EA201370030A1 - Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням - Google Patents

Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням

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Publication number
EA201370030A1
EA201370030A1 EA201370030A EA201370030A EA201370030A1 EA 201370030 A1 EA201370030 A1 EA 201370030A1 EA 201370030 A EA201370030 A EA 201370030A EA 201370030 A EA201370030 A EA 201370030A EA 201370030 A1 EA201370030 A1 EA 201370030A1
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EA
Eurasian Patent Office
Prior art keywords
antibodies
bifunctional
quantitative
vitro analysis
binding targets
Prior art date
Application number
EA201370030A
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English (en)
Inventor
Синуй Синтия Чень
Франческа Сиволи
Шалини Гупта
Original Assignee
Амген Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44630491&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201370030(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA201370030A1 publication Critical patent/EA201370030A1/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Abstract

Описывается способ количественного анализа in vitro. Данный неклеточный бифункциональный количественный анализ связывания мишени полезен для обнаружения как антитела-мишени IgG, такого как биологический препарат, в биологическом образце (например, образце сыворотки), так и присутствия нейтрализующих антител (NAb) к антителу-мишени IgG.
EA201370030A 2010-08-10 2011-08-10 Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням EA201370030A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37243210P 2010-08-10 2010-08-10
PCT/US2011/047289 WO2012021648A1 (en) 2010-08-10 2011-08-10 Dual function in vitro target binding assay for the detection of neutralizing antibodies against target antibodies

Publications (1)

Publication Number Publication Date
EA201370030A1 true EA201370030A1 (ru) 2013-06-28

Family

ID=44630491

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201370030A EA201370030A1 (ru) 2010-08-10 2011-08-10 Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням

Country Status (12)

Country Link
US (1) US20140072983A1 (ru)
EP (1) EP2603794A1 (ru)
JP (1) JP2013535692A (ru)
KR (1) KR20130097747A (ru)
CN (1) CN103314296A (ru)
AU (1) AU2011289426A1 (ru)
CA (1) CA2807673A1 (ru)
CL (1) CL2013000411A1 (ru)
EA (1) EA201370030A1 (ru)
MX (1) MX2013001632A (ru)
SG (1) SG187787A1 (ru)
WO (1) WO2012021648A1 (ru)

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US10144770B2 (en) * 2013-10-17 2018-12-04 National University Of Singapore Chimeric receptors and uses thereof in immune therapy
CN104459108A (zh) * 2014-11-19 2015-03-25 天津大学 一种多肽分子定向固定抗体的免疫检测材料及其制备方法
JP7215999B2 (ja) * 2016-12-21 2023-01-31 エフ．ホフマン－ラ ロシュ アーゲー 抗体またはリガンドの結合および機能を決定するためのアッセイ法
CN108562573B (zh) * 2018-04-20 2020-01-03 青岛大学 一种基于二碳化三钛二维金属碳化物催化鲁米诺电化学发光探针的生物传感器及制备方法
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Publication number Publication date
MX2013001632A (es) 2013-06-05
AU2011289426A1 (en) 2013-02-28
WO2012021648A1 (en) 2012-02-16
US20140072983A1 (en) 2014-03-13
SG187787A1 (en) 2013-03-28
EP2603794A1 (en) 2013-06-19
KR20130097747A (ko) 2013-09-03
CL2013000411A1 (es) 2013-11-08
JP2013535692A (ja) 2013-09-12
CA2807673A1 (en) 2012-02-16
CN103314296A (zh) 2013-09-18

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