JP2011168603A5 - - Google Patents

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Publication number
JP2011168603A5
JP2011168603A5 JP2011087496A JP2011087496A JP2011168603A5 JP 2011168603 A5 JP2011168603 A5 JP 2011168603A5 JP 2011087496 A JP2011087496 A JP 2011087496A JP 2011087496 A JP2011087496 A JP 2011087496A JP 2011168603 A5 JP2011168603 A5 JP 2011168603A5
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Japan
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phe
lys
arg
composition
peptide represented
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JP2011087496A
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Japanese (ja)
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JP2011168603A (ja
JP5650040B2 (ja
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JP2011087496A 2003-05-01 2011-04-11 細胞に分子を送達する方法及び担体複合体 Expired - Lifetime JP5650040B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46751603P 2003-05-01 2003-05-01
US60/467,516 2003-05-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006532552A Division JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体

Related Child Applications (1)

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JP2014178031A Division JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体

Publications (3)

Publication Number Publication Date
JP2011168603A JP2011168603A (ja) 2011-09-01
JP2011168603A5 true JP2011168603A5 (enExample) 2012-07-12
JP5650040B2 JP5650040B2 (ja) 2015-01-07

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Family Applications (6)

Application Number Title Priority Date Filing Date
JP2006532552A Expired - Lifetime JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体
JP2011087496A Expired - Lifetime JP5650040B2 (ja) 2003-05-01 2011-04-11 細胞に分子を送達する方法及び担体複合体
JP2014178031A Expired - Lifetime JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体
JP2016050272A Expired - Lifetime JP6395749B2 (ja) 2003-05-01 2016-03-14 細胞に分子を送達する方法及び担体複合体
JP2018133252A Expired - Lifetime JP6698756B2 (ja) 2003-05-01 2018-07-13 細胞に分子を送達する方法及び担体複合体
JP2020032792A Pending JP2020105184A (ja) 2003-05-01 2020-02-28 細胞に分子を送達する方法及び担体複合体

Family Applications Before (1)

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JP2006532552A Expired - Lifetime JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2014178031A Expired - Lifetime JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体
JP2016050272A Expired - Lifetime JP6395749B2 (ja) 2003-05-01 2016-03-14 細胞に分子を送達する方法及び担体複合体
JP2018133252A Expired - Lifetime JP6698756B2 (ja) 2003-05-01 2018-07-13 細胞に分子を送達する方法及び担体複合体
JP2020032792A Pending JP2020105184A (ja) 2003-05-01 2020-02-28 細胞に分子を送達する方法及び担体複合体

Country Status (17)

Country Link
US (6) US7704954B2 (enExample)
EP (7) EP1625149B1 (enExample)
JP (6) JP4879020B2 (enExample)
KR (1) KR101161823B1 (enExample)
CN (2) CN101214380A (enExample)
AU (1) AU2004252419B2 (enExample)
BR (1) BRPI0409911A (enExample)
CA (1) CA2524258C (enExample)
DK (4) DK2604621T3 (enExample)
ES (3) ES2520815T3 (enExample)
MX (1) MXPA05011773A (enExample)
NZ (1) NZ543410A (enExample)
PL (2) PL2604286T3 (enExample)
PT (2) PT2604286E (enExample)
SI (1) SI2604285T1 (enExample)
WO (1) WO2005001023A2 (enExample)
ZA (1) ZA200509229B (enExample)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030062788A (ko) * 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 ｍｐｈ1-ｂｔｍ 및 이것을포함하는 생명공학제품
EP3479838A1 (en) 2003-02-04 2019-05-08 Cornell Research Foundation, Inc. Uses of aromatic-cationic peptide
WO2005072295A2 (en) 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
EP1625149B1 (en) 2003-05-01 2016-02-17 Cornell Research Foundation, Inc. Method and carrier complexes for delivering molecules to cells
US7534819B2 (en) * 2005-06-10 2009-05-19 University Of Washington Compositions and methods for intracellular delivery of biotinylated cargo
CN103784937B (zh) 2005-09-16 2017-04-26 科内尔研究基金会 用于减少cd36表达的方法
DE602006016468D1 (de) * 2005-11-04 2010-10-07 Forhumantech Co Ltd Verfahren zur abgabe von fusionspolypeptid in eine zelle
WO2008015580A2 (en) * 2006-07-24 2008-02-07 Forhumantech. Co., Ltd. Pharmaceutical composition for alleviation and treatment of ischemic conditions and method for delivering the same
KR20090045940A (ko) * 2006-08-29 2009-05-08 포휴먼텍(주) 세포자멸사의 억제를 위한 약학 조성물, 및 이를 전달하는 방법
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
US7981446B2 (en) * 2007-11-26 2011-07-19 Forhumantech. Co., Ltd. Pharmaceutical compositions and methods for delivering nucleic acids into cells
JP5453320B2 (ja) 2008-02-07 2014-03-26 コーネル ユニヴァーシティー インスリン抵抗性を防止または処置するための方法
US8143219B2 (en) 2008-02-26 2012-03-27 Cornell University Methods for prevention and treatment of acute renal injury
AU2009294877C1 (en) * 2008-09-22 2015-05-07 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2012509902A (ja) 2008-11-24 2012-04-26 エルロン・セラピューティクス・インコーポレイテッド 改善された特性を有するペプチド模倣大環状分子
DE102008061044A1 (de) * 2008-12-11 2010-06-17 Henkel Ag & Co. Kgaa Zusammensetzung mit antioxidativ wirksamen Peptiden
JP2012521355A (ja) 2009-03-20 2012-09-13 ザ ジェネラル ホスピタル コーポレイション ディー ビー エイ マサチューセッツ ジェネラル ホスピタル 熱傷及び二次性合併症の予防及び治療方法
WO2011019809A1 (en) * 2009-08-12 2011-02-17 Cornell University Methods for preventing or treating metabolic syndrome
EP3292868A1 (en) 2009-08-24 2018-03-14 Stealth Peptides International, Inc. Methods and compositions for preventing or treating opthalmic conditions
CA2776581C (en) * 2009-10-05 2020-12-15 Cornell University Methods for the prevention or treatment of heart failure
US20110245183A1 (en) * 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
US20110245182A1 (en) * 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
EP2566880A4 (en) * 2010-05-03 2014-10-08 Stealth Peptides Int Inc AROMATIC-CATIONIC PEPTIDES AND USES THEREOF
CN102010461B (zh) * 2010-10-11 2014-02-12 华南理工大学 一种alpha螺旋状阳离子多肽分子及其制法和应用
GB201018125D0 (en) * 2010-10-26 2010-12-08 Marealis As Peptide
CN109705192A (zh) * 2011-03-24 2019-05-03 康奈尔大学 芳香族阳离子肽及其用途
CA2839408A1 (en) * 2011-06-14 2012-12-20 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
JP6025311B2 (ja) 2011-08-01 2016-11-16 キヤノン株式会社 眼科診断支援装置および方法
AU2012315586B2 (en) 2011-09-29 2017-07-20 Mayo Foundation For Medical Education And Research Aromatic-cationic peptides and methods for using same
CA2852454A1 (en) * 2011-10-17 2013-04-25 Cornell University Aromatic-cationic peptides and uses of same
CN104039342A (zh) 2011-10-18 2014-09-10 爱勒让治疗公司 拟肽大环化合物
CN104105499A (zh) * 2011-12-09 2014-10-15 康肽德生物医药技术有限公司 芳香族阳离子肽及其用途
NZ627528A (en) 2012-02-15 2016-05-27 Aileron Therapeutics Inc Peptidomimetic macrocycles
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CA2870200A1 (en) * 2012-04-12 2013-10-17 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
CA2880648A1 (en) * 2012-08-02 2014-02-06 Stealth Peptides International, Inc. Methods for treatment of atherosclerosis
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
US9850278B2 (en) 2013-04-25 2017-12-26 Carmel-Haifa University Economic Corp. Synthetic anti-inflammatory peptides and use thereof
WO2015134096A1 (en) * 2014-03-03 2015-09-11 Stealth Peptides International, Inc. Pharmaceutically relevant aromatic-cationic peptides
WO2015183995A2 (en) 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
EP3149035A4 (en) * 2014-05-28 2018-05-16 Stealth BioTherapeutics Corp Therapeutic compositions including therapeutic small molecules and uses thereof
US10125164B2 (en) 2014-06-25 2018-11-13 Flamma S.P.A. Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
JP2017523957A (ja) * 2014-06-30 2017-08-24 フラマ ソシエタ ペル アチオニＦｌａｍｍａ Ｓ．Ｐ．Ａ． Ｄ−アルギニル−２，６−ジメチル−ｌ−チロシル−ｌ−リシル−ｌ−フェニルアラニンアミドの製造方法
WO2016004093A2 (en) * 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
US20160228491A1 (en) * 2015-02-09 2016-08-11 Stealth Biotherapeutics Corp Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016209261A1 (en) * 2015-06-26 2016-12-29 Stealth Biotherapeutics Corp Therapeutic compositions including gramicidin s peptidyl conjugates or imidazole-substituted fatty acids, variants thereof, and uses thereof
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
JP7465494B2 (ja) 2015-10-21 2024-04-11 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン ナノ粒子での微小空洞及び虫歯の処置及び検出
CA3006698A1 (en) * 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
US20200032214A1 (en) 2016-11-16 2020-01-30 Luca Science Inc. Method for producing myocardial stem cell used for treatment and/or prevention of cardiac arrest
EP4039250A1 (en) * 2016-12-28 2022-08-10 Chugai Seiyaku Kabushiki Kaisha Self-emulsifying drug formulation for improving membrane permeability of compound
CN107230021B (zh) * 2017-06-08 2020-05-26 桂林理工大学 筛选供水管网泄漏区域的方法
WO2020002765A1 (en) * 2018-06-29 2020-01-02 Glykos Biomedical Oy Conjugates
JP7813464B2 (ja) 2019-12-27 2026-02-13 ルカ・サイエンス株式会社 サイズがより小さい単離されたミトコンドリアおよび単離されたミトコンドリアを内包している脂質膜ベースの小胞
US20230212570A1 (en) * 2020-04-23 2023-07-06 North Carolina State University Cell-penetrating peptide-microrna conjugates for intracellular cell delivery
MX2023002772A (es) 2020-09-09 2024-04-05 Social Profit Network Métodos y composiciones para el suministro de biotina a las mitocondrias.
CN117881411A (zh) 2021-06-01 2024-04-12 艾迪雅生物有限责任公司 用于眼部药物的延长释放药物递送系统和使用方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55500053A (enExample) * 1978-01-16 1980-01-31
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
ES2085865T3 (es) * 1988-06-30 1996-06-16 Astra Ab Analogos de dermorfina, sus metodos de preparacion, composiciones farmaceuticas, y metodos de tratamiento terapeutico que los emplean.
US5670617A (en) * 1989-12-21 1997-09-23 Biogen Inc Nucleic acid conjugates of tat-derived transport polypeptides
US5169934A (en) * 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
NL9001639A (nl) 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
IS4261A (is) 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
DE69630918T2 (de) * 1995-06-09 2004-10-28 Hisamitsu Pharmaceutical Co., Inc., Tosu Matrix für Iontophorese
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
CA2314267A1 (en) 1997-12-10 1999-06-17 Washington University Anti-pathogen system and methods of use thereof
CA2329709A1 (en) * 1998-04-24 1999-11-04 Mitokor Compounds and methods for treating mitochondria-associated diseases
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
SE9900961D0 (sv) 1999-03-16 1999-03-16 Astra Ab Novel compounds
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
ATE432993T1 (de) * 1999-10-04 2009-06-15 Univ New Jersey Med Tar rna bindende peptide
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20050192215A1 (en) * 2000-01-21 2005-09-01 Malabika Ghosh Methods and materials relating to novel polypeptides and polynucleotides
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
ATE496533T1 (de) * 2000-07-18 2011-02-15 Cornell Res Foundation Inc Medizinische verwendung von agonisten des mu- opioid rezeptors
US6900178B2 (en) * 2000-09-12 2005-05-31 University Of Kentucky Research Foundation Protection against ischemia and reperfusion injury
GB0026924D0 (en) * 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
AU2002306500C1 (en) * 2001-02-16 2006-09-28 Cellgate, Inc. Transporters comprising spaced arginine moieties
DE10121982B4 (de) * 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
US20070015146A1 (en) 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
EP3479838A1 (en) 2003-02-04 2019-05-08 Cornell Research Foundation, Inc. Uses of aromatic-cationic peptide
WO2005072295A2 (en) 2004-01-23 2005-08-11 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
EP1625149B1 (en) 2003-05-01 2016-02-17 Cornell Research Foundation, Inc. Method and carrier complexes for delivering molecules to cells
WO2005032481A2 (en) * 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
US20050272101A1 (en) 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
CN103784937B (zh) 2005-09-16 2017-04-26 科内尔研究基金会 用于减少cd36表达的方法
US20070259377A1 (en) 2005-10-11 2007-11-08 Mickey Urdea Diabetes-associated markers and methods of use thereof
US20080027082A1 (en) 2006-06-19 2008-01-31 Berthold Hocher Use of adenosine a1 antagonists in radiocontrast media induced nephropathy
JP5453320B2 (ja) 2008-02-07 2014-03-26 コーネル ユニヴァーシティー インスリン抵抗性を防止または処置するための方法
US8143219B2 (en) 2008-02-26 2012-03-27 Cornell University Methods for prevention and treatment of acute renal injury
WO2020005756A1 (en) 2018-06-29 2020-01-02 Reald Spark, Llc Stabilization for privacy display

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