BR112018005812A2 - ?método de imunoensaio para a detecção de um analito, kit de reagentes para detectar um analito por um imunoensaio e uso de um parceiro de ligação marcador-específico? - Google Patents
?método de imunoensaio para a detecção de um analito, kit de reagentes para detectar um analito por um imunoensaio e uso de um parceiro de ligação marcador-específico?Info
- Publication number
- BR112018005812A2 BR112018005812A2 BR112018005812A BR112018005812A BR112018005812A2 BR 112018005812 A2 BR112018005812 A2 BR 112018005812A2 BR 112018005812 A BR112018005812 A BR 112018005812A BR 112018005812 A BR112018005812 A BR 112018005812A BR 112018005812 A2 BR112018005812 A2 BR 112018005812A2
- Authority
- BR
- Brazil
- Prior art keywords
- marker
- analyte
- specific binding
- detecting
- binding partner
- Prior art date
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/539—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody involving precipitating reagent, e.g. ammonium sulfate
- G01N33/541—Double or second antibody, i.e. precipitating antibody
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56994—Herpetoviridae, e.g. cytomegalovirus, Epstein-Barr virus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5761—Hepatitis B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5768—Hepatitis A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Plasma & Fusion (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
Abstract
a invenção diz respeito a um método de imunoensaio para a detecção de um analito, tal como um antígeno ou um anticorpo em uma amostra isolada suspeita de conter o referido analito, pela incubação da referida amostra com uma pluralidade de parceiros de ligação, um dos quais possuindo um marcador detectável, em que é adicionado um parceiro de ligação marcador-específico que não possui um marcador, mas que se liga ao referido marcador detectável. o método é aplicável a uma grande variedade de analitos e provou ser particularmente útil para anticorpos da classe igg e igm presentes em amostras devido a infecções por agentes patogênicos. a invenção diz respeito ainda a um kit de reagentes uteis para o referido método compreendendo pelo menos dois parceiros de ligação específicos para o analito, um dos quais possuindo de um marcador detectável e um parceiro de ligação marcador-específico que se liga ao referido marcador detectável, mas que não possui um marcador detectável. além disso, a invenção abrange o uso de um parceiro de ligação marcador-específico que não possui um marcador detectável em um teste de diagnóstico in vitro para eliminar interferências causadas por anticorpos antimarcadores presentes em uma amostra.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15197192.6A EP3176580A1 (en) | 2015-12-01 | 2015-12-01 | Method for reduction of interferences in immunoassays |
PCT/EP2016/079170 WO2017093271A1 (en) | 2015-12-01 | 2016-11-30 | Method for reduction of interferences in immunoassays |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018005812A2 true BR112018005812A2 (pt) | 2018-10-16 |
Family
ID=54754553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018005812A BR112018005812A2 (pt) | 2015-12-01 | 2016-11-30 | ?método de imunoensaio para a detecção de um analito, kit de reagentes para detectar um analito por um imunoensaio e uso de um parceiro de ligação marcador-específico? |
Country Status (7)
Country | Link |
---|---|
US (1) | US11320423B2 (pt) |
EP (2) | EP3176580A1 (pt) |
JP (1) | JP6779293B2 (pt) |
KR (1) | KR102164266B1 (pt) |
CN (1) | CN108291912B (pt) |
BR (1) | BR112018005812A2 (pt) |
WO (1) | WO2017093271A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019175254A1 (en) | 2018-03-13 | 2019-09-19 | Roche Diagnostics Gmbh | Reduction of interferences in immunoassays |
WO2020061135A1 (en) * | 2018-09-18 | 2020-03-26 | Siemens Healthcare Diagnostics Inc. | Methods and reagents for zika virus immunoassays |
CN111122852A (zh) * | 2018-10-31 | 2020-05-08 | 博阳生物科技(上海)有限公司 | 一种均相化学发光分析方法及其应用 |
CN109444426A (zh) * | 2018-12-12 | 2019-03-08 | 郑州安图生物工程股份有限公司 | 消除捕获法IgM抗体检测系统中HAMA干扰的方法 |
JP7273195B2 (ja) * | 2019-05-13 | 2023-05-12 | エフ. ホフマン-ラ ロシュ アーゲー | 干渉抑制薬物動態イムノアッセイ |
CA3152057A1 (en) * | 2019-06-25 | 2020-12-30 | Veravas, Inc. | Compositions and methods for detecting and depleting sample interferences |
CN114258491A (zh) * | 2019-08-16 | 2022-03-29 | 深圳迈瑞生物医疗电子股份有限公司 | 全新型总抗体测定的免疫分析模式 |
CN111089961A (zh) * | 2019-12-26 | 2020-05-01 | 迪瑞医疗科技股份有限公司 | 一种弓形虫IgM抗体检测试剂盒及其制备方法 |
CN111089975A (zh) * | 2019-12-26 | 2020-05-01 | 迪瑞医疗科技股份有限公司 | 一种检测弓形虫IgG抗体化学发光免疫分析测定试剂盒及其制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4407423A1 (de) | 1994-03-05 | 1995-09-07 | Boehringer Mannheim Gmbh | Entstörmittel zum Einsatz bei Immunoassays |
DE19519973A1 (de) * | 1995-05-31 | 1996-12-05 | Boehringer Mannheim Gmbh | Entstörungsreagenz für die Bestimmung eines Analyten mit einem lumineszenzfähigen Metallkomplex |
DE19649389A1 (de) * | 1996-11-29 | 1998-06-04 | Boehringer Mannheim Gmbh | Antigenspezifischer IgM-Nachweis |
US6087088A (en) * | 1997-01-31 | 2000-07-11 | Bayer Corporation | Binding assays using more than one label for determining analyte in the presence of interfering factors |
CN1629309A (zh) * | 2004-08-24 | 2005-06-22 | 中国水产科学研究院黄海水产研究所 | 控制对虾病毒感染的受体阻断剂的筛选方法 |
US20070059682A1 (en) * | 2005-09-13 | 2007-03-15 | Rapid Pathogen Screening Inc. | Method to increase specificity and/or accuracy of lateral flow immunoassays |
US7732153B2 (en) * | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
TWI434855B (zh) | 2006-11-21 | 2014-04-21 | Hoffmann La Roche | 結合物及其在免疫分析中作為參考標準之用途 |
CA2686206A1 (en) * | 2007-05-07 | 2008-11-13 | Wyeth | Elimination of interference in immunoassays caused by anti-carbohydrate antibodies |
WO2009111729A1 (en) * | 2008-03-06 | 2009-09-11 | Ventana Medical Systems, Inc. | Anti-dnp antibodies and methods of use |
EP2108957A1 (en) | 2008-04-07 | 2009-10-14 | Koninklijke Philips Electronics N.V. | Compounds and methods for the labelling and affinity-selection of proteins |
US8614297B2 (en) * | 2008-12-22 | 2013-12-24 | Hoffmann-La Roche Inc. | Anti-idiotype antibody against an antibody against the amyloid β peptide |
JP2010172324A (ja) * | 2009-02-02 | 2010-08-12 | Tdk Corp | アプタマーを用いて微生物を検出する方法及びキット |
US8476079B2 (en) * | 2010-04-30 | 2013-07-02 | Abbott Point Of Care Inc. | Reagents for reducing leukocyte interference in immunoassays |
CA3043423A1 (en) * | 2010-08-17 | 2012-02-23 | F. Hoffmann-La Roche Ag | Anti-human igg1 antibody |
WO2013132338A2 (en) * | 2012-03-06 | 2013-09-12 | Calpro As | Competitive immunoassay for calprotectin |
EP2976642A4 (en) * | 2013-03-15 | 2016-09-21 | Harvard College | METHODS AND COMPOSITIONS FOR IMPROVING THE DETECTION AND / OR CAPTURE OF A TARGET ENTITY |
CN107003307B (zh) * | 2014-12-18 | 2020-04-07 | 豪夫迈·罗氏有限公司 | 降低干扰的方法 |
-
2015
- 2015-12-01 EP EP15197192.6A patent/EP3176580A1/en not_active Ceased
-
2016
- 2016-11-30 WO PCT/EP2016/079170 patent/WO2017093271A1/en active Application Filing
- 2016-11-30 BR BR112018005812A patent/BR112018005812A2/pt unknown
- 2016-11-30 CN CN201680070249.7A patent/CN108291912B/zh active Active
- 2016-11-30 KR KR1020187013476A patent/KR102164266B1/ko active IP Right Grant
- 2016-11-30 EP EP16805762.8A patent/EP3384288B1/en active Active
- 2016-11-30 JP JP2018528341A patent/JP6779293B2/ja active Active
-
2018
- 2018-06-01 US US15/995,572 patent/US11320423B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP6779293B2 (ja) | 2020-11-04 |
CN108291912A (zh) | 2018-07-17 |
KR102164266B1 (ko) | 2020-10-13 |
US20180348211A1 (en) | 2018-12-06 |
JP2019502110A (ja) | 2019-01-24 |
US11320423B2 (en) | 2022-05-03 |
EP3384288B1 (en) | 2024-01-10 |
CN108291912B (zh) | 2021-07-27 |
EP3384288A1 (en) | 2018-10-10 |
KR20180063313A (ko) | 2018-06-11 |
EP3176580A1 (en) | 2017-06-07 |
WO2017093271A1 (en) | 2017-06-08 |
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