JO3812B1 - أجسام مضادة ترتبط بالمركب الترابطي البشري للموت المبرمج 1 (pd-l1) - Google Patents

أجسام مضادة ترتبط بالمركب الترابطي البشري للموت المبرمج 1 (pd-l1)

Info

Publication number
JO3812B1
JO3812B1 JOP/2013/0368A JOP20130368A JO3812B1 JO 3812 B1 JO3812 B1 JO 3812B1 JO P20130368 A JOP20130368 A JO P20130368A JO 3812 B1 JO3812 B1 JO 3812B1
Authority
JO
Jordan
Prior art keywords
antibodies
human
antigen binding
complex
binding fragments
Prior art date
Application number
JOP/2013/0368A
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English (en)
Inventor
Bigler Michael
Liang Linda
Bourne Patricia
H Pierce Robert
Original Assignee
Merck Sharp & Dohme
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49885509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3812(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of JO3812B1 publication Critical patent/JO3812B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

<span dir="RTL">يتعلق الاختراع الحالي بتوفير أجسام مضادة معزولة ترتبط نوعيا ب </span>PD-L1<span dir="RTL"> البشري، و مجموعات الأدوات المشتملة على الأجسام المضادة ل </span>PD-L1<span dir="RTL"> أو الشظايا الرابطة و مجموعة من الكواشف لاكتشاف معقد من الجسم المضاد، أو شظية رابطة لمولد الضد منه، مرتبط ب </span>PD-L1<span dir="RTL"> البشري. و تعتبر الأجسام المضادة و الشظايا الرابطة لمولد الضد الواردة في الكشف الحالي مفيدة في الاكتشاف المناعي النسيجي الكيميائي للتعبير عن </span>PD-L1<span dir="RTL"> البشري في عينات الأنسجة. كذلك يتم توفير جزيئات أحماض نووية تشفر الأجسام المضادة و الشظايا الربطة لمولد الضد الواردة في الكشف الحالي، بالإضافة إلى نواقل التعبير و الخلايا العائلة للتعبير عنها.</span>
JOP/2013/0368A 2012-12-21 2013-12-18 أجسام مضادة ترتبط بالمركب الترابطي البشري للموت المبرمج 1 (pd-l1) JO3812B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261745386P 2012-12-21 2012-12-21

Publications (1)

Publication Number Publication Date
JO3812B1 true JO3812B1 (ar) 2021-01-31

Family

ID=49885509

Family Applications (1)

Application Number Title Priority Date Filing Date
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Country Status (24)

Country Link
US (1) US9709568B2 (ar)
EP (2) EP2935329B1 (ar)
JP (4) JP6586014B2 (ar)
KR (1) KR101780877B1 (ar)
CN (2) CN113321731B (ar)
AR (2) AR093984A1 (ar)
AU (1) AU2013361617B2 (ar)
BR (1) BR112015014833B8 (ar)
CA (1) CA2895191C (ar)
CY (1) CY1123708T1 (ar)
DK (1) DK2935329T3 (ar)
ES (1) ES2833046T3 (ar)
HR (1) HRP20201856T1 (ar)
HU (1) HUE052134T2 (ar)
JO (1) JO3812B1 (ar)
LT (1) LT2935329T (ar)
MX (1) MX361502B (ar)
PL (1) PL2935329T3 (ar)
PT (1) PT2935329T (ar)
RS (1) RS61083B1 (ar)
RU (1) RU2689953C2 (ar)
SI (1) SI2935329T1 (ar)
TW (1) TWI655209B (ar)
WO (1) WO2014100079A1 (ar)

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