MX361502B - Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano. - Google Patents

Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano.

Info

Publication number
MX361502B
MX361502B MX2015008045A MX2015008045A MX361502B MX 361502 B MX361502 B MX 361502B MX 2015008045 A MX2015008045 A MX 2015008045A MX 2015008045 A MX2015008045 A MX 2015008045A MX 361502 B MX361502 B MX 361502B
Authority
MX
Mexico
Prior art keywords
antibodies
human
binding fragments
antigen
legend
Prior art date
Application number
MX2015008045A
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English (en)
Other versions
MX2015008045A (es
Inventor
Robert H Pierce
Patricia Bourne
Linda Liang
Michael Bigler
Original Assignee
Merck Sharp & Dohme
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49885509&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX361502(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of MX2015008045A publication Critical patent/MX2015008045A/es
Publication of MX361502B publication Critical patent/MX361502B/es

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57557—Immunoassay; Biospecific binding assay; Materials therefor for cancer of other specific parts of the body, e.g. brain
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70532—B7 molecules, e.g. CD80, CD86

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a anticuerpos aislados que se unen específicamente a PD-L1 humano, así como fragmentos de unión a antígeno de dichos anticuerpos, y kits que comprenden los anticuerpos o fragmentos de unión anti-PD-L1 y una serie de reactivos para detectar un complejo del anticuerpo, o fragmento de unión a antígeno del mismo, unido a PD-L1 humano; los anticuerpos y fragmentos de unión a antígeno de esta divulgación son útiles para la detección inmunohistoquímica de la expresión de PD-L1 humano en muestras tisulares; también se proporcionan moléculas de ácido nucleico que codifican los anticuerpos y fragmentos de unión a antígeno de esta divulgación, así como vectores de expresión y células hospedadoras para la expresión de los mismos.
MX2015008045A 2012-12-21 2013-12-18 Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano. MX361502B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261745386P 2012-12-21 2012-12-21
PCT/US2013/075932 WO2014100079A1 (en) 2012-12-21 2013-12-18 Antibodies that bind to human programmed death ligand 1 (pd-l1)

Publications (2)

Publication Number Publication Date
MX2015008045A MX2015008045A (es) 2015-10-29
MX361502B true MX361502B (es) 2018-12-06

Family

ID=49885509

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015008045A MX361502B (es) 2012-12-21 2013-12-18 Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano.

Country Status (24)

Country Link
US (1) US9709568B2 (es)
EP (2) EP2935329B1 (es)
JP (4) JP6586014B2 (es)
KR (1) KR101780877B1 (es)
CN (2) CN113321731B (es)
AR (2) AR093984A1 (es)
AU (1) AU2013361617B2 (es)
BR (1) BR112015014833B8 (es)
CA (1) CA2895191C (es)
CY (1) CY1123708T1 (es)
DK (1) DK2935329T3 (es)
ES (1) ES2833046T3 (es)
HR (1) HRP20201856T1 (es)
HU (1) HUE052134T2 (es)
JO (1) JO3812B1 (es)
LT (1) LT2935329T (es)
MX (1) MX361502B (es)
PL (1) PL2935329T3 (es)
PT (1) PT2935329T (es)
RS (1) RS61083B1 (es)
RU (1) RU2689953C2 (es)
SI (1) SI2935329T1 (es)
TW (1) TWI655209B (es)
WO (1) WO2014100079A1 (es)

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