CY1123708T1 - Αντισωματα που συνδεονται προς τον ανθρωπινο προσδετη 1 (pd-l1) προγραμματισμενου θανατου - Google Patents

Αντισωματα που συνδεονται προς τον ανθρωπινο προσδετη 1 (pd-l1) προγραμματισμενου θανατου

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Publication number
CY1123708T1
CY1123708T1 CY20201101119T CY201101119T CY1123708T1 CY 1123708 T1 CY1123708 T1 CY 1123708T1 CY 20201101119 T CY20201101119 T CY 20201101119T CY 201101119 T CY201101119 T CY 201101119T CY 1123708 T1 CY1123708 T1 CY 1123708T1
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CY
Cyprus
Prior art keywords
antibodies
human
binding fragments
antigen
bind
Prior art date
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CY20201101119T
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English (en)
Inventor
Robert H. Pierce
Patricia BOURNE
Linda Liang
Michael Bigler
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Merck Sharp & Dohme Corp.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49885509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1123708(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of CY1123708T1 publication Critical patent/CY1123708T1/el

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Η παρούσα αποκάλυψη παρέχει απομονωθέντα αντισώματα που ειδικώς συνδέονται προς ανθρώπινο PD-L1, καθώς επίσης θραύσματα σύνδεσης αντιγόνου τέτοιων αντισωμάτων και κιτ που περιλαμβάνουν τα αντι-PD-L1 αντισώματα ή θραύσματα σύνδεσης και ένα σετ αντιδραστηρίων για ανίχνευση συμπλόκου του αντισώματος ή θραύσματος σύνδεσης αντιγόνου αυτού, που συνδέεται προς ανθρώπινο PD-L1. Τα αντισώματα και θραύσματα σύνδεσης αντιγόνου αυτής της αποκάλυψης είναι χρήσιμα για ανοσοϊστοχημική ανίχνευση έκφρασης ανθρώπινου PD-L1 σε δείγματα ιστού. Επίσης παρέχονται μόρια νουκλεϊνικού οξέος που κωδικοποιούν τα αντισώματα και θραύσματα σύνδεσης αντιγόνου της αποκάλυψης αυτής, καθώς επίσης φορείς έκφρασης και κύτταρα ξενιστές για έκφραση αυτών.
CY20201101119T 2012-12-21 2020-11-25 Αντισωματα που συνδεονται προς τον ανθρωπινο προσδετη 1 (pd-l1) προγραμματισμενου θανατου CY1123708T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745386P 2012-12-21 2012-12-21
PCT/US2013/075932 WO2014100079A1 (en) 2012-12-21 2013-12-18 Antibodies that bind to human programmed death ligand 1 (pd-l1)

Publications (1)

Publication Number Publication Date
CY1123708T1 true CY1123708T1 (el) 2022-03-24

Family

ID=49885509

Family Applications (1)

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CY20201101119T CY1123708T1 (el) 2012-12-21 2020-11-25 Αντισωματα που συνδεονται προς τον ανθρωπινο προσδετη 1 (pd-l1) προγραμματισμενου θανατου

Country Status (25)

Country Link
US (1) US9709568B2 (el)
EP (2) EP3783030A1 (el)
JP (4) JP6586014B2 (el)
KR (1) KR101780877B1 (el)
CN (2) CN113321731A (el)
AR (1) AR093984A1 (el)
AU (1) AU2013361617B2 (el)
BR (1) BR112015014833B8 (el)
CA (1) CA2895191C (el)
CY (1) CY1123708T1 (el)
DK (1) DK2935329T3 (el)
ES (1) ES2833046T3 (el)
HK (1) HK1210785A1 (el)
HR (1) HRP20201856T1 (el)
HU (1) HUE052134T2 (el)
JO (1) JO3812B1 (el)
LT (1) LT2935329T (el)
MX (1) MX361502B (el)
PL (1) PL2935329T3 (el)
PT (1) PT2935329T (el)
RS (1) RS61083B1 (el)
RU (1) RU2689953C2 (el)
SI (1) SI2935329T1 (el)
TW (1) TWI655209B (el)
WO (1) WO2014100079A1 (el)

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