MX344053B - Metodos para determinar isotipos de anticuerpos anti-farmacos. - Google Patents
Metodos para determinar isotipos de anticuerpos anti-farmacos.Info
- Publication number
- MX344053B MX344053B MX2013004305A MX2013004305A MX344053B MX 344053 B MX344053 B MX 344053B MX 2013004305 A MX2013004305 A MX 2013004305A MX 2013004305 A MX2013004305 A MX 2013004305A MX 344053 B MX344053 B MX 344053B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- ada
- present
- tnfa
- drug antibody
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
Abstract
La presente invención se refiere a métodos de ensayo para la determinación de uno o más isotipos de anticuerpo anti-fármaco (ADA) en una muestra. Como un ejemplo no limitativo, los ensayos de la presente invençión son particularmente útiles para determinar diferentes isotipos de ADA en muestras de pacientes positivos para ADA que reciben un fármaco anti-TNFa tal como REMICADETM (infliximab) o HUMIRATM (adalimumab). La presente invención también proporciona métodos para optimizar terapia y/o reducir toxicidad en sujetos que reciban inhibidores de TNFa para el tratamiento de enfermedades o trastornos mediados con TNFa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39426910P | 2010-10-18 | 2010-10-18 | |
PCT/US2011/056777 WO2012054532A1 (en) | 2010-10-18 | 2011-10-18 | Methods for determining anti-drug antibody isotypes |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013004305A MX2013004305A (es) | 2013-08-27 |
MX344053B true MX344053B (es) | 2016-12-02 |
Family
ID=45044693
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013004305A MX344053B (es) | 2010-10-18 | 2011-10-18 | Metodos para determinar isotipos de anticuerpos anti-farmacos. |
Country Status (13)
Country | Link |
---|---|
US (1) | US9784748B2 (es) |
EP (1) | EP2630495B1 (es) |
JP (1) | JP5960707B2 (es) |
KR (1) | KR101934247B1 (es) |
CN (1) | CN103299190B (es) |
AU (1) | AU2011317149B2 (es) |
BR (1) | BR112013009376A2 (es) |
CA (1) | CA2815026C (es) |
IL (1) | IL225534A (es) |
MX (1) | MX344053B (es) |
NZ (1) | NZ609363A (es) |
SG (1) | SG189391A1 (es) |
WO (1) | WO2012054532A1 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010062960A2 (en) | 2008-11-26 | 2010-06-03 | Cedars-Sinai Medical Center | METHODS OF DETERMINING RESPONSIVENESS TO ANTI-TNFα THERAPY IN INFLAMMATORY BOWEL DISEASE |
RU2571489C2 (ru) | 2009-10-26 | 2015-12-20 | Нестек С.А. | Способы выявления препаратов и аутоантител против tnf |
BR112013009376A2 (pt) | 2010-10-18 | 2016-07-26 | Nestec Sa | métodos para determinar isótipos de anticorpos antifármacos |
MX343324B (es) | 2011-07-06 | 2016-11-01 | Nestec Sa | Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. |
RU2638812C2 (ru) * | 2012-03-08 | 2017-12-15 | Ф. Хоффманн-Ля Рош Аг | Мультиплексный иммунохроматографический способ определения циркулирующих иммунокомплексов |
WO2014054013A1 (en) | 2012-10-05 | 2014-04-10 | Nestec S.A. | Methods for predicting and monitoring mucosal healing |
BR112015012482A2 (pt) * | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
CN104870982B (zh) * | 2012-12-20 | 2019-02-15 | 霍夫曼-拉罗奇有限公司 | 用于评估医学测量曲线的方法 |
WO2014122600A1 (en) | 2013-02-05 | 2014-08-14 | Nestec S.A. | Methods of selecting combination therapy for colorectal cancer patients |
US9017958B2 (en) * | 2013-03-12 | 2015-04-28 | Bloodcenter Research Foundation, Inc. | Method of simultaneous detection of heparin-induced immunoglobulins types G, A, and M |
CN105246501B (zh) | 2013-03-27 | 2021-01-12 | 雪松-西奈医学中心 | 通过抑制tl1a的功能和相关信号传导途径来减轻并逆转纤维化和炎症 |
EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
EP3077818B1 (en) | 2013-12-03 | 2020-02-05 | Prometheus Biosciences, Inc. | Methods for predicting post-operative recurrence of crohn's disease |
WO2015110989A1 (en) | 2014-01-23 | 2015-07-30 | Nestec S.A. | Biomarker panel for assessment of mucosal healing |
BR112017011545A2 (pt) | 2014-12-05 | 2018-03-13 | Nestec Sa | ensaio de desvio de mobilidade homogênea indireto para a detecção de produtos biológicos nas amostras do paciente |
WO2016135707A1 (en) | 2015-02-27 | 2016-09-01 | Nestec S.A. | Diagnosis of major depressive disorder, mild cognitive impairment, and alzheimer's disease and other neurologic and psychiatric disorders |
US9927443B2 (en) | 2015-04-10 | 2018-03-27 | Conquerab Inc. | Risk assessment for therapeutic drugs |
WO2017027771A1 (en) | 2015-08-13 | 2017-02-16 | Dyax Corp. | Evacuated blood collection tubes containing protease inhibitors for the assessment of contact system activation |
JP6084759B1 (ja) * | 2015-08-17 | 2017-02-22 | 積水メディカル株式会社 | 免疫学的検出方法及びこれに用いるテストストリップ |
EP3430172A4 (en) | 2016-03-17 | 2019-08-21 | Cedars-Sinai Medical Center | METHOD FOR DIAGNOSIS OF INFLAMMATORY ENDURANCE THROUGH RNASET2 |
US9903866B2 (en) | 2016-04-05 | 2018-02-27 | Conquerab Inc. | Portable devices for detection of antibodies against therapeutic drugs |
WO2019116234A1 (en) | 2017-12-12 | 2019-06-20 | Nestec S.A. | Methods for determining microbiome ribosomal rna composition changes |
CN110616258A (zh) * | 2019-01-24 | 2019-12-27 | 上海市第十人民医院 | 用于检测rs4077515多态性位点的物质在评价或辅助评价ABPA中的应用 |
US10914731B2 (en) * | 2019-02-21 | 2021-02-09 | Qinxue DING | Method of removing non-specific binding signals using microparticle assay |
JP2022533956A (ja) | 2019-05-14 | 2022-07-27 | プロメテウス バイオサイエンシーズ,インク. | Tl1a患者を選択する方法、システム、およびデバイス |
EP3990922A1 (en) * | 2019-06-25 | 2022-05-04 | ProciseDx Inc. | Detection of anti-tnf alpha drug biologics and anti-drug antibodies |
WO2023025364A1 (en) * | 2021-08-24 | 2023-03-02 | Fida Biosystems Aps | A method of determining an immunogenic response characteristic of a chemical substance |
Family Cites Families (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700466A (en) | 1981-09-08 | 1997-12-23 | The Rockefeller University | Method of ameliorating or preventing septic shock using a monoclonal antibody specific to cachectin/tumor necrosis factor |
US4459359A (en) | 1981-11-19 | 1984-07-10 | New York Blood Center, Inc. | Sensitive immunoassays of antigens or antibodies sequestered within immune complexes |
US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
FR2590674B1 (fr) | 1985-11-25 | 1989-03-03 | Inst Nat Sante Rech Med | Nouveaux reactifs de diagnostic |
DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
JPH0734015B2 (ja) * | 1988-04-25 | 1995-04-12 | 和光純薬工業株式会社 | 微量成分の新規測定法 |
US5223395A (en) | 1988-12-01 | 1993-06-29 | Centocor, Inc. | Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples |
EP0440044A1 (en) | 1990-01-31 | 1991-08-07 | Abbott Laboratories | Avoidance of human anti-mouse antibody interference in in vitro diagnostic testing |
US5094740A (en) | 1990-02-16 | 1992-03-10 | Glycomed, Inc. | Two-dimensional electrophoretic separation of carbohydrates |
GB9028123D0 (en) | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
US5582998A (en) | 1991-06-19 | 1996-12-10 | Boehringer Ingelheim International Gmbh | Monoclonal antibodies against human TNF-binding protein I (TNF-BP I) and immunoassays therefor |
JPH0566222A (ja) * | 1991-09-09 | 1993-03-19 | Tosoh Corp | 物質の分析方法 |
CA2150262C (en) | 1992-12-04 | 2008-07-08 | Kaspar-Philipp Holliger | Multivalent and multispecific binding proteins, their manufacture and use |
US5830675A (en) | 1993-03-10 | 1998-11-03 | Cedars-Sinai Medical Center | Methods for selectively detecting perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis, or type 1 autoimmune hepatitis |
DK0615129T3 (da) | 1993-03-10 | 2000-08-07 | Cedars Sinai Medical Center | Fremgangsmåder til selektiv påvisning af perinukleært anti-neutrophilt cytoplasmatisk antistof fra ulcerativ colitis eller |
ES2150970T3 (es) | 1993-09-07 | 2000-12-16 | Wako Pure Chem Ind Ltd | Procedimiento y reactivo para la medida de la actividad del complemento. |
JPH07110331A (ja) | 1993-09-07 | 1995-04-25 | Wako Pure Chem Ind Ltd | ヒト補体価測定方法及びヒト補体価測定用試薬組成物 |
JPH07140144A (ja) | 1993-11-19 | 1995-06-02 | S R L:Kk | アレルゲン特異的IgE抗体の測定方法および抗原抗体複合体の測定方法 |
WO1996020219A2 (en) | 1994-12-28 | 1996-07-04 | University Of Kentucky | Murine monoclonal anti-idiotype antibody 3h1 |
CN1198815A (zh) | 1996-08-12 | 1998-11-11 | 积水化学工业株式会社 | 用于测定细胞功能的容器、用于测定细胞功能的试剂盒以及用于测定细胞功能的方法 |
JP3718435B2 (ja) | 1996-08-12 | 2005-11-24 | 積水化学工業株式会社 | 細胞機能測定用容器及び細胞機能測定方法 |
US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
US6218129B1 (en) | 1998-05-15 | 2001-04-17 | Prometheus Laboratories, Inc. | Inflammatory bowel disease first step assay system |
US6309888B1 (en) | 1998-09-04 | 2001-10-30 | Leuven Research & Development Vzw | Detection and determination of the stages of coronary artery disease |
US6406862B1 (en) | 1998-10-06 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Army | Dip-stick assay for C-reactive protein |
DE19858777B4 (de) | 1998-12-18 | 2006-07-27 | Delta Biotechnology Ltd. | Verfahren zur teilweisen oder vollständigen Trennung von glykosilierten und nicht-glykosilierten Proteinen |
US6673550B2 (en) | 1999-04-30 | 2004-01-06 | Aclara Biosciences, Inc. | Electrophoretic tag reagents comprising fluorescent compounds |
US6680209B1 (en) | 1999-12-06 | 2004-01-20 | Biosite, Incorporated | Human antibodies as diagnostic reagents |
AR026946A1 (es) | 1999-12-16 | 2003-03-05 | Amgen Inc | Osteoprotegerina/receptores de factores de necrosis de tumores |
FR2806739B1 (fr) | 2000-03-27 | 2005-02-18 | Fond Jean Dausset Ceph | Genes impliques dans les maladies inflammatoires de l'intestin et leur utilisation |
US6838250B2 (en) | 2000-03-31 | 2005-01-04 | Ortho-Clinical Diagnostics, Inc. | Immunoassay for C-reactive protein |
AU4341502A (en) | 2000-10-30 | 2002-06-11 | Univ Michigan | Nod2 nucleic acids and proteins |
AU2735002A (en) | 2000-10-30 | 2002-05-15 | Univ Michigan | Nod2 nucleic acids and proteins |
US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US20030040027A1 (en) | 2001-08-16 | 2003-02-27 | Gerd Ritter | Method for determining protein component in a biological sample |
JP2003075443A (ja) * | 2001-09-03 | 2003-03-12 | Sekisui Chem Co Ltd | 標的物質測定試薬、それを用いた標的物質の測定方法 |
MXPA04004417A (es) | 2001-11-12 | 2004-08-11 | Merck Patent Gmbh | Anticuerpo anti-tnf alfa modificado. |
US20060110407A1 (en) | 2001-12-05 | 2006-05-25 | Shelley Stopera | Immune globulin formulations for the treatment and prevention of an orthopoxvirus infection |
GB0208817D0 (en) * | 2002-04-17 | 2002-05-29 | European Molecular Biology Lab Embl | Method for producing monoclonal antibodies |
US20040022792A1 (en) | 2002-06-17 | 2004-02-05 | Ralph Klinke | Method of stabilizing proteins at low pH |
US20060078944A1 (en) | 2002-08-01 | 2006-04-13 | Jun Kuai | Methods and reagents relating to inflammation and apoptosis |
US20040053263A1 (en) | 2002-08-30 | 2004-03-18 | Abreu Maria T. | Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease |
US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
US7662569B2 (en) | 2003-04-11 | 2010-02-16 | Cedars-Sinai Medical Center | Methods of assessing Crohn's disease patient phenotype by I2 serologic response |
WO2005094200A2 (en) | 2003-06-20 | 2005-10-13 | University Of Florida | Biomarkers for differentiating between type 2 and type 2 diabetes |
WO2005012353A1 (en) | 2003-08-01 | 2005-02-10 | Amgen Inc. | Crystalline tumor necrosis factor receptor 2 polypeptides |
JP2007528868A (ja) | 2003-08-14 | 2007-10-18 | ワイス | 抗ルイスy抗イディオタイプ抗体およびその使用 |
EP1519194A1 (en) | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
WO2005040798A1 (ja) * | 2003-10-29 | 2005-05-06 | Eisai Co., Ltd. | アルツハイマー病の診断方法 |
WO2005041896A2 (en) | 2003-11-03 | 2005-05-12 | Duke University | Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke |
ES2239532B1 (es) * | 2004-02-06 | 2006-11-01 | Proyecto De Biomedicina Cima S.L. | Metodo para evaluar el riesgo y la predisposicion a desarrollar una patologia relacionada con la presencia de autoanticuerpos frente a epcr. |
US20090275496A1 (en) | 2004-05-07 | 2009-11-05 | Peptimmune, Inc. | Effective quantitation of complex peptide mixtures in tissue samples and improved therapeutic methods |
CA2572263A1 (en) * | 2004-06-30 | 2006-01-12 | Centocor, Inc. | Detection or measurement of antibodies to antigenic proteins in biological tissues or samples |
WO2006012472A1 (en) | 2004-07-21 | 2006-02-02 | Qualyst, Inc. | Apparatus, kits and methods for evaluating binding interactions, for detecting and quantifying binding molecules, and for sample preparation |
US20060253263A1 (en) | 2005-04-11 | 2006-11-09 | Meshkin Brian J | Method to optimize drug selection, dosing and evaluation and to help predict therapeutic response and toxicity from immunosuppressant therapy |
US7601335B2 (en) | 2005-05-20 | 2009-10-13 | Genentech, Inc. | Pretreatment of a biological sample from an autoimmune disease subject |
CA2615846A1 (en) | 2005-07-21 | 2007-01-25 | Genmab A/S | Potency assays for antibody drug substance binding to an fc receptor |
US20090162374A1 (en) * | 2005-09-14 | 2009-06-25 | Geraghty Daniel E | Specific removal of activated immune cells |
JP2007147367A (ja) | 2005-11-25 | 2007-06-14 | Sekisui Chem Co Ltd | サイトカイン産生能の測定方法 |
DE102005057920A1 (de) | 2005-12-02 | 2007-06-28 | Strohner, Pavel, Dr. | Immunoassay zur simultanen immunchemischen Bestimmung eines Analyten (Antigen) und eines gegen den Analyten gerichteten Therapieantikörpers in Proben |
US20090061466A1 (en) * | 2006-03-09 | 2009-03-05 | Wolfgang Hoesel | Anti-drug antibody assay |
WO2008008349A2 (en) | 2006-07-11 | 2008-01-17 | Drexel University | Methods of quantitatively assessing inflammation with biosensing nanoparticles |
MX2009003048A (es) | 2006-09-21 | 2009-09-07 | Prometheus Lab Inc | Disposiciones a base de anticuerpo para detectar transductores de multiple señal en celulas circulantes raras. |
US20090035216A1 (en) | 2007-08-03 | 2009-02-05 | Biomonitor Aps | Method for determining in vivo biopharmaceutical concentration or bioavailability |
EP2200613B1 (en) | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
CA2712021A1 (en) | 2008-01-15 | 2009-07-23 | Stichting Sanquin Bloedvoorziening | Methods and kits for detecting antibodies against therapeutic antibodies |
EP2263085A4 (en) | 2008-03-05 | 2011-07-06 | Singulex Inc | METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE DETECTION OF MOLECULES |
RU2571489C2 (ru) | 2009-10-26 | 2015-12-20 | Нестек С.А. | Способы выявления препаратов и аутоантител против tnf |
BR112013009376A2 (pt) | 2010-10-18 | 2016-07-26 | Nestec Sa | métodos para determinar isótipos de anticorpos antifármacos |
BR112013020981A2 (pt) | 2011-02-17 | 2016-10-11 | Nestec Sa | ensaios para a detecção de auto-anticorpos para os fármacos anti-tnf<244> |
US20130266963A1 (en) | 2011-07-06 | 2013-10-10 | Nestec S.A. | Assay for detecting neutralizing autoantibodies to biologic therapy |
MX343324B (es) | 2011-07-06 | 2016-11-01 | Nestec Sa | Ensayos para detectar auto anticuerpos neutralizadores de la terapia biologica con tnf alpha. |
US20130295685A1 (en) | 2012-04-10 | 2013-11-07 | Nestec S.A. | Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies |
US20140051184A1 (en) | 2012-08-15 | 2014-02-20 | Nestec S.A. | Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies thereto |
BR112015012482A2 (pt) | 2012-11-30 | 2017-07-11 | Nestec Sa | ensaios para detecção de autoanticorpos neutralizantes à terapia com produtos biológicos |
-
2011
- 2011-10-18 BR BR112013009376A patent/BR112013009376A2/pt not_active Application Discontinuation
- 2011-10-18 MX MX2013004305A patent/MX344053B/es active IP Right Grant
- 2011-10-18 AU AU2011317149A patent/AU2011317149B2/en not_active Ceased
- 2011-10-18 JP JP2013535017A patent/JP5960707B2/ja not_active Expired - Fee Related
- 2011-10-18 CN CN201180060851.XA patent/CN103299190B/zh not_active Expired - Fee Related
- 2011-10-18 SG SG2013027875A patent/SG189391A1/en unknown
- 2011-10-18 NZ NZ60936311A patent/NZ609363A/en not_active IP Right Cessation
- 2011-10-18 KR KR1020137012681A patent/KR101934247B1/ko active IP Right Grant
- 2011-10-18 CA CA2815026A patent/CA2815026C/en active Active
- 2011-10-18 EP EP11788248.0A patent/EP2630495B1/en active Active
- 2011-10-18 WO PCT/US2011/056777 patent/WO2012054532A1/en active Application Filing
-
2013
- 2013-04-02 IL IL225534A patent/IL225534A/en active IP Right Grant
- 2013-04-17 US US13/865,139 patent/US9784748B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2011317149A1 (en) | 2013-05-02 |
WO2012054532A1 (en) | 2012-04-26 |
CA2815026C (en) | 2018-11-20 |
CA2815026A1 (en) | 2012-04-26 |
IL225534A (en) | 2017-03-30 |
NZ609363A (en) | 2015-04-24 |
US20130344621A1 (en) | 2013-12-26 |
BR112013009376A2 (pt) | 2016-07-26 |
MX2013004305A (es) | 2013-08-27 |
CN103299190B (zh) | 2017-02-15 |
KR20130139289A (ko) | 2013-12-20 |
SG189391A1 (en) | 2013-05-31 |
JP2014500482A (ja) | 2014-01-09 |
JP5960707B2 (ja) | 2016-08-02 |
EP2630495B1 (en) | 2017-02-08 |
EP2630495A1 (en) | 2013-08-28 |
KR101934247B1 (ko) | 2019-01-02 |
CN103299190A (zh) | 2013-09-11 |
IL225534A0 (en) | 2013-06-27 |
AU2011317149B2 (en) | 2015-05-07 |
US9784748B2 (en) | 2017-10-10 |
RU2013122871A (ru) | 2014-11-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX344053B (es) | Metodos para determinar isotipos de anticuerpos anti-farmacos. | |
ZA202008068B (en) | Use of high-temperature-resistant cas protein, and method and reagent kit for detecting target nucleic acid molecule | |
MX2020009021A (es) | Ensayos para detectar la presencia o la cantidad de un anticuerpo antifarmaco. | |
MX2009004460A (es) | Inmunoensayo de analitos en muestras que contienen anticuerpos anti-analito endogenos. | |
CA2844033C (en) | Method for detecting pancreatic cancer | |
MX2013003161A (es) | Dispositivos, metodos y kits de inmunocromatografia. | |
MX2007014815A (es) | Metodos de inmunoanalisis mejorados. | |
ATE425266T1 (de) | Aptamer-nanopartikelkonjugate und verwendungsverfahren zur detektion von zielanalyten | |
ATE527543T1 (de) | Testvorrichtung zur schnelldiagnose | |
WO2011119934A3 (en) | Methods and materials for detecting colorectal neoplasm | |
BR112012017014A2 (pt) | ensaio para anticorpos de víris jc | |
HK1115636A1 (en) | Use of cyfra 21-1 as a marker for colorectal cancer cyfra 21-1 | |
WO2007114986A3 (en) | Cooperative probes and methods of using them | |
MX2020000186A (es) | Ensayos para evaluar los niveles de anticuerpos neutralizantes en sujetos tratados con un fármaco biológico y usos de los mismos en medicina personalizada. | |
MX2019006098A (es) | Ensayo de anticuerpos. | |
EP1930445A4 (en) | KIT AND METHOD FOR DETECTING UROTHELIAL CANCER | |
CA2942605C (en) | Methods for identifying a biomarker indicative of a reduced drug response using a thermal shift assay | |
WO2008131261A3 (en) | Peptide biomarkers of cardiovascular disease | |
EA201370030A1 (ru) | Бифункциональный количественный анализ in vitro связывания мишени для обнаружения нейтрализующих антител к антителам-мишеням | |
MX2022013738A (es) | Ensayo de anticuerpos neutralizantes para proteinas terapeuticas. | |
WO2012021741A3 (en) | Lateral flow assays for non-diagnostic analytes | |
EP3922983A3 (en) | Improved low sample volume urinalysis assay strip, analytical kits, and methods of use related thereto | |
RU2014110231A (ru) | Мембранный белок микровезикул и его применение | |
WO2005115394A3 (en) | Prenyl-electrostatic switch, and methods of use | |
Sato et al. | Phos-tag immunoblot analysis for detecting IRF5 phosphorylation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |