HK1252652A1 - 用於治療癌症的pd-1拮抗劑和cpg-c型寡核苷酸的組合產品 - Google Patents

用於治療癌症的pd-1拮抗劑和cpg-c型寡核苷酸的組合產品

Info

Publication number
HK1252652A1
HK1252652A1 HK18111959.6A HK18111959A HK1252652A1 HK 1252652 A1 HK1252652 A1 HK 1252652A1 HK 18111959 A HK18111959 A HK 18111959A HK 1252652 A1 HK1252652 A1 HK 1252652A1
Authority
HK
Hong Kong
Prior art keywords
cpg
antagonist
combination
treating cancer
type oligonucleotide
Prior art date
Application number
HK18111959.6A
Other languages
English (en)
Inventor
Ying Yu
Andrew Evan Denker
Svetlana Sadekova
Uyen Truong Phan
Robert A Kastelein
David Ross Kaufman
Robert L Coffman
Cristiana Guiducci
Robert S Janssen
Original Assignee
Merck Sharp & Dohme
Dynavax Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Dynavax Tech Corp filed Critical Merck Sharp & Dohme
Publication of HK1252652A1 publication Critical patent/HK1252652A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
HK18111959.6A 2015-05-29 2018-09-18 用於治療癌症的pd-1拮抗劑和cpg-c型寡核苷酸的組合產品 HK1252652A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562168449P 2015-05-29 2015-05-29
US201562169309P 2015-06-01 2015-06-01

Publications (1)

Publication Number Publication Date
HK1252652A1 true HK1252652A1 (zh) 2019-05-31

Family

ID=57441888

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18111959.6A HK1252652A1 (zh) 2015-05-29 2018-09-18 用於治療癌症的pd-1拮抗劑和cpg-c型寡核苷酸的組合產品

Country Status (13)

Country Link
US (2) US10751412B2 (zh)
EP (2) EP3302501B1 (zh)
JP (2) JP6893608B2 (zh)
KR (1) KR20180014009A (zh)
CN (1) CN108025018B (zh)
AU (1) AU2016271018A1 (zh)
BR (1) BR112017025562A2 (zh)
CA (1) CA2986126A1 (zh)
HK (1) HK1252652A1 (zh)
MA (1) MA44699A (zh)
MX (1) MX2017015308A (zh)
RU (1) RU2017145558A (zh)
WO (1) WO2016196173A1 (zh)

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CN111321159B (zh) * 2018-12-14 2023-12-12 中天(上海)生物科技有限公司 用于免疫调节的嵌合核酸分子及其应用
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WO2022110010A1 (zh) * 2020-11-27 2022-06-02 苏州吉玛基因股份有限公司 免疫激活剂、抗原和抗体在制备预防、治疗肿瘤产品中的应用
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Also Published As

Publication number Publication date
MA44699A (fr) 2021-05-05
CN108025018B (zh) 2021-08-17
JP6893608B2 (ja) 2021-06-23
JP2021102627A (ja) 2021-07-15
JP2018516911A (ja) 2018-06-28
EP3892284B1 (en) 2024-05-22
AU2016271018A1 (en) 2017-11-30
MX2017015308A (es) 2018-07-06
CN108025018A (zh) 2018-05-11
US10751412B2 (en) 2020-08-25
US20180169229A1 (en) 2018-06-21
BR112017025562A2 (pt) 2018-08-07
EP3302501B1 (en) 2021-09-22
EP3302501A1 (en) 2018-04-11
CA2986126A1 (en) 2016-12-08
EP3892284A1 (en) 2021-10-13
WO2016196173A1 (en) 2016-12-08
US11918648B2 (en) 2024-03-05
EP3302501A4 (en) 2019-02-27
US20210196819A1 (en) 2021-07-01
JP7236483B2 (ja) 2023-03-09
RU2017145558A (ru) 2019-07-01
KR20180014009A (ko) 2018-02-07

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