WO2016154412A9 - Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer - Google Patents
Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer Download PDFInfo
- Publication number
- WO2016154412A9 WO2016154412A9 PCT/US2016/023969 US2016023969W WO2016154412A9 WO 2016154412 A9 WO2016154412 A9 WO 2016154412A9 US 2016023969 W US2016023969 W US 2016023969W WO 2016154412 A9 WO2016154412 A9 WO 2016154412A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- antagonist
- combination
- pancreatic cancer
- based vaccine
- treating pancreatic
- Prior art date
Links
- 241000186781 Listeria Species 0.000 title 1
- 229940124060 PD-1 antagonist Drugs 0.000 title 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 title 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title 1
- 201000002528 pancreatic cancer Diseases 0.000 title 1
- 208000008443 pancreatic carcinoma Diseases 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Environmental Sciences (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562138644P | 2015-03-26 | 2015-03-26 | |
US62/138,644 | 2015-03-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2016154412A2 WO2016154412A2 (en) | 2016-09-29 |
WO2016154412A9 true WO2016154412A9 (en) | 2016-11-17 |
Family
ID=56978635
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2016/023969 WO2016154412A2 (en) | 2015-03-26 | 2016-03-24 | Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer |
Country Status (2)
Country | Link |
---|---|
TW (1) | TW201705968A (en) |
WO (1) | WO2016154412A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
CN103687611A (en) | 2011-03-11 | 2014-03-26 | 阿德瓦希斯公司 | Listeria-based adjuvants |
KR20140134695A (en) | 2012-03-12 | 2014-11-24 | 어드박시스, 인크. | Suppressor cell function inhibition following listeria vaccine treatment |
CN106456726A (en) | 2014-02-18 | 2017-02-22 | 阿德瓦希斯公司 | Biomarker directed multi-target immunotherapy |
MA39849A (en) | 2014-04-24 | 2017-03-01 | Advaxis Inc | Recombinant listeria vaccine strains and methods of producing the same |
MA41644A (en) | 2015-03-03 | 2018-01-09 | Advaxis Inc | LISTERIA-BASED COMPOSITIONS INCLUDING A MINIGEN EXPRESSION SYSTEM CODING PEPTIDES, AND METHODS OF USE THEREOF |
SG11201707383PA (en) | 2015-03-13 | 2017-10-30 | Cytomx Therapeutics Inc | Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof |
CN108368170B (en) | 2015-07-13 | 2022-04-15 | 西托姆克斯治疗公司 | anti-PD-1 antibodies, activatable anti-PD-1 antibodies, and methods of use thereof |
RU2729116C2 (en) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Identification, production and use of neoantigens |
SG10202105561PA (en) | 2016-11-30 | 2021-07-29 | Advaxis Inc | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
JP2020522486A (en) | 2017-06-01 | 2020-07-30 | サイトメックス セラピューティクス インコーポレイテッド | Activatable anti-PDL1 antibody and method of using the same |
JP7284156B2 (en) | 2017-09-19 | 2023-05-30 | アドバクシス, インコーポレイテッド | Compositions and methods for lyophilization of bacteria or Listeria strains |
AU2018348165A1 (en) | 2017-10-10 | 2020-05-21 | Gritstone Bio, Inc. | Neoantigen identification using hotspots |
US11885815B2 (en) | 2017-11-22 | 2024-01-30 | Gritstone Bio, Inc. | Reducing junction epitope presentation for neoantigens |
-
2016
- 2016-03-24 WO PCT/US2016/023969 patent/WO2016154412A2/en active Application Filing
- 2016-03-25 TW TW105109634A patent/TW201705968A/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2016154412A2 (en) | 2016-09-29 |
TW201705968A (en) | 2017-02-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2016154412A9 (en) | Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer | |
HK1232153A1 (en) | Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer pd-1 ido1 | |
HK1253276A1 (en) | Treatment of cancer using inhibitors of tgf-beta and pd-1 | |
IL258955A (en) | Compositions and methods for treatment of cancer | |
IL254131B (en) | Pd-1 / pd-l1 inhibitors for the treatment of cancer | |
HK1252652A1 (en) | Combination of a pd-1 antagonist and cpg-c type oligonucleotide for treating cancer | |
IL250187B (en) | Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer | |
IL263178A (en) | Pd-1 / pd-l1 inhibitors for cancer treatment | |
IL246760A0 (en) | Combination of a pd-1 antagonist and a vegfr inhibitor for treating cancer | |
EP3393475A4 (en) | Methods of treating cancer | |
EP3288383A4 (en) | Methods of treating cancer | |
EP3169363A4 (en) | Methods of treating cancer using tigit inhibitors and anti-cancer agents | |
IL254133A0 (en) | Combination of a pd-1 antagonist and eribulin for treating cancer | |
EP3227317A4 (en) | Methods and compositons for treating cancer | |
EP3110443A4 (en) | Combination method for treatment of cancer | |
EP3200815A4 (en) | Methods and compositions for treating cancer | |
EP3353204A4 (en) | Methods and compositions for treatment of cancer | |
EP3325006A4 (en) | Methods of treating cd166-expressing cancer | |
EP3215140A4 (en) | Compositions and methods of diazeniumdiolate-based prodrugs for treating cancer | |
EP3328372A4 (en) | Compositions and methods of treating cancer | |
EP3298141A4 (en) | Compositions and methods for treating cancer | |
EP3200801A4 (en) | Methods of treating pancreatic cancer | |
EP3268028A4 (en) | Compositions and methods for treating cancer | |
EP3160591A4 (en) | Compositions and methods for treating cancer | |
AU2022231657A1 (en) | Compositions and Methods for Treating Cancer |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 16769672 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 16769672 Country of ref document: EP Kind code of ref document: A2 |