BR112013026580A2 - método para quantificar múltiplas imunoglobulinas específicas de antígeno e para calibrar um dispositivo adequado, sistema de teste multialergeno, e, kit de partes - Google Patents

método para quantificar múltiplas imunoglobulinas específicas de antígeno e para calibrar um dispositivo adequado, sistema de teste multialergeno, e, kit de partes

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Publication number
BR112013026580A2
BR112013026580A2 BR112013026580A BR112013026580A BR112013026580A2 BR 112013026580 A2 BR112013026580 A2 BR 112013026580A2 BR 112013026580 A BR112013026580 A BR 112013026580A BR 112013026580 A BR112013026580 A BR 112013026580A BR 112013026580 A2 BR112013026580 A2 BR 112013026580A2
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BR
Brazil
Prior art keywords
specific
antigen
calibrating
specific immunoglobulins
kit
Prior art date
Application number
BR112013026580A
Other languages
English (en)
Inventor
Andrea Crisanti
Francesca Baldracchini
Mauro Maccari
Original Assignee
Microtest Matrices Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microtest Matrices Ltd filed Critical Microtest Matrices Ltd
Publication of BR112013026580A2 publication Critical patent/BR112013026580A2/pt

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

método para quantificar múltiplas imunoglobulinas específicas de antígeno e para calibrar um dispositivo adequado, sistema de teste multialergeno, e, kit de partes a invenção fornece um método de quantificar múltiplas imunoglobulinas específicas de antígeno em uma amostra de teste, o método compreendendo utilizar uma diluição em série de anticorpos anti-imunoglobulina, fragmentos ou derivados destes, imobilizados em um suporte sólido em combinação com uma diluição em série de uma amostra de referência de imunoglobulina para gerar múltiplas curvas de capacidade de ligação. tais curvas de capacidade de ligação são combinadas com curvas dose-resposta específicas, geradas para cada antígeno específico a ser testado, usando amostras de soro de reatividade conhecida para esses antígenos para fornecer um sistema de calibragem que permite análise mais precisa de imunoglobulina específica de antígeno em uma amostra. a invenção também diz respeito a métodos para calibrar um dispositivo adequado para ensaiar múltiplas imunoglobulinas específicas de antígeno que ligam nos múltiplos antígenos, ou seus fragmentos imobilizados, em um suporte sólido. são também fornecidos um sistema e kits de teste multialérgenos para uso nos métodos.
BR112013026580A 2011-04-18 2012-04-17 método para quantificar múltiplas imunoglobulinas específicas de antígeno e para calibrar um dispositivo adequado, sistema de teste multialergeno, e, kit de partes BR112013026580A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1106478.9A GB2490652A (en) 2011-04-18 2011-04-18 Methods of quantifying antibodies, especially IgE antibodies in a sample
PCT/GB2012/050846 WO2012143709A1 (en) 2011-04-18 2012-04-17 Immunoassay

Publications (1)

Publication Number Publication Date
BR112013026580A2 true BR112013026580A2 (pt) 2016-12-27

Family

ID=44147123

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013026580A BR112013026580A2 (pt) 2011-04-18 2012-04-17 método para quantificar múltiplas imunoglobulinas específicas de antígeno e para calibrar um dispositivo adequado, sistema de teste multialergeno, e, kit de partes

Country Status (13)

Country Link
US (2) US20140141995A1 (pt)
EP (1) EP2699905B1 (pt)
JP (1) JP5826917B2 (pt)
KR (1) KR101629921B1 (pt)
CN (1) CN103547921B (pt)
AU (1) AU2012246064B2 (pt)
BR (1) BR112013026580A2 (pt)
CA (1) CA2833654A1 (pt)
GB (1) GB2490652A (pt)
MX (1) MX2013012143A (pt)
RU (1) RU2594066C2 (pt)
WO (1) WO2012143709A1 (pt)
ZA (1) ZA201307642B (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102539748A (zh) * 2011-12-30 2012-07-04 苏州浩欧博生物医药有限公司 一种利用酶联板进行多指标酶联免疫吸附检测的方法
WO2013148498A1 (en) 2012-03-27 2013-10-03 Ventana Medical Systems, Inc. Signaling conjugates and methods of use
WO2017044905A1 (en) * 2015-09-09 2017-03-16 Biomerica, Inc. Compositions, devices, and methods of osteoarthritis sensitivity testing
US20170089893A1 (en) * 2015-09-24 2017-03-30 Globallergy, Llc Chromatographic immune assay for the detection of allergic sensitivities
WO2017160869A1 (en) * 2016-03-15 2017-09-21 Biomerica, Inc. Compositions, devices, and methods of fibromyalgia sensitivity testing
WO2017168506A1 (ja) * 2016-03-28 2017-10-05 日立化成株式会社 特異的ＩｇＥ検査方法及び特異的ＩｇＥ検査装置
US11651866B2 (en) 2016-10-17 2023-05-16 Reliant Immune Diagnostics, Inc. System and method for real-time insurance quote in response to a self-diagnostic test
US11107585B2 (en) 2016-10-17 2021-08-31 Reliant Immune Diagnostics, Inc System and method for a digital consumer medical wallet and storehouse
US9857372B1 (en) 2016-10-17 2018-01-02 Reliant Immune Diagnostics, LLC Arbovirus indicative birth defect risk test
US11579145B2 (en) 2016-10-17 2023-02-14 Reliant Immune Diagnostics, Inc. System and method for image analysis of medical test results
US11693002B2 (en) 2016-10-17 2023-07-04 Reliant Immune Diagnostics, Inc. System and method for variable function mobile application for providing medical test results using visual indicia to determine medical test function type
US10902951B2 (en) 2016-10-17 2021-01-26 Reliant Immune Diagnostics, Inc. System and method for machine learning application for providing medical test results using visual indicia
US11802868B2 (en) 2016-10-17 2023-10-31 Reliant Immune Diagnostics, Inc. System and method for variable function mobile application for providing medical test results
EP3674712A1 (en) 2017-01-18 2020-07-01 Essen Instruments, Inc. D/B/A Essen BioScience, Inc. Methods and reagents for determining immunoglobulin gamma (igg) antibody isotype concentration from biological samples
CN108802399A (zh) * 2017-04-28 2018-11-13 中国医学科学院基础医学研究所 一种检测过敏原的新型蛋白质芯片
EP3639031A4 (en) * 2017-06-15 2021-05-05 Sunstone Scientific Limited. METHOD OF IHC ANTIGEN IMAGE SCALE EXTRAPOLATION
US11662564B2 (en) 2017-06-15 2023-05-30 Shenzhen Prs Limited Paraffin shield coating for microscope slide
WO2019002935A1 (en) * 2017-06-26 2019-01-03 Bio-Rad Europe Gmbh IN SITU SERIES DILUTION METHOD
CA3086860A1 (en) * 2018-01-05 2019-07-11 Network Immunology Inc. A combination of plasma immunoglobulin and antigen- specific immunoglobulin for the modification of the immune system and the treatment or prevention of allergic diseases
EP3779443A4 (en) * 2018-04-06 2022-05-04 Slsbio Co., Ltd. NEW IMMUNOGLOBULIN E EPITOPE, BINDING ANTIBODY AND KIT FOR THE ANALYSIS OF IMMUNOGLOBULIN E IN A SAMPLE CONTAINING IT
KR102070794B1 (ko) * 2019-01-21 2020-01-29 (의료)길의료재단 효소 모방 나노자임에 기반한 면역학적 분석에 의한 IgE 검출 및 알러지 진단법
WO2021015123A1 (ja) * 2019-07-25 2021-01-28 東レ株式会社 アレルゲン固定化担体の製造方法及びアレルゲン特異的抗体の検出方法
US20210382070A1 (en) * 2020-06-04 2021-12-09 The Chinese University Of Hong Kong Diagnostic biomarkers for shrimp allergy
CN113777320A (zh) * 2021-08-02 2021-12-10 青岛理工大学 基于分泌物的人体免疫力测试方法
US20230253072A1 (en) * 2021-12-30 2023-08-10 Invitrogen Bioservices India Private Limited Computer implemented methods for detecting analytes in immunoassays

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4528267A (en) * 1982-11-26 1985-07-09 Axionics, Inc. Fluorometirc enzyme inhibition immunoassay for measuring potency of allergen extracts
US4539292A (en) * 1982-12-29 1985-09-03 Reid Michael J Immunoassay technique for specific immunoglobulin E
JPH03239961A (ja) * 1990-02-16 1991-10-25 Hitachi Chem Co Ltd アレルギー診断法
JPH08285852A (ja) * 1995-04-14 1996-11-01 Tokiwa Kagaku Kogyo Kk ヒトプロレニン測定試薬及びそれを用いた測定方法
DE60020119T2 (de) * 1999-06-18 2005-10-06 Biacore Ab Verfahren und Vorrichtung zur Untersuchung von Wirksstoffskandidaten und zur Bestimmung ihrer pharmakokinetischen Parametern
EP1195606A1 (en) 2000-10-03 2002-04-10 VBC-Genomics Forschungsges.m.b.H. Allergen-microarray assay
FR2822049B1 (fr) * 2001-03-13 2003-08-01 Dbv Medica 1 Patch destine notamment a depister l'etat de sensibilisation d'un sujet a un allergene, procede de fabrication et utilisation
ATE439588T1 (de) * 2001-05-04 2009-08-15 Biosite Inc Diagnostische marker für akute herzerkrankungen und verfahren des gebrauchs
JP2002350447A (ja) * 2001-05-24 2002-12-04 Wako Pure Chem Ind Ltd 生理活性物質固定化担体及びその製造方法、固定化生理活性物質、試料中の対象成分分析方法、並びに試料中の対象成分分析用キット
US20030073249A1 (en) * 2001-07-07 2003-04-17 Lee Duen Allergen detection chip
EP1478379A4 (en) * 2001-12-28 2005-12-21 Campina Bv HUMANIZED LACTOFERRIN AND ITS APPLICATIONS
US20060008895A1 (en) * 2004-07-08 2006-01-12 Hsiu-Mei Chen Microarray chip for detection of immunoglobulin
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
JP2006317254A (ja) * 2005-05-12 2006-11-24 Futaba Electronics:Kk 匂い測定装置と匂い測定方法と匂い測定用プログラム
EP1909105A1 (en) * 2006-10-06 2008-04-09 Royal College of Surgeons in Ireland A method of determining platelet function
CN101178406A (zh) * 2007-12-05 2008-05-14 杭州浙大生物基因工程有限公司 过敏原特异性抗体IgE ELISA检测试剂盒及其制备方法
JP5747315B2 (ja) * 2009-05-12 2015-07-15 学校法人藤田学園 糖鎖不全ヒトＩｇＡ１ヒンジ部を認識する抗体及びその用途
GB201002601D0 (en) * 2010-02-16 2010-03-31 Microtest Matrices Ltd Allergen microarray

Also Published As

Publication number Publication date
GB2490652A (en) 2012-11-14
RU2594066C2 (ru) 2016-08-10
WO2012143709A1 (en) 2012-10-26
CN103547921B (zh) 2016-06-01
CA2833654A1 (en) 2012-10-26
AU2012246064A1 (en) 2013-10-24
JP2014512535A (ja) 2014-05-22
EP2699905A1 (en) 2014-02-26
ZA201307642B (en) 2014-08-27
JP5826917B2 (ja) 2015-12-02
GB201106478D0 (en) 2011-06-01
US20170328892A1 (en) 2017-11-16
KR101629921B1 (ko) 2016-06-13
US20140141995A1 (en) 2014-05-22
KR20130138843A (ko) 2013-12-19
RU2013151081A (ru) 2015-05-27
MX2013012143A (es) 2014-03-27
AU2012246064B2 (en) 2016-04-21
CN103547921A (zh) 2014-01-29
EP2699905B1 (en) 2021-04-14

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25A Requested transfer of rights approved

Owner name: LUMIRADX UK LIMITED (GB)

B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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