EA202090749A1 - Способы совместной терапии для иммуномодуляции - Google Patents

Способы совместной терапии для иммуномодуляции

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Publication number
EA202090749A1
EA202090749A1 EA202090749A EA202090749A EA202090749A1 EA 202090749 A1 EA202090749 A1 EA 202090749A1 EA 202090749 A EA202090749 A EA 202090749A EA 202090749 A EA202090749 A EA 202090749A EA 202090749 A1 EA202090749 A1 EA 202090749A1
Authority
EA
Eurasian Patent Office
Prior art keywords
methods
immunomodulation
joint therapy
vista
tim
Prior art date
Application number
EA202090749A
Other languages
English (en)
Inventor
Поттайил Говиндан Наир Сасикумар
Муралидхара Рамачандра
Рагхувир Калладжхари Рамачандра
Адам С. Лазорчак
Тимоти Л. Вайант
Original Assignee
Ориджен Дискавери Текнолоджис Лимитед
Кьюрис, Инк
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ориджен Дискавери Текнолоджис Лимитед, Кьюрис, Инк filed Critical Ориджен Дискавери Текнолоджис Лимитед
Publication of EA202090749A1 publication Critical patent/EA202090749A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Настоящее изобретение относится к способам, включающим введение соединений, которые ингибируют пути VISTA и PD-1 (например, PD-1, PD-L1 или PD-L2), совместно с соединением, которое ингибирует пути TIM-3 и PD-1 (например, PD-1, PD-L1 или PD-L2). Изобретение также относится к лечению нарушений путем ингибирования иммуносупрессивных сигналов, индуцируемых VISTA, TIM-3, PD-1, PD-L1 и/или PD-L2.
EA202090749A 2017-11-06 2018-10-31 Способы совместной терапии для иммуномодуляции EA202090749A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741039497 2017-11-06
PCT/IB2018/058533 WO2019087092A1 (en) 2017-11-06 2018-10-31 Conjoint therapies for immunomodulation

Publications (1)

Publication Number Publication Date
EA202090749A1 true EA202090749A1 (ru) 2020-08-19

Family

ID=64744758

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202090749A EA202090749A1 (ru) 2017-11-06 2018-10-31 Способы совместной терапии для иммуномодуляции

Country Status (9)

Country Link
US (2) US11497735B2 (ru)
EP (1) EP3706798A1 (ru)
JP (2) JP7378395B2 (ru)
KR (1) KR20200084333A (ru)
CN (1) CN111386128A (ru)
AU (1) AU2018360389A1 (ru)
CA (1) CA3081675A1 (ru)
EA (1) EA202090749A1 (ru)
WO (1) WO2019087092A1 (ru)

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US11213530B2 (en) * 2020-03-05 2022-01-04 Lawrence Richard Bernstein Gallium in the treatment of coronavirus disease
CN111991559B (zh) * 2020-09-03 2022-03-22 中山大学 受体酪氨酸激酶抑制剂在制备预防和/或治疗新型冠状病毒感染药物中的应用
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Also Published As

Publication number Publication date
WO2019087092A1 (en) 2019-05-09
AU2018360389A1 (en) 2020-05-07
US20230081191A1 (en) 2023-03-16
US11497735B2 (en) 2022-11-15
KR20200084333A (ko) 2020-07-10
JP2023182597A (ja) 2023-12-26
JP2021503446A (ja) 2021-02-12
CA3081675A1 (en) 2019-05-09
US20200289477A1 (en) 2020-09-17
CN111386128A (zh) 2020-07-07
JP7378395B2 (ja) 2023-11-13
EP3706798A1 (en) 2020-09-16

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