2010-08-26 | Transmolecular, Inc. | Systemic Administration of Chlorotoxin Agents for the Diagnosis and Treatment of Tumors |
US7904868B2 (en) | 2007-10-17 | 2011-03-08 | International Business Machines Corporation | Structures including means for lateral current carrying capability improvement in semiconductor devices |
CA2702611A1 (en) | 2007-10-19 | 2009-04-23 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
US8846036B2 (en) | 2007-10-19 | 2014-09-30 | Abbott Laboratories | Antibodies that bind to mammalian NGAL and uses thereof |
US20090269777A1 (en) | 2007-10-19 | 2009-10-29 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
US20090176274A1 (en) | 2007-10-19 | 2009-07-09 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
US20090123946A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Immunoassays and kits for the detection of ngal |
US20090123970A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Glycosylated mammalian ngal and use thereof |
US20090124022A1 (en) | 2007-10-19 | 2009-05-14 | Abbott Laboratories | Antibodies that bind to mammalian ngal and uses thereof |
JP2011503587A (ja) | 2007-11-15 | 2011-01-27 | バイオポルト ディアグノスティックス エイ/エス | 独特の分子形態を有するタンパク質バイオマーカーの診断における使用 |
EP3320923B1 (en) | 2008-01-18 | 2022-04-06 | Visen Medical, Inc. | Fluorescent imaging agents |
WO2009108762A2 (en) | 2008-02-26 | 2009-09-03 | The Penn State Research Foundation | Methods and compositions for treatment of retinoid-responsive conditions |
US8093060B2 (en) | 2008-02-28 | 2012-01-10 | Canon Kabushiki Kaisha | Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same |
CA2715034C (en) | 2008-03-14 | 2016-12-06 | Visen Medical, Inc. | Integrin targeting agents and in-vivo and in-vitro imaging methods using the same |
EP2282755A4 (en) * | 2008-03-20 | 2015-06-17 | Morphotek Inc | INHIBITION OF ANGIOGENESIS |
GB0807831D0 (en) | 2008-04-29 | 2008-06-04 | Cambridge Entpr Ltd | Agents for imaging cell death |
CN101270158B (zh) | 2008-04-30 | 2010-12-22 | 武汉大学 | 一种靶向抗神经胶质瘤蛋白及制备方法和用途 |
US8227439B2 (en) * | 2008-05-15 | 2012-07-24 | Morphotek, Inc. | Treatment of metastatic tumors |
JP2009300110A (ja) | 2008-06-10 | 2009-12-24 | Olympus Corp | 移植細胞の光学的検出方法又はイメージング方法 |
EP2313430B1 (en) | 2008-06-24 | 2018-05-02 | Technische Universität München | Muteins of hngal and related proteins with affinity for a given target |
AR073582A1 (es) | 2008-09-12 | 2010-11-17 | Nitto Denko Corp | Agentes de produccion de imagenes de enfermedades fibroticas.conjugado. metodo |
US20100098637A1 (en) | 2008-09-23 | 2010-04-22 | The Regents Of The University Of Michigan | Dye-loaded nanoparticle |
CN101381405B (zh) | 2008-09-24 | 2011-07-27 | 武汉摩尔生物科技有限公司 | 基因工程肿瘤靶向kct-w1多肽及制备方法和用途 |
JP2010085108A (ja) | 2008-09-29 | 2010-04-15 | Nano Factory:Kk | 生体光イメージング用プローブ |
US20100105150A1 (en) | 2008-10-24 | 2010-04-29 | Abbott Laboratories | Isolated human autoantibodies to neutrophil gelatinase-associated lipocalin (ngal) and methods and kits for the detection of human autoantibodies to ngal |
CN102791827B (zh) | 2009-11-09 | 2016-11-16 | 华盛顿大学商业化中心 | 官能化发色聚合物点及其生物共轭体 |
CN101921769B (zh) | 2010-01-11 | 2012-07-25 | 山西大学 | 一种重组腺病毒及其制备方法和应用 |
WO2011094671A2 (en) | 2010-01-29 | 2011-08-04 | The Uab Research Foundation | N-terminally conjugated polypeptides for targeted therapy and diagnosis |
KR101923235B1 (ko) | 2010-02-04 | 2018-11-28 | 에이자이 아이엔씨. | 클로로톡신 폴리펩티드 및 그의 접합체 및 용도 |
CN101824084A (zh) | 2010-04-08 | 2010-09-08 | 山西大学 | 靶向性抗胶质瘤蛋白质及其应用 |
AU2011253424B2 (en) * | 2010-05-11 | 2016-02-04 | Fred Hutchinson Cancer Center | Chlorotoxin variants, conjugates, and methods for their use |
US9051382B2 (en) | 2010-08-16 | 2015-06-09 | Pieris Ag | Human neutrophil gelatinase-associated lipocalin (hNGAL) muteins that bind hepcidin and nucleic acid encoding such |
CN104877016A (zh) * | 2015-04-30 | 2015-09-02 | 温州生物材料与工程研究所 | 折叠氯代毒素、氯代毒素变异体与折叠氯代毒素变异体及其制备工艺 |
-
2011
- 2011-02-04 KR KR1020127023002A patent/KR101923235B1/ko active IP Right Grant
- 2011-02-04 CN CN201180012427.8A patent/CN102844044B/zh active Active
- 2011-02-04 PT PT117404640T patent/PT2531206T/pt unknown
- 2011-02-04 US US13/577,169 patent/US9018347B2/en active Active
- 2011-02-04 CA CA2788824A patent/CA2788824C/en active Active
- 2011-02-04 HU HUE11740464A patent/HUE034119T2/en unknown
- 2011-02-04 ES ES11740464.0T patent/ES2638871T3/es active Active
- 2011-02-04 LT LTEP11740464.0T patent/LT2531206T/lt unknown
- 2011-02-04 DK DK11740464.0T patent/DK2531206T3/en active
- 2011-02-04 JP JP2012552126A patent/JP5858932B2/ja active Active
- 2011-02-04 EP EP11740464.0A patent/EP2531206B1/en active Active
- 2011-02-04 RS RS20170847A patent/RS56231B1/sr unknown
- 2011-02-04 CN CN201610856180.2A patent/CN106995493B/zh active Active
- 2011-02-04 SI SI201131279T patent/SI2531206T1/sl unknown
- 2011-02-04 WO PCT/US2011/023823 patent/WO2011097533A1/en active Application Filing
- 2011-02-04 AU AU2011213678A patent/AU2011213678B2/en active Active
- 2011-02-04 EP EP17173578.0A patent/EP3238735A1/en active Pending
- 2011-02-04 PL PL11740464T patent/PL2531206T3/pl unknown
-
2012
- 2012-08-02 IL IL221278A patent/IL221278B/en active IP Right Grant
-
2014
- 2014-08-01 US US14/450,182 patent/US9234015B2/en active Active
-
2015
- 2015-08-24 JP JP2015164731A patent/JP6027200B2/ja active Active
- 2015-12-01 US US14/956,261 patent/US9637526B2/en active Active
-
2016
- 2016-10-13 JP JP2016201676A patent/JP6181265B2/ja active Active
-
2017
- 2017-03-23 US US15/468,085 patent/US10183975B2/en active Active
- 2017-08-28 HR HRP20171291TT patent/HRP20171291T1/hr unknown
- 2017-08-30 CY CY20171100911T patent/CY1119276T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL221278A0 (en) | Chlorotoxin polypeptides and conjugates and uses thereof | |
HRP20181493T1 (hr) | Konjugati epsilon-polilizin i njihova primjena | |
HK1258140A1 (zh) | 經修飾鬆弛素多肽及其用途 | |
EP2593469A4 (en) | MODIFIED PROTEINS AND POLYPEPTIDES AND USES THEREOF | |
ZA201303134B (en) | Modified factor ix polypeptides and uses thereof | |
IL222961A0 (en) | Novel dna-dinding proteins and uses thereof | |
IL222930A0 (en) | Chlorotoxin variants, conjugates and methods for their use | |
GB0916578D0 (en) | Polypeptides and uses thereof | |
GB0916576D0 (en) | Polypeptides and uses thereof | |
EP2588490A4 (en) | SHORT AND D-AMINO ACID-CONTAINING POLYPEPTIDES FOR THERAPEUTIC CONJUGATES AND THEIR USES | |
ZA201200716B (en) | Modified factor ix polypeptides and uses thereof | |
EP2483292A4 (en) | LOVD VARIANT POLYPEPTIDES AND USES THEREOF | |
EP2513137A4 (en) | PEPTIDES DERIVED FROM SAPOSINE-A AND USES THEREOF | |
IL216626A0 (en) | Albumin-amyloid peptide conjugates and uses thereof | |
EP2646059A4 (en) | PROTEASE-DERIVABLE POLYPEPTIDES AND USES THEREOF | |
EP2408808A4 (en) | TERMINAL-FUNCTIONALIZED CONJUGATES AND THEIR USE | |
GB0905790D0 (en) | Novel polypeptides and use thereof |