BR112018073178A2 - método, matriz e uso dos mesmos - Google Patents
método, matriz e uso dos mesmosInfo
- Publication number
- BR112018073178A2 BR112018073178A2 BR112018073178-1A BR112018073178A BR112018073178A2 BR 112018073178 A2 BR112018073178 A2 BR 112018073178A2 BR 112018073178 A BR112018073178 A BR 112018073178A BR 112018073178 A2 BR112018073178 A2 BR 112018073178A2
- Authority
- BR
- Brazil
- Prior art keywords
- pancreatic cancer
- determining
- test sample
- associated disease
- methods
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
a presente invenção fornece um método para diagnosticar ou determinar um estado de doença associada ao câncer pancreático que compreende ou consiste nas etapas de: (a) fornecer uma amostra de um indivíduo a ser testada; e (b) determinar uma assinatura de biomarcador da amostra de teste medindo-se a presença e/ou quantidade na amostra de teste de um ou mais biomarcadores selecionados a partir do grupo definido na tabela a; em que a presença e/ou quantidade na amostra de teste do um ou mais biomarcadores selecionados a partir do grupo definido na tabela a é indicativa da doença associada ao câncer pancreático no indivíduo; usos e métodos para determinar um estado de doença associada ao câncer pancreático e métodos para tratar câncer pancreático, juntamente com matrizes e kits para uso no mesmo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1608192.9A GB201608192D0 (en) | 2016-05-10 | 2016-05-10 | Method, array and use thereof |
GB1608192.9 | 2016-05-10 | ||
PCT/EP2017/061202 WO2017194613A2 (en) | 2016-05-10 | 2017-05-10 | Method, array and use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018073178A2 true BR112018073178A2 (pt) | 2019-02-19 |
Family
ID=56297465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018073178-1A BR112018073178A2 (pt) | 2016-05-10 | 2017-05-10 | método, matriz e uso dos mesmos |
Country Status (13)
Country | Link |
---|---|
US (2) | US20200011872A1 (pt) |
EP (2) | EP3907509A3 (pt) |
JP (2) | JP2019516981A (pt) |
KR (1) | KR20190005858A (pt) |
CN (1) | CN109564221A (pt) |
AU (1) | AU2017261762A1 (pt) |
BR (1) | BR112018073178A2 (pt) |
CA (1) | CA3022022A1 (pt) |
GB (1) | GB201608192D0 (pt) |
IL (1) | IL262824A (pt) |
MX (1) | MX2018013621A (pt) |
RU (1) | RU2018138639A (pt) |
WO (1) | WO2017194613A2 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100105571A1 (en) | 2007-03-27 | 2010-04-29 | Carl Arne Krister Borrebaeck | Protein Signature/Markers for the Detection of Adenocarcinoma |
SG11201909949XA (en) | 2017-05-24 | 2019-11-28 | Pandion Therapeutics Inc | Targeted immunotolerance |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
WO2020236875A1 (en) | 2019-05-20 | 2020-11-26 | Pandion Therapeutics, Inc. | Madcam targeted immunotolerance |
US11981715B2 (en) | 2020-02-21 | 2024-05-14 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a CD39 effector |
GB202010970D0 (en) | 2020-07-16 | 2020-09-02 | Immunovia Ab | Methods, arrays and uses thereof |
WO2022109105A1 (en) * | 2020-11-18 | 2022-05-27 | Pandion Operations, Inc. | Madcam targeted therapeutics and uses thereof |
WO2022204332A1 (en) * | 2021-03-24 | 2022-09-29 | Combangio, Inc. | Compositions comprising c-met agonist antibodies and methods for use in ocular treatment |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3169789D1 (en) | 1980-05-02 | 1985-05-15 | Edward P Davis | Leg aid device |
US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4486530A (en) | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US5856090A (en) | 1994-09-09 | 1999-01-05 | The Scripps Research Institute | DNA-methylase linking reaction |
GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
US7429452B2 (en) * | 2002-10-31 | 2008-09-30 | Hoffmann-La Roche Inc. | Methods for diagnosis and therapy of pancreatic cancer and composition useful therein |
US9005613B2 (en) * | 2003-06-16 | 2015-04-14 | Immunomedics, Inc. | Anti-mucin antibodies for early detection and treatment of pancreatic cancer |
WO2007013360A2 (en) * | 2005-07-27 | 2007-02-01 | Oncotherapy Science, Inc. | Pancreatic cancer related gene cst6 and gabrp |
US20100105571A1 (en) * | 2007-03-27 | 2010-04-29 | Carl Arne Krister Borrebaeck | Protein Signature/Markers for the Detection of Adenocarcinoma |
JP5931874B2 (ja) * | 2010-08-13 | 2016-06-08 | ソマロジック・インコーポレーテッド | 膵癌バイオマーカーおよびその使用 |
GB201103726D0 (en) * | 2011-03-04 | 2011-04-20 | Immunovia Ab | Method, array and use thereof |
WO2013052480A1 (en) * | 2011-10-03 | 2013-04-11 | The Board Of Regents Of The University Of Texas System | Marker-based prognostic risk score in colon cancer |
WO2013106844A2 (en) * | 2012-01-13 | 2013-07-18 | Oncocyte Corporation | Methods and compositions for the treatment and diaginosis of pancreatic cancer |
KR20140094180A (ko) * | 2013-01-21 | 2014-07-30 | 연세대학교 산학협력단 | 보체인자 b 단백질에 특이적으로 결합하는 폴리펩타이드 또는 항체를 포함하는 췌장암 진단용 조성물 |
WO2014160499A2 (en) * | 2013-03-13 | 2014-10-02 | Creatics Llc | Methods and compositions for detecting pancreatic cancer |
US20160055297A1 (en) * | 2013-04-17 | 2016-02-25 | Lg Electronics Inc. | Method for extracting biomarker for diagnosing pancreatic cancer, computing device therefor, biomarker for diagnosing pancreatic cancer and device for diagnosing pancreatic cancer including the same |
RU2693006C2 (ru) * | 2013-10-01 | 2019-07-01 | Торэй Индастриз, Инк. | Способ выявления опухоли поджелудочной железы, антитела и набор для выявления опухоли поджелудочной железы |
GB201319878D0 (en) * | 2013-11-11 | 2013-12-25 | Immunovia Ab | Method, Array and use thereof |
US10451628B2 (en) * | 2014-05-07 | 2019-10-22 | University Of Utah Research Foundation | Biomarkers and methods for diagnosis of early stage pancreatic ductal adenocarcinoma |
KR20150129932A (ko) * | 2014-05-12 | 2015-11-23 | 연세대학교 산학협력단 | 보체인자 b 단백질에 특이적으로 결합하는 항체를 포함하는 췌장암 진단용 키트 |
CN105092845A (zh) * | 2015-07-10 | 2015-11-25 | 深圳市贝沃德克生物技术研究院有限公司 | 胰腺癌蛋白生物标记物、用途及其检测芯片和检测装置 |
GB201516801D0 (en) * | 2015-09-22 | 2015-11-04 | Immunovia Ab | Method, array and use thereof |
-
2016
- 2016-05-10 GB GBGB1608192.9A patent/GB201608192D0/en not_active Ceased
-
2017
- 2017-05-10 CN CN201780028945.6A patent/CN109564221A/zh active Pending
- 2017-05-10 WO PCT/EP2017/061202 patent/WO2017194613A2/en unknown
- 2017-05-10 US US16/097,420 patent/US20200011872A1/en not_active Abandoned
- 2017-05-10 KR KR1020187032184A patent/KR20190005858A/ko active IP Right Grant
- 2017-05-10 MX MX2018013621A patent/MX2018013621A/es unknown
- 2017-05-10 RU RU2018138639A patent/RU2018138639A/ru not_active Application Discontinuation
- 2017-05-10 CA CA3022022A patent/CA3022022A1/en not_active Abandoned
- 2017-05-10 EP EP21171277.3A patent/EP3907509A3/en not_active Withdrawn
- 2017-05-10 AU AU2017261762A patent/AU2017261762A1/en not_active Abandoned
- 2017-05-10 EP EP17725897.7A patent/EP3455632A2/en not_active Withdrawn
- 2017-05-10 JP JP2018559285A patent/JP2019516981A/ja active Pending
- 2017-05-10 BR BR112018073178-1A patent/BR112018073178A2/pt not_active IP Right Cessation
-
2018
- 2018-11-06 IL IL262824A patent/IL262824A/en unknown
-
2021
- 2021-06-28 JP JP2021106544A patent/JP2021165745A/ja active Pending
- 2021-12-08 US US17/545,076 patent/US20220206004A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
GB201608192D0 (en) | 2016-06-22 |
AU2017261762A1 (en) | 2018-11-15 |
JP2019516981A (ja) | 2019-06-20 |
EP3907509A3 (en) | 2021-12-29 |
KR20190005858A (ko) | 2019-01-16 |
MX2018013621A (es) | 2019-04-25 |
IL262824A (en) | 2018-12-31 |
EP3907509A2 (en) | 2021-11-10 |
CA3022022A1 (en) | 2017-11-16 |
RU2018138639A3 (pt) | 2020-10-30 |
CN109564221A (zh) | 2019-04-02 |
JP2021165745A (ja) | 2021-10-14 |
RU2018138639A (ru) | 2020-06-10 |
WO2017194613A2 (en) | 2017-11-16 |
WO2017194613A3 (en) | 2017-12-21 |
EP3455632A2 (en) | 2019-03-20 |
US20220206004A1 (en) | 2022-06-30 |
US20200011872A1 (en) | 2020-01-09 |
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Legal Events
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B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2670 DE 08-03-2022 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |