JP2011168603A5 - - Google Patents

Download PDF

Info

Publication number
JP2011168603A5
JP2011168603A5 JP2011087496A JP2011087496A JP2011168603A5 JP 2011168603 A5 JP2011168603 A5 JP 2011168603A5 JP 2011087496 A JP2011087496 A JP 2011087496A JP 2011087496 A JP2011087496 A JP 2011087496A JP 2011168603 A5 JP2011168603 A5 JP 2011168603A5
Authority
JP
Japan
Prior art keywords
phe
lys
arg
composition
peptide represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011087496A
Other languages
English (en)
Other versions
JP2011168603A (ja
JP5650040B2 (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2011168603A publication Critical patent/JP2011168603A/ja
Publication of JP2011168603A5 publication Critical patent/JP2011168603A5/ja
Application granted granted Critical
Publication of JP5650040B2 publication Critical patent/JP5650040B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Claims (3)

  1. Phe-D-Arg-Phe-Lys-NH 2 なる配列によって表されるペプチド。
  2. Phe-D-Arg-Phe-Lys-NH 2 なる配列によって表されるペプチドを含む組成物。
  3. 製薬的に許容される担体を含む請求項２記載の組成物。
JP2011087496A 2003-05-01 2011-04-11 細胞に分子を送達する方法及び担体複合体 Expired - Lifetime JP5650040B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46751603P 2003-05-01 2003-05-01
US60/467,516 2003-05-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2006532552A Division JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014178031A Division JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体

Publications (3)

Publication Number Publication Date
JP2011168603A JP2011168603A (ja) 2011-09-01
JP2011168603A5 true JP2011168603A5 (ja) 2012-07-12
JP5650040B2 JP5650040B2 (ja) 2015-01-07

Family

ID=33551404

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2006532552A Expired - Lifetime JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体
JP2011087496A Expired - Lifetime JP5650040B2 (ja) 2003-05-01 2011-04-11 細胞に分子を送達する方法及び担体複合体
JP2014178031A Expired - Lifetime JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体
JP2016050272A Expired - Lifetime JP6395749B2 (ja) 2003-05-01 2016-03-14 細胞に分子を送達する方法及び担体複合体
JP2018133252A Expired - Lifetime JP6698756B2 (ja) 2003-05-01 2018-07-13 細胞に分子を送達する方法及び担体複合体
JP2020032792A Pending JP2020105184A (ja) 2003-05-01 2020-02-28 細胞に分子を送達する方法及び担体複合体

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2006532552A Expired - Lifetime JP4879020B2 (ja) 2003-05-01 2004-05-03 細胞に分子を送達する方法及び担体複合体

Family Applications After (4)

Application Number Title Priority Date Filing Date
JP2014178031A Expired - Lifetime JP5995930B2 (ja) 2003-05-01 2014-09-02 細胞に分子を送達する方法及び担体複合体
JP2016050272A Expired - Lifetime JP6395749B2 (ja) 2003-05-01 2016-03-14 細胞に分子を送達する方法及び担体複合体
JP2018133252A Expired - Lifetime JP6698756B2 (ja) 2003-05-01 2018-07-13 細胞に分子を送達する方法及び担体複合体
JP2020032792A Pending JP2020105184A (ja) 2003-05-01 2020-02-28 細胞に分子を送達する方法及び担体複合体

Country Status (18)

Country Link
US (6) US7704954B2 (ja)
EP (7) EP2604287B1 (ja)
JP (6) JP4879020B2 (ja)
KR (1) KR101161823B1 (ja)
CN (2) CN100506841C (ja)
AU (1) AU2004252419B2 (ja)
BR (1) BRPI0409911A (ja)
CA (1) CA2524258C (ja)
DK (4) DK1625149T3 (ja)
ES (3) ES2694574T3 (ja)
HK (6) HK1089450A1 (ja)
MX (1) MXPA05011773A (ja)
NZ (1) NZ543410A (ja)
PL (2) PL2604285T3 (ja)
PT (2) PT2604286E (ja)
SI (1) SI2604285T1 (ja)
WO (1) WO2005001023A2 (ja)
ZA (1) ZA200509229B (ja)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030062788A (ko) * 2002-01-19 2003-07-28 포휴먼텍(주) 생체분자 전달 펩타이드 ｍｐｈ1-ｂｔｍ 및 이것을포함하는 생명공학제품
EP3144009A1 (en) 2003-02-04 2017-03-22 Cornell Research Foundation, Inc. Uses of aromatic-cationic peptide
DK1625149T3 (en) 2003-05-01 2016-05-30 Cornell Res Foundation Inc METHOD AND carrying complexes for delivery of molecules to cells
CA2554166C (en) 2004-01-23 2014-07-29 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
US7534819B2 (en) * 2005-06-10 2009-05-19 University Of Washington Compositions and methods for intracellular delivery of biotinylated cargo
JP5416971B2 (ja) * 2005-09-16 2014-02-12 コーネル リサーチ ファウンデイション インコーポレイテッド Ｃｄ３６の発現を減少させる方法
DE602006016468D1 (de) * 2005-11-04 2010-10-07 Forhumantech Co Ltd Verfahren zur abgabe von fusionspolypeptid in eine zelle
CN101490080A (zh) * 2006-07-24 2009-07-22 为人技术株式会社 用于缓解和治疗缺血性病症的药物组合物及其输送方法
EP2057195A4 (en) * 2006-08-29 2010-05-12 Forhumantech Co Ltd PHARMACEUTICAL COMPOSITION FOR THE SUPPRESSION OF APOPTOSIS AND METHOD OF ADMINISTERING THE SAME
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN101730708B (zh) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 缝合多肽
US7981446B2 (en) * 2007-11-26 2011-07-19 Forhumantech. Co., Ltd. Pharmaceutical compositions and methods for delivering nucleic acids into cells
CN104107417B (zh) 2008-02-07 2017-04-12 康奈尔大学 用于预防或治疗胰岛素抵抗性的方法
CN101951936A (zh) 2008-02-26 2011-01-19 康奈尔大学 用于防止和治疗急性肾损伤的方法
WO2010034034A1 (en) * 2008-09-22 2010-03-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
EP2352507A4 (en) 2008-11-24 2012-04-25 Aileron Therapeutics Inc PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES
DE102008061044A1 (de) * 2008-12-11 2010-06-17 Henkel Ag & Co. Kgaa Zusammensetzung mit antioxidativ wirksamen Peptiden
CN102573881A (zh) 2009-03-20 2012-07-11 通用医疗公司以马萨诸塞州通用医疗公司名义经营 预防和治疗烧伤损伤和继发性并发症的方法
CN102647994A (zh) * 2009-08-12 2012-08-22 康奈尔大学 预防或治疗代谢综合症的方法
EP2470191B1 (en) * 2009-08-24 2014-05-07 Stealth Peptides International, Inc. Methods and compositions for preventing or treating ophthalmic conditions
CN102711785A (zh) * 2009-10-05 2012-10-03 康奈尔大学 预防或治疗心力衰竭的方法
US20110245183A1 (en) * 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
US20110245182A1 (en) * 2010-04-06 2011-10-06 Perricone Nicholas V Topical Uses of Szeto-Schiller Peptides
JP2013532124A (ja) * 2010-05-03 2013-08-15 ステルス ペプチドズ インターナショナル インコーポレイテッド 芳香族系陽イオンペプチド及びその使用
CN102010461B (zh) * 2010-10-11 2014-02-12 华南理工大学 一种alpha螺旋状阳离子多肽分子及其制法和应用
GB201018125D0 (en) 2010-10-26 2010-12-08 Marealis As Peptide
EP2688579A4 (en) * 2011-03-24 2015-10-21 Univ Cornell AROMATIC-CATIONIC PEPTIDES AND USES THEREOF
CA2839408A1 (en) * 2011-06-14 2012-12-20 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
JP6025311B2 (ja) 2011-08-01 2016-11-16 キヤノン株式会社 眼科診断支援装置および方法
JP6157481B2 (ja) 2011-09-29 2017-07-05 メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ 芳香族陽イオン性ペプチドおよびその使用方法
WO2013059071A1 (en) * 2011-10-17 2013-04-25 Cornell University Aromatic-cationic peptides and uses of same
WO2013059525A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
EP3466439A1 (en) * 2011-12-09 2019-04-10 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
CN108912211A (zh) 2012-02-15 2018-11-30 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
SG11201404648PA (en) 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
AU2013245805A1 (en) * 2012-04-12 2014-10-30 Stealth Peptides International, Inc. Aromatic-cationic peptides and uses of same
JP2015529655A (ja) * 2012-08-02 2015-10-08 ステルス ペプチドズ インターナショナル インコーポレイテッド アテローム性硬化症の処置方法
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
WO2014174517A1 (en) 2013-04-25 2014-10-30 Carmel-Haifa University Economic Corp. Synthetic anti-inflammatory peptides and use thereof
JP2017512762A (ja) * 2014-03-03 2017-05-25 ステルス バイオセラピューティックス コープ 薬学的に妥当な芳香族カチオン性ペプチド及びその生成方法
WO2015183988A1 (en) * 2014-05-28 2015-12-03 Stealth Peptides International, Inc. Therapeutic compositions including therapeutic small molecules and uses thereof
EP3148565A4 (en) * 2014-05-28 2018-06-06 Stealth Biotherapeutics Corp Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
PL3160984T3 (pl) 2014-06-25 2021-10-25 Flamma S.P.A. Sposób wytwarzania d-arginylo-2,6-dimetylo-l-tyrozylo-l-lizylol- fenyloalaninoamidu
SI3160985T1 (sl) * 2014-06-30 2021-11-30 Flamma S.P.A. Postopek za pripravo D-arginil-2,6-dimetil-L-tirosil-L-lisil-L- fenilalaninamida
WO2016004093A2 (en) * 2014-07-01 2016-01-07 Stealth Biotherapeutics Corp Therapeutic compositions including galectin-3 inhibitors and uses thereof
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US20160228491A1 (en) * 2015-02-09 2016-08-11 Stealth Biotherapeutics Corp Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
WO2016209261A1 (en) * 2015-06-26 2016-12-29 Stealth Biotherapeutics Corp Therapeutic compositions including gramicidin s peptidyl conjugates or imidazole-substituted fatty acids, variants thereof, and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
BR112018007986A2 (pt) * 2015-10-21 2020-02-18 Poznan Univ Of Medical Sciences detecção e tratamento de cáries e microcavidades com nanopartículas
CA3006698A1 (en) * 2015-11-30 2017-06-08 Peter Schiller Aromatic-cationic peptides conjugated to antioxidants and their use in treating complex regional pain syndrome
US20200032214A1 (en) 2016-11-16 2020-01-30 Luca Science Inc. Method for producing myocardial stem cell used for treatment and/or prevention of cardiac arrest
US20190380958A1 (en) * 2016-12-28 2019-12-19 Chugai Seiyaku Kabushiki Kaisha Self-emulsifying drug formulation for improving membrane permeability of compound
CN107230021B (zh) * 2017-06-08 2020-05-26 桂林理工大学 筛选供水管网泄漏区域的方法
CN112672765A (zh) * 2018-06-29 2021-04-16 格莱科斯生物医药公司 结合物
EP4081192A2 (en) 2019-12-27 2022-11-02 LUCA Science Inc. Isolated mitochondria with smaller size and lipid membrane-based vesicles encapsulating isolated mitochondria
WO2021216499A1 (en) * 2020-04-23 2021-10-28 North Carolina State University Cell-penetrating peptide-microrna conjugates for intracellular cell delivery
GB2614162A (en) 2020-09-09 2023-06-28 Social Profit Network Methods and compositions for delivery of biotin to mitochondria

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2967069D1 (en) * 1978-01-16 1984-08-02 Univ Boston Effecting cellular uptake of molecules
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
EP0350221B1 (en) * 1988-06-30 1996-04-17 Astra Aktiebolag Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same
US5602100A (en) * 1988-06-30 1997-02-11 Astra Ab Dermorphin analogs having pharmacological activity
US5652122A (en) * 1989-12-21 1997-07-29 Frankel; Alan Nucleic acids encoding and methods of making tat-derived transport polypeptides
US5169934A (en) * 1990-05-14 1992-12-08 Anergen, Inc. Intracellularly cleavable compounds
NL9001639A (nl) 1990-07-19 1992-02-17 Amc Amsterdam Pt-houdende verbinding, werkwijze voor de bereiding ervan, alsmede toepassing van dergelijke verbindingen.
US5714327A (en) 1990-07-19 1998-02-03 Kreatech Diagnostics Platinum-containing compounds, methods for their preparation and applications thereof
US5554728A (en) * 1991-07-23 1996-09-10 Nexstar Pharmaceuticals, Inc. Lipid conjugates of therapeutic peptides and protease inhibitors
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5674534A (en) 1992-06-11 1997-10-07 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5716644A (en) 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
IS4261A (is) 1994-02-21 1995-08-22 Astra Aktiebolag Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra
EP0747092B1 (en) * 1995-06-09 2003-12-03 Hisamitsu Pharmaceutical Co., Inc. Matrix for iontophoresis
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US5885958A (en) * 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US5989463A (en) 1997-09-24 1999-11-23 Alkermes Controlled Therapeutics, Inc. Methods for fabricating polymer-based controlled release devices
JP2002505077A (ja) * 1997-12-10 2002-02-19 ワシントン大学 抗病原体システムおよびその使用方法
AU3965699A (en) * 1998-04-24 1999-11-16 Mitokor Compounds and methods for treating mitochondria-associated diseases
US7138103B2 (en) * 1998-06-22 2006-11-21 Immunomedics, Inc. Use of bi-specific antibodies for pre-targeting diagnosis and therapy
US6703381B1 (en) * 1998-08-14 2004-03-09 Nobex Corporation Methods for delivery therapeutic compounds across the blood-brain barrier
US6245740B1 (en) 1998-12-23 2001-06-12 Amgen Inc. Polyol:oil suspensions for the sustained release of proteins
SE9900961D0 (sv) 1999-03-16 1999-03-16 Astra Ab Novel compounds
US6669951B2 (en) * 1999-08-24 2003-12-30 Cellgate, Inc. Compositions and methods for enhancing drug delivery across and into epithelial tissues
JP2003511045A (ja) * 1999-10-04 2003-03-25 ユニバーシティー オブ メディシン アンド デンティストリー オブ ニュー ジャージー Ｒｎａ結合化合物の同定方法
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
US20050192215A1 (en) * 2000-01-21 2005-09-01 Malabika Ghosh Methods and materials relating to novel polypeptides and polynucleotides
GB0005703D0 (en) * 2000-03-09 2000-05-03 Alpharma As Compounds
AU2001277908A1 (en) * 2000-07-18 2002-01-30 Cornell Research Foundation Inc. Medicinal uses of mu-opioid receptor agonists
US6900178B2 (en) * 2000-09-12 2005-05-31 University Of Kentucky Research Foundation Protection against ischemia and reperfusion injury
GB0026924D0 (en) * 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
DE60233137D1 (de) * 2001-02-16 2009-09-10 Univ R Transporter mit beabstandeten arginin-teilchen
DE10121982B4 (de) * 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanopartikel aus Protein mit gekoppeltem Apolipoprotein E zur Überwindung der Blut-Hirn-Schranke und Verfahren zu ihrer Herstellung
US20070015146A1 (en) 2001-05-22 2007-01-18 Gene Logic, Inc. Molecular nephrotoxicology modeling
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
EP3144009A1 (en) * 2003-02-04 2017-03-22 Cornell Research Foundation, Inc. Uses of aromatic-cationic peptide
DK1625149T3 (en) * 2003-05-01 2016-05-30 Cornell Res Foundation Inc METHOD AND carrying complexes for delivery of molecules to cells
WO2005032481A2 (en) * 2003-09-30 2005-04-14 Scios Inc. Quinazoline derivatives as medicaments
CA2554166C (en) 2004-01-23 2014-07-29 Cornell Research Foundation, Inc. Methods for reducing oxidative damage
US20050272101A1 (en) 2004-06-07 2005-12-08 Prasad Devarajan Method for the early detection of renal injury
JP5416971B2 (ja) 2005-09-16 2014-02-12 コーネル リサーチ ファウンデイション インコーポレイテッド Ｃｄ３６の発現を減少させる方法
US20070259377A1 (en) 2005-10-11 2007-11-08 Mickey Urdea Diabetes-associated markers and methods of use thereof
US20080027082A1 (en) 2006-06-19 2008-01-31 Berthold Hocher Use of adenosine a1 antagonists in radiocontrast media induced nephropathy
CN104107417B (zh) 2008-02-07 2017-04-12 康奈尔大学 用于预防或治疗胰岛素抵抗性的方法
CN101951936A (zh) 2008-02-26 2011-01-19 康奈尔大学 用于防止和治疗急性肾损伤的方法
WO2020005756A1 (en) 2018-06-29 2020-01-02 Reald Spark, Llc Stabilization for privacy display

Similar Documents

Publication Publication Date Title
JP2011168603A5 (ja)
JP2012081521A5 (ja)
JP2013525942A5 (ja)
JP2011170856A5 (ja)
MX2013012542A (es) Compuestos de amida y aplicacion farmaceutica para el mismo.
JP2011105738A5 (ja)
JP2015501646A5 (ja)
JP2013532130A5 (ja)
JP2013543797A5 (ja)
ITAN20120150A1 (it) Servomeccanismo per l'apertura di una serratura.
EA201370149A1 (ru) Антагонисты рецептора
FI20116212A (fi) Polypeptidi
JP2012044147A5 (ja)
JP2011170857A5 (ja)
JP2011181497A5 (ja)
EP2668951A4 (en) 1,2,4-OXADIAZOL DERIVATIVES AS MODULATOR RECEPTOR MEDICINES FOR GLP-1 PEPTIDE
DK2785675T5 (da) 5,5-dimethyl-2-propyl-hexahydro-2,4a-methanonaphthalen-1-on som duftmiddel
IT1404107B1 (it) Portamenu'.
ITMI20111829A1 (it) Procedimento per la preparazione di una composizione a base di equolo
CA2735430A1 (en) Straight-n-go
TH117776B (th) ชิ้นส่วนก่อสร้าง
TH122029B (th) ด้ามแปรงสีฟัน
TH120671B (th) ด้ามแปรงสีฟัน
TH117781B (th) ชิ้นส่วนก่อสร้าง
TH117782B (th) ชิ้นส่วนก่อสร้าง