CN114258491A - 全新型总抗体测定的免疫分析模式 - Google Patents

全新型总抗体测定的免疫分析模式 Download PDF

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CN114258491A
CN114258491A CN201980099341.XA CN201980099341A CN114258491A CN 114258491 A CN114258491 A CN 114258491A CN 201980099341 A CN201980099341 A CN 201980099341A CN 114258491 A CN114258491 A CN 114258491A
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antigen
hcv
reagent
kit
solid support
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王頔
何建文
夏莹
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/075—Adenoviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

一种全新型总抗体测定的免疫分析模式并据此提供的一种用于检测人血液样本内的感染性疾病的抗体的试剂盒，该试剂盒包括：含至少一种包被在固相支持物上的抗原和包被在固相支持物上的抗人IgM抗体第一试剂；以及含至少一种经标记的抗原和经标记的抗人IgG抗体的第二试剂；其中，至少一种包被在固相支持物上的抗原中的至少一种抗原和至少一种经标记的抗原中的至少一种抗原能与样本中的同一IgG抗体或同一IgM抗体结合。该试剂盒能够在克服因检测原理带来的弊端的同时保留各检测原理的优势。此外，还提供了一种检测样本中病原体感染后产生的抗体的方法。

Description

PCT国内申请，说明书已公开。

Claims (25)

  1. PCT国内申请，权利要求书已公开。
CN201980099341.XA 2019-08-16 2019-08-16 全新型总抗体测定的免疫分析模式 Pending CN114258491A (zh)

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PCT/CN2019/100978 WO2021030935A1 (zh) 2019-08-16 2019-08-16 全新型总抗体测定的免疫分析模式

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CN114258491A true CN114258491A (zh) 2022-03-29

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CN201980099341.XA Pending CN114258491A (zh) 2019-08-16 2019-08-16 全新型总抗体测定的免疫分析模式

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US (1) US20220170932A1 (zh)
EP (1) EP4016080A4 (zh)
CN (1) CN114258491A (zh)
WO (1) WO2021030935A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021072607A1 (zh) * 2019-10-14 2021-04-22 深圳迈瑞生物医疗电子股份有限公司 用于检测hcv抗体的试剂盒以及方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITTO980473A1 (it) * 1998-06-02 1999-12-02 Sorin Diagnostics S R L Nuovo procedimento per la rivelazione di anticorpi e/o isotipi di anticorpi specifici per almeno due differenti fasi di un'infezione
JP5005511B2 (ja) * 2007-02-09 2012-08-22 アボットジャパン株式会社 非特異反応を減少させた免疫診断薬
FR2917173B1 (fr) * 2007-06-08 2009-07-31 Bio Rad Pasteur Sa Procede multiplexe de detection d'une infection
WO2010021989A1 (en) * 2008-08-19 2010-02-25 Bio-Rad Laboratories, Inc. Multiplex assay for rheumatoid arthritis
US9612236B2 (en) * 2010-06-17 2017-04-04 Koninklijke Philips N.V. Multi epitope assay
CN102375052A (zh) * 2010-08-17 2012-03-14 复旦大学附属华山医院 一种在同一体系中检测IgM抗体和IgG抗体的方法
US20140093976A1 (en) * 2012-10-01 2014-04-03 CytoMedical Design Group LLC Compositions, systems and methods that detect and/or remove cross-reactive antibodies from a biological sample
EP3176580A1 (en) * 2015-12-01 2017-06-07 Roche Diagnostics GmbH Method for reduction of interferences in immunoassays
CN107202889B (zh) * 2017-07-21 2018-12-18 苏州华益美生物科技有限公司 四病原体同步检测试剂盒及其应用和制备
KR102047978B1 (ko) * 2017-11-22 2019-11-22 바디텍메드(주) 측방유동 면역 분석 기반의 항ccp 항체 및 류마티스인자를 이용한 류마티스 관절염 진단 방법

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US20220170932A1 (en) 2022-06-02
EP4016080A4 (en) 2023-01-11
EP4016080A1 (en) 2022-06-22
WO2021030935A1 (zh) 2021-02-25

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