MA40344A - Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer - Google Patents

Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer

Info

Publication number
MA40344A
MA40344A MA040344A MA40344A MA40344A MA 40344 A MA40344 A MA 40344A MA 040344 A MA040344 A MA 040344A MA 40344 A MA40344 A MA 40344A MA 40344 A MA40344 A MA 40344A
Authority
MA
Morocco
Prior art keywords
antagonist
listeria
combination
prostate cancer
based vaccine
Prior art date
Application number
MA040344A
Other languages
English (en)
Inventor
David J Mauro
Rodolfo F Perini
Robert Petit
Original Assignee
Advaxis Inc
Merck Sharpe And Dohme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advaxis Inc, Merck Sharpe And Dohme Corp filed Critical Advaxis Inc
Publication of MA40344A publication Critical patent/MA40344A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
    • A61K39/001194—Prostate specific antigen [PSA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/80—Vaccine for a specifically defined cancer
    • A61K2039/884—Vaccine for a specifically defined cancer prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des polythérapies comprenant un antagoniste du récepteur de mort programmée 1 (pd -1) et une souche de listeria qui exprime un antigène spécifique des tissus de la prostate (psa), et l'utilisation de polythérapies pour le traitement du cancer de la prostate.
MA040344A 2014-07-18 2015-07-17 Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer MA40344A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462026221P 2014-07-18 2014-07-18
US201462039011P 2014-08-19 2014-08-19

Publications (1)

Publication Number Publication Date
MA40344A true MA40344A (fr) 2016-01-21

Family

ID=55079087

Family Applications (1)

Application Number Title Priority Date Filing Date
MA040344A MA40344A (fr) 2014-07-18 2015-07-17 Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer

Country Status (11)

Country Link
US (2) US9907849B2 (fr)
EP (1) EP3193921A4 (fr)
KR (1) KR20170052569A (fr)
CN (2) CN106999561A (fr)
AU (1) AU2015289533B2 (fr)
CA (1) CA2955612C (fr)
IL (1) IL250187B (fr)
MA (1) MA40344A (fr)
MX (1) MX2017000857A (fr)
SG (2) SG11201701149SA (fr)
WO (1) WO2016011357A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
US8771702B2 (en) * 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
DK2170959T3 (da) * 2007-06-18 2014-01-13 Merck Sharp & Dohme Antistoffer mod human programmeret dødsreceptor pd-1
CA2829960A1 (fr) 2011-03-11 2012-09-20 John Rothman Adjuvants a base de listeria
WO2013138337A1 (fr) 2012-03-12 2013-09-19 Advaxis Inhibition de la fonction des cellules suppresseurs après traitement par un vaccin à base de listeria
US9212224B2 (en) 2012-05-15 2015-12-15 Bristol-Myers Squibb Company Antibodies that bind PD-L1 and uses thereof
EA035037B1 (ru) 2013-12-12 2020-04-21 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Антитело к pd-1, его антигенсвязывающий фрагмент и их медицинское применение
CN106456726A (zh) 2014-02-18 2017-02-22 阿德瓦希斯公司 生物标志物导向的多靶点免疫治疗
SG10202011841WA (en) 2014-04-24 2021-01-28 Advaxis Inc Recombinant listeria vaccine strains and methods of producing the same
MA41644A (fr) 2015-03-03 2018-01-09 Advaxis Inc Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation
MX2017011644A (es) 2015-03-13 2017-12-04 Cytomx Therapeutics Inc Anticuerpos anti-pdl1, anticuerpos anti-pdl1 activables y metodos de uso de los mismos.
JP2018514550A (ja) 2015-04-28 2018-06-07 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 抗ｐｄ−１抗体および抗ｃｔｌａ−４抗体を使用するｐｄ−ｌ１陰性黒色腫の処置
WO2016176504A1 (fr) * 2015-04-28 2016-11-03 Bristol-Myers Squibb Company Traitement du mélanome pd-l1 positif à l'aide d'un anticorps anti-pd-1
CA2991976A1 (fr) 2015-07-13 2017-01-19 Cytomx Therapeutics, Inc. Anticorps anti-pd-1, anticorps anti-pd-1 activables, et leurs procedes d'utilisation
KR20180027576A (ko) * 2015-07-14 2018-03-14 브리스톨-마이어스 스큅 컴퍼니 면역 체크포인트 억제제를 사용하여 암을 치료하는 방법
TWI765875B (zh) 2015-12-16 2022-06-01 美商磨石生物公司 新抗原辨識、製造及用途
CN117024599A (zh) * 2016-02-05 2023-11-10 奥里尼斯生物科学私人有限公司 双特异性信号传导剂及其用途
EP3413927A4 (fr) * 2016-02-12 2019-11-27 Madison Vaccines Inc. Cancérothérapie
WO2018027524A1 (fr) 2016-08-09 2018-02-15 Innovent Biologics (Suzhou) Co., Ltd. Formule d'anticorps anti-pd-1.
KR20190082850A (ko) 2016-11-30 2019-07-10 어드박시스, 인크. 반복되는 암 돌연변이를 표적화하는 면역원 조성물 및 그것의 사용 방법
RU2019138507A (ru) 2017-05-02 2021-06-02 Мерк Шарп И Доум Корп. Составы антител против lag3 и совместные составы антител против lag3 и антител против pd-1
JOP20190260A1 (ar) 2017-05-02 2019-10-31 Merck Sharp & Dohme صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
US11168144B2 (en) 2017-06-01 2021-11-09 Cytomx Therapeutics, Inc. Activatable anti-PDL1 antibodies, and methods of use thereof
NZ762881A (en) 2017-09-19 2024-03-22 Advaxis Inc Compositions and methods for lyophilization of bacteria or listeria strains
EP3694532A4 (fr) 2017-10-10 2021-07-14 Gritstone Oncology, Inc. Identification de néo-antigènes au moyen de points chauds
JP2021503897A (ja) 2017-11-22 2021-02-15 グリットストーン オンコロジー インコーポレイテッド 新生抗原のためのジャンクションエピトープ提示の低減
RU2020129827A (ru) 2018-02-13 2022-03-14 Мерк Шарп И Доум Корп. Способы лечения злокачественного новообразования с использованием антител против pd-1
WO2020033283A1 (fr) * 2018-08-09 2020-02-13 Merck Sharp & Dohme Corp. Compositions et méthodes de traitement du cancer avec une association d'anticorps anti-récepteur de mort programmée (pd-1) et de vicriviroc
WO2020055702A1 (fr) * 2018-09-13 2020-03-19 Merck Sharp & Dohme Corp. Association d'un antagoniste de pd-1 et d'un antagoniste de lag3 pour le traitement du cancer colorectal à réparation efficace des mésappariements/ne présentant pas d'instabilité élevée des microsatellites
EP3730153A1 (fr) 2019-04-26 2020-10-28 Medizinische Hochschule Hannover Immunothérapie personnalisée pour le traitement du cancer
US20220362308A1 (en) * 2019-09-24 2022-11-17 Novome Biotechnologies, Inc. Oral administration of genetically engineered bacteria
CN110898012B (zh) * 2019-12-06 2021-08-10 北京大学 一种包载过氧化氢酶且连接pd-l1抗体的脂质体及其制备方法
WO2023211868A1 (fr) * 2022-04-29 2023-11-02 Merck Sharp & Dohme Llc Formulations stables d'anticorps anti-ilt4 ou de fragments de liaison à l'antigène de ceux-ci en combinaison avec des anticorps anti-pd-1 et leurs procédés d'utilisation
WO2024026253A1 (fr) * 2022-07-25 2024-02-01 Agensys, Inc. Méthodes de traitement de patients atteints d'un cancer urothélial localement avancé ou métastatique avec des conjugués anticorps-médicament (cam) qui se lient à des protéines 191p4d12 en combinaison avec du pembrolizumab
WO2024047585A2 (fr) * 2022-08-31 2024-03-07 Proviva Therapeutics (Hong Kong) Limited Protéines de fusion anticorps-procytokine il-15

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPH10510433A (ja) 1995-06-06 1998-10-13 アイシス・ファーマシューティカルス・インコーポレーテッド 高いキラル純度のホスホロチオエート結合を有するオリゴヌクレオチド
US5985662A (en) 1995-07-13 1999-11-16 Isis Pharmaceuticals Inc. Antisense inhibition of hepatitis B virus replication
EP2298900A1 (fr) 1996-09-17 2011-03-23 Novartis Vaccines and Diagnostics, Inc. Compositions et procédés de traitement de maladies intracellulaires
GB9726555D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Vaccine
US9012141B2 (en) 2000-03-27 2015-04-21 Advaxis, Inc. Compositions and methods comprising KLK3 of FOLH1 antigen
CA2404164A1 (fr) 2000-03-29 2001-10-04 The Trustees Of The University Of Pennsylvania Compositions et procedes renforcant l'immunogenicite d'antigenes
US6855320B2 (en) 2000-03-29 2005-02-15 The Trustees Of The University Of Pennsylvania Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity
US8771702B2 (en) 2001-03-26 2014-07-08 The Trustees Of The University Of Pennsylvania Non-hemolytic LLO fusion proteins and methods of utilizing same
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
AU2003288675B2 (en) 2002-12-23 2010-07-22 Medimmune Limited Antibodies against PD-1 and uses therefor
EP1591527B1 (fr) 2003-01-23 2015-08-26 Ono Pharmaceutical Co., Ltd. Substance specifique a pd-1 humain
CN109485727A (zh) 2005-05-09 2019-03-19 小野药品工业株式会社 程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
MX2007015942A (es) 2005-07-01 2008-03-07 Medarex Inc Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada.
DK2170959T3 (da) 2007-06-18 2014-01-13 Merck Sharp & Dohme Antistoffer mod human programmeret dødsreceptor pd-1
US9017660B2 (en) * 2009-11-11 2015-04-28 Advaxis, Inc. Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors
US20110129499A1 (en) 2008-05-19 2011-06-02 Paulo Maciag Dual delivery system for heterologous antigens
AU2009288289B2 (en) 2008-08-25 2012-11-08 Amplimmune, Inc. PD-1 antagonists and methods of use thereof
CN102264762B (zh) 2008-09-26 2018-03-27 达纳-法伯癌症研究公司 人抗pd‑1、pd‑l1和pd‑l2的抗体及其应用
TWI686405B (zh) 2008-12-09 2020-03-01 建南德克公司 抗ｐｄ-ｌ１抗體及其於增進ｔ細胞功能之用途
EP2504028A4 (fr) 2009-11-24 2014-04-09 Amplimmune Inc Inhibition simultanée de pd-l1/pd-l2
CN102469782A (zh) 2010-06-18 2012-05-23 哈洛资源公司 包含壳聚糖的固态共混物的制剂及方法
CA2829960A1 (fr) * 2011-03-11 2012-09-20 John Rothman Adjuvants a base de listeria
KR102031020B1 (ko) * 2011-03-31 2019-10-14 머크 샤프 앤드 돔 코포레이션 인간 프로그램화된 사멸 수용체 pd-1에 대한 항체의 안정한 제제 및 관련된 치료
KR102049817B1 (ko) 2011-08-01 2019-12-02 제넨테크, 인크. Pd-1 축 결합 길항제 및 mek 억제제를 사용하는 암 치료 방법
AU2012370450B2 (en) 2012-02-21 2017-02-02 Merck Patent Gmbh Cyclic diaminopyrimidine derivatives
AR093984A1 (es) 2012-12-21 2015-07-01 Merck Sharp & Dohme Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
EP2938627B1 (fr) 2012-12-27 2019-03-20 Aduro Biotech, Inc. Partenaires de fusion de type peptides signal favorisant l'expression de séquences antigéniques dans les bactéries du genre listeria et leurs procédés de préparation et d'utilisation

Also Published As

Publication number Publication date
CN106999561A (zh) 2017-08-01
MX2017000857A (es) 2017-10-11
IL250187B (en) 2020-10-29
US20160022814A1 (en) 2016-01-28
CN114984228A (zh) 2022-09-02
IL250187A0 (en) 2017-03-30
US20180185483A1 (en) 2018-07-05
AU2015289533B2 (en) 2021-04-01
CA2955612C (fr) 2022-05-17
SG10201913696YA (en) 2020-03-30
AU2015289533A1 (en) 2017-03-02
SG11201701149SA (en) 2017-04-27
EP3193921A1 (fr) 2017-07-26
EP3193921A4 (fr) 2018-04-25
WO2016011357A1 (fr) 2016-01-21
KR20170052569A (ko) 2017-05-12
US9907849B2 (en) 2018-03-06
CA2955612A1 (fr) 2016-01-21

Similar Documents

Publication Publication Date Title
MA40344A (fr) Combinaison d'un antagoniste de pd-1 et d'un vaccin à base de listeria pour le traitement du cancer
MX2016010082A (es) Combinacion de un antagonista de proteina de muerte programada 1 (pd-1) y un inhibidor del receptor del factor de crecimiento endotelial vascular (vegfr) para tratar cancer.
IL270720A (en) Combination of treatments for cancer treatment
PH12016501550B1 (en) Combination of a pd-1 antagonist and an ido1 inhibitor for treating cancer
MX2017015308A (es) Combinacion de un antagonista de pd-1 y un oligonucleotido tipo cpg-c para tratar cancer.
PH12017501857A1 (en) Pd-l1 antagonist combination treatments
IL249658A0 (en) Methods of treating cancer using tigit inhibitors and anticancer agents
HK1251862A1 (zh) 治療癌症的方法和組合物
IL249065A0 (en) Combination of treatments for cancer treatment
MX2016002273A (es) Tratamiento de cancer con una combinacion de un antagonista de proteina de muerte programada 1 y dinaciclib.
TW201613635A (en) Combination of a PD-1 antagonist and a 4-1BB agonist for treating cancer
IL265786A (en) Materials and methods for increasing radiotherapy against cancer
IL273395A (en) Combined therapies for cancer treatment
MX2017011206A (es) Combinacion de un antagonista con muerte programada 1 (pd-1) y eribulina para el tratamiento de cancer.
LT3200815T (lt) Būdai ir kompozicijos, skirti vėžio gydymui
IL261047A (en) Taf1 inhibitors for the therapy of cancer
EP3131552A4 (fr) Méthodes de traitement du cancer à l'aide d'une polythérapie avec des inhibiteurs de la kinase tor
HK1253277A1 (zh) Ep4受體拮抗劑用於治療nash相關肝癌的用途
ZA201900438B (en) Combination therapies for treating cancer
IL245861A0 (en) Use of substances to treat drug-resistant tumors
EP3131550A4 (fr) Méthodes de traitement du cancer au moyen d'une multithérapie à base d'un inhibiteur de la kinase tor
IL274866A (en) Preparations and methods for the treatment of cancer
GB201417819D0 (en) Agents for cancer therapy
GB201515213D0 (en) Combination therapy for PD-L1 negative tumors
GB201418640D0 (en) Agents and methods for treatment of cancer