BR112017025562A2 - métodos para tratar câncer em um indivíduo e para tratar um indivíduo humano diagnosticado com câncer - Google Patents

métodos para tratar câncer em um indivíduo e para tratar um indivíduo humano diagnosticado com câncer

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Publication number
BR112017025562A2
BR112017025562A2 BR112017025562A BR112017025562A BR112017025562A2 BR 112017025562 A2 BR112017025562 A2 BR 112017025562A2 BR 112017025562 A BR112017025562 A BR 112017025562A BR 112017025562 A BR112017025562 A BR 112017025562A BR 112017025562 A2 BR112017025562 A2 BR 112017025562A2
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BR
Brazil
Prior art keywords
cancer
treating
individual
methods
diagnosed
Prior art date
Application number
BR112017025562A
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English (en)
Inventor
Yu Ying
Evan Denker Andrew
Sadekova Svetlana
Truong Phan Uyen
A. Kastelein Robert
Ross Kaufman David
L. Coffman Robert
Guiducci Cristiana
S. Janssen Robert
Original Assignee
Merck Sharp & Dohme Corp.
Dynavax Technologies Corporation
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Publication date
Application filed by Merck Sharp & Dohme Corp., Dynavax Technologies Corporation filed Critical Merck Sharp & Dohme Corp.
Publication of BR112017025562A2 publication Critical patent/BR112017025562A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

a presente descrição descreve terapias de combinação compreendendo um antagonista do receptor de morte programada 1 (pd-1) e um agonista do receptor 9 do tipo toll (tlr9) que é um oligonucleotídeo tipo cpg-c, e o uso das terapias de combinação para o tratamento de câncer.
BR112017025562A 2015-05-29 2016-05-26 métodos para tratar câncer em um indivíduo e para tratar um indivíduo humano diagnosticado com câncer BR112017025562A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562168449P 2015-05-29 2015-05-29
US201562169309P 2015-06-01 2015-06-01
PCT/US2016/034275 WO2016196173A1 (en) 2015-05-29 2016-05-26 Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer

Publications (1)

Publication Number Publication Date
BR112017025562A2 true BR112017025562A2 (pt) 2018-08-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017025562A BR112017025562A2 (pt) 2015-05-29 2016-05-26 métodos para tratar câncer em um indivíduo e para tratar um indivíduo humano diagnosticado com câncer

Country Status (13)

Country Link
US (2) US10751412B2 (pt)
EP (2) EP3892284B1 (pt)
JP (2) JP6893608B2 (pt)
KR (1) KR20180014009A (pt)
CN (1) CN108025018B (pt)
AU (1) AU2016271018A1 (pt)
BR (1) BR112017025562A2 (pt)
CA (1) CA2986126A1 (pt)
HK (1) HK1252652A1 (pt)
MA (1) MA44699A (pt)
MX (1) MX2017015308A (pt)
RU (1) RU2017145558A (pt)
WO (1) WO2016196173A1 (pt)

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Also Published As

Publication number Publication date
RU2017145558A (ru) 2019-07-01
US10751412B2 (en) 2020-08-25
EP3302501B1 (en) 2021-09-22
CN108025018B (zh) 2021-08-17
JP6893608B2 (ja) 2021-06-23
US20180169229A1 (en) 2018-06-21
US20210196819A1 (en) 2021-07-01
EP3302501A1 (en) 2018-04-11
JP2018516911A (ja) 2018-06-28
MX2017015308A (es) 2018-07-06
WO2016196173A1 (en) 2016-12-08
EP3892284A1 (en) 2021-10-13
EP3302501A4 (en) 2019-02-27
HK1252652A1 (zh) 2019-05-31
JP7236483B2 (ja) 2023-03-09
US11918648B2 (en) 2024-03-05
AU2016271018A1 (en) 2017-11-30
CN108025018A (zh) 2018-05-11
EP3892284B1 (en) 2024-05-22
JP2021102627A (ja) 2021-07-15
CA2986126A1 (en) 2016-12-08
KR20180014009A (ko) 2018-02-07
MA44699A (fr) 2021-05-05

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