BR112015022844A8 - método para determinar a presença ou ausência de anticorpos específicos do doador em uma amostra biológica, sistema e kit para praticar o mesmo - Google Patents
método para determinar a presença ou ausência de anticorpos específicos do doador em uma amostra biológica, sistema e kit para praticar o mesmo Download PDFInfo
- Publication number
- BR112015022844A8 BR112015022844A8 BR112015022844A BR112015022844A BR112015022844A8 BR 112015022844 A8 BR112015022844 A8 BR 112015022844A8 BR 112015022844 A BR112015022844 A BR 112015022844A BR 112015022844 A BR112015022844 A BR 112015022844A BR 112015022844 A8 BR112015022844 A8 BR 112015022844A8
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- donor
- absence
- biological sample
- complex
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
- G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56977—HLA or MHC typing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4716—Complement proteins, e.g. anaphylatoxin, C3a, C5a
Abstract
methods of detecting donor-specific antibodies and systems for practicing the same abstract: provided are methods for determining the presence or absence of donor specific antibodies in a biological sample. the methods include mixing a cellular sample from a donor with a biological sample from a recipient under conditions sufficient for recipient immune antibodies, if present, to bind to donor cell surface antigen (ag) to form an immune antibody-ag complex, contacting the mixture with beads comprising an antibody that specifically binds the immune antibody-ag complex (e.g., the ag or immune antibody) on a surface thereof, adding under lysis conditions a detectably-labeled antibody that specifically binds the immune antibody-ag complex bound to the beads, and detecting the presence or absence of the detectably-labeled antibody bound to the immune antibody-ag complex to determine the presence or absence of donor specific antibodies in the biological sample from the recipient. systems and kits for practicing the subject methods are also provided. tradução do resumo resumo "métodos para detecção de anticorpos para doadores específicos e sistemas para pratica destes" são apresentados métodos para determinar a presença ou ausência de anticorpos específicos ao doador in uma amostra biológica. os métodos incluem misturar uma amostra celular a partir de um doador com uma amostra biológica a partir de um recipiente sob condições suficientes para anticorpos imunológicos do recipiente, caso presente, para ligar ao antígeno de superfície de célula doadora (ag) para formar um complexo de anticorpo imunológico ag, por em contato a mistura com microesferas que compreende um anticorpo que se liga especificamente ao complexo de anticorpo imunológico ag (por exemplo, o ag ou o anticorpo imunológico) em uma superfície do mesmo, adicionar sob condições de lise um anticorpo detectavelmente marcado que se liga especificamente ao complexo de anticorpo imunológico ag ligado às microesferas, e detectar a presença ou ausência do anticorpo detectavelmente marcado ligado ao complexo de anticorpo imunológico ag para determinar a presença ou ausência de anticorpos específicos ao doador na amostra biológica a partir do recipiente. os sistemas e os kits para praticar os métodos também são fornecidos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361782003P | 2013-03-14 | 2013-03-14 | |
US61/782,003 | 2013-03-14 | ||
PCT/US2014/026406 WO2014151763A1 (en) | 2013-03-14 | 2014-03-13 | Methods of detecting donor-specific antibodies and systems for practicing the same |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112015022844A2 BR112015022844A2 (pt) | 2017-07-18 |
BR112015022844A8 true BR112015022844A8 (pt) | 2019-11-26 |
BR112015022844B1 BR112015022844B1 (pt) | 2023-01-24 |
Family
ID=51581037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015022844-5A BR112015022844B1 (pt) | 2013-03-14 | 2014-03-13 | Método para determinar a presença ou ausência de anticorpos específicos do doador em uma amostra biológica, sistema e kit para praticar o mesmo |
Country Status (8)
Country | Link |
---|---|
US (3) | US10101337B2 (pt) |
EP (2) | EP2972348B1 (pt) |
JP (1) | JP6548631B2 (pt) |
CN (1) | CN105308457B (pt) |
AU (1) | AU2014236882B2 (pt) |
BR (1) | BR112015022844B1 (pt) |
CA (1) | CA2905954C (pt) |
WO (1) | WO2014151763A1 (pt) |
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AU2009322607B2 (en) | 2008-12-01 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for detection of complement fixing antibodies |
EP2972348B1 (en) | 2013-03-14 | 2018-08-15 | The Board of Trustees of The Leland Stanford Junior University | Methods of detecting donor-specific antibodies |
US10527613B2 (en) | 2015-11-10 | 2020-01-07 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarker detection methods and systems and kits for practicing same |
WO2018039637A1 (en) * | 2016-08-26 | 2018-03-01 | Juno Therapeutics, Inc. | Methods of enumerating particles present in a cell composition |
JP6952295B2 (ja) * | 2016-09-09 | 2021-10-20 | 国立大学法人金沢大学 | ヒト抗hlaモノクローナル抗体の作製方法 |
CN110178034A (zh) * | 2017-01-18 | 2019-08-27 | 埃森仪器公司Dba埃森生物科学公司 | 用于从生物样品中测定免疫球蛋白γ(IgG)抗体同种型浓度的方法和试剂 |
CN107976535B (zh) * | 2017-11-03 | 2020-03-20 | 科美诊断技术股份有限公司 | 一种检测样本中目标IgM抗体的均相免疫检测试剂盒及其使用方法和应用 |
JP2022531660A (ja) * | 2019-05-06 | 2022-07-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 移植拒絶反応の非hlaマーカー |
CN111257566B (zh) * | 2020-01-22 | 2023-03-24 | 苏州才博医学科技有限公司 | 用于检测同种异体的、或供者特异性的非hla抗体的方法 |
CN111413505B (zh) * | 2020-04-08 | 2023-03-24 | 苏州才博医学科技有限公司 | 全面检测非hla类供者特异性抗体的细胞学方法 |
CN112924696A (zh) * | 2021-01-27 | 2021-06-08 | 浙江大学 | 一种检测人绒毛滋养细胞外泌体hla-e水平评估母胎免疫耐受的方法 |
CN114019154A (zh) * | 2021-11-09 | 2022-02-08 | 河北博因生物科技有限公司 | 基于流式细胞术用于补体检测的试剂盒及制备方法和应用 |
CN115125251B (zh) * | 2022-08-22 | 2023-11-03 | 广东忠信生物科技有限公司 | 一种高效获得特异性全人单克隆抗体基因的方法和应用 |
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2014
- 2014-03-13 EP EP14770220.3A patent/EP2972348B1/en active Active
- 2014-03-13 WO PCT/US2014/026406 patent/WO2014151763A1/en active Application Filing
- 2014-03-13 CA CA2905954A patent/CA2905954C/en active Active
- 2014-03-13 EP EP18182248.7A patent/EP3435080A1/en not_active Withdrawn
- 2014-03-13 BR BR112015022844-5A patent/BR112015022844B1/pt active IP Right Grant
- 2014-03-13 JP JP2016502124A patent/JP6548631B2/ja active Active
- 2014-03-13 CN CN201480026715.2A patent/CN105308457B/zh active Active
- 2014-03-13 AU AU2014236882A patent/AU2014236882B2/en active Active
- 2014-03-13 US US14/775,150 patent/US10101337B2/en active Active
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2018
- 2018-08-22 US US16/109,481 patent/US10746744B2/en active Active
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2020
- 2020-08-17 US US16/995,614 patent/US11796547B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2014151763A1 (en) | 2014-09-25 |
AU2014236882B2 (en) | 2019-01-31 |
US10101337B2 (en) | 2018-10-16 |
EP2972348A1 (en) | 2016-01-20 |
US20160033524A1 (en) | 2016-02-04 |
CN105308457B (zh) | 2018-07-10 |
CN105308457A (zh) | 2016-02-03 |
BR112015022844A2 (pt) | 2017-07-18 |
US20210199662A1 (en) | 2021-07-01 |
US10746744B2 (en) | 2020-08-18 |
BR112015022844B1 (pt) | 2023-01-24 |
CA2905954C (en) | 2022-03-22 |
EP2972348B1 (en) | 2018-08-15 |
CA2905954A1 (en) | 2014-09-25 |
JP2016515215A (ja) | 2016-05-26 |
EP3435080A1 (en) | 2019-01-30 |
US20190079096A1 (en) | 2019-03-14 |
JP6548631B2 (ja) | 2019-07-24 |
US11796547B2 (en) | 2023-10-24 |
EP2972348A4 (en) | 2016-08-31 |
AU2014236882A1 (en) | 2015-09-24 |
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