BRPI0923199B8 - método para determinar a presença de anticorpos de fixação de complemento - Google Patents

método para determinar a presença de anticorpos de fixação de complemento

Info

Publication number
BRPI0923199B8
BRPI0923199B8 BRPI0923199A BRPI0923199A BRPI0923199B8 BR PI0923199 B8 BRPI0923199 B8 BR PI0923199B8 BR PI0923199 A BRPI0923199 A BR PI0923199A BR PI0923199 A BRPI0923199 A BR PI0923199A BR PI0923199 B8 BRPI0923199 B8 BR PI0923199B8
Authority
BR
Brazil
Prior art keywords
complement
complement factor
factor
exogenous human
autologous
Prior art date
Application number
BRPI0923199A
Other languages
English (en)
Inventor
B Tyan Dolly
Chen Ge
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of BRPI0923199A2 publication Critical patent/BRPI0923199A2/pt
Publication of BRPI0923199B1 publication Critical patent/BRPI0923199B1/pt
Publication of BRPI0923199B8 publication Critical patent/BRPI0923199B8/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

Abstract

métodos e composições para detecção de anticorpos com fixação de complemento. a invenção fornece métodos para detecção sensível e específica de anticorpos com fixação de complemento em uma amostra biológica usando o fator de complemento c1q, incluindo fator de complemento autólogo c1q presente na amostra biológica e um anticorpo marcado de forma detectável que se liga ao fator de complemento autólogo c1q, fator de complexo exógeno humano c1q e um anticorpo marcado de forma detectável que se liga ao fator de complemento humano exógeno c1q, fator de complemento humano exógeno c1q marcado de forma detectável, ou uma combinação de fator de complemento autólogo c1q e fator de complemento humano exógeno c1q. a invenção também apresenta kits, sistemas e dispositivos para uso nos métodos da invenção.
BRPI0923199A 2008-12-01 2009-11-25 método para determinar a presença de anticorpos de fixação de complemento BRPI0923199B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11894908P 2008-12-01 2008-12-01
US61/118,949 2008-12-01
PCT/US2009/065984 WO2010065425A1 (en) 2008-12-01 2009-11-25 Methods and compositions for detection of complement fixing antibodies

Publications (3)

Publication Number Publication Date
BRPI0923199A2 BRPI0923199A2 (pt) 2016-02-16
BRPI0923199B1 BRPI0923199B1 (pt) 2020-10-20
BRPI0923199B8 true BRPI0923199B8 (pt) 2021-07-27

Family

ID=42233567

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0923199A BRPI0923199B8 (pt) 2008-12-01 2009-11-25 método para determinar a presença de anticorpos de fixação de complemento

Country Status (8)

Country Link
US (1) US10338080B2 (pt)
EP (2) EP3460480B1 (pt)
JP (2) JP5792626B2 (pt)
CN (2) CN105866426B (pt)
AU (1) AU2009322607B2 (pt)
BR (1) BRPI0923199B8 (pt)
CA (1) CA2740192C (pt)
WO (1) WO2010065425A1 (pt)

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US20160041185A1 (en) * 2013-03-14 2016-02-11 The Board Of Trustees Of The Leland Stanford Junior University Methods of Detecting Complement Fixing and Non-Complement Fixing Antibodies and Systems for Practicing the Same
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JP7153494B2 (ja) * 2018-07-27 2022-10-14 シスメックス株式会社 生体粒子の測定方法、非特異シグナルの検出方法、生体粒子測定方法及び生体粒子を検出するための試薬キット
AU2020270071A1 (en) * 2019-05-06 2021-10-21 The Regents Of The University Of California Non-HLA markers of transplant rejection
CN111812336A (zh) * 2020-08-10 2020-10-23 苏州康和顺医疗技术有限公司 用于检测冠状病毒抗体的检测试剂盒及其制备方法
EP4226155A1 (en) * 2020-10-09 2023-08-16 Takeda Vaccines, Inc. Methods for determining complement-fixing antibodies
WO2022212704A1 (en) * 2021-03-31 2022-10-06 Takeda Vaccines, Inc. Methods for characterizing the immune response of a subject to a dengue virus composition
EP4089413A1 (en) * 2021-05-12 2022-11-16 Cisbio Bioassays Method for determining the binding of an antibody to the complement component 1q (c1q)

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Also Published As

Publication number Publication date
CN105866426B (zh) 2018-11-23
BRPI0923199B1 (pt) 2020-10-20
CN102203610A (zh) 2011-09-28
AU2009322607B2 (en) 2015-05-14
US20110281757A1 (en) 2011-11-17
JP2015007651A (ja) 2015-01-15
EP2353005A4 (en) 2012-10-17
EP3460480B1 (en) 2022-11-02
JP5792626B2 (ja) 2015-10-14
CA2740192A1 (en) 2010-06-10
EP2353005B1 (en) 2018-10-03
BRPI0923199A2 (pt) 2016-02-16
JP2012510618A (ja) 2012-05-10
CA2740192C (en) 2019-12-31
WO2010065425A1 (en) 2010-06-10
CN105866426A (zh) 2016-08-17
AU2009322607A1 (en) 2010-06-10
EP3460480A1 (en) 2019-03-27
EP2353005A1 (en) 2011-08-10
US10338080B2 (en) 2019-07-02

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